Corticosteroids for community-acquired pneumonia - overstated benefits and understated risks.
PMID: 31287999 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 6, 2019 Category: Respiratory Medicine Authors: Waterer G, Metersky ML Tags: Chest Source Type: research

Subtyping COPD using visual and quantitative CT features.
Abstract BACKGROUND: Multiple studies have identified COPD subtypes using visual or quantitative evaluation of CT images. However, there has been no systematic assessment of a combined visual and quantitative CT classification. We integrated visually defined patterns of emphysema with quantitative imaging features and spirometry data to produce a set of ten non-overlapping CT subtypes, and we assessed differences between subtypes in demographic features, physiology, longitudinal disease progression, and mortality. METHODS: We evaluated 9,080 current and former smokers in the COPDGene study with available volu...
Source: Chest - July 5, 2019 Category: Respiratory Medicine Authors: Park J, Hobbs BD, Crapo JD, Make BJ, Regan EA, Humphries S, Carey VJ, Lynch DA, Silverman EK, COPDGene Investigators Tags: Chest Source Type: research

Patient-level trajectories and outcomes after low-dose CT screening in the National Lung Screening Trial.
Abstract BACKGROUND: Shared decision-making is an essential element of low-dose computed tomography (LDCT) screening for lung cancer. Understanding patient-level outcomes from the National Lung Screening Trial (NLST) is critical to effectively communicate risks and benefits of screening to patients. METHODS: We performed a secondary analysis of data collected in the NLST. We determined outcomes of each individual LDCT performed in the NLST (downstream evaluation, complications, lung cancer diagnoses), and compared outcomes at the test-level to outcomes calculated at the patient-level for those randomized to L...
Source: Chest - July 5, 2019 Category: Respiratory Medicine Authors: Iaccarino JM, Silvestri GA, Wiener RS Tags: Chest Source Type: research

The CHEST Editorial Team: Serving Our Contributors and Readers.
PMID: 31279360 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Mazzone PJ Tags: Chest Source Type: research

POINT: Can Shared Decision-Making of Physicians and Patients Improve Outcomes in Lung Cancer Screening? Yes.
PMID: 31279361 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Wiener RS Tags: Chest Source Type: research

COUNTERPOINT: Can Shared Decision-Making of Physicians and Patients Improve Outcomes in Lung Cancer Screening? No.
PMID: 31279362 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Slatore CG Tags: Chest Source Type: research

Rebuttal From Dr Wiener.
PMID: 31279363 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Wiener RS Tags: Chest Source Type: research

Proprioception.
PMID: 31279364 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Greenbaum-Maya K Tags: Chest Source Type: research

Marian Rash.
PMID: 31279365 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Christman B Tags: Chest Source Type: research

Nurse's Station.
PMID: 31279366 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Ramos PJ Tags: Chest Source Type: research

A Recollection of Evolution in Scuba Diving Class.
PMID: 31279367 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Ellery C Tags: Chest Source Type: research

Flames.
PMID: 31279368 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Ellery C Tags: Chest Source Type: research

Request to "Update" the 2019 Update of Guidelines for Management of Pulmonary Arterial Hypertension.
Request to "Update" the 2019 Update of Guidelines for Management of Pulmonary Arterial Hypertension. Chest. 2019 Jul;156(1):187 Authors: Durrani J, Toor A PMID: 31279369 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Durrani J, Toor A Tags: Chest Source Type: research

Response.
PMID: 31279370 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Klinger JR, Elliott G, Levine DJ, Bossone E, Duvall L, Fagan K, Frantsve-Hawley J, Kawut SM, Ryan JJ, Rosenzweig EB, Sederstrom N, Steen VD, Badesch DB Tags: Chest Source Type: research

Response.
PMID: 31279371 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Choi P Tags: Chest Source Type: research

Is "Noninvasive Ventilation" the Way to Prevent Respiratory Failure in Amyotrophic Lateral Sclerosis?
Is "Noninvasive Ventilation" the Way to Prevent Respiratory Failure in Amyotrophic Lateral Sclerosis? Chest. 2019 Jul;156(1):189 Authors: Bach JR, Chiou M PMID: 31279372 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Bach JR, Chiou M Tags: Chest Source Type: research

