Relationship between lung volumes and heterogeneity in the response to elexacaftor/tezacaftor/ivacaftor in patients with cystic fibrosis and advanced lung disease
Chest. 2024 Mar 21:S0012-3692(24)00404-5. doi: 10.1016/j.chest.2024.03.033. Online ahead of print.ABSTRACTBACKGROUND: The effects of elexacaftor/tezacaftor/ivacaftor (ETI) on respiratory outcomes for people with CF (pwCF) were demonstrated by several clinical trials, mainly based on simple spirometry. However, gains in lung function may vary greatly between patients, but predictors of FEV1 change after treatment are still missing.RESEARCH QUESTION: Which ventilatory parameters are involved in the heterogeneity of FEV1 change after 12-month ETI treatment in pwCF with advanced lung disease?STUDY DESIGN: AND METHODS: This was...
Source: Chest - March 23, 2024 Category: Respiratory Medicine Authors: Andrea Gramegna Gianfranco Alicandro Chiara Premuda Francesca Lucca Lucia Pinali Mariangela Retucci Valentina Vespro Maria Carmela Andrisani Gianpaolo Carraffiello Francesco Amati Sonia Volpi Stefano Aliberti Marco Cipolli Francesco Blasi Source Type: research
Relationship between lung volumes and heterogeneity in the response to elexacaftor/tezacaftor/ivacaftor in patients with cystic fibrosis and advanced lung disease
Chest. 2024 Mar 21:S0012-3692(24)00404-5. doi: 10.1016/j.chest.2024.03.033. Online ahead of print.ABSTRACTBACKGROUND: The effects of elexacaftor/tezacaftor/ivacaftor (ETI) on respiratory outcomes for people with CF (pwCF) were demonstrated by several clinical trials, mainly based on simple spirometry. However, gains in lung function may vary greatly between patients, but predictors of FEV1 change after treatment are still missing.RESEARCH QUESTION: Which ventilatory parameters are involved in the heterogeneity of FEV1 change after 12-month ETI treatment in pwCF with advanced lung disease?STUDY DESIGN: AND METHODS: This was...
Source: Chest - March 23, 2024 Category: Respiratory Medicine Authors: Andrea Gramegna Gianfranco Alicandro Chiara Premuda Francesca Lucca Lucia Pinali Mariangela Retucci Valentina Vespro Maria Carmela Andrisani Gianpaolo Carraffiello Francesco Amati Sonia Volpi Stefano Aliberti Marco Cipolli Francesco Blasi Source Type: research
Relationship between lung volumes and heterogeneity in the response to elexacaftor/tezacaftor/ivacaftor in patients with cystic fibrosis and advanced lung disease
Chest. 2024 Mar 21:S0012-3692(24)00404-5. doi: 10.1016/j.chest.2024.03.033. Online ahead of print.ABSTRACTBACKGROUND: The effects of elexacaftor/tezacaftor/ivacaftor (ETI) on respiratory outcomes for people with CF (pwCF) were demonstrated by several clinical trials, mainly based on simple spirometry. However, gains in lung function may vary greatly between patients, but predictors of FEV1 change after treatment are still missing.RESEARCH QUESTION: Which ventilatory parameters are involved in the heterogeneity of FEV1 change after 12-month ETI treatment in pwCF with advanced lung disease?STUDY DESIGN: AND METHODS: This was...
Source: Chest - March 23, 2024 Category: Respiratory Medicine Authors: Andrea Gramegna Gianfranco Alicandro Chiara Premuda Francesca Lucca Lucia Pinali Mariangela Retucci Valentina Vespro Maria Carmela Andrisani Gianpaolo Carraffiello Francesco Amati Sonia Volpi Stefano Aliberti Marco Cipolli Francesco Blasi Source Type: research
The Role of Pediatric Psychologists in Critical Care: Lessons Learned and Future Directions in Integrating Mental Health Care into Pediatric Intensive Care Units
Chest. 2024 Mar 19:S0012-3692(24)00398-2. doi: 10.1016/j.chest.2024.03.028. Online ahead of print.ABSTRACTPediatric psychologist are essential staff in the pediatric intensive care unit (PICU). Their role in caring for critically ill children aligns with clinical practice guidelines for the mental health care needs of this population of patients. This paper highlights the role of pediatric psychology in the PICU through illustrative case examples. We discuss lessons learned and future directions for the development and provision of mental health services in PICUs. We address relevant ways for critical care providers to und...
