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Condition: Osteoarthritis

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Total 352 results found since Jan 2013.

LncRNA ANRIL impacts the progress of osteoarthritis via regulating proliferation and apoptosis of osteoarthritis synoviocytes.
CONCLUSIONS: We suggest that lncRNA ANRIL was closely related to osteoarthritis. ANRIL may be involved in the development and progression of osteoarthritis and become a potential target for diagnosis and treatment in OA. PMID: 31799639 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - December 7, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

The pro-inflammatory effect of NR4A3 in osteoarthritis.
In this study, high expression of NR4A3 in human osteoarthritis (OA) cartilage was firstly observed. To explore the relationship between NR4A3 and OA, we used a lentivirus overexpression system to simulate its high expression and study its role in OA. Additionally, siRNA-mediated knockdown of NR4A3 was used to confirm the findings of overexpression experiments. The results showed the stimulatory effect of IL-1β on cartilage matrix-degrading enzyme expression such as MMP-3, 9, INOS and COX-2 was enhanced in NR4A3-overexpressed chondrocytes and decreased in NR4A3-knockdown chondrocytes at both mRNA and protein levels, while...
Source: J Cell Mol Med - November 6, 2019 Category: Molecular Biology Authors: Ma C, Wu L, Song L, He Y, Adel Abdo Moqbel S, Yan S, Sheng K, Wu H, Ran J, Wu L Tags: J Cell Mol Med Source Type: research

Elevated levels of 15-lipoxygenase-1 contribute to the abnormal phenotypes of osteoblasts in human osteoarthritis
In conclusion, our results suggested that the expression of 15-LOX-1 on osteoblasts from the subchondral bone increased in OA. 15-LOX-1 inhibited autophagy by activated mTORC1, which in turn upregulated the markers of abnormal osteoblast phenotypes RUNX2, COL1, and OCN.
Source: Life Sciences - November 6, 2019 Category: Biology Source Type: research

15-Lipoxygenase-1 in osteoblasts promotes TGF-β1 expression via inhibiting autophagy in human osteoarthritis
ConclusionIn the present study, our findings suggested that 15-Lipoxygenase-1 in Osteoblasts Promotes TGF-β1 expression via inhibiting autophagy in human Osteoarthritis. These novel results suggested that 15-Lipoxygenase-1 expressed by subchondral bone osteoblasts might be a promising therapeutic target in human OA.Graphical abstract
Source: Biomedicine and Pharmacotherapy - November 5, 2019 Category: Drugs & Pharmacology Source Type: research

15-Lipoxygenase-1 in osteoblasts promotes TGF- β1 expression via inhibiting autophagy in human osteoarthritis.
CONCLUSION: In the present study, our findings suggested that 15-Lipoxygenase-1 in Osteoblasts Promotes TGF-β1 expression via inhibiting autophagy in human Osteoarthritis. These novel results suggested that 15-Lipoxygenase-1 expressed by subchondral bone osteoblasts might be a promising therapeutic target in human OA. PMID: 31704612 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 4, 2019 Category: Drugs & Pharmacology Authors: Wan Y, Lv Y, Li L, Yin Z Tags: Biomed Pharmacother Source Type: research

Abnormal thyroid hormone receptor signaling in osteoarthritic osteoblasts regulates microangiogenesis in subchondral bone
Publication date: Available online 22 October 2019Source: Life SciencesAuthor(s): Li Lei, Meng Li, Yiqun Pang, Jun Wang, Yunpeng Wan, Chen Zhu, Yin ZongshengAbstractAimsPrevious study indicated that the increase of local bio-availability of 3′3′5-triiodothyronine (T3) influenced osteoarthritis (OA) initiation. We aimed to investigate the role of thyroid hormone receptors (THRs) signaling in OA osteoblasts.Materials and methodsTHRs expression in OA was detected by immunohistochemistry, immunofluorescence, RT-qPCR and western blotting. These effects on the expression of angiogenesis-related factors were examined after TH...
Source: Life Sciences - October 23, 2019 Category: Biology Source Type: research

Down-regulation of MiR-138-5p Protects Chondrocytes ATDC5 and CHON-001 from IL-1 β-induced Inflammation Via Up-regulating SOX9.
CONCLUSION: miR-138-5p can arrest the proliferation and migration of CHON-001 and ATDC5 via restraining SOX9, and facilitate the apoptosis and inflammation. This study revealed the protective effect of down-regulated miR-138-5p on inflammatory injury of chondrocytes caused by IL-1β. PMID: 31486753 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - September 4, 2019 Category: Drugs & Pharmacology Authors: Chunlei H, Chang Z, Sheng L, Yanchun Z, Lulin L, Daozhang C Tags: Curr Pharm Des Source Type: research

miR-940 regulates the inflammatory response of chondrocytes by targeting MyD88 in osteoarthritis.
In conclusion, the pathogenesis of OA can be regulated by miR-940/MyD88 axis, which can be achieved through the combined signaling mechanism of MyD88/NF-κB signaling, induced with the help of IL-1β. PMID: 31435813 [PubMed - as supplied by publisher]
Source: Molecular and Cellular Biochemistry - August 20, 2019 Category: Biochemistry Authors: Cao J, Liu Z, Zhang L, Li J Tags: Mol Cell Biochem Source Type: research

