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Drug: Acetylcysteine
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Total 2370 results found since Jan 2013.
Selenium-dependent glutathione peroxidase 1 regulates transcription of elongase 3 in murine tissues
This study explored underlying mechanisms of GPX1 in regulating tissue fatty acid (FA) biosynthesis. GPX1 OE, KO, and wild-type (WT) mice (n = 5, male, 3-6 months old) were fed a Se-adequate diet (0.3 mg/kg) and assayed for liver and adipose tissue FA profiles and mRNA levels of key enzymes of FA biosynthesis and redox-responsive transcriptional factors (TFs). These three genotypes of mice (n = 5) were injected intraperitoneally with diquat, ebselen, and N-acetylcysteine (NAC) at 10, 50, and 50 mg/kg of body weight, respectively, and killed at 0 and 12 h after the injections to detect mRNA levels of FA elongases and desatu...
Source: Free Radical Biology and Medicine - September 19, 2023 Category: Biology Authors: Ziqiao Sun Kun Wu Chenhan Feng Xin Gen Lei Source Type: research
ACA-28, an anticancer compound, induces Pap1 nuclear accumulation via ROS-dependent and -independent mechanisms in fission yeast
MicroPubl Biol. 2023 Aug 31;2023. doi: 10.17912/micropub.biology.000711. eCollection 2023.ABSTRACTThe nucleocytoplasmic transport of proteins is an important mechanism to control cell fate. Pap1 is a fission yeast nucleocytoplasmic shuttling transcription factor of which localization is redox regulated. The nuclear export factor Crm1/exportin negatively regulates Pap1 by exporting it from the nucleus to the cytoplasm. Here, we describe the effect of an anti-cancer compound ACA-28, an improved derivative of 1'-acetoxychavicol acetate (ACA), on the subcellular distribution of Pap1. ACA-28 induced nuclear accumulation of Pap1...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Teruaki Takasaki Reo Obana Daiki Fujiwara Naofumi Tomimoto Golam Iftakhar Khandakar Ryosuke Satoh Reiko Sugiura Source Type: research
Reactive Oxygen Species-Mediated Mitophagy and Cell Apoptosis are Involved in the Toxicity of Aluminum Chloride Exposure in GC-2spd
This study aimed to examine the impact of AlCl3 exposure on mitophagy and mitochondrial apoptosis in testicular tissue and mouse spermatocytes. Reactive oxygen species (ROS) and ATP levels were measured in GC-2spd after AlCl3 exposure using a multifunctional enzyme labeler. The changes in mitochondrial membrane potential (MMP) and TUNEL were observed through confocal laser microscopy, and the expression of proteins associated with mitophagy and apoptosis was analyzed using Western blot. Our results demonstrated that AlCl3 exposure disrupted mitophagy and increased apoptosis-related protein expression in testicular tissues....
Source: Biological Trace Element Research - September 15, 2023 Category: Biology Authors: Hui- Xin Peng Fu Chai Ke-Heng Chen Yan-Xin Huang Guang-Ji Wei Huixiong Yuan Yan-Fang Pang Shi-Hua Luo Chun-Fang Wang Wen-Cheng Chen Source Type: research
Chronic exposure to low-dose deltamethrin can lead to colon tissue injury through PRDX1 inactivation-induced mitochondrial oxidative stress injury and gut microbial dysbiosis
CONCLUSION: Chronic exposure to DLM, even at small doses, can cause damage to the colon tissue, which cannot be ignored. The production and use of pesticides such as DLM should be strictly regulated during agricultural production.PMID:37714033 | DOI:10.1016/j.ecoenv.2023.115475
Source: Ecotoxicology and Environmental Safety - September 15, 2023 Category: Environmental Health Authors: Rulan Ma Tuanhe Sun Xueni Wang Kaijie Ren Tianhao Min Xin Xie Dangdang Wang Kang Li Yong Zhang Kun Zhu Caijing Mo Chengxue Dang Yong Yang Hao Zhang Source Type: research
Reactive Oxygen Species-Mediated Mitophagy and Cell Apoptosis are Involved in the Toxicity of Aluminum Chloride Exposure in GC-2spd
This study aimed to examine the impact of AlCl3 exposure on mitophagy and mitochondrial apoptosis in testicular tissue and mouse spermatocytes. Reactive oxygen species (ROS) and ATP levels were measured in GC-2spd after AlCl3 exposure using a multifunctional enzyme labeler. The changes in mitochondrial membrane potential (MMP) and TUNEL were observed through confocal laser microscopy, and the expression of proteins associated with mitophagy and apoptosis was analyzed using Western blot. Our results demonstrated that AlCl3 exposure disrupted mitophagy and increased apoptosis-related protein expression in testicular tissues....