Rebuttal From Dr Slatore.
PMID: 31279373 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Slatore CG Tags: Chest Source Type: research

Gastroesophageal Reflux Disease and Idiopathic Pulmonary Fibrosis: No Data for Supporting a Relationship After a Systematic Review.
PMID: 31279374 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Corrao S, Natoli G, Argano C, Scichilone N Tags: Chest Source Type: research

Response.
d Méthot D PMID: 31279375 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Lacasse Y, Leblanc É, Bédard Méthot D Tags: Chest Source Type: research

Pulmonary Arteries and Microcirculation in  COPD With Pulmonary Hypertension: Bystander or Culprit?
Pulmonary Arteries and Microcirculation in COPD With Pulmonary Hypertension: Bystander or Culprit? Chest. 2019 Jul;156(1):4-6 Authors: Tuder RM, Cool CD PMID: 31279376 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Tuder RM, Cool CD Tags: Chest Source Type: research

Pulmonary Edema After Initiation of Parenteral Prostaglandin Therapy: More Common Than We Think but How Clinically Important Is It?
PMID: 31279377 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Robbins IM Tags: Chest Source Type: research

High Lung Allocation Scores and Lung Transplantation: Is There a Ceiling?
PMID: 31279378 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Meyer KC Tags: Chest Source Type: research

A 19-Year-Old Young Man With Breathlessness and Opacity in the Left Hemithorax.
PMID: 31279379 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Muthu V, Sagar S, Sehgal IS, Thurai Prasad K, Dhooria S, Singla V, Agarwal R Tags: Chest Source Type: research

A 37-Year-Old Man With Pleuritic Chest  Pain.
A 37-Year-Old Man With Pleuritic Chest Pain. Chest. 2019 Jul;156(1):e15-e21 Authors: Galant-Swafford J, Light M, Onaitis MW, Rawlings SA, Fierer J, Landsberg JW Abstract CASE PRESENTATION: A 37-year-old man with poorly controlled type 2 diabetes presented with severe right-sided pleuritic chest pain, respiratory splinting, and cough. Two weeks earlier, he had been evaluated at an urgent care for cough and was prescribed a 5-day course of azithromycin for bronchitis. He then presented to our ED reporting mild, right-sided pleuritic chest pain. Vital signs were normal, and his chest radiograph show...
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Galant-Swafford J, Light M, Onaitis MW, Rawlings SA, Fierer J, Landsberg JW Tags: Chest Source Type: research

A 15-Year-Old Girl With Sleep-Onset Insomnia and Poor Sleep Quality.
Abstract CASE PRESENTATION: A 15-year-old girl was referred to us for sleep difficulties and restless sleep. The parent stated that she was always a poor sleeper, having difficulty falling asleep and frequent nocturnal awakenings since she was a very young child, but in the past 6 months the symptoms had worsened. She slept in her own room and in her own bed. Her bedtime was 10:30 pm, staying in bed anywhere from 2 to 5 h before she could fall asleep. During this time, she felt discomfort in her legs with the urge to move her legs and relief after movement. This sensation was worse at night or when sitti...
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: DelRosso LM, Jackson CV, Ferri R Tags: Chest Source Type: research

Α 57-Year-Old Woman With ARDS, Cachexia, and a 2-Month Fever.
Α 57-Year-Old Woman With ARDS, Cachexia, and a 2-Month Fever. Chest. 2019 Jul;156(1):e27-e31 Authors: Tsolaki V, Manoulakas E, Makris D, Boutlas S, Daniil Z, Gourgoulianis KI, Zakynthinos E Abstract CASE PRESENTATION: A 57-year-old homemaker and rural inhabitant of Central Greece (ex-smoker, 25 pack-years), was admitted to the ICU because of acute hypoxemic respiratory failure with diffuse bilateral alveolar infiltrates. Her medical history was unremarkable. She had been looking after her mother in a farmhouse with goats and a dog for the previous 6 months. She had not ingested any unpasteu...
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Tsolaki V, Manoulakas E, Makris D, Boutlas S, Daniil Z, Gourgoulianis KI, Zakynthinos E Tags: Chest Source Type: research

