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Condition: Osteoarthritis

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Total 352 results found since Jan 2013.

Elucidating the Role of Protandim and 6 ‐Gingerol in Protection Against Osteoarthritis
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - July 26, 2016 Category: Biochemistry Authors: Jamilah Abusarah, Houda Abir Benabdoun, Qin Shi, Bertrand Lussier, Johanne Martel ‐Pelletier, Michel Malo, Julio C. Fernandes, Fátima Pereira de Souza, Hassan Fahmi, Mohamed Benderdour Tags: Article Source Type: research

Clock gene Bmal1 modulates human cartilage gene expression by crosstalk with Sirt1.
Abstract The critical regulation of peripheral circadian gene implicated in osteoarthritis (OA) has been recently recognized, however the causative role and clinical potential of the peripheral circadian rhythm attributable to such effects remains elusive. The purpose of this study was to elucidate the role of a circadian gene Bmal1 in human cartilage and pathophysiology of osteoarthritis. In our present study, the mRNA and protein levels of circadian rhythm genes, including NAD(+) and Sirt1 in human knee articular cartilage were determined. In OA cartilage, the levels of both Bmal1 and NAD(+) decreased significan...
Source: Endocrinology - June 1, 2016 Category: Endocrinology Authors: Yang W, Kang X, Liu J, Li H, Ma Z, Jin X, Qian Z, Xie T, Qin N, Feng D, Pan W, Chen Q, Sun H, Wu S Tags: Endocrinology Source Type: research

Agrin mediates chondrocyte homeostasis and requires both LRP4 and {alpha}-dystroglycan to enhance cartilage formation in vitro and in vivo
Conclusions We have discovered that agrin strongly promotes chondrocyte differentiation and cartilage formation in vivo. Our results identify agrin as a novel potent anabolic growth factor with strong therapeutic potential in cartilage regeneration.
Source: Annals of the Rheumatic Diseases - May 9, 2016 Category: Rheumatology Authors: Eldridge, S., Nalesso, G., Ismail, H., Vicente-Greco, K., Kabouridis, P., Ramachandran, M., Niemeier, A., Herz, J., Pitzalis, C., Perretti, M., Dell'Accio, F. Tags: Open access, Immunology (including allergy), Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis Basic and translational research Source Type: research

Intraarticular injection of lipid nanoparticle-sirna, a novel cartilage delivery system to attenuate cartilage degeneration in rat anterior cruciate ligament transection osteoarthritis model
Purpose: Osteoarthritis (OA) is a degenerative disease of the articular joints characterized by slow but progressive loss of cartilage. Our previous study showed that conditional deletion of Indian Hedgehog (Ihh) in chondrocytes attenuates OA progression, suggesting the possibility that blocking Ihh signaling can be used as a therapeutic approach to prevent or delay cartilage degeneration. However, Ihh gene deletion is currently not a therapeutic option as it is lethal in animals. RNA interference (RNAi) provides a means to knockdown Ihh without the severe side effects caused by chemical inhibitors.
Source: Osteoarthritis and Cartilage - March 20, 2016 Category: Rheumatology Authors: S. Wang, X. Wei, Y. Chang, J. Zhou, C. Chen, Y. Zhang, L. Wei Tags: Therapy- Intraarticular Source Type: research

Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms
Conclusions These results support the potential of HT as a chondroprotective nutraceutical compound against OA, not merely for its antioxidant ability, but as an autophagy and SIRT-1 inducer as well. General Significance. HT may exert a cytoprotective action by promoting autophagy in cell types that may be damaged in degenerative diseases by oxidative and other stress stimuli. Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) General Subjects - March 5, 2016 Category: Biochemistry Source Type: research

Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms.
CONCLUSIONS: These results support the potential of HT as a chondroprotective nutraceutical compound against OA, not merely for its antioxidant ability, but as an autophagy and SIRT-1 inducer as well. GENERAL SIGNIFICANCE: HT may exert a cytoprotective action by promoting autophagy in cell types that may be damaged in degenerative diseases by oxidative and other stress stimuli. PMID: 26947008 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - March 3, 2016 Category: Biochemistry Authors: Cetrullo S, D'Adamo S, Guidotti S, Borzì RM, Flamigni F Tags: Biochim Biophys Acta Source Type: research

Biphasic activation of nuclear factor-kappa B in chondrocyte death induced by interleukin-1beta: The expression of inducible nitric oxide synthase and phagocyte-type NADPH oxidase through immediate and monocarboxylate transporter-1-mediated late-phase activation of nuclear factor-kappa B
Conclusion We found that MCT-1 contributed to the expression of NOX-2 via late-phase activation of nuclear factor κB in a ROS-dependent manner in cells exposed to IL-1β. Hence, MCT-1 could be a potential target for the treatment of degenerative joint diseases.
Source: Journal of Oral Biosciences - February 24, 2016 Category: Biomedical Science Source Type: research

GREM1 Is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness.
CONCLUSION: GREM1 is highly expressed in RA joints, and functions as a regulator of survival, proliferation, migration, and invasion of RA-FLS. PMID: 26834210 [PubMed - as supplied by publisher]
Source: J Rheumatol - February 1, 2016 Category: Rheumatology Authors: Han EJ, Yoo SA, Kim GM, Hwang D, Cho CS, You S, Kim WU Tags: J Rheumatol Source Type: research

