Lung response to a higher positive end-expiratory pressure in mechanically ventilated patients with COVID-19
Chest. 2021 Oct 16:S0012-3692(21)04100-3. doi: 10.1016/j.chest.2021.10.012. Online ahead of print.ABSTRACTBACKGROUND: International guidelines suggest using a higher (>10 cmH2O) positive end-expiratory pressure (PEEP) in patients with moderate-to-severe acute respiratory distress syndrome (ARDS) due to the novel coronavirus disease (COVID-19). However, even if oxygenation generally improves with a higher PEEP, compliance and arterial carbon dioxide tension (PaCO2) frequently do not, as if recruitment was small.RESEARCH QUESTION: Is the potential for lung recruitment small in patients with early ARDS due to COVID-19?STUD...
Source: Chest - October 19, 2021 Category: Respiratory Medicine Authors: Alessandro Protti Alessandro Santini Francesca Pennati Chiara Chiurazzi Massimo Cressoni Michele Ferrari Giacomo E Iapichino Luca Carenzo Ezio Lanza Giorgio Picardo Pietro Caironi Andrea Aliverti Maurizio Cecconi Source Type: research

Lung response to a higher positive end-expiratory pressure in mechanically ventilated patients with COVID-19
Chest. 2021 Oct 16:S0012-3692(21)04100-3. doi: 10.1016/j.chest.2021.10.012. Online ahead of print.ABSTRACTBACKGROUND: International guidelines suggest using a higher (>10 cmH2O) positive end-expiratory pressure (PEEP) in patients with moderate-to-severe acute respiratory distress syndrome (ARDS) due to the novel coronavirus disease (COVID-19). However, even if oxygenation generally improves with a higher PEEP, compliance and arterial carbon dioxide tension (PaCO2) frequently do not, as if recruitment was small.RESEARCH QUESTION: Is the potential for lung recruitment small in patients with early ARDS due to COVID-19?STUD...
Source: Chest - October 19, 2021 Category: Respiratory Medicine Authors: Alessandro Protti Alessandro Santini Francesca Pennati Chiara Chiurazzi Massimo Cressoni Michele Ferrari Giacomo E Iapichino Luca Carenzo Ezio Lanza Giorgio Picardo Pietro Caironi Andrea Aliverti Maurizio Cecconi Source Type: research

Lung response to a higher positive end-expiratory pressure in mechanically ventilated patients with COVID-19
Chest. 2021 Oct 16:S0012-3692(21)04100-3. doi: 10.1016/j.chest.2021.10.012. Online ahead of print.ABSTRACTBACKGROUND: International guidelines suggest using a higher (>10 cmH2O) positive end-expiratory pressure (PEEP) in patients with moderate-to-severe acute respiratory distress syndrome (ARDS) due to the novel coronavirus disease (COVID-19). However, even if oxygenation generally improves with a higher PEEP, compliance and arterial carbon dioxide tension (PaCO2) frequently do not, as if recruitment was small.RESEARCH QUESTION: Is the potential for lung recruitment small in patients with early ARDS due to COVID-19?STUD...
Source: Chest - October 19, 2021 Category: Respiratory Medicine Authors: Alessandro Protti Alessandro Santini Francesca Pennati Chiara Chiurazzi Massimo Cressoni Michele Ferrari Giacomo E Iapichino Luca Carenzo Ezio Lanza Giorgio Picardo Pietro Caironi Andrea Aliverti Maurizio Cecconi Source Type: research

Prevalence of Alpha-1 Antitrypsin Deficiency, Self-reported Behavior Change, and Healthcare Engagement Among Direct-to-Consumer Recipients of a Personalized Genetic Risk Report
Chest. 2021 Oct 14:S0012-3692(21)04099-X. doi: 10.1016/j.chest.2021.09.041. Online ahead of print.ABSTRACTBACKGROUND: Alpha-1 antitrypsin deficiency (AATD) is an autosomal co-dominant condition that predisposes to emphysema, cirrhosis, panniculitis, and vasculitis. Under-recognition has prompted efforts to enhance early detection and testing of at-risk individuals. Direct-to-consumer (DTC) genetic testing represents an additional method of detection.RESEARCH QUESTION: The study addressed three questions: 1) Does a DTC testing service identify previously undetected individuals with AATD? 2) What was the time interval betwee...
Source: Chest - October 17, 2021 Category: Respiratory Medicine Authors: James R Ashenhurst Hoang Nhan Janie F Shelton Shirley Wu Joyce Y Tung Sarah L Elson 23andMe Research Team James K Stoller Source Type: research