Source: Chest - March 21, 2024 Category: Respiratory Medicine Authors: Kristin Canavera Patricia Marik Nicole M Schneider Jacquelyn Smith Source Type: research
The association of pregnancy with outcomes among critically ill reproductive-aged women: A propensity-score matched retrospective cohort analysis
Chest. 2024 Mar 19:S0012-3692(24)00400-8. doi: 10.1016/j.chest.2024.03.030. Online ahead of print.ABSTRACTBACKGROUND: The maternal mortality rate in the US is unacceptably high. However, the relative contribution of pregnancy to these outcomes is unknown. Studies comparing outcomes among pregnant versus non-pregnant critically ill patients show mixed results and are limited by small sample sizes.RESEARCH QUESTION: What is the association of pregnancy with critical illness outcomes?STUDY DESIGN AND METHODS: We performed a retrospective cohort study of 18-55-year-old women who received invasive mechanical ventilation (MV) on...
Source: Chest - March 21, 2024 Category: Respiratory Medicine Authors: Rachel Kohn Deepshikha C Ashana Kelly C Vranas Elizabeth M Viglianti Katrina Hauschildt Catherine Chen Emily A Vail Leslie Moroz Hayley B Gershengorn Source Type: research
The Role of Pediatric Psychologists in Critical Care: Lessons Learned and Future Directions in Integrating Mental Health Care into Pediatric Intensive Care Units
Chest. 2024 Mar 19:S0012-3692(24)00398-2. doi: 10.1016/j.chest.2024.03.028. Online ahead of print.ABSTRACTPediatric psychologist are essential staff in the pediatric intensive care unit (PICU). Their role in caring for critically ill children aligns with clinical practice guidelines for the mental health care needs of this population of patients. This paper highlights the role of pediatric psychology in the PICU through illustrative case examples. We discuss lessons learned and future directions for the development and provision of mental health services in PICUs. We address relevant ways for critical care providers to und...
Source: Chest - March 21, 2024 Category: Respiratory Medicine Authors: Kristin Canavera Patricia Marik Nicole M Schneider Jacquelyn Smith Source Type: research
The association of pregnancy with outcomes among critically ill reproductive-aged women: A propensity-score matched retrospective cohort analysis
Chest. 2024 Mar 19:S0012-3692(24)00400-8. doi: 10.1016/j.chest.2024.03.030. Online ahead of print.ABSTRACTBACKGROUND: The maternal mortality rate in the US is unacceptably high. However, the relative contribution of pregnancy to these outcomes is unknown. Studies comparing outcomes among pregnant versus non-pregnant critically ill patients show mixed results and are limited by small sample sizes.RESEARCH QUESTION: What is the association of pregnancy with critical illness outcomes?STUDY DESIGN AND METHODS: We performed a retrospective cohort study of 18-55-year-old women who received invasive mechanical ventilation (MV) on...
Source: Chest - March 21, 2024 Category: Respiratory Medicine Authors: Rachel Kohn Deepshikha C Ashana Kelly C Vranas Elizabeth M Viglianti Katrina Hauschildt Catherine Chen Emily A Vail Leslie Moroz Hayley B Gershengorn Source Type: research
Laryngeal Dysfunction Manifesting as Chronic Refractory Cough and Dyspnea Laryngeal Physiology in Respiratory Health and Disease
Chest. 2024 Mar 18:S0012-3692(24)00396-9. doi: 10.1016/j.chest.2024.03.026. Online ahead of print.ABSTRACTTOPIC IMPORTANCE: Laryngeal dysfunction as a cause of chronic refractory cough (CRC) and episodic dyspnea is often missed which results in unnecessary testing and delays in diagnosis. Understanding laryngeal roles in breathing and airway protection can help to appreciate the propensity to laryngeal dysfunction with aging, chronic lung disease and sleep apnea.REVIEW FINDINGS: The human larynx is a complex muscular structure that undertakes multiple roles of breathing, vocalization, coughing and swallowing. To undertake ...
