The role of P2X7 receptor in prognosis and metastasis of colorectal cancer
ConclusionsP2X7R expression might be a potential biomarker for prognosis and metastasis of CRC. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - July 3, 2019 Category: Biomedical Science Source Type: research

The role of P2X7 receptor in prognosis and metastasis of colorectal cancer.
CONCLUSIONS: P2X7R expression might be a potential biomarker for prognosis and metastasis of CRC. PMID: 31276917 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - July 2, 2019 Category: Biomedical Science Authors: Zhang Y, Ding J, Wang L Tags: Adv Med Sci Source Type: research

The potential role of inflammation in cryptogenic stroke
Publication date: September 2019Source: Advances in Medical Sciences, Volume 64, Issue 2Author(s): Paulina Gąsiorek, Maciej Banach, Agata Sakowicz, Andrzej Głąbiński, Bożena Sosnowska, Marek Maciejewski, Agata Bielecka-DabrowaAbstractPurposeThe study aimed to identify biomarkers predictive of cryptogenic stroke in patients aged
Source: Advances in Medical Sciences - June 30, 2019 Category: Biomedical Science Source Type: research

The potential role of inflammation in cryptogenic stroke.
Abstract PURPOSE: The study aimed to identify biomarkers predictive of cryptogenic stroke in patients aged
Source: Advances in Medical Sciences - June 28, 2019 Category: Biomedical Science Authors: Gąsiorek P, Banach M, Sakowicz A, Głąbiński A, Sosnowska B, Maciejewski M, Bielecka-Dabrowa A Tags: Adv Med Sci Source Type: research

Effect of quinolinic acid – A uremic toxin from tryptophan metabolism – On hemostatic profile in rat and mouse thrombosis models
ConclusionsWe demonstrated the first evidence for the opposite biological effects of QA on hemostasis in rat and mouse thrombosis models. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - June 8, 2019 Category: Biomedical Science Source Type: research

Effect of quinolinic acid - A uremic toxin from tryptophan metabolism - On hemostatic profile in rat and mouse thrombosis models.
CONCLUSIONS: We demonstrated the first evidence for the opposite biological effects of QA on hemostasis in rat and mouse thrombosis models. PMID: 31176868 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - June 6, 2019 Category: Biomedical Science Authors: Leszczyńska A, Misztal T, Marcińczyk N, Kamiński T, Kramkowski K, Chabielska E, Pawlak D Tags: Adv Med Sci Source Type: research

Selected elements of extracellular matrix of the skin in diabetes and insulin resistance
ConclusionsInsulin and metformin improve the quality of the skin in rats with diabetes and insulin resistance, by restoring the content of hyaluronic acid to the healthy skin level. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - May 28, 2019 Category: Biomedical Science Source Type: research

Editorial Board
Publication date: March 2019Source: Advances in Medical Sciences, Volume 64, Issue 1Author(s): (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - May 27, 2019 Category: Biomedical Science Source Type: research

Selected elements of extracellular matrix of the skin in diabetes and insulin resistance.
CONCLUSIONS: Insulin and metformin improve the quality of the skin in rats with diabetes and insulin resistance, by restoring the content of hyaluronic acid to the healthy skin level. PMID: 31146169 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - May 27, 2019 Category: Biomedical Science Authors: Niczyporuk M, Knaś M, Car H Tags: Adv Med Sci Source Type: research

State of the art – sirtuin 1 in kidney pathology – clinical relevance
Publication date: September 2019Source: Advances in Medical Sciences, Volume 64, Issue 2Author(s): Angelika Bazyluk, Jolanta Malyszko, Tomasz Hryszko, Edyta ZbrochAbstractSirtuins represent a group of nicotinamide adenine dinucleotide dependent histone deacetylases, which regulates various biological pathways by promoting chromatin silencing and transcriptional repression. Therefore, they are linked to cellular energy metabolism, mitochondrial biogenesis, stress response, apoptosis, inflammation and fibrosis. Since sirtuin 1 became a promising candidate for targeted therapies of numerous conditions, researchers have been i...
Source: Advances in Medical Sciences - May 22, 2019 Category: Biomedical Science Source Type: research