A 58-Year-Old Woman With Postoperative ST Segment Elevation on Telemetry.
PMID: 31279383 [PubMed - in process] (Source: Chest)
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Helwani MA, Casali D, Ablordeppey E Tags: Chest Source Type: research

A 48-Year-Old Man With Excessive Drooling and Descending Paralysis Requiring Mechanical Ventilation.
Abstract CASE PRESENTATION: A 48-year-old man presented with a chief report of worsening dysphagia for 5 days. Initially, he had difficulty swallowing solids, but it has progressed to difficulty with liquids. There was associated sialorrhea, hypophonia, slurring of speech, hoarseness of voice, cough, and prominent upper extremity weakness. Of note, 2 weeks ago, the patient had an upper respiratory tract infection (including otitis media) that was treated with amoxicillin-clavulanate. His wife and son were also recently sick with an upper respiratory tract infection. His medical history included hypertens...
Source: Chest - July 1, 2019 Category: Respiratory Medicine Authors: Matayeva E, Henson T, Alaverdian A, Iqbal J, Akella J Tags: Chest Source Type: research

Monitoring Pulmonary Arterial Hypertension Using an Implantable Hemodynamic Sensor.
CONCLUSIONS: The CardioMEMS HF System provided useful information to monitor PAH therapy, and demonstrated short- and long-term safety. Larger clinical trials are needed before its widespread use to guide therapy in severe PAH patients with right-sided HF. PMID: 31265832 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - June 29, 2019 Category: Respiratory Medicine Authors: Benza RL, Doyle M, Lasorda D, Parikh KS, Correa-Jaque P, Badie N, Ginn G, Airhart S, Franco V, Kanwar M, Murali S, Raina A, Agarwal R, Rajagopal S, White J, Biederman R Tags: Chest Source Type: research

Publishing a clinical research manuscript: Guidance for early career researchers with a focus on pulmonary and critical care medicine.
PMID: 31265833 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - June 29, 2019 Category: Respiratory Medicine Authors: Viglianti EM, Admon AJ, Carlton EF, Hensley MK, Prescott HC, Iwashyna TJ, McSparron JI Tags: Chest Source Type: research

"Clinician Strategies to Improve the Care of Patients Using Supplemental Oxygen".
This article reviews four key clinician strategies to improve the care of adult patients receiving supplemental oxygen in the outpatient setting in the United States. The current barriers to adequate oxygen services are substantial and complex and include decreased reimbursement to Durable Medical Equipment (DME) companies, a substantially lower number of available DME suppliers, difficult communication with DME suppliers, rigid patient testing, prescription, and documentation requirements, and unclear patient benefit and adherence. Recent data documenting frequent and varied problems reflect the significant impact of supp...
Source: Chest - June 29, 2019 Category: Respiratory Medicine Authors: Jacobs SS Tags: Chest Source Type: research

The Emerging Role of Neutrophil Extracellular Traps in Respiratory Disease.
Abstract Neutrophil extracellular traps (NETs) are extrusions of intracellular DNA and attached granular material which enable bacterial killing. NETs are increasingly recognised for their role in the pathogenesis of respiratory disease. NETs are composed of a complex mix of intracellular derived material which neutrophils organise within the cytoplasm then expel in a non-directed manner in the vicinity of invading organisms. Combined, these trap and destroy multiple genera of microbes including bacteria, fungi, viruses and protozoans, limiting infection especially where phagocytosis is not possible. Initially NET...
Source: Chest - June 29, 2019 Category: Respiratory Medicine Authors: Twaddell SH, Baines KJ, Grainge C, Gibson PG Tags: Chest Source Type: research