Cardiovascular Events during and after Bronchiectasis Exacerbations and Long-Term Mortality
Chest. 2021 Oct 14:S0012-3692(21)04101-5. doi: 10.1016/j.chest.2021.10.013. Online ahead of print.ABSTRACTBACKGROUND: Population-based and retrospective studies have shown that risk for cardiovascular events such as arrythmias, ischemic episodes or heart failure, increase during and after bronchiectasis exacerbations.RESEARCH QUESTION: What are the risk factors for cardiovascular events (CVE) during and after bronchiectasis exacerbations and its impact on mortality?STUDY DESIGN AND METHODS: This was a post-hoc retrospective analysis of a prospective observational study of 250 patients with bronchiectasis at two tertiary ca...
Source: Chest - October 17, 2021 Category: Respiratory Medicine Authors: Ra úl Méndez Laura Feced Victoria Alcaraz-Serrano Paula Gonz ález-Jiménez Leyre Bouzas Ricardo Alonso Luis Mart ínez-Dolz David Herv ás Laia Fern ández-Barat Antoni Torres Rosario Men éndez Source Type: research

Prevalence of Alpha-1 Antitrypsin Deficiency, Self-reported Behavior Change, and Healthcare Engagement Among Direct-to-Consumer Recipients of a Personalized Genetic Risk Report
Chest. 2021 Oct 14:S0012-3692(21)04099-X. doi: 10.1016/j.chest.2021.09.041. Online ahead of print.ABSTRACTBACKGROUND: Alpha-1 antitrypsin deficiency (AATD) is an autosomal co-dominant condition that predisposes to emphysema, cirrhosis, panniculitis, and vasculitis. Under-recognition has prompted efforts to enhance early detection and testing of at-risk individuals. Direct-to-consumer (DTC) genetic testing represents an additional method of detection.RESEARCH QUESTION: The study addressed three questions: 1) Does a DTC testing service identify previously undetected individuals with AATD? 2) What was the time interval betwee...
Source: Chest - October 17, 2021 Category: Respiratory Medicine Authors: James R Ashenhurst Hoang Nhan Janie F Shelton Shirley Wu Joyce Y Tung Sarah L Elson 23andMe Research Team James K Stoller Source Type: research

Cardiovascular Events during and after Bronchiectasis Exacerbations and Long-Term Mortality
Chest. 2021 Oct 14:S0012-3692(21)04101-5. doi: 10.1016/j.chest.2021.10.013. Online ahead of print.ABSTRACTBACKGROUND: Population-based and retrospective studies have shown that risk for cardiovascular events such as arrythmias, ischemic episodes or heart failure, increase during and after bronchiectasis exacerbations.RESEARCH QUESTION: What are the risk factors for cardiovascular events (CVE) during and after bronchiectasis exacerbations and its impact on mortality?STUDY DESIGN AND METHODS: This was a post-hoc retrospective analysis of a prospective observational study of 250 patients with bronchiectasis at two tertiary ca...
Source: Chest - October 17, 2021 Category: Respiratory Medicine Authors: Ra úl Méndez Laura Feced Victoria Alcaraz-Serrano Paula Gonz ález-Jiménez Leyre Bouzas Ricardo Alonso Luis Mart ínez-Dolz David Herv ás Laia Fern ández-Barat Antoni Torres Rosario Men éndez Source Type: research

Complications of critical COVID-19: Diagnostic and therapeutic considerations for the mechanically ventilated patient
We present diagnostic and therapeutic considerations for the mechanically ventilated COVID-19 patient who shows persistent or worsening signs of critical illness, and we offer an approach to managing this complex but common scenario.PMID:34655568 | DOI:10.1016/j.chest.2021.10.011 (Source: Chest)
Source: Chest - October 16, 2021 Category: Respiratory Medicine Authors: David M Maslove Stephanie Sibley J Gordon Boyd Ewan C Goligher Laveena Munshi Isaac I Bogoch Bram Rochwerg Source Type: research