Efficacy of daratumumab monotherapy in real-world heavily pretreated patients with relapsed or refractory multiple myeloma
ConclusionDaratumumab monotherapy has significant activity and good tolerance in heavily pretreated RRMM patients. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - May 22, 2019 Category: Biomedical Science Source Type: research

Efficacy of daratumumab monotherapy in real-world heavily pretreated patients with relapsed or refractory multiple myeloma.
CONCLUSION: Daratumumab monotherapy has significant activity and good tolerance in heavily pretreated RRMM patients. PMID: 31125864 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - May 21, 2019 Category: Biomedical Science Authors: Salomon-Perzyński A, Walter-Croneck A, Usnarska-Zubkiewicz L, Dytfeld D, Zielińska P, Wojciechowska M, Hołojda J, Robak P, Pasternak A, Knopińska-Posłuszny W, Hawrylecka D, Wójtowicz M, Szeremet A, Osowiecki M, Mordak-Domagała M, Zaucha JM, Giannop Tags: Adv Med Sci Source Type: research

State of the art - sirtuin 1 in kidney pathology - clinical relevance.
Abstract Sirtuins represent a group of nicotinamide adenine dinucleotide dependent histone deacetylases, which regulates various biological pathways by promoting chromatin silencing and transcriptional repression. Therefore, they are linked to cellular energy metabolism, mitochondrial biogenesis, stress response, apoptosis, inflammation and fibrosis. Since sirtuin 1 became a promising candidate for targeted therapies of numerous conditions, researchers have been investigating its activator. As for now, natural agents and antidiabetic drug - metformin, have been found to activate sirtuin 1. Sirtuin 1 is able to imp...
Source: Advances in Medical Sciences - May 21, 2019 Category: Biomedical Science Authors: Bazyluk A, Malyszko J, Hryszko T, Zbroch E Tags: Adv Med Sci Source Type: research

microRNA expression profile in Smooth Muscle Cells isolated from thoracic aortic aneurysm samples
ConclusionsFurther studies are required to improve our understanding of the pathophysiology underlying TAA, which may aid the development of novel, targeted therapies. The pivotal role of miRNAs in the cardiovascular system provides a new perspective on the pathophysiology of thoracic aortic aneurysms. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - April 23, 2019 Category: Biomedical Science Source Type: research

Original research article Parainfluenza virus infection enhances NSAIDs–induced inhibition of PGE2 generation and COX-2 expression in human airway epithelial cells
ConclusionVirus infection in airway epithelial cells enhances inhibitory effect of NSAIDs on prostaglandin E2 generation. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - April 23, 2019 Category: Biomedical Science Source Type: research

Assessment of serum levels of DIO1 and DIO3 in patients diagnosed with COPD
Publication date: September 2019Source: Advances in Medical Sciences, Volume 64, Issue 2Author(s): Elżbieta Gałecka, Anna Kumor-Kisielewska, Paweł GórskiAbstractPurposeChronic obstructive pulmonary disease is the most common chronic lung disease, which may be caused by different pathological processes, including inflammation. Furthermore, signs of changes in thyroid hormone levels are found in some patients. Deiodinases (DIOs) are selenoproteins (enzymes) involved in the synthesis of thyroid hormones. It has been found that these molecules are involved in inflammatory processes. We carried out this preliminary st...
Source: Advances in Medical Sciences - April 23, 2019 Category: Biomedical Science Source Type: research

microRNA expression profile in Smooth Muscle Cells isolated from thoracic aortic aneurysm samples.
CONCLUSIONS: Further studies are required to improve our understanding of the pathophysiology underlying TAA, which may aid the development of novel, targeted therapies. The pivotal role of miRNAs in the cardiovascular system provides a new perspective on the pathophysiology of thoracic aortic aneurysms. PMID: 31022558 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - April 22, 2019 Category: Biomedical Science Authors: Kasprzyk-Pawelec A, Wojciechowska A, Kuc M, Zielinski J, Parulski A, Kusmierczyk M, Lutynska A, Kozar-Kaminska K Tags: Adv Med Sci Source Type: research