Evaluation of the normal airway morphology using optical coherence tomography.
Abstract BACKGROUND: The anatomical location of small airways, the distribution of airway cartilage and their correlation with ageing have not been well elucidated. OBJECTIVE: To explore the morphological characteristics of small airways in vivo, and how airway structural changes correlate with age using endobronchial optical coherence tomography (EB-OCT). METHODS: We recruited 112 subjects with peripheral pulmonary nodules. Participants underwent computed tomography, spirometry, and EB-OCT measurements. We measured the airway internal diamaeter (Dmean), inner area (Ai), airway wall area percentage (Aw%)...
Source: Chest - June 29, 2019 Category: Respiratory Medicine Authors: Su ZQ, Guan WJ, Li SY, Feng JX, Zhou ZQ, Chen Y, Zhong ML, Zhong NS Tags: Chest Source Type: research

Preoperative Evaluation of Patients With Interstitial Lung Disease.
PMID: 31265837 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - June 29, 2019 Category: Respiratory Medicine Authors: Patel NM, Kulkarni T, Dilling D, Scholand MB, Interstitial and Diffuse Lung Disease Network Steering Committee Tags: Chest Source Type: research

Ultrasound Billing for Intensivists.
This article will summarize the requirements for documentation and image storage that must be met in order to obtain reimbursement for POCUS services. PMID: 31255580 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - June 27, 2019 Category: Respiratory Medicine Authors: Koenig SJ, Lou BX, Moskowitz Y, Narasimhan M, Mayo PH Tags: Chest Source Type: research

MiRNAs in Lung Diseases.
Abstract Chronic inflammatory diseases of the lung are often life-threating and are a leading cause of morbidity in our communities. MicroRNA (miR) are now recognized to play critical roles in a wide-range of cellular functions including the regulation immunological processes, which are often dysregulated in chronic respiratory diseases. These small non-coding RNA molecules regulate networks of genes by inhibiting translation by targeting one or multiple messenger RNA transcripts. In this review we highlight discoveries that identify important roles for miRs in the regulation of specific pathogenic features of a r...
Source: Chest - June 27, 2019 Category: Respiratory Medicine Authors: Hoefel G, Tay H, Foster P Tags: Chest Source Type: research

Low Tidal Volumes for Everyone?
Abstract Since the first description of mechanical ventilation, our understanding of the positive and negative effects of this form of life support has continued to evolve. In order to maintain "normal" aeration of the lungs and "normal" blood gas measurements, patients often require much higher airway pressures and tidal volumes than would be expected in a healthy, spontaneously breathing adult. In the early days of mechanical ventilation the goal was to normalize the blood gas, but over the last several decades, we have developed a much better appreciation for the deleterious effects of mecha...
Source: Chest - June 27, 2019 Category: Respiratory Medicine Authors: Rackley CR, MacIntyre NR Tags: Chest Source Type: research

Direct acting oral anticoagulants (DOACs) in critically ill patients.
Abstract The direct acting oral anticoagulants (DOACs) have been increasingly utilized over vitamin K antagonists (VKA) in recent years because they do not require monitoring and have an immediate anti-coagulation effect. In general, DOACs have shown a better safety profile and non-inferiority for venous thromboembolism (VTE) prophylaxis and treatment, and stroke prevention in patients with atrial fibrillation, when compared to VKA agents in the non-ICU population. Whether this holds true in patients who are critically ill remains unknown. In this review, we will address the role of DOACs in special ICU population...
Source: Chest - June 25, 2019 Category: Respiratory Medicine Authors: Rali P, Gangemi A, Moores A, Mohrien K, Moores L Tags: Chest Source Type: research

Transmission of oral pressure compromises oronasal CPAP efficacy to treat Obstructive Sleep Apnea.
Abstract BACKGROUND: Oronasal mask is frequently used to treat OSA. In contrast to nasal CPAP, the effectiveness of oronasal CPAP varies for unknown mechanisms. We hypothesized that oral breathing and pressure transmission through the mouth compromises oronasal CPAP efficacy. METHODS: Thirteen OSA patients, well adapted to oronasal CPAP, were monitored by full polysomnography, pharyngeal pressure catheter and nasoendoscope. Patients slept with low doses of midazolam using an oronasal mask with sealed nasal and oral compartments. CPAP was titrated during oronasal and nasal routes, then reduced to induce stable...
Source: Chest - June 22, 2019 Category: Respiratory Medicine Authors: Madeiro F, Andrade RGS, Piccin VS, Pinheiro GDL, Moriya HT, Genta PR, Lorenzi-Filho G Tags: Chest Source Type: research

