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Drug: Acetylcysteine
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Total 2370 results found since Jan 2013.
Metabolism, Pharmacokinetics and Excretion of < sup > 14 < /sup > CDimethyl Fumarate in Healthy Volunteers: An Example of Xenobiotic Biotransformation Following Endogenous Metabolic Pathways
Xenobiotica. 2023 May 22:1-28. doi: 10.1080/00498254.2023.2217506. Online ahead of print.ABSTRACTDelayed-release dimethyl fumarate (DMF), Tecfidera®, is approved globally for treating relapsing-remitting multiple sclerosis. The disposition of DMF was determined in humans after administration of a single oral dose of [14C]DMF, and the total recovery was estimated to be between 58.4% to 75.0%, primarily through expired air.The absorption of [14C]DMF-derived radioactivity was rapid, with Tmax at 1h postdose. Glucose was the predominant circulating metabolite, accounting for ∼60% of the total extractable radioactivity. Cyst...
Source: Xenobiotica - May 22, 2023 Category: Research Authors: Lin Xu Chi-Chi Peng Kate Dawson Scott Stecher James Woodworth Chandra Prakash Source Type: research
Metabolism, pharmacokinetics and excretion of < sup > 14 < /sup > Cdimethyl fumarate in healthy volunteers: an example of xenobiotic biotransformation following endogenous metabolic pathways
Xenobiotica. 2023 Jun 1:1-10. doi: 10.1080/00498254.2023.2217506. Online ahead of print.ABSTRACTDelayed-release dimethyl fumarate (DMF), Tecfidera®, is approved globally for treating relapsing-remitting multiple sclerosis. The disposition of DMF was determined in humans after administration of a single oral dose of [14C]DMF, and the total recovery was estimated to be between 58.4% to 75.0%, primarily through expired air.The absorption of [14C]DMF-derived radioactivity was rapid, with Tmax at 1h postdose. Glucose was the predominant circulating metabolite, accounting for ∼60% of the total extractable radioactivity. Cyste...
Source: Xenobiotica - May 22, 2023 Category: Research Authors: Lin Xu Chi-Chi Peng Kate Dawson Scott Stecher James Woodworth Chandra Prakash Source Type: research
Metabolism, Pharmacokinetics and Excretion of < sup > 14 < /sup > CDimethyl Fumarate in Healthy Volunteers: An Example of Xenobiotic Biotransformation Following Endogenous Metabolic Pathways
Xenobiotica. 2023 May 22:1-28. doi: 10.1080/00498254.2023.2217506. Online ahead of print.ABSTRACTDelayed-release dimethyl fumarate (DMF), Tecfidera®, is approved globally for treating relapsing-remitting multiple sclerosis. The disposition of DMF was determined in humans after administration of a single oral dose of [14C]DMF, and the total recovery was estimated to be between 58.4% to 75.0%, primarily through expired air.The absorption of [14C]DMF-derived radioactivity was rapid, with Tmax at 1h postdose. Glucose was the predominant circulating metabolite, accounting for ∼60% of the total extractable radioactivity. Cyst...
Source: Xenobiotica - May 22, 2023 Category: Research Authors: Lin Xu Chi-Chi Peng Kate Dawson Scott Stecher James Woodworth Chandra Prakash Source Type: research
Metabolism, pharmacokinetics and excretion of < sup > 14 < /sup > Cdimethyl fumarate in healthy volunteers: an example of xenobiotic biotransformation following endogenous metabolic pathways
Xenobiotica. 2023 Jun 1:1-10. doi: 10.1080/00498254.2023.2217506. Online ahead of print.ABSTRACTDelayed-release dimethyl fumarate (DMF), Tecfidera®, is approved globally for treating relapsing-remitting multiple sclerosis. The disposition of DMF was determined in humans after administration of a single oral dose of [14C]DMF, and the total recovery was estimated to be between 58.4% to 75.0%, primarily through expired air.The absorption of [14C]DMF-derived radioactivity was rapid, with Tmax at 1h postdose. Glucose was the predominant circulating metabolite, accounting for ∼60% of the total extractable radioactivity. Cyste...
Source: Xenobiotica - May 22, 2023 Category: Research Authors: Lin Xu Chi-Chi Peng Kate Dawson Scott Stecher James Woodworth Chandra Prakash Source Type: research
Metabolism, Pharmacokinetics and Excretion of < sup > 14 < /sup > CDimethyl Fumarate in Healthy Volunteers: An Example of Xenobiotic Biotransformation Following Endogenous Metabolic Pathways
Xenobiotica. 2023 May 22:1-28. doi: 10.1080/00498254.2023.2217506. Online ahead of print.ABSTRACTDelayed-release dimethyl fumarate (DMF), Tecfidera®, is approved globally for treating relapsing-remitting multiple sclerosis. The disposition of DMF was determined in humans after administration of a single oral dose of [14C]DMF, and the total recovery was estimated to be between 58.4% to 75.0%, primarily through expired air.The absorption of [14C]DMF-derived radioactivity was rapid, with Tmax at 1h postdose. Glucose was the predominant circulating metabolite, accounting for ∼60% of the total extractable radioactivity. Cyst...