Original research article Parainfluenza virus infection enhances NSAIDs-induced inhibition of PGE2 generation and COX-2 expression in human airway epithelial cells.
CONCLUSION: Virus infection in airway epithelial cells enhances inhibitory effect of NSAIDs on prostaglandin E2 generation. PMID: 31022559 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - April 22, 2019 Category: Biomedical Science Authors: Lewandowska-Polak A, Brauncajs M, Jarzębska M, Pawełczyk M, Kurowski M, Makowska J, Kowalski ML Tags: Adv Med Sci Source Type: research

Assessment of serum levels of DIO1 and DIO3 in patients diagnosed with COPD.
ski P Abstract PURPOSE: Chronic obstructive pulmonary disease is the most common chronic lung disease, which may be caused by different pathological processes, including inflammation. Furthermore, signs of changes in thyroid hormone levels are found in some patients. Deiodinases (DIOs) are selenoproteins (enzymes) involved in the synthesis of thyroid hormones. It has been found that these molecules are involved in inflammatory processes. We carried out this preliminary study to investigate the levels of two deiodinases, i.e. type 1 deiodinase (DIO1) and type 3 deiodinase (DIO3), and their possible association with...
Source: Advances in Medical Sciences - April 22, 2019 Category: Biomedical Science Authors: Gałecka E, Kumor-Kisielewska A, Górski P Tags: Adv Med Sci Source Type: research

Ultrasound images in hepatic alveolar echinococcosis and clinical stage of the disease
ConclusionsThe ultrasonographic appearance of the lesion in liver AE cannot determine the therapeutic management. Treatment plan should be established based on the PMN classification. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - April 18, 2019 Category: Biomedical Science Source Type: research

Ultrasound images in hepatic alveolar echinococcosis and clinical stage of the disease.
CONCLUSIONS: The ultrasonographic appearance of the lesion in liver AE cannot determine the therapeutic management. Treatment plan should be established based on the PMN classification. PMID: 31003201 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - April 16, 2019 Category: Biomedical Science Authors: Sulima M, Nahorski W, Gorycki T, Wołyniec W, Wąż P, Felczak-Korzybska I, Szostakowska B, Sikorska K Tags: Adv Med Sci Source Type: research

Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas
Publication date: September 2019Source: Advances in Medical Sciences, Volume 64, Issue 2Author(s): Jan Lukas, Jola Pospech, Christina Oppermann, Christina Hund, Katharina Iwanov, Supansa Pantoom, Janine Petters, Moritz Frech, Susanne Seemann, Franziska-Gisela Thiel, Jana-Marielle Modenbach, Robert Bolsmann, Laura de Freitas Chama, Franziska Kraatz, Firas El-Hage, Manuel Gronbach, Annelie Klein, Regina Müller, Sabine Salloch, Frank-Ulrich WeissAbstractThe endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and secretory proteins. The fraction of protein passing through the ER represents a large ...
Source: Advances in Medical Sciences - April 10, 2019 Category: Biomedical Science Source Type: research

Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary circulation in patients with systemic sclerosis
ConclusionDoppler resting and exercise echocardiography may provide a reliable, noninvasive method for determining resting and exercise sPAP, mPAP, and PVR in SSc patients, although it may underestimate or overestimate these values in some individuals. Doppler echocardiography does not replace RHC for definite hemodynamic assessment of suspected PH. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - April 10, 2019 Category: Biomedical Science Source Type: research

Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas.
rüger E, Mayerle J, Delcea M, Kragl U, Beller M, Rolfs A, Lerch MM, Sendler M Abstract The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and secretory proteins. The fraction of protein passing through the ER represents a large proportion of the total protein in the cell. Protein folding, glycosylation, sorting and transport are essential tasks of the ER and a compromised ER folding network has been recognized to be a key component in the disease pathogenicity of common neurodegenerative, metabolic and malignant diseases. On the other hand, the ER protein folding machinery also ho...
Source: Advances in Medical Sciences - April 9, 2019 Category: Biomedical Science Authors: Lukas J, Pospech J, Oppermann C, Hund C, Iwanov K, Pantoom S, Petters J, Frech M, Seemann S, Thiel FG, Modenbach JM, Bolsmann R, de Freitas Chama L, Kraatz F, El-Hage F, Gronbach M, Klein A, Müller R, Salloch S, Weiss FU, Simon P, Wagh P, Klemenz A, Krü Tags: Adv Med Sci Source Type: research

Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary circulation in patients with systemic sclerosis.
CONCLUSION: Doppler resting and exercise echocardiography may provide a reliable, noninvasive method for determining resting and exercise sPAP, mPAP, and PVR in SSc patients, although it may underestimate or overestimate these values in some individuals. Doppler echocardiography does not replace RHC for definite hemodynamic assessment of suspected PH. PMID: 30974403 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - April 8, 2019 Category: Biomedical Science Authors: Ciurzyński M, Bienias P, Ciesielska K, Chrzanowska A, Dudzik-Niewiadomska I, Kurnicka K, Domienik-Karłowicz J, Siwicka M, Sobieraj P, Kalińska-Bienias A, Kurzyna M, Pruszczyk P Tags: Adv Med Sci Source Type: research

Clinical importance of sex differences in dyspnea and its sex related determinants in asthma and COPD patients
ConclusionsAlthough more apparent in asthma, it was revealed for the first time, that sex has a strong influence on the magnitude of dyspnea perception, both in asthma and COPD. Therefore, sex related dyspnea sensation should probably be included in clinical assessment and patient treatment. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - April 5, 2019 Category: Biomedical Science Source Type: research

Diagnostic accuracy of frontotemporal dementia. An artificial intelligence-powered study of symptoms, imaging and clinical judgement
ConclusionsThe study proves that the algorithm can efficiently guide clinical practice and improve the accuracy of the diagnosis of FTD whilst making the process of auditing faster and more economically viable. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - April 3, 2019 Category: Biomedical Science Source Type: research

Clinical importance of sex differences in dyspnea and its sex related determinants in asthma and COPD patients.
CONCLUSIONS: Although more apparent in asthma, it was revealed for the first time, that sex has a strong influence on the magnitude of dyspnea perception, both in asthma and COPD. Therefore, sex related dyspnea sensation should probably be included in clinical assessment and patient treatment. PMID: 30953955 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - April 3, 2019 Category: Biomedical Science Authors: Skoczyński S, Zejda J, Brożek G, Glinka K, Waz S, Kotulska B, Barczyk A Tags: Adv Med Sci Source Type: research

Combined pulmonary fibrosis and emphysema: How does cohabitation affect respiratory functions?
Publication date: September 2019Source: Advances in Medical Sciences, Volume 64, Issue 2Author(s): Fatma Çiftci, Başak Gülpınar, Çetin Atasoy, Oya Kayacan, Sevgi SaryalAbstractPurposeCombined pulmonary fibrosis and emphysema (CPFE) has emerged as a new syndrome with characteristics of both fibrosis and emphysema. We determined the impacts of radiologic emphysema severity on pulmonary function tests (PFTs), exercise capacity and mortality.Patients and methodsIPF patients (n = 110) diagnosed at the Chest Diseases Clinic between September 2013 and January 2016 were enrolled in the study and ...
Source: Advances in Medical Sciences - April 2, 2019 Category: Biomedical Science Source Type: research

