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Condition: Osteoarthritis

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Total 352 results found since Jan 2013.

METTL3-mediated m6A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression
Conclusions Our study revealed the important role of FLS senescence in OA progression. Targeted METTL3 inhibition could alleviate the senescence of FLS and limit OA development in experimental animal models, providing a potential strategy for OA therapy.
Source: Annals of the Rheumatic Diseases - January 4, 2022 Category: Rheumatology Authors: Chen, X., Gong, W., Shao, X., Shi, T., Zhang, L., Dong, J., Shi, Y., Shen, S., Qin, J., Jiang, Q., Guo, B. Tags: ARD, Osteoarthritis Source Type: research

Physalin A Inhibits MAPK and NF- κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect
In conclusion, our work demonstrates that PA exhibits a chondroprotective effect that may be mediated by integrin αVβ3. Thus, PA or integrin αVβ3 might be a promising agent or molecular target for the treatment of OA.
Source: Frontiers in Pharmacology - December 1, 2021 Category: Drugs & Pharmacology Source Type: research

The potential role of mechanosensitive ion channels in substrate stiffness-regulated Ca < sup > 2+ < /sup > response in chondrocytes
CONCLUSIONS: Collectively, these findings indicate that chondrocytes might perceive and distinguish the different PCM stiffness by using different mechanosensitive ion channels.PMID:34814790 | DOI:10.1080/03008207.2021.2007902
Source: Connective Tissue Research - November 24, 2021 Category: Research Authors: Genlai Du Weiyi Chen Li Li Quanyou Zhang Source Type: research

CDDO-Im ameliorates osteoarthritis and inhibits chondrocyte apoptosis in mice via enhancing Nrf2-dependent autophagy
Acta Pharmacol Sin. 2021 Nov 9. doi: 10.1038/s41401-021-00782-6. Online ahead of print.ABSTRACTOsteoarthritis (OA) is the most prevalent chronic degenerative joint disease with few treatment options. The pathogenesis of OA is characterized by sustained inflammation, oxidative stress and chondrocyte apoptosis that eventually lead to cartilage degradation and joint dysfunction. In the present study, we identified a synthetic triterpenoid CDDO-Im(1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl] imidazole) as an activator of Nrf2 (nuclear factor erythroid 2-related factor 2) that displayed strong anti-OA effects. We showed tha...
Source: Acta Pharmacologica Sinica - November 10, 2021 Category: Drugs & Pharmacology Authors: Jian Dong Kai-Jia Zhang Gao-Cai Li Xing-Ren Chen Jia-Jia Lin Jia-Wei Li Zhong-Yang Lv Zhao-Zhi Deng Jin Dai Wangsen Cao Qing Jiang Source Type: research