Long-term treatment with azathioprine and mycophenolate mofetil for myositis-related interstitial lung disease.
CONCLUSIONS: In M-ILD, AZA treatment was associated with improved FVC%, DLCO%, and prednisone dose. Patients treated with MMF had improved FVC% and prednisone dose. After 36 months, patients treated with AZA used a lower prednisone dose than those treated with MMF. PMID: 31238042 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - June 22, 2019 Category: Respiratory Medicine Authors: Huapaya JA, Silhan L, Pinal-Fernandez I, Casal-Dominguez M, Johnson C, Albayda J, Paik JJ, Abanti S, Mammen AL, Christopher-Stine L, Danoff SK Tags: Chest Source Type: research

Gene Expression Alterations in the Bronchial Epithelium of Electronic Cigarette Users.
Abstract BACKGROUND: While electronic cigarette (ECIG) use has increased in the United States, their potential health effects remain uncertain. Understanding the effects of tobacco cigarette (TCIG) smoke on bronchial airway epithelial gene-expression have previously provided insights into tobacco-related disease pathogenesis. Identifying the impact of ECIGs on airway gene-expression could provide insights into their potential long-term health effects. We sought to compare the bronchial airway gene-expression profiles of former TCIG smokers now using ECIGs with the profiles of former and current TCIG smokers. ...
Source: Chest - June 21, 2019 Category: Respiratory Medicine Authors: Corbett SE, Nitzberg M, Moses E, Kleerup E, Wang T, Perdomo C, Perdomo C, Liu G, Zhang S, Liu H, Elashoff DA, Brooks DR, O'Connor GT, Dubinett SM, Spira A, Lenburg ME Tags: Chest Source Type: research

Objectively Measured Chronic Lung Injury on Chest Computed Tomography.
Abstract BACKGROUND: Tobacco smoke exposure is associated with emphysema and pulmonary fibrosis, both of which are irreversible. We have developed a new objective computed tomography (CT) analysis tool that combines densitometry with machine learning to detect high attenuation changes in visually normal appearing lung (NormHA) that may precede these diseases. METHODS: We trained the classification tool by placing 34528 training points in chest CT scans from 297 COPDGene participants. The tool was then used to classify lung tissue in 9038 participants as normal, emphysema, fibrotic/interstitial, or NormHA. Ass...
Source: Chest - June 21, 2019 Category: Respiratory Medicine Authors: Harmouche R, Ash SY, Putman RK, Hunninghake GM, San Jose Estepar R, Martinez FJ, Choi AM, Lynch DA, Hatabu H, Han MK, Bowler RP, Kalhan R, Rosas IO, Washko GR, San Jose Estepar R, COPDGene Investigators Tags: Chest Source Type: research

Age-Stratified National Trends in Pulmonary Embolism Admissions.
CONCLUSIONS: Between 2000 and 2015 the rate of hospitalization for PE increased across all age groups. Despite improvements in average LOS and inpatient mortality, hospitalizations became more expensive, and patients required more resources (i.e. home health) upon discharge. This increased resource utilization was most apparent in elderly patients. This suggests that targeted clinical trials designed to improve outcomes in all age brackets are needed. PMID: 31233745 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - June 21, 2019 Category: Respiratory Medicine Authors: Pauley ED, Orgel R, Rossi J, Strassle PD Tags: Chest Source Type: research

