Mechanism of molecular interaction of sitagliptin with human DPP < sub > 4 < /sub > enzyme - New Insights
CONCLUSION: The stable interaction between the sitagliptin ligand and the DPP4 enzyme was demonstrated through molecular docking simulations. The findings presented in this work enhance the understanding of the physicochemical properties of the sitagliptin interaction site, supporting the design of more efficient gliptin-like iDPP4 inhibitors.PMID:37837799 | DOI:10.1016/j.advms.2023.10.002 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - October 14, 2023 Category: Biomedical Science Authors: Michelangelo Bauwelz Gonzatti Jos é Edvar Monteiro Júnior Ant ônio José Rocha Jonathas Sales de Oliveira Ant ônio José de Jesus Evangelista F átima Morgana Pio Fonseca V ânia Marilande Ceccatto Aricl écio Cunha de Oliveira Jos é Ednésio da Cruz Source Type: research
CRISPR/Cas9-mediated high-mobility group A2 knockout inhibits cell proliferation and invasion in papillary thyroid carcinoma cells
CONCLUSION: The CRISPR/Cas9-mediated HMGA2 knockout in the TPC-1 cell line inhibited cell proliferation and invasion, which might be due to the blockage of the cell cycle in the G2/M phase and the promotion of cell necrosis.PMID:37837800 | DOI:10.1016/j.advms.2023.10.001 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - October 14, 2023 Category: Biomedical Science Authors: Shan Jin Hong Yong Yousheng Liu Wuyuntu Bao Source Type: research
Monocyte-to-lymphocyte ratio correlates with parathyroid hormone concentration in patients with severe symptomatic aortic stenosis
CONCLUSIONS: PTH concentration correlates with monocyte-to-lymphocyte and platelet-to-lymphocyte ratios in calcified AS.PMID:37837798 | DOI:10.1016/j.advms.2023.09.011 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - October 14, 2023 Category: Biomedical Science Authors: Anna Olasi ńska-Wiśniewska Tomasz Urbanowicz Kajetan Grodecki Piotr K übler Bart łomiej Perek Marek Grygier Marcin Misterski Maciej Walczak Mateusz Szot Marek Jemielity Source Type: research
Mechanism of molecular interaction of sitagliptin with human DPP < sub > 4 < /sub > enzyme - New Insights
CONCLUSION: The stable interaction between the sitagliptin ligand and the DPP4 enzyme was demonstrated through molecular docking simulations. The findings presented in this work enhance the understanding of the physicochemical properties of the sitagliptin interaction site, supporting the design of more efficient gliptin-like iDPP4 inhibitors.PMID:37837799 | DOI:10.1016/j.advms.2023.10.002 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - October 14, 2023 Category: Biomedical Science Authors: Michelangelo Bauwelz Gonzatti Jos é Edvar Monteiro Júnior Ant ônio José Rocha Jonathas Sales de Oliveira Ant ônio José de Jesus Evangelista F átima Morgana Pio Fonseca V ânia Marilande Ceccatto Aricl écio Cunha de Oliveira Jos é Ednésio da Cruz Source Type: research
CRISPR/Cas9-mediated high-mobility group A2 knockout inhibits cell proliferation and invasion in papillary thyroid carcinoma cells
CONCLUSION: The CRISPR/Cas9-mediated HMGA2 knockout in the TPC-1 cell line inhibited cell proliferation and invasion, which might be due to the blockage of the cell cycle in the G2/M phase and the promotion of cell necrosis.PMID:37837800 | DOI:10.1016/j.advms.2023.10.001 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - October 14, 2023 Category: Biomedical Science Authors: Shan Jin Hong Yong Yousheng Liu Wuyuntu Bao Source Type: research
Biological, genetic and epigenetic markers in ulcerative colitis
Adv Med Sci. 2023 Oct 7;68(2):386-395. doi: 10.1016/j.advms.2023.09.010. Online ahead of print.ABSTRACTIn this review, we have summarized the existing knowledge of ulcerative colitis (UC) markers based on current literature, specifically, the roles of potential new biomarkers, such as circulating, fecal, genetic, and epigenetic alterations, in UC onset, disease activity, and in therapy response. UC is a complex multifactorial inflammatory disease. There are many invasive and non-invasive diagnostic methods in UC, including several laboratory markers which are employed in diagnosis and disease assessment; however, colonosco...