Diagnostic accuracy of frontotemporal dementia. An artificial intelligence-powered study of symptoms, imaging and clinical judgement.
CONCLUSIONS: The study proves that the algorithm can efficiently guide clinical practice and improve the accuracy of the diagnosis of FTD whilst making the process of auditing faster and more economically viable. PMID: 30952029 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - April 1, 2019 Category: Biomedical Science Authors: Brzezicki MA, Kobetić MD, Neumann S, Pennington C Tags: Adv Med Sci Source Type: research

Combined pulmonary fibrosis and emphysema: How does cohabitation affect respiratory functions?
can O, Saryal S Abstract PURPOSE: Combined pulmonary fibrosis and emphysema (CPFE) has emerged as a new syndrome with characteristics of both fibrosis and emphysema. We determined the impacts of radiologic emphysema severity on pulmonary function tests (PFTs), exercise capacity and mortality. PATIENTS AND METHODS: IPF patients (n = 110) diagnosed at the Chest Diseases Clinic between September 2013 and January 2016 were enrolled in the study and followed up until June 2017. Visual and digital emphysema scores, PFTs, pulmonary artery pressure (sPAP), 6-minute walking test, composite physiologic in...
Source: Advances in Medical Sciences - April 1, 2019 Category: Biomedical Science Authors: Çiftci F, Gülpınar B, Atasoy Ç, Kayacan O, Saryal S Tags: Adv Med Sci Source Type: research

Can hepatokines be regarded as novel non-invasive serum biomarkers of intrahepatic lipid content in obese children?
ConclusionsFGF-21 can be considered as a suitable biomarker in predicting TILC and fatty liver in obese children. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - March 27, 2019 Category: Biomedical Science Source Type: research

Can hepatokines be regarded as novel non-invasive serum biomarkers of intrahepatic lipid content in obese children?
CONCLUSIONS: FGF-21 can be considered as a suitable biomarker in predicting TILC and fatty liver in obese children. PMID: 30921653 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - March 25, 2019 Category: Biomedical Science Authors: Flisiak-Jackiewicz M, Bobrus-Chociej A, Wasilewska N, Tarasow E, Wojtkowska M, Lebensztejn DM Tags: Adv Med Sci Source Type: research

Transcriptional activity of epigenetic remodeling genes declines in keratinocytes after in vitro expansion
ConclusionsTransmission to in vitro environment challenges cellular signalling and metabolism. The regulation of epigenetic remodelling maintains the balance between cellular plasticity and phenotype deviation. This preliminary research demonstrated reduced activity of genes responsible for epigenetic modifications of DNA and histones in in vitro expanded epidermal cells. This observation indicates that epigenome re-patterning in cultured epidermal cells is significantly less intensive than in the skin. Also, this observation may imply that after adaptation to in vitro conditions, the epigenome does not undergo extensive t...
Source: Advances in Medical Sciences - March 20, 2019 Category: Biomedical Science Source Type: research

Transcriptional activity of epigenetic remodeling genes declines in keratinocytes after in vitro expansion.
CONCLUSIONS: Transmission to in vitro environment challenges cellular signalling and metabolism. The regulation of epigenetic remodelling maintains the balance between cellular plasticity and phenotype deviation. This preliminary research demonstrated reduced activity of genes responsible for epigenetic modifications of DNA and histones in in vitro expanded epidermal cells. This observation indicates that epigenome re-patterning in cultured epidermal cells is significantly less intensive than in the skin. Also, this observation may imply that after adaptation to in vitro conditions, the epigenome does not undergo extensive...
Source: Advances in Medical Sciences - March 19, 2019 Category: Biomedical Science Authors: Kamińska J, Langa P, Deptuła M, Zieliński J, Sachadyn P, Wardowska A, Pikuła M Tags: Adv Med Sci Source Type: research

Novel potential biomarkers for pancreatic cancer – A systematic review
ConclusionPresented proteins might be potential biomarkers in the diagnosis and progression of PC. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - March 5, 2019 Category: Biomedical Science Source Type: research