MiR-502-5p inhibits IL-1β-induced chondrocyte injury by targeting TRAF2.
In conclusion, miR-502-5p may exhibit a protective effect on IL-1β-induced chondrocyte injury by targeting TRAF2 and inhibiting NF-κB signaling pathway. PMID: 26861148 [PubMed - as supplied by publisher]
Source: Cellular Immunology - February 1, 2016 Category: Allergy & Immunology Authors: Zhang G, Sun Y, Wang Y, Liu R, Bao Y, Li Q Tags: Cell Immunol Source Type: research

hsa-miR-15a exerts protective effects against osteoarthritis by targeting aggrecanase-2 (ADAMTS5) in human chondrocytes.
Abstract The aim of the present study was to examine the expression levels and role of hsa-miR-15a in osteoarthritis (OA), as well as the associated mechanisms. The expression levels of hsa-miR-15a and A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (ADAMTS5, also known as aggrecanase-2) were measured by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) in both OA and normal chondrocytes. hsa-miR‑21 mimics or antisense oligonucleotides (ASO) were co-transfected into the chondrocytes to examine the effects on the putative binding sites compa...
Source: International Journal of Molecular Medicine - December 23, 2015 Category: Molecular Biology Authors: Lu X, Lin J, Jin J, Qian W, Weng X Tags: Int J Mol Med Source Type: research

Laminins and Nidogens in the Pericellular Matrix of Chondrocytes: Their Role in Osteoarthritis and Chondrogenic Differentiation.
This study reveals that the influence of the pericellular matrix on CPCs is important for the expression of the major regulator transcription factors, SOX9 and RUNX2. Our novel findings that laminins and nidogen-2 drive CPCs toward chondrogenesis may help in the elucidation of new treatment strategies for cartilage tissue regeneration. PMID: 26683663 [PubMed - as supplied by publisher]
Source: The American Journal of Pathology - December 10, 2015 Category: Pathology Authors: Schminke B, Frese J, Bode C, Goldring MB, Miosge N Tags: Am J Pathol Source Type: research

Laminins and Nidogens in the Pericellular Matrix of Chondrocytes
The aim of this study was to investigate the role of laminins and nidogen-2 in osteoarthritis (OA) and their potential to support chondrogenic differentiation. We applied immunohistochemistry, electron microscopy, siRNA, quantitative RT-PCR, Western blot, and proteome analysis for the investigation of cartilage tissue and isolated chondrocytes in three-dimensional culture obtained from patients with late-stage knee OA and nidogen-2 knockout mice. We demonstrate that subunits of laminins appear in OA cartilage and that nidogen-2–null mice exhibit typical osteoarthritic features.
Source: American Journal of Pathology - December 9, 2015 Category: Pathology Authors: Boris Schminke, Jenny Frese, Christa Bode, Mary B. Goldring, Nicolai Miosge Tags: Regular Article Source Type: research

Osteopontin inhibits HIF-2α mRNA expression in osteoarthritic chondrocytes.
Authors: Cheng C, Zhang FJ, Tian J, Tu M, Xiong YL, Luo W, Li YS, Song BB, Gao SG, Lei GH Abstract The aim of the present study was to investigate the in vitro effect of osteopontin (OPN) on the expression of hypoxia-inducible factor-2α (HIF-2α) in chondrocytes and the role of OPN in osteoarthritis (OA). Cartilage was purified from the tibial surfaces of patients with OA of the knee and cultured in vitro to obtain chondrocytes. Recombinant human OPN (rhOPN) and OPN small interfering RNA (siRNA) were used to treat the chondrocytes, and the changes in the expression levels of the HIF-2α gene were measured. An anti...
Source: Experimental and Therapeutic Medicine - November 18, 2015 Category: Journals (General) Tags: Exp Ther Med Source Type: research

A homeostatic function of CXCR2 signalling in articular cartilage
Conclusions Our study demonstrates an important physiological role for CXCR1/2 signalling in maintaining cartilage homeostasis and suggests that the loss of ELR+ CXC chemokines during cartilage breakdown in osteoarthritis contributes to the characteristic loss of chondrocyte phenotypic stability.
Source: Annals of the Rheumatic Diseases - November 10, 2015 Category: Rheumatology Authors: Sherwood, J., Bertrand, J., Nalesso, G., Poulet, B., Pitsillides, A., Brandolini, L., Karystinou, A., De Bari, C., Luyten, F. P., Pitzalis, C., Pap, T., Dell'Accio, F. Tags: Open access, Immunology (including allergy), Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis Basic and translational research Source Type: research

p21 deficiency is susceptible to osteoarthritis through STAT3 phosphorylation
Conclusions: The lack of p21 has catabolic effects by regulation of aggrecan and MMP-13 expression through STAT3 phosphorylation in the cartilage tissue. p21 may function as a regulator of transcriptional factors other than the inhibitor of cell cycle progression in the cartilage tissue. Thus, the regulation of p21 may be a therapeutic strategy for the treatment of OA.
Source: Arthritis Research and Therapy - November 7, 2015 Category: Rheumatology Authors: Shinya HayashiTakaaki FujishiroShingo HashimotoNoriyuki KanzakiNobuaki ChinzeiShinsuke KiharaKoji TakayamaTomoyuki MatsumotoKotaro NishidaMasahiro KurosakaRyosuke Kuroda Source Type: research