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Drug: Acetylcysteine
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Total 2370 results found since Jan 2013.
Role of ferroptosis in the pathogenesis and as a therapeutic target of inflammatory bowel disease (Review)
Int J Mol Med. 2023 Jun;51(6):53. doi: 10.3892/ijmm.2023.5256. Epub 2023 May 19.ABSTRACTFerroptosis, a novel form of regulated cell death, is characterized by the accumulation of labile iron and lipid peroxidation, and the excessive production of reactive oxygen species (ROS). Although ferroptosis lies at the center of crucial biological activities involving O2, iron and polyunsaturated fatty acids (PUFAs), which are essential for cell proliferation and growth, the interaction between these molecules could also mediate the accumulation of toxic levels of ROS and lipid peroxides, which can then cause damage to cellular memb...
Source: International Journal of Molecular Medicine - May 19, 2023 Category: Molecular Biology Authors: Dickson Kofi Wiredu Ocansey Jintao Yuan Zhiping Wei Fei Mao Zhaoyang Zhang Source Type: research
Rationale and evidence for the adjunctive use of N-acetylcysteine in multidrug-resistant infections
Eur Rev Med Pharmacol Sci. 2023 May;27(9):4316-4325. doi: 10.26355/eurrev_202305_32342.ABSTRACTBacterial multidrug resistance has been a serious issue for healthcare systems in recent decades, responsible for many infections and deaths. Due to the increasing incidence of antimicrobial resistance and scarce treatment options, research is focused on finding possible therapeutic adjuvants able to increase the efficacy of antibiotics. The aim of this article is a review of available evidence on the use of N-acetylcysteine (NAC). MEDLINE/PubMed was searched for appropriate keywords. In vitro and in vivo preclinical studies, cli...
Source: Pharmacological Reviews - May 19, 2023 Category: Drugs & Pharmacology Authors: A Oliva L Pallecchi G M Rossolini F Travaglino P Zanatta Source Type: research
Role of ferroptosis in the pathogenesis and as a therapeutic target of inflammatory bowel disease (Review)
Int J Mol Med. 2023 Jun;51(6):53. doi: 10.3892/ijmm.2023.5256. Epub 2023 May 19.ABSTRACTFerroptosis, a novel form of regulated cell death, is characterized by the accumulation of labile iron and lipid peroxidation, and the excessive production of reactive oxygen species (ROS). Although ferroptosis lies at the center of crucial biological activities involving O2, iron and polyunsaturated fatty acids (PUFAs), which are essential for cell proliferation and growth, the interaction between these molecules could also mediate the accumulation of toxic levels of ROS and lipid peroxides, which can then cause damage to cellular memb...
Source: Molecular Medicine - May 19, 2023 Category: Molecular Biology Authors: Dickson Kofi Wiredu Ocansey Jintao Yuan Zhiping Wei Fei Mao Zhaoyang Zhang Source Type: research
Rationale and evidence for the adjunctive use of N-acetylcysteine in multidrug-resistant infections
Eur Rev Med Pharmacol Sci. 2023 May;27(9):4316-4325. doi: 10.26355/eurrev_202305_32342.ABSTRACTBacterial multidrug resistance has been a serious issue for healthcare systems in recent decades, responsible for many infections and deaths. Due to the increasing incidence of antimicrobial resistance and scarce treatment options, research is focused on finding possible therapeutic adjuvants able to increase the efficacy of antibiotics. The aim of this article is a review of available evidence on the use of N-acetylcysteine (NAC). MEDLINE/PubMed was searched for appropriate keywords. In vitro and in vivo preclinical studies, cli...
Source: Pharmacological Reviews - May 19, 2023 Category: Drugs & Pharmacology Authors: A Oliva L Pallecchi G M Rossolini F Travaglino P Zanatta Source Type: research
Role of ferroptosis in the pathogenesis and as a therapeutic target of inflammatory bowel disease (Review)
Int J Mol Med. 2023 Jun;51(6):53. doi: 10.3892/ijmm.2023.5256. Epub 2023 May 19.ABSTRACTFerroptosis, a novel form of regulated cell death, is characterized by the accumulation of labile iron and lipid peroxidation, and the excessive production of reactive oxygen species (ROS). Although ferroptosis lies at the center of crucial biological activities involving O2, iron and polyunsaturated fatty acids (PUFAs), which are essential for cell proliferation and growth, the interaction between these molecules could also mediate the accumulation of toxic levels of ROS and lipid peroxides, which can then cause damage to cellular memb...