Source: Biological Trace Element Research - September 15, 2023 Category: Biology Authors: Hui- Xin Peng Fu Chai Ke-Heng Chen Yan-Xin Huang Guang-Ji Wei Huixiong Yuan Yan-Fang Pang Shi-Hua Luo Chun-Fang Wang Wen-Cheng Chen Source Type: research
Chronic exposure to low-dose deltamethrin can lead to colon tissue injury through PRDX1 inactivation-induced mitochondrial oxidative stress injury and gut microbial dysbiosis
CONCLUSION: Chronic exposure to DLM, even at small doses, can cause damage to the colon tissue, which cannot be ignored. The production and use of pesticides such as DLM should be strictly regulated during agricultural production.PMID:37714033 | DOI:10.1016/j.ecoenv.2023.115475
Source: Ecotoxicology and Environmental Safety - September 15, 2023 Category: Environmental Health Authors: Rulan Ma Tuanhe Sun Xueni Wang Kaijie Ren Tianhao Min Xin Xie Dangdang Wang Kang Li Yong Zhang Kun Zhu Caijing Mo Chengxue Dang Yong Yang Hao Zhang Source Type: research
Acid sphingomyelinase mediates ferroptosis induced by high glucose via autophagic degradation of GPX4 in type 2 diabetic osteoporosis
CONCLUSION: ASM-mediated autophagy activation induces osteoblast ferroptosis under HG conditions through the degradation of GPX4, providing a novel mechanistic insight into the treatment and prevention of T2DOP.PMID:37710183 | DOI:10.1186/s10020-023-00724-4
Source: Molecular Medicine - September 14, 2023 Category: Molecular Biology Authors: Yun-Xia Du Yan-Tao Zhao Yong-Xin Sun Ai-Hua Xu Source Type: research
2023 Canadian Thoracic Society Guideline on Pharmacotherapy in Patients With Stable COPD
Chest. 2023 Sep 6:S0012-3692(23)05275-3. doi: 10.1016/j.chest.2023.08.014. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease patient care must include confirming a diagnosis with postbronchodilator spirometry. Because of the clinical heterogeneity and the reality that airflow obstruction assessed by spirometry only partially reflects disease severity, a thorough clinical evaluation of the patient should include assessment of symptom burden and risk of exacerbations that permits the implementation of evidence-informed pharmacologic and nonpharmacologic interventions. This guideline provides recommendations...
Source: Chest - September 10, 2023 Category: Respiratory Medicine Authors: Jean Bourbeau Mohit Bhutani Paul Hernandez Shawn D Aaron Marie-France Beauchesne Sophie B Kermelly Anthony D'Urzo Avtar Lal Fran çois Maltais Jeffrey D Marciniuk Sunita Mulpuru Erika Penz Don D Sin Anne Van Dam Joshua Wald Brandie L Walker Darcy D Marcin Source Type: research
Structure-guided approach to modify the substrate specificity of the protein human deglycase-1 (hDJ-1)
Biochem Biophys Res Commun. 2023 Sep 1;679:122-128. doi: 10.1016/j.bbrc.2023.08.058. Online ahead of print.ABSTRACTGlycation is a non-enzymatic reaction wherein sugars or dicarbonyls such as methylglyoxal (MGO) and glyoxal (GO) react with proteins, leading to protein inactivation. The hydrolysing enzyme human deglycase-1 (hDJ-1) is reported to decrease glycative stress by deglycating the modified proteins, specifically at cysteine, lysine, and arginine sites. This specificity of hDJ-1 is thought to be regulated by its active site cysteine residue (Cys106). Structural analysis of hDJ-1 by molecular docking and simulation st...
Source: Biochemical and Biophysical Research communications - September 9, 2023 Category: Biochemistry Authors: Sera A Fernandes Subrata Dasgupta Rashmi S Tupe Ejaj K Pathan Source Type: research
