Acid sphingomyelinase mediates ferroptosis induced by high glucose via autophagic degradation of GPX4 in type 2 diabetic osteoporosis

CONCLUSION: ASM-mediated autophagy activation induces osteoblast ferroptosis under HG conditions through the degradation of GPX4, providing a novel mechanistic insight into the treatment and prevention of T2DOP.PMID:37710183 | DOI:10.1186/s10020-023-00724-4

Source: Molecular Medicine - September 14, 2023 Category: Molecular Biology Authors: Yun-Xia Du Yan-Tao Zhao Yong-Xin Sun Ai-Hua Xu Source Type: research