Percent of time in range 70-139mg/dL is associated with reduced mortality among critically ill patients receiving intravenous insulin infusion.
Abstract INTRODUCTION: In addition to hyperglycemia, hypoglycemia, and glycemic variability, reduced time in targeted blood glucose range (TIR) is associated with increased risk of death in critically ill patients. This relationship between TIR and mortality may be confounded by diabetic status and antecedent glycemic control. METHODS: We retrospectively analyzed critically ill patients managed with the same intravenous insulin protocol at multiple centers. We calculated the percent of TIR between 70-139 mg/dl. We excluded patients with diabetic ketoacidosis, patients who had fewer than 10 blood glucose readi...
Source: Chest - June 12, 2019 Category: Respiratory Medicine Authors: Lanspa MJ, Krinsley JS, Hersh AM, Wilson EL, Holmen JR, Orme JF, Morris AH, Hirshberg EL Tags: Chest Source Type: research

Proteomic Profiling to Identify Blood Biomarkers Predictive of Response to Azithromycin in Children and Adolescents with Cystic Fibrosis.
Abstract BACKGROUND: Azithromycin reduces pulmonary exacerbation (PEx) risk in cystic fibrosis (CF) but not all individuals benefit. The goal of this study was to discover blood protein biomarkers predictive of clinical response to azithromycin treatment in CF children and adolescents. METHODS: Novel proteomic technologies were applied to examine 188 serum and plasma proteins from 40 CF subjects randomized to azithromycin in the AZ0004 trial. Early change in blood protein levels from day 0 to day 28 of treatment were examined in relation to changes in FEV1 % predicted (ppFEV1) and weight by day 28 and 168, an...
Source: Chest - June 12, 2019 Category: Respiratory Medicine Authors: Dong K, Singh A, Ng RT, Sin DD, Tebbutt SJ, Ratjen F, Quon BS Tags: Chest Source Type: research

Solving the Opioid Crisis: Respiratory Depression by Opioids as Critical Endpoint.
In conclusion, a better understanding of the underlying mechanisms linking pain relief with control of breathing is essential to identify pain therapies with minimal or no respiratory side-effects. PMID: 31194974 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - June 10, 2019 Category: Respiratory Medicine Authors: Montandon G, Slutsky AS Tags: Chest Source Type: research

Prevalence and Clinical Significance of Antineutrophil Cytoplasmic Antibodies in North American Patients with Idiopathic Pulmonary Fibrosis.
CONCLUSIONS: ANCA-antibody positivity is uncommon in North American patients with IPF and not associated with baseline disease severity or transplant-free survival; however, a significant proportion of MPO-positive IPF patients develop clinical vasculitis.; Abbreviation List: ANCA: Antineutrophil cytoplasmic antibodies; CLIA: Clinical Laboratory Improvement Amendments; CT: Computed tomography; CTD: Connective tissue disease; DLCO: Diffusing capacity of the lung for carbon monoxide; FEV1: Forced expiratory volume in one second; FVC: Forced vital capacity; HR: Hazard ratio; ILD: Interstitial lung disease; IPF: Idiopathic pul...
Source: Chest - June 7, 2019 Category: Respiratory Medicine Authors: Liu GY, Ventura IB, Achtar-Zadeh N, Elicker BM, Jones KD, Wolters PJ, Collard HR, Adegunsoye A, Strek ME, Ley B Tags: Chest Source Type: research

To Procalcitonin, or Not to Procalcitonin?
PMID: 31174628 [PubMed - in process] (Source: Chest)
Source: Chest - June 1, 2019 Category: Respiratory Medicine Authors: Kalil AC, Lisboa T Tags: Chest Source Type: research

Clinical Impact of Antimicrobial Resistance: Using New Tools to Answer Old Questions.
PMID: 31174629 [PubMed - in process] (Source: Chest)
Source: Chest - June 1, 2019 Category: Respiratory Medicine Authors: Niederman MS Tags: Chest Source Type: research

Do Not Forget to Assess the Muscle Integrity  in Patients With COPD.
Do Not Forget to Assess the Muscle Integrity in Patients With COPD. Chest. 2019 Jun;155(6):1090-1091 Authors: Cerri S, Clini E PMID: 31174630 [PubMed - in process] (Source: Chest)
Source: Chest - June 1, 2019 Category: Respiratory Medicine Authors: Cerri S, Clini E Tags: Chest Source Type: research