Genetic aberrations of homologous recombination repair pathways in prostate cancer: The prognostic and therapeutic implications
Adv Med Sci. 2023 Sep 25;68(2):359-365. doi: 10.1016/j.advms.2023.09.008. Online ahead of print.ABSTRACTProstate cancer (PC) is the second most common cancer in men worldwide. Homologous recombination repair (HRR) gene defects have been identified in a significant proportion of metastatic castration-resistant PC (mCRPC) and are associated with an increased risk of PC and more aggressive PC. Importantly, it has been well-documented that poly ADP-ribose polymerase (PARP) inhibition in cells with HR deficiency (HRD) can cause cell death. This has been exploited for the targeted treatment of PC patients with HRD by PARP inhibi...
Source: Advances in Medical Sciences - September 27, 2023 Category: Biomedical Science Authors: Hamidreza Saeidi Ikmal Hisyam Bakrin Chandramathi Samudi Raju Patimah Ismail Mohsen Saraf Mohd Ghani Khairul-Asri Source Type: research
Adjunctive use of platelet-rich fibrin in surgical treatment of furcation defects: A systematic review
Adv Med Sci. 2023 Sep 25;68(2):366-371. doi: 10.1016/j.advms.2023.09.009. Online ahead of print.ABSTRACTPeriodontitis is an infectious disease characterized by the inflammatory destruction of the tooth supporting tissues. In multi-rooted teeth, this process leads to periodontal destruction within furcations creating defects demanding in terms of treatment. Regeneration of class II furcation involvement, although possible, is considered an unpredictable procedure, especially in terms of the bone fill. The interest in wound healing improvement by additional use of autologous concentrates of growth factors remains high in man...
Source: Advances in Medical Sciences - September 27, 2023 Category: Biomedical Science Authors: Anna Skurska Marek Chwiedosik Zuzanna Ślebioda Source Type: research
Frontal EEG alterations induced by hippocampal amyloid pathology in rats
CONCLUSION: Our findings indicate that spontaneous frontal EEG beta and alpha activity were significantly affected by the intrahippocampal injection of Aβ1-42. However, the results suggest that the power ratios of these bands are more sensitive to the hippocampal amyloid pathology. As such, it is proposed that the rFBA may be a more effective biomarker for diagnosing hippocampal pathology induced by Aβ1-42.PMID:37757662 | DOI:10.1016/j.advms.2023.09.006 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - September 27, 2023 Category: Biomedical Science Authors: Enis Hidisoglu Giuseppe Chiantia Source Type: research
Genetic aberrations of homologous recombination repair pathways in prostate cancer: The prognostic and therapeutic implications
Adv Med Sci. 2023 Sep 25;68(2):359-365. doi: 10.1016/j.advms.2023.09.008. Online ahead of print.ABSTRACTProstate cancer (PC) is the second most common cancer in men worldwide. Homologous recombination repair (HRR) gene defects have been identified in a significant proportion of metastatic castration-resistant PC (mCRPC) and are associated with an increased risk of PC and more aggressive PC. Importantly, it has been well-documented that poly ADP-ribose polymerase (PARP) inhibition in cells with HR deficiency (HRD) can cause cell death. This has been exploited for the targeted treatment of PC patients with HRD by PARP inhibi...
Source: Advances in Medical Sciences - September 27, 2023 Category: Biomedical Science Authors: Hamidreza Saeidi Ikmal Hisyam Bakrin Chandramathi Samudi Raju Patimah Ismail Mohsen Saraf Mohd Ghani Khairul-Asri Source Type: research
Adjunctive use of platelet-rich fibrin in surgical treatment of furcation defects: A systematic review
Adv Med Sci. 2023 Sep 25;68(2):366-371. doi: 10.1016/j.advms.2023.09.009. Online ahead of print.ABSTRACTPeriodontitis is an infectious disease characterized by the inflammatory destruction of the tooth supporting tissues. In multi-rooted teeth, this process leads to periodontal destruction within furcations creating defects demanding in terms of treatment. Regeneration of class II furcation involvement, although possible, is considered an unpredictable procedure, especially in terms of the bone fill. The interest in wound healing improvement by additional use of autologous concentrates of growth factors remains high in man...
