Filtered By:
Condition: Osteoarthritis
This page shows you your search results in order of date. This is page number 5.
Order by Relevance | Date
Total 352 results found since Jan 2013.
MiR146a modulates chondrogenesis of bone marrow mesenchymal stem cells by modulating Lsm11 expression
This study aimed to determine the function of miR146a in the chondrogenic differentiation of MSCs and the potential mechanisms involved. MiR146a expression increased during chondrogenesis. MiR146a knockout (KO) led to the increased chondrogenesis of MSCs compared to that in wild-type (WT) MSCs, whereas the overexpression of miR146a by mimics resulted in the decreased chondrogenesis of MSCs, as determined by the mRNA expression of collagen, type II, alpha 1 (COL2A1), aggrecan, cartilage oligomeric matrix protein (COMP), and matrix metallopeptidase 13 (MMP13). Furthermore, cartilage defects could be treated better when injec...
Source: American Journal of Physiology. Cell Physiology - March 20, 2023 Category: Cytology Authors: Yuhang Liu Xudong Zhang Xiaodong Chen Bingjun Zhang Liming Dai Chenglong Wang Yang Li Xiaoling Zhang Source Type: research
Macrophage ‐derived extracellular vesicles trigger non‐canonical pyroptosis in chondrocytes leading to cartilage catabolism in osteoarthritis
ConclusionsOur results provide a new insight into the pathological mechanisms of OA and suggest that non-canonical pyroptosis in chondrocytes represents an attractive therapeutic target for future treatment.
Source: Arthritis and Rheumatology - March 17, 2023 Category: Rheumatology Authors: Taku Ebata,
Mohamad Alaa Terkawi,
Keita Kitahara,
Syunichi Yokota,
Junki Shiota,
Yoshio Nishida,
Gen Matsumae,
Hend Alhasan,
Masanari Hamasaki,
Kazutoshi Hontani,
Tomohiro Shimizu,
Daisuke Takahashi,
Tsutomu Endo,
Tomohiro Onodera,
Ken Kadoy Tags: Full Length Source Type: research
DNA methylation regulates Sirtuin 1 expression in osteoarthritic chondrocytes
CONCLUSIONS: Our results suggest the impact of DNA methylation on SIRT1 suppression in OA chondrocytes contributing to OA pathogenesis.PMID:36913826 | DOI:10.1016/j.advms.2023.02.002
Source: Advances in Medical Sciences - March 13, 2023 Category: Biomedical Science Authors: Aliki-Alexandra Papageorgiou Malamo Litsaki Evanthia Mourmoura Ioanna Papathanasiou Aspasia Tsezou Source Type: research
IL-10 enhances cell-to-cell communication in chondrocytes via STAT3 signaling pathway
Cell Signal. 2023 Jan 18:110605. doi: 10.1016/j.cellsig.2023.110605. Online ahead of print.ABSTRACTGap junction intercellular communication (GJIC) allows the transfer of material, message and energy between cells, which influences cell behaviors including cell proliferation, migration, differentiation and apoptosis and determines cell fate. Interleukin-10 (IL-10), a versatile cytokine, attracts more and more attention in the cartilage pathology such as osteoarthritis (OA) due to its potential in anti-inflammatory and wound repair. However, whether IL-10 can mediate GJIC in chondrocytes remains elusive. In the current study...
Source: Cellular Signalling - January 21, 2023 Category: Cytology Authors: Daimo Guo Shiyi Kan Li Zhang Zhixing Niu Mengmeng Duan Yang Liu Xiaohua Pu Mingru Bai Caixia Pi Demao Zhang Chenchen Zhou Jing Xie Source Type: research
A pH-responsive metal-organic framework for the co-delivery of HIF-2 α siRNA and curcumin for enhanced therapy of osteoarthritis
The occurrence of osteoarthritis (OA) is highly correlated with the reduction of joint lubrication performance, in which persistent excessive inflammation and irreversible destruction of cartilage dominate the...