Source: International Journal of Molecular Medicine - May 19, 2023 Category: Molecular Biology Authors: Dickson Kofi Wiredu Ocansey Jintao Yuan Zhiping Wei Fei Mao Zhaoyang Zhang Source Type: research
NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF- κB and TGF-β/Smad signaling pathways in diabetic nephropathy
CONCLUSIONS: These data suggest that NQO1 alleviates diabetes-induced renal inflammation and fibrosis by regulating the TLR4/NF-κB and TGF-β/Smad signaling pathways.PMID:37196773 | DOI:10.1016/j.cellsig.2023.110712
Source: Cellular Signalling - May 17, 2023 Category: Cytology Authors: Duojun Qiu Shan Song Ning Chen Yawei Bian Chen Yuan Wei Zhang Huijun Duan Yonghong Shi Source Type: research
Combination treatment of cordycepin and radiation induces MA-10 mouse Leydig tumor cell death via ROS accumulation and DNA damage
Am J Cancer Res. 2023 Apr 15;13(4):1329-1346. eCollection 2023.ABSTRACTLeydig cell tumor is the most frequent non-germ cell tumors of testis. The biggest challenge of using radiotherapy to treat testicular cancer is in effectively killing cancer cells and maintaining reproductive function after treatment. Our recently published article showed that cordycepin could enhance radiosensitivity to induce mouse Leydig tumor cell apoptosis by inducing cell cycle arrest, caspase pathway and endoplasmic reticulum (ER) stress. In the present study, the potency and mechanism of a previous combination treatment protocol on reactive oxy...
Source: Cell Research - May 11, 2023 Category: Cytology Authors: Yi-Ping Lee Chin-Ru Lin Sih-Shang Chen Rong-Jane Chen Yuan-Hua Wu Ying-Hui Chen Bu-Miin Huang Source Type: research
Engineered lipid liquid crystalline nanoparticles as an inhaled nanoplatform for mucus penetration enhancement
In this study, a lipid liquid crystalline nanoparticle NLP@Z with surface zwitterion material hexadecyl betaine (HB) modification and N-acetylcysteine (NAC) encapsulation was presented to exert the combination strategy of mucus-inert surface and mucus degradation. The HB modification endowed NLP@Z mucus-inert surface to inhibit the interaction between NLP@Z and mucins, and the encapsulated NAC could effectively degrade the mucins and further decrease the mucus viscosity. This combination strategy was proved to significantly promote the mucus penetration performance and enhance epithelial cell uptake. In addition, the propo...
Source: Cell Research - May 8, 2023 Category: Cytology Authors: Wenhao Wang Jingxuan Zeng Peili Luo Jiayi Fang Qingao Pei Jinwu Yan Chune Zhu Wei Chen Yanyun Liu Zhengwei Huang Ying Huang Chuanbin Wu Xin Pan Source Type: research
ROS inhibition increases KDM6A-mediated NOX2 transcription and promotes macrophages oxidative stress and M1 polarization
In this study, lipopolysaccharide (LPS) was used to stimulate macrophages to increase the ROS in cells, and N-acetylcysteine (NAC) was used to reduce ROS. Inflammatory factors such as interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α) were used to evaluate the M1 polarization level of macrophages. Chip was used to detect the tri-methylation at lysine 27 of histone H3 (H3K27me3) level at the promoter site. It was found that the decrease of ROS in macrophages would also cause the increase of the H3K27me3 demethylase KDM6A and lead to the reduction of H3K27me3 in the NOX2 promoter, which wou...
Source: Cell Stress and Chaperones - May 4, 2023 Category: Cytology Authors: Yunxi Zhao Luyang Wang Mingwei Liu Anning Du Ming Qiu Huanyu Shu Lu Li Xiangqing Kong Wei Sun Source Type: research