"novel mechanisms targeted by drug trials in pulmonary arterial hypertension"
Chest. 2021 Oct 13:S0012-3692(21)04093-9. doi: 10.1016/j.chest.2021.10.010. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is a rare disease associated with abnormally elevated pulmonary pressures and right heart failure resulting in high morbidity and mortality. While PAH prognosis has improved with the introduction of pulmonary vasodilators, disease progression remains a major problem. Given that available therapies are inadequate for preventing small vessel loss and obstruction, there is an active interest in identifying drugs capable of targeting angiogenesis and mechanisms involved in regulation o...
Source: Chest - October 16, 2021 Category: Respiratory Medicine Authors: David F Condon Stuti Agarwal Ananya Chakraborty Natasha Auer Rocio Vazquez Hiral Patel Roham T Zamanian Vinicio A de Jesus Perez David F Condon Source Type: research

Complications of critical COVID-19: Diagnostic and therapeutic considerations for the mechanically ventilated patient
We present diagnostic and therapeutic considerations for the mechanically ventilated COVID-19 patient who shows persistent or worsening signs of critical illness, and we offer an approach to managing this complex but common scenario.PMID:34655568 | DOI:10.1016/j.chest.2021.10.011 (Source: Chest)
Source: Chest - October 16, 2021 Category: Respiratory Medicine Authors: David M Maslove Stephanie Sibley J Gordon Boyd Ewan C Goligher Laveena Munshi Isaac I Bogoch Bram Rochwerg Source Type: research

"novel mechanisms targeted by drug trials in pulmonary arterial hypertension"
Chest. 2021 Oct 13:S0012-3692(21)04093-9. doi: 10.1016/j.chest.2021.10.010. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is a rare disease associated with abnormally elevated pulmonary pressures and right heart failure resulting in high morbidity and mortality. While PAH prognosis has improved with the introduction of pulmonary vasodilators, disease progression remains a major problem. Given that available therapies are inadequate for preventing small vessel loss and obstruction, there is an active interest in identifying drugs capable of targeting angiogenesis and mechanisms involved in regulation o...
Source: Chest - October 16, 2021 Category: Respiratory Medicine Authors: David F Condon Stuti Agarwal Ananya Chakraborty Natasha Auer Rocio Vazquez Hiral Patel Roham T Zamanian Vinicio A de Jesus Perez David F Condon Source Type: research

The Right Ventricular-Pulmonary Arterial Coupling and Diastolic Function Response to Therapy in Pulmonary Arterial Hypertension
Chest. 2021 Oct 9:S0012-3692(21)04086-1. doi: 10.1016/j.chest.2021.09.040. Online ahead of print.ABSTRACTBACKGROUND: Multiparametric risk assessment is used in pulmonary arterial hypertension (PAH) to target therapy. However, this strategy is imperfect as most patients remain in intermediate or high risk after initial treatment with low risk being the goal. Metrics of right ventricular (RV) adaptation are promising tools that may help refine our therapeutic strategy.RESEARCH QUESTION: Does RV adaptation predict therapeutic response over time?STUDY DESIGN AND METHODS: We evaluated 52 incident treatment naïve patients w...
Source: Chest - October 12, 2021 Category: Respiratory Medicine Authors: Rebecca R Vanderpool Kendall S Hunter Michael Insel Joe G N Garcia Edward J Bedrick Ryan J Tedford Franz P Rischard Source Type: research

The Right Ventricular-Pulmonary Arterial Coupling and Diastolic Function Response to Therapy in Pulmonary Arterial Hypertension
Chest. 2021 Oct 9:S0012-3692(21)04086-1. doi: 10.1016/j.chest.2021.09.040. Online ahead of print.ABSTRACTBACKGROUND: Multiparametric risk assessment is used in pulmonary arterial hypertension (PAH) to target therapy. However, this strategy is imperfect as most patients remain in intermediate or high risk after initial treatment with low risk being the goal. Metrics of right ventricular (RV) adaptation are promising tools that may help refine our therapeutic strategy.RESEARCH QUESTION: Does RV adaptation predict therapeutic response over time?STUDY DESIGN AND METHODS: We evaluated 52 incident treatment naïve patients w...
Source: Chest - October 12, 2021 Category: Respiratory Medicine Authors: Rebecca R Vanderpool Kendall S Hunter Michael Insel Joe G N Garcia Edward J Bedrick Ryan J Tedford Franz P Rischard Source Type: research

