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Condition: Osteoarthritis
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Total 352 results found since Jan 2013.
MAGL regulates synovial macrophage polarization vis inhibition of mitophagy in osteoarthritic pain
In conclusion, in the present study, it was shown that MAGL regulated synovial macrophage polarization by inhibiting mitophagy in OA.PMID:37144506 | DOI:10.3892/mmr.2023.13004
Source: Molecular Medicine Reports - May 5, 2023 Category: Molecular Biology Authors: Chengyong Gu Mo Chen Xueyan Li Dechun Geng Chen Wang Source Type: research
CX-4945 inhibits fibroblast-like synoviocytes functions through the CK2-p53 axis to reduce rheumatoid arthritis disease severity
Int Immunopharmacol. 2023 Apr 13;119:110163. doi: 10.1016/j.intimp.2023.110163. Online ahead of print.ABSTRACTFibroblast-like synoviocytes (FLS) mediate many pathological processes in rheumatoid arthritis (RA), including pannus formation, bone erosion, and inflammation. RA FLS have unique aggressive phenotypes and exhibit several tumor cell-like characteristics, including hyperproliferation, excessive migration and invasion. Casein kinase 2 (CK2) is reportedly overexpressed in numerous tumor types, and targeted inhibition of CK2 has therapeutic benefits for tumors. However, the expression level of CK2 and its functions in ...
Source: International Immunopharmacology - April 15, 2023 Category: Allergy & Immunology Authors: Yanping Luo Yunxuan Lei Xin Guo Dehao Zhu Haiyang Zhang Zizhen Guo Zichong Xu Hanqing Zhao Yebin Xi Xiaochun Peng Lianbo Xiao Zhaojun Wang Xiaoyin Niu Guangjie Chen Source Type: research
MiR146a modulates chondrogenesis of bone marrow mesenchymal stem cells by modulating Lsm11 expression
This study aimed to determine the function of miR146a in the chondrogenic differentiation of MSCs and the potential mechanisms involved. MiR146a expression increased during chondrogenesis. MiR146a knockout (KO) led to the increased chondrogenesis of MSCs compared to that in wild-type (WT) MSCs, whereas the overexpression of miR146a by mimics resulted in the decreased chondrogenesis of MSCs, as determined by the mRNA expression of collagen, type II, alpha 1 (COL2A1), aggrecan, cartilage oligomeric matrix protein (COMP), and matrix metallopeptidase 13 (MMP13). Furthermore, cartilage defects could be treated better when injec...
Source: Am J Physiol Cell Ph... - March 20, 2023 Category: Cytology Authors: Yuhang Liu Xudong Zhang Xiaodong Chen Bingjun Zhang Liming Dai Chenglong Wang Yang Li Xiaoling Zhang Source Type: research