Astragalus polysaccharide ameliorates lipopolysaccharide-induced cell injury in ATDC5 cells via miR-92a/KLF4 mediation
ConclusionsThe present study reveals that APS protects ATDC5 cells against LPS induced-injury by regulation of miR-92a/KLF4 axis and suppressing NF-κB and p38MAPK signal pathways.Graphical abstract
Source: Biomedicine and Pharmacotherapy - July 12, 2019 Category: Drugs & Pharmacology Source Type: research

Eupatilin protects chondrocytes from apoptosis via activating sestrin2-dependent autophagy.
Abstract Cartilage degradation is the main characterization of osteoarthritis (OA). Accumulating evidence suggests that chondrocyte apoptosis and autophagy are associated with cartilage degradation. Thus, we investigated the protective effect and underlying mechanism of eupatilin for treating OA. IL-1β was used to simulate OA in vitro. Data show that eupatilin treatment attenuated IL-1β-induced apoptosis of chondrocytes. Autophagy was also activated by eupatilin in a dose-dependent manner. Then, pretreatment with chloroquine (CQ), an autophagic inhibitor, decreased eupatilin-induced autophagy and increased apopt...
Source: International Immunopharmacology - July 11, 2019 Category: Allergy & Immunology Authors: Lou Y, Wu J, Liang J, Yang C, Wang K, Wang J, Guo X Tags: Int Immunopharmacol Source Type: research

Transforming growth factor β1 promotes fibroblast-like synoviocytes migration and invasion via TGF-β1/Smad signaling in rheumatoid arthritis.
Abstract Migration and invasion are important characteristics of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs), which are involved in joint damage and contribute to rheumatoid arthritis (RA) pathology. However, the underlying mechanisms remain unclear. Because epithelial-mesenchymal transition (EMT) is a key mechanism related to migration and invasion in cancer cells, we investigated the relationship between EMT and RA-FLSs and explored whether the transforming growth factor β1 (TGF-β1)/Smad signaling pathway is involved. In vivo, fibroblast-like synoviocytes (FLSs) were isolated from the synovium ...
Source: Molecular and Cellular Biochemistry - July 10, 2019 Category: Biochemistry Authors: Zhu D, Zhao J, Lou A, Huang Q, OuYang Q, Zhu J, Fan M, He Y, Ren H, Yang M Tags: Mol Cell Biochem Source Type: research

Astragalus polysaccharide ameliorates lipopolysaccharide-induced cell injury in ATDC5 cells via miR-92a/KLF4 mediation.
CONCLUSIONS: The present study reveals that APS protects ATDC5 cells against LPS induced-injury by regulation of miR-92a/KLF4 axis and suppressing NF-κB and p38MAPK signal pathways. PMID: 31302422 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2019 Category: Drugs & Pharmacology Authors: Fan L, Li M, Cao FY, Zeng ZW, Li XB, Ma C, Ru JT, Wu XJ Tags: Biomed Pharmacother Source Type: research

Applications of RNA interference in the treatment of arthritis.
Abstract RNA interference (RNAi) is a cellular mechanism for post-transcriptional gene regulation mediated by small interfering RNA (siRNA) and microRNA. siRNA-based therapy holds significant promise for the treatment of a wide-range of arthritic diseases. siRNA selectively suppresses the expression of a gene product and can thus achieve the specificity that is lacking in small molecule inhibitors. The potential use of siRNA-based therapy in arthritis, however, has not progressed to clinical trials despite ample evidence for efficacy in preclinical studies. One of the main challenges to clinical translation is the...
Source: Translational Research : the journal of laboratory and clinical medicine - July 9, 2019 Category: Laboratory Medicine Authors: Rai MF, Pan H, Yan H, Sandell LJ, Pham CTN, Wickline SA Tags: Transl Res Source Type: research

Directed elimination of senescent cells attenuates development of osteoarthritis by inhibition of c-IAP and XIAP
Publication date: Available online 26 June 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Wang Peilin, Teng Songsong, Zhuang Chengyu, Cui Zhi, Ma Chunhui, Yu Yinxian, Zhou Lei, Mao Min, Wang Zongyi, Yang Mengkai, Xu Jing, Zhang Tao, Wang Zhuoying, Yin Fei, Yi ChengqingAbstractAging drives the accumulation of senescent cells (SnCs) by secreting factors that cause the senescence-associated secretory phenotype (SASP), including stem cells in the bone marrow, which contribute to aging-related bone degradation. Osteoarthritis (OA) is a serious chronic injury disease, and increasing age is...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - June 27, 2019 Category: Molecular Biology Source Type: research

MiR-19b-3p attenuates IL-1 β induced extracellular matrix degradation and inflammatory injury in chondrocytes by targeting GRK6.
MiR-19b-3p attenuates IL-1β induced extracellular matrix degradation and inflammatory injury in chondrocytes by targeting GRK6. Mol Cell Biochem. 2019 Jun 21;: Authors: Duan L, Duan D, Wei W, Sun Z, Xu H, Guo L, Wu X Abstract Osteoarthritis (OA) is characterized by degradation of articular cartilage. MiRNAs are involved in the regulation of chondrogenesis and OA. We aimed to investigate effects and mechanisms of miR-19b-3p in regulating chondrocytes viability, cartilage degradation and inflammatory response. Primary chondrocytes were isolated from cartilages in control subjects and patients with OA. ...
Source: Molecular and Cellular Biochemistry - June 20, 2019 Category: Biochemistry Authors: Duan L, Duan D, Wei W, Sun Z, Xu H, Guo L, Wu X Tags: Mol Cell Biochem Source Type: research