Source: Chest - March 20, 2024 Category: Respiratory Medicine Authors: Krishna M Sundar Amanda Stark Michael J Morris Source Type: research
Comparison of contemporary risk scores in all groups of pulmonary hypertension - a PVRI GoDeep meta-registry analysis
Chest. 2024 Mar 18:S0012-3692(24)00309-X. doi: 10.1016/j.chest.2024.03.018. Online ahead of print.ABSTRACTBACKGROUND: Pulmonary hypertension (PH) is a heterogeneous disease with poor prognosis. Accurate risk stratification is essential for guiding treatment decisions in pulmonary arterial hypertension (PAH). While various risk models were developed for PAH, their comparative prognostic potential requires further exploration. Additionally, the applicability of risk scores in PH groups beyond group 1 remains to be investigated.RESEARCH QUESTION: Are risk scores originally developed for PAH predictive in PH group 1-4?STUDY DE...
Source: Chest - March 20, 2024 Category: Respiratory Medicine Authors: Athiththan Yogeswaran Henning Gall Meike F ünderich Martin R Wilkins Luke Howard David G Kiely Allan Lawrie Paul M Hassoun Yuriy Sirenklo Olena Torbas Andrew J Sweatt Roham T Zamanian Paul G Williams Marlize Frauendorf Alexandra Arvanitaki George Giannak Source Type: research
The association between sputum culture conversion and mortality in cavitary Mycobacterium avium complex pulmonary disease
Chest. 2024 Mar 18:S0012-3692(24)00397-0. doi: 10.1016/j.chest.2024.03.027. Online ahead of print.ABSTRACTBACKGROUND: The association between treatment outcome and the mortality of Mycobacterium avium complex (MAC) pulmonary disease (PD) with cavitary lesions is unclear. Here, we assessed the impact of culture conversion on mortality in patients with cavitary Mycobacterium avium complex pulmonary disease.RESEARCH QUESTION: Is the achievement of sputum culture conversion in MAC-PD with cavitary lesions associated with the prognosis?STUDY DESIGN AND METHODS: From 2002 to 2020, 351 patients with cavitary MAC-PD (105 with the ...
Source: Chest - March 20, 2024 Category: Respiratory Medicine Authors: Ju Kwang Lee Seonok Kim Yong Pil Chong Hyun Joo Lee Tae Sun Shim Kyung-Wook Jo Source Type: research
Laryngeal Dysfunction Manifesting as Chronic Refractory Cough and Dyspnea Laryngeal Physiology in Respiratory Health and Disease
Chest. 2024 Mar 18:S0012-3692(24)00396-9. doi: 10.1016/j.chest.2024.03.026. Online ahead of print.ABSTRACTTOPIC IMPORTANCE: Laryngeal dysfunction as a cause of chronic refractory cough (CRC) and episodic dyspnea is often missed which results in unnecessary testing and delays in diagnosis. Understanding laryngeal roles in breathing and airway protection can help to appreciate the propensity to laryngeal dysfunction with aging, chronic lung disease and sleep apnea.REVIEW FINDINGS: The human larynx is a complex muscular structure that undertakes multiple roles of breathing, vocalization, coughing and swallowing. To undertake ...