Source: Advances in Medical Sciences - September 27, 2023 Category: Biomedical Science Authors: Anna Skurska Marek Chwiedosik Zuzanna Ślebioda Source Type: research
Frontal EEG alterations induced by hippocampal amyloid pathology in rats
CONCLUSION: Our findings indicate that spontaneous frontal EEG beta and alpha activity were significantly affected by the intrahippocampal injection of Aβ1-42. However, the results suggest that the power ratios of these bands are more sensitive to the hippocampal amyloid pathology. As such, it is proposed that the rFBA may be a more effective biomarker for diagnosing hippocampal pathology induced by Aβ1-42.PMID:37757662 | DOI:10.1016/j.advms.2023.09.006 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - September 27, 2023 Category: Biomedical Science Authors: Enis Hidisoglu Giuseppe Chiantia Source Type: research
Genetic aberrations of homologous recombination repair pathways in prostate cancer: The prognostic and therapeutic implications
Adv Med Sci. 2023 Sep 25;68(2):359-365. doi: 10.1016/j.advms.2023.09.008. Online ahead of print.ABSTRACTProstate cancer (PC) is the second most common cancer in men worldwide. Homologous recombination repair (HRR) gene defects have been identified in a significant proportion of metastatic castration-resistant PC (mCRPC) and are associated with an increased risk of PC and more aggressive PC. Importantly, it has been well-documented that poly ADP-ribose polymerase (PARP) inhibition in cells with HR deficiency (HRD) can cause cell death. This has been exploited for the targeted treatment of PC patients with HRD by PARP inhibi...
Source: Advances in Medical Sciences - September 27, 2023 Category: Biomedical Science Authors: Hamidreza Saeidi Ikmal Hisyam Bakrin Chandramathi Samudi Raju Patimah Ismail Mohsen Saraf Mohd Ghani Khairul-Asri Source Type: research
Adjunctive use of platelet-rich fibrin in surgical treatment of furcation defects: A systematic review
Adv Med Sci. 2023 Sep 25;68(2):366-371. doi: 10.1016/j.advms.2023.09.009. Online ahead of print.ABSTRACTPeriodontitis is an infectious disease characterized by the inflammatory destruction of the tooth supporting tissues. In multi-rooted teeth, this process leads to periodontal destruction within furcations creating defects demanding in terms of treatment. Regeneration of class II furcation involvement, although possible, is considered an unpredictable procedure, especially in terms of the bone fill. The interest in wound healing improvement by additional use of autologous concentrates of growth factors remains high in man...
Source: Advances in Medical Sciences - September 27, 2023 Category: Biomedical Science Authors: Anna Skurska Marek Chwiedosik Zuzanna Ślebioda Source Type: research
Frontal EEG alterations induced by hippocampal amyloid pathology in rats
CONCLUSION: Our findings indicate that spontaneous frontal EEG beta and alpha activity were significantly affected by the intrahippocampal injection of Aβ1-42. However, the results suggest that the power ratios of these bands are more sensitive to the hippocampal amyloid pathology. As such, it is proposed that the rFBA may be a more effective biomarker for diagnosing hippocampal pathology induced by Aβ1-42.PMID:37757662 | DOI:10.1016/j.advms.2023.09.006 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - September 27, 2023 Category: Biomedical Science Authors: Enis Hidisoglu Giuseppe Chiantia Source Type: research
Genetic aberrations of homologous recombination repair pathways in prostate cancer: The prognostic and therapeutic implications
Adv Med Sci. 2023 Sep 25;68(2):359-365. doi: 10.1016/j.advms.2023.09.008. Online ahead of print.ABSTRACTProstate cancer (PC) is the second most common cancer in men worldwide. Homologous recombination repair (HRR) gene defects have been identified in a significant proportion of metastatic castration-resistant PC (mCRPC) and are associated with an increased risk of PC and more aggressive PC. Importantly, it has been well-documented that poly ADP-ribose polymerase (PARP) inhibition in cells with HR deficiency (HRD) can cause cell death. This has been exploited for the targeted treatment of PC patients with HRD by PARP inhibi...