The Right Ventricular-Pulmonary Arterial Coupling and Diastolic Function Response to Therapy in Pulmonary Arterial Hypertension
Chest. 2021 Oct 9:S0012-3692(21)04086-1. doi: 10.1016/j.chest.2021.09.040. Online ahead of print.ABSTRACTBACKGROUND: Multiparametric risk assessment is used in pulmonary arterial hypertension (PAH) to target therapy. However, this strategy is imperfect as most patients remain in intermediate or high risk after initial treatment with low risk being the goal. Metrics of right ventricular (RV) adaptation are promising tools that may help refine our therapeutic strategy.RESEARCH QUESTION: Does RV adaptation predict therapeutic response over time?STUDY DESIGN AND METHODS: We evaluated 52 incident treatment naïve patients w...
Source: Chest - October 12, 2021 Category: Respiratory Medicine Authors: Rebecca R Vanderpool Kendall S Hunter Michael Insel Joe G N Garcia Edward J Bedrick Ryan J Tedford Franz P Rischard Source Type: research

The Right Ventricular-Pulmonary Arterial Coupling and Diastolic Function Response to Therapy in Pulmonary Arterial Hypertension
Chest. 2021 Oct 9:S0012-3692(21)04086-1. doi: 10.1016/j.chest.2021.09.040. Online ahead of print.ABSTRACTBACKGROUND: Multiparametric risk assessment is used in pulmonary arterial hypertension (PAH) to target therapy. However, this strategy is imperfect as most patients remain in intermediate or high risk after initial treatment with low risk being the goal. Metrics of right ventricular (RV) adaptation are promising tools that may help refine our therapeutic strategy.RESEARCH QUESTION: Does RV adaptation predict therapeutic response over time?STUDY DESIGN AND METHODS: We evaluated 52 incident treatment naïve patients w...
Source: Chest - October 12, 2021 Category: Respiratory Medicine Authors: Rebecca R Vanderpool Kendall S Hunter Michael Insel Joe G N Garcia Edward J Bedrick Ryan J Tedford Franz P Rischard Source Type: research

Rivaroxaban versus Dalteparin in Cancer-Associated Thromboembolism: A Randomized Trial
Chest. 2021 Oct 7:S0012-3692(21)04079-4. doi: 10.1016/j.chest.2021.09.037. Online ahead of print.ABSTRACTBACKGROUND: Direct oral anticoagulants (DOACs) are an alternative to low-molecular-weight heparin for treating cancer-associated venous thromboembolism (VTE).RESEARCH QUESTION: Is rivaroxaban as efficient and safe as dalteparin to treat patients with cancer-associated VTE?STUDY DESIGN AND METHODS: In a randomized open-label non-inferiority trial, patients with active cancer who had proximal deep-vein thrombosis (DVT) and/or pulmonary embolism (PE) were randomly assigned to therapeutic doses of rivaroxaban or dalteparin ...
Source: Chest - October 10, 2021 Category: Respiratory Medicine Authors: Benjamin Planquette Laurent Bertoletti Ana ïs Charles-Nelson Silvy Laporte Claire Grange Isabelle Mah é Gilles Pernod Antoine Elias Francis Couturaud Nicolas Falvo Marie Antoinette Sevestre Val érie Ray Alexis Burnod Nicolas Brebion Pierre-Marie Roy Mi Source Type: research

Nontuberculous mycobacterial pulmonary disease: clinical epidemiology, risk factors and diagnosis
Chest. 2021 Oct 7:S0012-3692(21)04084-8. doi: 10.1016/j.chest.2021.10.003. Online ahead of print.ABSTRACTNontuberculous mycobacterial pulmonary disease (NTM-PD) continues to impose a significant clinical burden of disease on susceptible patients. The incidence of NTM-PD is rising globally but it remains a condition that is challenging to diagnose and treat effectively. This review provides an update on the global epidemiology, risk factors and diagnostic considerations associated with the management of NTM-PD.PMID:34627854 | DOI:10.1016/j.chest.2021.10.003 (Source: Chest)
Source: Chest - October 10, 2021 Category: Respiratory Medicine Authors: Kartik Kumar Michael R Loebinger Source Type: research