IL-1α and IL-6 predict vascular events or death in patients with cerebral small vessel disease—Data from the SHEF-CSVD study
ConclusionsOur study demonstrated the important prognostic role of various circulation markers of inflammation in individuals with different clinical signs and radiological markers of CSVD. The strongest association occurred between IL-1α, IL-6 and recurrent stroke, other vascular events and death. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - March 5, 2019 Category: Biomedical Science Source Type: research

Contribution of sialic acids to integrin α5β1 functioning in melanoma cells
ConclusionsOur data suggest that in primary melanoma cells integrin α5β1 action is more likely dependent on its glycosylation profile, i.e. the presence of SA residues, which influence (decreased) their invasion properties and may facilitate malignant melanoma progression. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - March 5, 2019 Category: Biomedical Science Source Type: research

Novel potential biomarkers for pancreatic cancer - A systematic review.
CONCLUSION: Presented proteins might be potential biomarkers in the diagnosis and progression of PC. PMID: 30844662 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - March 4, 2019 Category: Biomedical Science Authors: Litman-Zawadzka A, Łukaszewicz-Zając M, Mroczko B Tags: Adv Med Sci Source Type: research

IL-1 α and IL-6 predict vascular events or death in patients with cerebral small vessel disease-Data from the SHEF-CSVD study.
CONCLUSIONS: Our study demonstrated the important prognostic role of various circulation markers of inflammation in individuals with different clinical signs and radiological markers of CSVD. The strongest association occurred between IL-1α, IL-6 and recurrent stroke, other vascular events and death. PMID: 30844663 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - March 4, 2019 Category: Biomedical Science Authors: Staszewski J, Skrobowska E, Piusińska-Macoch R, Brodacki B, Stępień A Tags: Adv Med Sci Source Type: research

Contribution of sialic acids to integrin α5β1 functioning in melanoma cells.
CONCLUSIONS: Our data suggest that in primary melanoma cells integrin α5β1 action is more likely dependent on its glycosylation profile, i.e. the presence of SA residues, which influence (decreased) their invasion properties and may facilitate malignant melanoma progression. PMID: 30844664 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - March 4, 2019 Category: Biomedical Science Authors: Kolasińska E, Janik ME, Lityńska A, Przybyło M Tags: Adv Med Sci Source Type: research

Clinical characteristics of autoimmune pancreatitis with IgG4 related kidney disease
Publication date: September 2019Source: Advances in Medical Sciences, Volume 64, Issue 2Author(s): Sawako Kuruma, Terumi Kamisawa, Masataka Kikuyama, Kazuro Chiba, Ryoko Shimizuguchi, Satomi Koizumi, Taku TabataAbstractPurposeTo clarify the clinical characteristics of autoimmune pancreatitis (AIP) in immunoglobulin (Ig)G4-related kidney disease (IgG4-RKD).Patients and methodsA total of 92 patients with AIP were divided into an IgG4-RKD-positive group (RKD-P group, n = 13) and an IgG4-RKD-negative group (RKD-N group, n = 79) on the basis of the diagnostic criteria for IgG4-RKD. Clinical character...
Source: Advances in Medical Sciences - March 1, 2019 Category: Biomedical Science Source Type: research

Exercise training program in patients with NYHA III class systolic heart failure - Parallel comparison to the effects of resynchronization therapy
ConclusionsSignificant improvement in exercise tolerance capacity and increase of LVEF were observed in similar extent both in heart failure patients with CRT and with ICD undergoing the rehabilitation program. Regular, controlled exercise trainings provided additional, safe and easy to conduct therapeutic option for heart failure patients with no indications for CRT. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - February 28, 2019 Category: Biomedical Science Source Type: research