Source: Journal of Nanobiotechnology - January 17, 2023 Category: Nanotechnology Authors: Zi-Jian Zhang, Ying-Ke Hou, Ming-Wa Chen, Xue-Zhao Yu, Si-Yu Chen, Ya-Ru Yue, Xiong-Tian Guo, Jin-Xiang Chen and Quan Zhou Tags: Research Source Type: research
I κB kinase ε contributes to the pathogenesis of osteoarthritis by promoting cartilage degradation
ConclusionThese results suggest that IKK ε regulates cartilage degradation through a catabolic response mediated by NF-κB signaling, and is a potential target for OA treatment. Furthermore, BAY-985 may serve a major compound in drugs developed for OA.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - December 19, 2022 Category: Rheumatology Authors: Taisuke Uchida,
Yukio Akasaki,
Takuya Sueishi,
Ichiro Kurakazu,
Masakazu Toya,
Masanari Kuwahara,
Ryota Hirose,
Yuki Hyodo,
Hidetoshi Tsushima,
Martin K. Lotz,
Yasuharu Nakashima Tags: Full Length Source Type: research
Targeted inhibition of TXNRD1 prevents cartilage extracellular matrix degeneration by activating Nrf2 pathway in osteoarthritis
Biochem Biophys Res Commun. 2022 Oct 19;635:267-276. doi: 10.1016/j.bbrc.2022.10.059. Online ahead of print.ABSTRACTOsteoarthritis, a prevalent orthopedic disease, can affect the elderly and causes impairment. The degradation and aberrant homeostasis of cartilage extracellular matrix figure pivotally in the progression of osteoarthritis. Thioredoxin systems plays a role in a wide range of biological processes, including cell proliferation, apoptosis, and oxidative stress. The present study aimed to investigate the unique function and underlying pathophysiological mechanism of TXNRD1 in chondrocytes. An upregulated expressi...
Source: Biochemical and Biophysical Research communications - October 29, 2022 Category: Biochemistry Authors: Jianhui Liang Song Wang Jiawei Hu Xin Hong Meisong Zhu Xuqiang Liu Momen Alswadeh Fengbo Mo Min Dai Source Type: research
Indole-3-aldehyde alleviates chondrocytes inflammation through the AhR-NF- κB signalling pathway
CONCLUSIONS: 3-IAld reduced inflammation through the AhR-NF-κB signalling pathway in IL-1β-induced chondrocytes, which is expected to provide a new therapeutic strategy for OA.PMID:36252481 | DOI:10.1016/j.intimp.2022.109314
Source: International Immunopharmacology - October 17, 2022 Category: Allergy & Immunology Authors: Huangming Zhuang Bin Li Ting Xie Changgeng Xu Xunshan Ren Fuze Jiang Tianrun Lei Panghu Zhou Source Type: research
Cationic amino acid transporter-1 (CAT-1) promotes fibroblast-like synoviocyte proliferation and cytokine secretion by taking up L-arginine in rheumatoid arthritis
CONCLUSION: CAT-1 is upregulated and promotes FLS proliferation by taking up L-arginine, thereby promoting RA progression.PMID:36253807 | DOI:10.1186/s13075-022-02921-8
Source: Cell Research - October 17, 2022 Category: Cytology Authors: Ying Lu Chongbo Hao Shanshan Yu Zuan Ma Xuelian Fu Mingqing Qin Menglei Ding Zengguang Xu Lieying Fan Source Type: research
Indole-3-aldehyde alleviates chondrocytes inflammation through the AhR-NF- κB signalling pathway
CONCLUSIONS: 3-IAld reduced inflammation through the AhR-NF-κB signalling pathway in IL-1β-induced chondrocytes, which is expected to provide a new therapeutic strategy for OA.PMID:36252481 | DOI:10.1016/j.intimp.2022.109314
Source: International Immunopharmacology - October 17, 2022 Category: Allergy & Immunology Authors: Huangming Zhuang Bin Li Ting Xie Changgeng Xu Xunshan Ren Fuze Jiang Tianrun Lei Panghu Zhou Source Type: research