Rivaroxaban versus Dalteparin in Cancer-Associated Thromboembolism: A Randomized Trial
Chest. 2021 Oct 7:S0012-3692(21)04079-4. doi: 10.1016/j.chest.2021.09.037. Online ahead of print.ABSTRACTBACKGROUND: Direct oral anticoagulants (DOACs) are an alternative to low-molecular-weight heparin for treating cancer-associated venous thromboembolism (VTE).RESEARCH QUESTION: Is rivaroxaban as efficient and safe as dalteparin to treat patients with cancer-associated VTE?STUDY DESIGN AND METHODS: In a randomized open-label non-inferiority trial, patients with active cancer who had proximal deep-vein thrombosis (DVT) and/or pulmonary embolism (PE) were randomly assigned to therapeutic doses of rivaroxaban or dalteparin ...
Source: Chest - October 10, 2021 Category: Respiratory Medicine Authors: Benjamin Planquette Laurent Bertoletti Ana ïs Charles-Nelson Silvy Laporte Claire Grange Isabelle Mah é Gilles Pernod Antoine Elias Francis Couturaud Nicolas Falvo Marie Antoinette Sevestre Val érie Ray Alexis Burnod Nicolas Brebion Pierre-Marie Roy Mi Source Type: research

Nontuberculous mycobacterial pulmonary disease: clinical epidemiology, risk factors and diagnosis
Chest. 2021 Oct 7:S0012-3692(21)04084-8. doi: 10.1016/j.chest.2021.10.003. Online ahead of print.ABSTRACTNontuberculous mycobacterial pulmonary disease (NTM-PD) continues to impose a significant clinical burden of disease on susceptible patients. The incidence of NTM-PD is rising globally but it remains a condition that is challenging to diagnose and treat effectively. This review provides an update on the global epidemiology, risk factors and diagnostic considerations associated with the management of NTM-PD.PMID:34627854 | DOI:10.1016/j.chest.2021.10.003 (Source: Chest)
Source: Chest - October 10, 2021 Category: Respiratory Medicine Authors: Kartik Kumar Michael R Loebinger Source Type: research

Introducing the Severe Asthma Series of Invited Reviews
Chest. 2021 Oct;160(4):1151-1152. doi: 10.1016/j.chest.2021.08.056.NO ABSTRACTPMID:34625156 | DOI:10.1016/j.chest.2021.08.056 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Praveen Akuthota David J Jackson Michael E Wechsler Source Type: research

Bronchiectasis in Australian First Nations Children: Looking Inside the Gunyah
Chest. 2021 Oct;160(4):1153-1154. doi: 10.1016/j.chest.2021.06.052.NO ABSTRACTPMID:34625157 | DOI:10.1016/j.chest.2021.06.052 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Ahmad Kantar Source Type: research

Hospital or Home?: A Pandemic Decision Tool in  Context
Chest. 2021 Oct;160(4):1155-1156. doi: 10.1016/j.chest.2021.06.024.NO ABSTRACTPMID:34625158 | PMC:PMC8490856 | DOI:10.1016/j.chest.2021.06.024 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Emily Brigham Ann M Parker Source Type: research

An Obvious Paradigm: Choosing Bronchodilators and Inhaled Corticosteroids for Their Pharmacologic Characteristics
Chest. 2021 Oct;160(4):1157-1159. doi: 10.1016/j.chest.2021.06.025.NO ABSTRACTPMID:34625159 | DOI:10.1016/j.chest.2021.06.025 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Mario Cazzola Maria Gabriella Matera Source Type: research

Benefits of Angiotensin-Converting Enzyme Inhibitors and Angiotensin-Receptor Blockers on Progression of Emphysema and Lung Function Decline
Chest. 2021 Oct;160(4):1160-1162. doi: 10.1016/j.chest.2021.06.023.NO ABSTRACTPMID:34625160 | DOI:10.1016/j.chest.2021.06.023 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Xander Bertels Lies Lahousse Source Type: research

