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Drug: Acetylcysteine
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Total 2370 results found since Jan 2013.
N-acetylcysteine ameliorates erectile dysfunction in rats with hyperlipidemia by inhibiting oxidative stress and corpus cavernosum smooth muscle cells phenotypic modulation
This report focuses on the therapeutic effect of NAC in restoring erectile function using a hyperlipidemic rat model by preventing CCSMC phenotypic modulation and attenuating oxidative stress.PMID:37534881 | DOI:10.4103/aja202324
Source: Asian Journal of Andrology - August 3, 2023 Category: Urology & Nephrology Authors: Wei Ding Jun-Hong Fan Li-Ren Zhong Nan-Xiong Wang Lu-Hao Liu Hai-Bo Zhang Li Wang Ming-Qiang Wang Bing-Lin He An-Yang Wei Source Type: research
Organogold(III)-dithiocarbamate compounds and their coordination analogues as anti-tumor and anti-leishmanial metallodrugs
J Inorg Biochem. 2023 Jul 29;247:112346. doi: 10.1016/j.jinorgbio.2023.112346. Online ahead of print.ABSTRACTThe limited chemical stability of gold(III)-based compounds in physiological environment has been a challenge in drug discovery, and organometallic chemistry might provide the solution to overcome this issue. In this work, four novel cationic organogold(III)-dithiocarbamate complexes of general structure [(C^N)AuIIIDTC]PF6 (C1a - C4a, DTC = dithiocarbamate, L1 - L4, C^N = 2-anilinopyridine) are presented, and compared to their coordination gold(III)-dithiocarbamate analogues [AuIIIDTCCl2] (C1b - C4b), as potential a...
Source: Journal of Inorganic Biochemistry - August 3, 2023 Category: Biochemistry Authors: Ana Luiza de Andrade Querino Alessandra Mara de Sousa Sophie R Thomas Geraldo Magela de Lima Dalton Dittz Angela Casini Rubens Lima do Monte-Neto Heveline Silva Source Type: research
N-acetylcysteine ameliorates erectile dysfunction in rats with hyperlipidemia by inhibiting oxidative stress and corpus cavernosum smooth muscle cells phenotypic modulation
This report focuses on the therapeutic effect of NAC in restoring erectile function using a hyperlipidemic rat model by preventing CCSMC phenotypic modulation and attenuating oxidative stress.PMID:37534881 | DOI:10.4103/aja202324
Source: Asian Journal of Andrology - August 3, 2023 Category: Urology & Nephrology Authors: Wei Ding Jun-Hong Fan Li-Ren Zhong Nan-Xiong Wang Lu-Hao Liu Hai-Bo Zhang Li Wang Ming-Qiang Wang Bing-Lin He An-Yang Wei Source Type: research
N-Acetylcysteine amide (NACA) and dinaca inhibit H < sub > 2 < /sub > O < sub > 2 < /sub > -INDUCED cataract formation ex VIVO IN pig and rat lenses
Exp Eye Res. 2023 Aug 1:109610. doi: 10.1016/j.exer.2023.109610. Online ahead of print.ABSTRACTOxidative stress plays a central role in cataract formation suggesting that antioxidants might slow cataract progression. The anticataract activity of N-acetylcysteine amide (NACA) and (2 R, 2 R')-3,3'-disulfanediyl bis(2-acetamidopropanamide) (diNACA) and/or N-acetylcysteine (NAC), were evaluated in porcine and rat lens models. Cataractogenesis via oxidation was induced with H2O2 and/or glucose oxidase (GO). Porcine lenses were incubated in 0.1 mM, 1 mM, or 10 mM NAC, NACA or diNACA for 24 h. Lenses were then transferred to medi...
Source: Experimental Eye Research - August 3, 2023 Category: Opthalmology Authors: R M Martis A C Grey H Wu G M Wall P J Donaldson J C Lim Source Type: research
N-acetylcysteine ameliorates erectile dysfunction in rats with hyperlipidemia by inhibiting oxidative stress and corpus cavernosum smooth muscle cells phenotypic modulation
This report focuses on the therapeutic effect of NAC in restoring erectile function using a hyperlipidemic rat model by preventing CCSMC phenotypic modulation and attenuating oxidative stress.PMID:37534881 | DOI:10.4103/aja202324
Source: Asian Journal of Andrology - August 3, 2023 Category: Urology & Nephrology Authors: Wei Ding Jun-Hong Fan Li-Ren Zhong Nan-Xiong Wang Lu-Hao Liu Hai-Bo Zhang Li Wang Ming-Qiang Wang Bing-Lin He An-Yang Wei Source Type: research
Ticlopidine induces embryonic development toxicity and hepatotoxicity in zebrafish by upregulating the oxidative stress signaling pathway
In conclusion, ticlopidine might inhibit normal development and liver proliferation in zebrafish by upregulation of oxidative stress levels, thus leading to embryonic developmental toxicity and hepatotoxicity. In this study, we used zebrafish as a model organism to elucidate the developmental toxicity and hepatotoxicity induced by ticlopidine upregulation of oxidative stress signaling pathway in zebrafish, providing a theoretical basis for clinical application.PMID:37531924 | DOI:10.1016/j.ecoenv.2023.115283
Source: Ecotoxicology and Environmental Safety - August 2, 2023 Category: Environmental Health Authors: Rong Xu Pengxiang Xu Haiyan Wei Yong Huang Xiaodan Zhu Chuanming Lin Zhimin Yan Liuyan Xin Lin Li Weiming Lv Shuqin Zeng Guiyou Tian Jinze Ma Bo Cheng Huiqiang Lu Yijian Chen Source Type: research
Use of thiols and implications for the use of inhaled corticosteroids in the presence of oxidative stress in COPD
CONCLUSIONS: Further clinical trials of antioxidant agents with and without ICS are needed to better understand the place of thiol-based drugs in the treatment of patients with COPD.PMID:37517999 | DOI:10.1186/s12931-023-02500-8
Source: Respiratory Care - July 30, 2023 Category: Respiratory Medicine Authors: Mario Cazzola Clive P Page Jadwiga A Wedzicha Bartolome R Celli Antonio Anzueto Maria Gabriella Matera Source Type: research