Source: Chest - March 20, 2024 Category: Respiratory Medicine Authors: Krishna M Sundar Amanda Stark Michael J Morris Source Type: research
Comparison of contemporary risk scores in all groups of pulmonary hypertension - a PVRI GoDeep meta-registry analysis
Chest. 2024 Mar 18:S0012-3692(24)00309-X. doi: 10.1016/j.chest.2024.03.018. Online ahead of print.ABSTRACTBACKGROUND: Pulmonary hypertension (PH) is a heterogeneous disease with poor prognosis. Accurate risk stratification is essential for guiding treatment decisions in pulmonary arterial hypertension (PAH). While various risk models were developed for PAH, their comparative prognostic potential requires further exploration. Additionally, the applicability of risk scores in PH groups beyond group 1 remains to be investigated.RESEARCH QUESTION: Are risk scores originally developed for PAH predictive in PH group 1-4?STUDY DE...
Source: Chest - March 20, 2024 Category: Respiratory Medicine Authors: Athiththan Yogeswaran Henning Gall Meike F ünderich Martin R Wilkins Luke Howard David G Kiely Allan Lawrie Paul M Hassoun Yuriy Sirenklo Olena Torbas Andrew J Sweatt Roham T Zamanian Paul G Williams Marlize Frauendorf Alexandra Arvanitaki George Giannak Source Type: research
The association between sputum culture conversion and mortality in cavitary Mycobacterium avium complex pulmonary disease
Chest. 2024 Mar 18:S0012-3692(24)00397-0. doi: 10.1016/j.chest.2024.03.027. Online ahead of print.ABSTRACTBACKGROUND: The association between treatment outcome and the mortality of Mycobacterium avium complex (MAC) pulmonary disease (PD) with cavitary lesions is unclear. Here, we assessed the impact of culture conversion on mortality in patients with cavitary Mycobacterium avium complex pulmonary disease.RESEARCH QUESTION: Is the achievement of sputum culture conversion in MAC-PD with cavitary lesions associated with the prognosis?STUDY DESIGN AND METHODS: From 2002 to 2020, 351 patients with cavitary MAC-PD (105 with the ...
Source: Chest - March 20, 2024 Category: Respiratory Medicine Authors: Ju Kwang Lee Seonok Kim Yong Pil Chong Hyun Joo Lee Tae Sun Shim Kyung-Wook Jo Source Type: research
Rates and Risk Factors of Progression in Patients with Nontuberculous Mycobacterial Pulmonary Disease: Secondary Analysis of a Prospective Cohort Study
Chest. 2024 Mar 16:S0012-3692(24)00394-5. doi: 10.1016/j.chest.2024.03.024. Online ahead of print.ABSTRACTBACKGROUND: The clinical course of nontuberculous mycobacterial pulmonary disease (NTM-PD) is varied, and a watchful waiting management strategy is appropriate for a subset of patients. Understanding disease progression and risk factors for progression is essential for deciding on an appropriate follow-up strategy.RESEARCH QUESTION: What is the rate of NTM-PD progression, and what are the predictors of progression?STUDY DESIGN AND METHODS: Patients with NTM-PD who were enrolled in a prospective observational cohort stu...
Source: Chest - March 18, 2024 Category: Respiratory Medicine Authors: Kwonhyung Hyung Sung-A Kim Joong-Yub Kim Nakwon Kwak Jae-Joon Yim Source Type: research
Nationwide increasing incidence of Nontuberculous Mycobacterial diseases among adults in Denmark- eighteen years of follow-up
In this study, we determined the incidence and prevalence of NTM infections and focused on social risk factors. Additionally, we described persons suffering from pulmonary and extrapulmonary NTM.RESEARCH QUESTION: What is the incidence and prevalence of NTM and what are the characteristics of the affected patients?METHODS: This is a nationwide retrospective register-based cohort study in Denmark. Adult patients with NTM diagnosis in the Danish national registers from 2000-2017 were classified as having either pulmonary or extrapulmonary NTM disease.RESULTS: We identified 1,146 adults with an NTM diagnosis. 661 patients had...
Source: Chest - March 18, 2024 Category: Respiratory Medicine Authors: Andreas A Pedersen Anders L økke Andreas Fl øe Rikke Ibsen Isik S Johansen Ole Hilberg Source Type: research