Can Abdominal Muscle Ultrasonography During Spontaneous Breathing and Cough Predict Reintubation in Mechanically Ventilated Patients?
Chest. 2021 Oct;160(4):1163-1164. doi: 10.1016/j.chest.2021.07.006.NO ABSTRACTPMID:34625161 | DOI:10.1016/j.chest.2021.07.006 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Savino Spadaro Gaetano Scaramuzzo Carlo Alberto Volta Source Type: research

Frailty Screening in Critical Care at Scale
Chest. 2021 Oct;160(4):1165-1166. doi: 10.1016/j.chest.2021.06.031.NO ABSTRACTPMID:34625162 | DOI:10.1016/j.chest.2021.06.031 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Richard J Pugh Nazir I Lone Source Type: research

The Severe ARDS Generating Evidence (SAGE) Study: A Call for Action in the Daily Clinical Practice
Chest. 2021 Oct;160(4):1167-1168. doi: 10.1016/j.chest.2021.07.2158.NO ABSTRACTPMID:34625163 | PMC:PMC8490917 | DOI:10.1016/j.chest.2021.07.2158 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Emanuele Rezoagli Giacomo Bellani Source Type: research

Smoke Signals: Promise of Nicotine as a Treatment for Pulmonary Sarcoidosis
Chest. 2021 Oct;160(4):1169-1170. doi: 10.1016/j.chest.2021.06.051.NO ABSTRACTPMID:34625164 | DOI:10.1016/j.chest.2021.06.051 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Maneesh Bhargava Margaret M Mroz Lisa A Maier Source Type: research

A Paradox, A Paradox, A Most Ingenious Paradox!
Chest. 2021 Oct;160(4):1171-1173. doi: 10.1016/j.chest.2021.05.034.NO ABSTRACTPMID:34625165 | DOI:10.1016/j.chest.2021.05.034 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Andrew Bush Source Type: research

Aerosol Generation During Exercise: Implications for Preventing Viral Transmission In and Out of the Exercise Laboratory
Chest. 2021 Oct;160(4):1174-1176. doi: 10.1016/j.chest.2021.05.065.NO ABSTRACTPMID:34625166 | PMC:PMC8490916 | DOI:10.1016/j.chest.2021.05.065 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Michael Klompas Chanu Rhee Source Type: research

Neutrophil Elastase: Finding Its Way From Mechanism, via Biomarker to Treatment Target in Pulmonary Hypertension?
Chest. 2021 Oct;160(4):1177-1178. doi: 10.1016/j.chest.2021.06.068.NO ABSTRACTPMID:34625167 | DOI:10.1016/j.chest.2021.06.068 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Harm Jan Bogaard Jurjan Aman Source Type: research

Negative Prognostic Impact of Biventricular Ballooning in Takotsubo Syndrome: When Two Is Not Better Than One
Chest. 2021 Oct;160(4):1179-1180. doi: 10.1016/j.chest.2021.06.013.NO ABSTRACTPMID:34625168 | DOI:10.1016/j.chest.2021.06.013 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Rodolfo Citro Eduardo Bossone Source Type: research

Assessing Performance of Bronchoscopic Diagnostic Techniques: Looking for Combinations That Offer Synergy
Chest. 2021 Oct;160(4):1181-1183. doi: 10.1016/j.chest.2021.05.038.NO ABSTRACTPMID:34625169 | DOI:10.1016/j.chest.2021.05.038 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: David E Ost Source Type: research

POINT: Should Fellowship Interviews Remain Exclusively Virtual? Yes
Chest. 2021 Oct;160(4):1184-1186. doi: 10.1016/j.chest.2021.05.020.NO ABSTRACTPMID:34625170 | PMC:PMC8493559 | DOI:10.1016/j.chest.2021.05.020 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Ba şak Çoruh Source Type: research

COUNTERPOINT: Should Fellowship Interviews Remain Exclusively Virtual? No
Chest. 2021 Oct;160(4):1187-1189. doi: 10.1016/j.chest.2021.05.017.NO ABSTRACTPMID:34625171 | PMC:PMC8490855 | DOI:10.1016/j.chest.2021.05.017 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: J Shirine Allam Source Type: research