Source: Advances in Medical Sciences - September 27, 2023 Category: Biomedical Science Authors: Hamidreza Saeidi Ikmal Hisyam Bakrin Chandramathi Samudi Raju Patimah Ismail Mohsen Saraf Mohd Ghani Khairul-Asri Source Type: research
Adjunctive use of platelet-rich fibrin in surgical treatment of furcation defects: A systematic review
Adv Med Sci. 2023 Sep 25;68(2):366-371. doi: 10.1016/j.advms.2023.09.009. Online ahead of print.ABSTRACTPeriodontitis is an infectious disease characterized by the inflammatory destruction of the tooth supporting tissues. In multi-rooted teeth, this process leads to periodontal destruction within furcations creating defects demanding in terms of treatment. Regeneration of class II furcation involvement, although possible, is considered an unpredictable procedure, especially in terms of the bone fill. The interest in wound healing improvement by additional use of autologous concentrates of growth factors remains high in man...
Source: Advances in Medical Sciences - September 27, 2023 Category: Biomedical Science Authors: Anna Skurska Marek Chwiedosik Zuzanna Ślebioda Source Type: research
Frontal EEG alterations induced by hippocampal amyloid pathology in rats
CONCLUSION: Our findings indicate that spontaneous frontal EEG beta and alpha activity were significantly affected by the intrahippocampal injection of Aβ1-42. However, the results suggest that the power ratios of these bands are more sensitive to the hippocampal amyloid pathology. As such, it is proposed that the rFBA may be a more effective biomarker for diagnosing hippocampal pathology induced by Aβ1-42.PMID:37757662 | DOI:10.1016/j.advms.2023.09.006 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - September 27, 2023 Category: Biomedical Science Authors: Enis Hidisoglu Giuseppe Chiantia Source Type: research
Genetic aberrations of homologous recombination repair pathways in prostate cancer: The prognostic and therapeutic implications
Adv Med Sci. 2023 Sep 25;68(2):359-365. doi: 10.1016/j.advms.2023.09.008. Online ahead of print.ABSTRACTProstate cancer (PC) is the second most common cancer in men worldwide. Homologous recombination repair (HRR) gene defects have been identified in a significant proportion of metastatic castration-resistant PC (mCRPC) and are associated with an increased risk of PC and more aggressive PC. Importantly, it has been well-documented that poly ADP-ribose polymerase (PARP) inhibition in cells with HR deficiency (HRD) can cause cell death. This has been exploited for the targeted treatment of PC patients with HRD by PARP inhibi...
Source: Advances in Medical Sciences - September 27, 2023 Category: Biomedical Science Authors: Hamidreza Saeidi Ikmal Hisyam Bakrin Chandramathi Samudi Raju Patimah Ismail Mohsen Saraf Mohd Ghani Khairul-Asri Source Type: research
Adjunctive use of platelet-rich fibrin in surgical treatment of furcation defects: A systematic review
Adv Med Sci. 2023 Sep 25;68(2):366-371. doi: 10.1016/j.advms.2023.09.009. Online ahead of print.ABSTRACTPeriodontitis is an infectious disease characterized by the inflammatory destruction of the tooth supporting tissues. In multi-rooted teeth, this process leads to periodontal destruction within furcations creating defects demanding in terms of treatment. Regeneration of class II furcation involvement, although possible, is considered an unpredictable procedure, especially in terms of the bone fill. The interest in wound healing improvement by additional use of autologous concentrates of growth factors remains high in man...
Source: Advances in Medical Sciences - September 27, 2023 Category: Biomedical Science Authors: Anna Skurska Marek Chwiedosik Zuzanna Ślebioda Source Type: research
Frontal EEG alterations induced by hippocampal amyloid pathology in rats
CONCLUSION: Our findings indicate that spontaneous frontal EEG beta and alpha activity were significantly affected by the intrahippocampal injection of Aβ1-42. However, the results suggest that the power ratios of these bands are more sensitive to the hippocampal amyloid pathology. As such, it is proposed that the rFBA may be a more effective biomarker for diagnosing hippocampal pathology induced by Aβ1-42.PMID:37757662 | DOI:10.1016/j.advms.2023.09.006 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - September 27, 2023 Category: Biomedical Science Authors: Enis Hidisoglu Giuseppe Chiantia Source Type: research