Source: Xenobiotica - May 22, 2023 Category: Research Authors: Lin Xu Chi-Chi Peng Kate Dawson Scott Stecher James Woodworth Chandra Prakash Source Type: research
Role of ferroptosis in the pathogenesis and as a therapeutic target of inflammatory bowel disease (Review)
Int J Mol Med. 2023 Jun;51(6):53. doi: 10.3892/ijmm.2023.5256. Epub 2023 May 19.ABSTRACTFerroptosis, a novel form of regulated cell death, is characterized by the accumulation of labile iron and lipid peroxidation, and the excessive production of reactive oxygen species (ROS). Although ferroptosis lies at the center of crucial biological activities involving O2, iron and polyunsaturated fatty acids (PUFAs), which are essential for cell proliferation and growth, the interaction between these molecules could also mediate the accumulation of toxic levels of ROS and lipid peroxides, which can then cause damage to cellular memb...
Source: Molecular Medicine - May 19, 2023 Category: Molecular Biology Authors: Dickson Kofi Wiredu Ocansey Jintao Yuan Zhiping Wei Fei Mao Zhaoyang Zhang Source Type: research
Rationale and evidence for the adjunctive use of N-acetylcysteine in multidrug-resistant infections
Eur Rev Med Pharmacol Sci. 2023 May;27(9):4316-4325. doi: 10.26355/eurrev_202305_32342.ABSTRACTBacterial multidrug resistance has been a serious issue for healthcare systems in recent decades, responsible for many infections and deaths. Due to the increasing incidence of antimicrobial resistance and scarce treatment options, research is focused on finding possible therapeutic adjuvants able to increase the efficacy of antibiotics. The aim of this article is a review of available evidence on the use of N-acetylcysteine (NAC). MEDLINE/PubMed was searched for appropriate keywords. In vitro and in vivo preclinical studies, cli...
Source: Pharmacological Reviews - May 19, 2023 Category: Drugs & Pharmacology Authors: A Oliva L Pallecchi G M Rossolini F Travaglino P Zanatta Source Type: research
Role of ferroptosis in the pathogenesis and as a therapeutic target of inflammatory bowel disease (Review)
Int J Mol Med. 2023 Jun;51(6):53. doi: 10.3892/ijmm.2023.5256. Epub 2023 May 19.ABSTRACTFerroptosis, a novel form of regulated cell death, is characterized by the accumulation of labile iron and lipid peroxidation, and the excessive production of reactive oxygen species (ROS). Although ferroptosis lies at the center of crucial biological activities involving O2, iron and polyunsaturated fatty acids (PUFAs), which are essential for cell proliferation and growth, the interaction between these molecules could also mediate the accumulation of toxic levels of ROS and lipid peroxides, which can then cause damage to cellular memb...
Source: International Journal of Molecular Medicine - May 19, 2023 Category: Molecular Biology Authors: Dickson Kofi Wiredu Ocansey Jintao Yuan Zhiping Wei Fei Mao Zhaoyang Zhang Source Type: research
1-Nitropyrene disrupts testicular steroidogenesis via oxidative stress-evoked PERK-eIF2 α pathway
Ecotoxicol Environ Saf. 2023 May 17;259:115027. doi: 10.1016/j.ecoenv.2023.115027. Online ahead of print.ABSTRACTOur previous study showed 1-Nitropyrene (1-NP) exposure disrupted testicular testosterone synthesis in mouse, but the exact mechanism needs further investigation. The present research found 4-phenylbutyric acid (4-PBA), an endoplasmic reticulum (ER) stress inhibitor, recovered 1-NP-induced ER stress and testosterone synthases reduction in TM3 cells. GSK2606414, a protein kinase-like ER kinase (PERK) kinase inhibitor, attenuated 1-NP-induced PERK-eukaryotic translation initiation factor 2α (eIF2α) signaling act...
Source: Ecotoxicology and Environmental Safety - May 19, 2023 Category: Environmental Health Authors: Xiu-Liang Li Yu-Lin Liu Jia-Yu Liu Yan-Yan Zhu Xin-Xin Zhu Wei-Wei Zhang Jian Li Ye Zhao Ling-Li Zhao Cheng Zhang Hua Wang De-Xiang Xu Lan Gao Source Type: research