Rebuttal From Dr Çoruh
Chest. 2021 Oct;160(4):1189-1190. doi: 10.1016/j.chest.2021.05.018.NO ABSTRACTPMID:34625172 | DOI:10.1016/j.chest.2021.05.018 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Ba şak Çoruh Source Type: research

Rebuttal From Dr Allam
Chest. 2021 Oct;160(4):1190-1191. doi: 10.1016/j.chest.2021.05.022.NO ABSTRACTPMID:34625173 | DOI:10.1016/j.chest.2021.05.022 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: J Shirine Allam Source Type: research

Connective Tissue Disease-Interstitial Lung Disease-Associated Mortality Rates and Years of Potential Life Lost in the United States
Chest. 2021 Oct;160(4):1368-1371. doi: 10.1016/j.chest.2021.03.034. Epub 2021 Aug 7.NO ABSTRACTPMID:34625174 | DOI:10.1016/j.chest.2021.03.034 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Mauricio Salinas Joshua J Solomon Evans R Fern ández Pérez Source Type: research

Arts and ARDS: The Critical Importance of Medical Humanities
Chest. 2021 Oct;160(4):1568-1571. doi: 10.1016/j.chest.2021.05.028.NO ABSTRACTPMID:34625175 | DOI:10.1016/j.chest.2021.05.028 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Briseida Mema Andrew Helmers Kyung-Seo Kay Min Laura E Navne Source Type: research

Reserve Systems for Allocation of Scarce Medical Resources During the COVID-19 Pandemic: The Path From April 2020 to April 2021
Chest. 2021 Oct;160(4):1572-1575. doi: 10.1016/j.chest.2021.06.001.NO ABSTRACTPMID:34625176 | PMC:PMC8490915 | DOI:10.1016/j.chest.2021.06.001 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Parag A Pathak Tayfun S önmez M Utku Ünver Source Type: research

Correction to Collaborators in Acknowledgments in: Decision-Making on Withholding or Withdrawing Life Support in the ICU: A Worldwide Perspective
Chest. 2021 Oct;160(4):1576-1577. doi: 10.1016/j.chest.2021.08.054.NO ABSTRACTPMID:34625177 | DOI:10.1016/j.chest.2021.08.054 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Source Type: research

Lung Cancer Screening Quality Criteria: A Population Perspective
Chest. 2021 Oct;160(4):e329-e331. doi: 10.1016/j.chest.2021.05.006.NO ABSTRACTPMID:34625178 | DOI:10.1016/j.chest.2021.05.006 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Cristina Candal-Pedreira Alberto Ruano-Ravina Mariano Provencio Alberto Fern ández-Villar M ónica Pérez-Ríos Source Type: research

Oral Positive Expiratory Pressure Device for Excessive Dynamic Airway Collapse Caused by Emphysema
Chest. 2021 Oct;160(4):e333-e337. doi: 10.1016/j.chest.2021.04.059.ABSTRACTExcessive dynamic airway collapse (EDAC) contributes to breathlessness and reduced quality of life in individuals with emphysema. We tested a novel, portable, oral positive expiratory pressure (o-PEP) device in a patient with emphysema and EDAC. MRI revealed expiratory tracheal narrowing to 80 mm2 that increased to 170 mm2 with the o-PEP device. After 2-weeks use of the o-PEP device for 33% to 66% of activities, breathlessness, quality of life, and exertional dyspnea improved compared with minimal clinically important differences (MCID): University ...
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Muhammad Ahsan Zafar Ruchira Sengupta Alister Bates Jason C Woods Christopher Radchenko Francis X McCormack Ralph J Panos Source Type: research

A Rare Cause of Respiratory Insufficiency in a 30-Year-Old Transgender Woman
Chest. 2021 Oct;160(4):e339-e342. doi: 10.1016/j.chest.2021.05.054.ABSTRACTA 30-year-old transgender woman who was HIV positive presented to the ED with progressive severe dyspnea and hemoptysis that started 1 day earlier. The patient was undergoing antiretroviral therapy with emtricitabine-rilpivirine-tenofovir with good compliance and feminizing hormone therapy with cyproterone acetate. She was otherwise healthy and was not taking any other medications.PMID:34625180 | DOI:10.1016/j.chest.2021.05.054 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Nicola Langiano Alessandro Brussa Ilaria Riccardi Francesco Meroi Francesco Toso Daniela Cesselli Luigi Vetrugno Tiziana Bove Source Type: research

