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Condition: Osteoarthritis
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Total 352 results found since Jan 2013.
CDDO-Im ameliorates osteoarthritis and inhibits chondrocyte apoptosis in mice via enhancing Nrf2-dependent autophagy
Acta Pharmacol Sin. 2021 Nov 9. doi: 10.1038/s41401-021-00782-6. Online ahead of print.ABSTRACTOsteoarthritis (OA) is the most prevalent chronic degenerative joint disease with few treatment options. The pathogenesis of OA is characterized by sustained inflammation, oxidative stress and chondrocyte apoptosis that eventually lead to cartilage degradation and joint dysfunction. In the present study, we identified a synthetic triterpenoid CDDO-Im(1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl] imidazole) as an activator of Nrf2 (nuclear factor erythroid 2-related factor 2) that displayed strong anti-OA effects. We showed tha...
Source: Acta Pharmacologica Sinica - November 10, 2021 Category: Drugs & Pharmacology Authors: Jian Dong Kai-Jia Zhang Gao-Cai Li Xing-Ren Chen Jia-Jia Lin Jia-Wei Li Zhong-Yang Lv Zhao-Zhi Deng Jin Dai Wangsen Cao Qing Jiang Source Type: research
Amelioration of Posttraumatic Osteoarthritis in Mice Using Intraarticular Silencing of Periostin via Nanoparticle ‐Based Small Interfering RNA
ConclusionIA delivery of the periostin –siRNA nanocomplex represents a promising clinical approach to mitigate the severity of joint degeneration in OA. Our findings may thus provide an unequivocal scientific rationale for longitudinal studies of this approach. Utilizing a cartilage-specific gene-knockout strategy will further illumina te the functional role of periostin in OA.
Source: Arthritis and Rheumatology - October 28, 2021 Category: Rheumatology Authors: Xin Duan,
Lei Cai,
Christine T. N. Pham,
Yousef Abu ‐Amer,
Hua Pan,
Robert H. Brophy,
Samuel A. Wickline,
Muhammad Farooq Rai Tags: Full Length Source Type: research
Mechanism of high expression of high mobility group protein 1 in a rat model of knee osteoarthritis
CONCLUSION: In the pathological process of KOA, NLRPs inflammasome-mediated FLS pyroptosis causes massive release of HMGB1, which is associated with the activation of the downstream molecule caspase-1.PMID:34549703 | DOI:10.12122/j.issn.1673-4254.2021.08.03
Source: Journal of Southern Medical University - September 22, 2021 Category: Universities & Medical Training Authors: W Mei B Hong G Huang Source Type: research
