Impact of NMDA receptors block versus GABA-A receptors modulation on synaptic plasticity and brain electrical activity in metabolic syndrome

CONCLUSIONS: Both Allo and Memantine boosted the outcome parameters in the animal model of MetS. Allo markedly improved the anxiety-like behavior in the form of significantly decreased grooming frequency compared to the Memantine-treated groups. Both drugs were associated with increased hippocampal GFAP and BDNF expression, indicating an improvement in synaptic plasticity and so, cognition-related behaviors.PMID:38561071 | DOI:10.1016/j.advms.2024.03.008

Source: Advances in Medical Sciences - April 1, 2024 Category: Biomedical Science Authors: Shaimaa Nasr Amin Sherif Ahmed Shaltout Walaa Bayoumie El Gazzar Noha Samir Abdel Latif Ghada Al-Jussani Yasmeen Jamal Alabdallat Khaled Anwer Albakri Dalia Azmy Elberry Source Type: research