Enhanced glycolysis by ATPIF1 gene inactivation increased the anti-bacterial activities of neutrophils through induction of ROS and lactic acid

This study suggests that the inactivation of the Atpif1 gene enhances glucose metabolism in neutrophils, resulting in increased bactericidal activity mediated by elevated levels of ROS and LA. Inhibiting ATPIF1 may be a potential approach to enhance antibacterial immunity.PMID:37558010 | DOI:10.1016/j.bbadis.2023.166820

Source: Biochimica et Biophysica Acta - August 9, 2023 Category: Biochemistry Authors: Genshen Zhong Ying Guo Xue Gong Meiqi Xu Qi Wang Minna Wu Xiaoying Zhang Yinming Liang Weidong Zhao Hui Wang Jianping Ye Source Type: research