A 30-Year-Old Immune Deficient Woman With Persistent Cough and Shortness of Breath
Chest. 2021 Oct;160(4):e343-e346. doi: 10.1016/j.chest.2021.05.055.ABSTRACTA 30-year-old woman was referred with increasing shortness of breath and cough in the setting of GATA2 deficiency. She initially presented 9 years previously with recurrent episodes of pneumonia and sinusitis. Genetic testing revealed a heterozygous GATA2 mutation (c.988C>T). She has since had multiple infections that have included necrotizing fasciitis of the right thumb, recurrent pilonidal infections (which required 23 procedures), esophageal candidiasis, and human papillomavirus-positive high-grade squamous intraepithelial lesion of the cervi...
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Daffolyn Rachael Fels Elliott Michael P Combs Anil K Attili Carol F Farver Source Type: research

A 70-Year-Old Man With Cough and Recurrent Respiratory Infections
Chest. 2021 Oct;160(4):e347-e350. doi: 10.1016/j.chest.2021.05.010.ABSTRACTA 70-year-old man was referred for evaluation of recurrent respiratory infections requiring antibiotics and chronic cough over 3 years. Two months prior to presentation, he started to develop blood-tinged sputum but not frank hemoptysis. He otherwise denied any fever, chills, night sweats, or weight loss. He had dyspnea during the respiratory infections but not otherwise. His medical history was significant for chronic rhinitis without sinusitis and a low serum IgM level. He was a never smoker and a farmer but otherwise had no significant or specifi...
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Michelle B Herberts Tucker F Johnson Patricio Escalante Source Type: research

A 58-Year-Old Woman With a History of Cardiac Myxoma Presents With Pulmonary Nodules
Chest. 2021 Oct;160(4):e351-e355. doi: 10.1016/j.chest.2021.04.060.ABSTRACTA 58-year-old woman presented to a pulmonology clinic for evaluation of bilateral pulmonary nodules. Two years previously, she had presented with atrioventricular nodal reentrant tachycardia. During evaluation for her tachyarrhythmia, transthoracic echocardiogram (TTE) revealed a large, homogenous, highly mobile right atrial and ventricular mass. She underwent electrophysiologic ablation, tricuspid valve annular ring replacement, and resection of the mass, which pathology confirmed to be a myxoma. Now, a recent abdomen and pelvis CT study obtained f...
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Lindsay M Forbes Nathan D Hensley York E Miller Source Type: research

A 51-Year-Old Man With a Large Posterior Mediastinal Mass
Chest. 2021 Oct;160(4):e357-e363. doi: 10.1016/j.chest.2021.04.058.ABSTRACTA 51-year-old White male never-smoker presented with intermittent cough and progressive dyspnea. His symptoms started after an exposure to bat guano while cleaning his attic approximately 9 months earlier. He has received several courses of antibiotic and corticosteroid for these symptoms, with short-term relief.PMID:34625184 | DOI:10.1016/j.chest.2021.04.058 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Hau Chieng Jean-Paul Hafner Lezah Mccarthy Ammoura Ibrahim Ria Itty Woon H Chong Biplab Saha Edward Conuel Source Type: research

A 50-Year-Old Woman With Shortness of Breath
Chest. 2021 Oct;160(4):e365-e368. doi: 10.1016/j.chest.2020.10.098.NO ABSTRACTPMID:34625185 | DOI:10.1016/j.chest.2020.10.098 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Padmaraj D Duvvuri Chetan Bhardwaj Keattiyoat Wattanakit Source Type: research

A 56-Year-Old Woman With Nonresolving Pneumonia
Chest. 2021 Oct;160(4):e369-e370. doi: 10.1016/j.chest.2020.10.097.NO ABSTRACTPMID:34625186 | DOI:10.1016/j.chest.2020.10.097 (Source: Chest)
Source: Chest - October 9, 2021 Category: Respiratory Medicine Authors: Mohammad Arabiat Priyanka Bhat Rodney Steff Karan Singh Source Type: research