Hepcidin – Potential biomarker of contrast-induced acute kidney injury in patients undergoing percutaneous coronary interventions
ConclusionsOur findings suggest that serum hepcidin might be an early predictive biomarker of ruling out CI-AKI after PCI, thereby contributing to early patient risk stratification. However, our data needs to be validated in large cohorts with various stages of CKD. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - February 27, 2019 Category: Biomedical Science Source Type: research

Anti-angiogenic efficacy in invasive breast carcinoma patients depends on clinicopathological determinants
ConclusionsAnti-angiogenic potential is divergent in relation to the clinicopathological determinants. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - February 27, 2019 Category: Biomedical Science Source Type: research

Circadian clock genes and circadian phenotypes in patients with myocardial infarction
ConclusionOur data suggest that genetic variations in some circadian clock genes might be related to circadian phenotype (i.e., chronotype and daytime sleepiness) in patients with myocardial infarction. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - February 27, 2019 Category: Biomedical Science Source Type: research

Analysis of chosen SNVs in GPC5, CD58 and IRF8 genes in multiple sclerosis patients
Publication date: September 2019Source: Advances in Medical Sciences, Volume 64, Issue 2Author(s): Monika Chorąży, Natalia Wawrusiewicz-Kurylonek, Renata Posmyk, Agata Zajkowska, Katarzyna Kapica-Topczewska, Adam Jacek Krętowski, Jan Kochanowicz, Alina KułakowskaAbstractPurposeMultiple sclerosis (MS) is an autoimmune disease of the central nervous system with a neurodegenerative compound. Heterogenetic background of autoimmunity pathway components has been suggested in the MS pathogenesis. The main aim of our study was to evaluate the association between selected polymorphisms of theCD58, IRF8 and GPC5 genes and treatm...
Source: Advances in Medical Sciences - February 27, 2019 Category: Biomedical Science Source Type: research

Significance of BRCA1 expression in breast and ovarian cancer patients with brain metastasis – A multicentre study
ConclusionsPatients with BC and OC and brain metastases have a frequent loss of BRCA1 expression. The role of ERα, PR, HER2, SDF1, CXCR4, AEG1, BRMS1 in metastatic process needs further studies. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - February 27, 2019 Category: Biomedical Science Source Type: research

Clinical characteristics of autoimmune pancreatitis with IgG4 related kidney disease.
Abstract PURPOSE: To clarify the clinical characteristics of autoimmune pancreatitis (AIP) in immunoglobulin (Ig)G4-related kidney disease (IgG4-RKD). PATIENTS AND METHODS: A total of 92 patients with AIP were divided into an IgG4-RKD-positive group (RKD-P group, n = 13) and an IgG4-RKD-negative group (RKD-N group, n = 79) on the basis of the diagnostic criteria for IgG4-RKD. Clinical characteristics, including: age; sex; the presence of extrapancreatic lesions other than renal lesions, proteinuria, and hematuria; serum concentrations of IgG, IgG4, IgE, and creatinine; and urinary ...
Source: Advances in Medical Sciences - February 27, 2019 Category: Biomedical Science Authors: Kuruma S, Kamisawa T, Kikuyama M, Chiba K, Shimizuguchi R, Koizumi S, Tabata T Tags: Adv Med Sci Source Type: research

Significance of BRCA1 expression in breast and ovarian cancer patients with brain metastasis - A multicentre study.
CONCLUSIONS: Patients with BC and OC and brain metastases have a frequent loss of BRCA1 expression. The role of ERα, PR, HER2, SDF1, CXCR4, AEG1, BRMS1 in metastatic process needs further studies. PMID: 30822630 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - February 26, 2019 Category: Biomedical Science Authors: Szarszewska M, Markowska A, Jach R, Marszałek A, Filas V, Bednarek W, Olejek A, Tomczak P, Sajdak S, Nowak-Markwitz E, Jaszczyńska-Nowinka K, Stanisławiak-Rudowicz J, Gryboś A, Chudecka-Głaz A, Gryboś M, Adamska K, Ramlau R, Markowska J, Knapp P Tags: Adv Med Sci Source Type: research