Source: Advances in Medical Sciences - October 9, 2023 Category: Biomedical Science Authors: Gemma Caliendo Giovanna D'Elia Jasmine Makker Luana Passariello Luisa Albanese Anna Maria Molinari Maria Teresa Vietri Source Type: research
Biological, genetic and epigenetic markers in ulcerative colitis
Adv Med Sci. 2023 Oct 7;68(2):386-395. doi: 10.1016/j.advms.2023.09.010. Online ahead of print.ABSTRACTIn this review, we have summarized the existing knowledge of ulcerative colitis (UC) markers based on current literature, specifically, the roles of potential new biomarkers, such as circulating, fecal, genetic, and epigenetic alterations, in UC onset, disease activity, and in therapy response. UC is a complex multifactorial inflammatory disease. There are many invasive and non-invasive diagnostic methods in UC, including several laboratory markers which are employed in diagnosis and disease assessment; however, colonosco...
Source: Advances in Medical Sciences - October 9, 2023 Category: Biomedical Science Authors: Gemma Caliendo Giovanna D'Elia Jasmine Makker Luana Passariello Luisa Albanese Anna Maria Molinari Maria Teresa Vietri Source Type: research
Biological, genetic and epigenetic markers in ulcerative colitis
Adv Med Sci. 2023 Oct 7;68(2):386-395. doi: 10.1016/j.advms.2023.09.010. Online ahead of print.ABSTRACTIn this review, we have summarized the existing knowledge of ulcerative colitis (UC) markers based on current literature, specifically, the roles of potential new biomarkers, such as circulating, fecal, genetic, and epigenetic alterations, in UC onset, disease activity, and in therapy response. UC is a complex multifactorial inflammatory disease. There are many invasive and non-invasive diagnostic methods in UC, including several laboratory markers which are employed in diagnosis and disease assessment; however, colonosco...
Source: Advances in Medical Sciences - October 9, 2023 Category: Biomedical Science Authors: Gemma Caliendo Giovanna D'Elia Jasmine Makker Luana Passariello Luisa Albanese Anna Maria Molinari Maria Teresa Vietri Source Type: research
Biological, genetic and epigenetic markers in ulcerative colitis
Adv Med Sci. 2023 Oct 7;68(2):386-395. doi: 10.1016/j.advms.2023.09.010. Online ahead of print.ABSTRACTIn this review, we have summarized the existing knowledge of ulcerative colitis (UC) markers based on current literature, specifically, the roles of potential new biomarkers, such as circulating, fecal, genetic, and epigenetic alterations, in UC onset, disease activity, and in therapy response. UC is a complex multifactorial inflammatory disease. There are many invasive and non-invasive diagnostic methods in UC, including several laboratory markers which are employed in diagnosis and disease assessment; however, colonosco...
Source: Advances in Medical Sciences - October 9, 2023 Category: Biomedical Science Authors: Gemma Caliendo Giovanna D'Elia Jasmine Makker Luana Passariello Luisa Albanese Anna Maria Molinari Maria Teresa Vietri Source Type: research
Biological, genetic and epigenetic markers in ulcerative colitis
Adv Med Sci. 2023 Oct 7;68(2):386-395. doi: 10.1016/j.advms.2023.09.010. Online ahead of print.ABSTRACTIn this review, we have summarized the existing knowledge of ulcerative colitis (UC) markers based on current literature, specifically, the roles of potential new biomarkers, such as circulating, fecal, genetic, and epigenetic alterations, in UC onset, disease activity, and in therapy response. UC is a complex multifactorial inflammatory disease. There are many invasive and non-invasive diagnostic methods in UC, including several laboratory markers which are employed in diagnosis and disease assessment; however, colonosco...
Source: Advances in Medical Sciences - October 9, 2023 Category: Biomedical Science Authors: Gemma Caliendo Giovanna D'Elia Jasmine Makker Luana Passariello Luisa Albanese Anna Maria Molinari Maria Teresa Vietri Source Type: research
The TGFBI gene and protein expression in topotecan resistant ovarian cancer cell lines
CONCLUSION: The expression of TGFBI in ovarian cancer cell lines suggests its role in the development of drug resistance.PMID:37806183 | DOI:10.1016/j.advms.2023.09.013 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - October 8, 2023 Category: Biomedical Science Authors: Karolina Wojtowicz Monika Świerczewska Micha ł Nowicki Rados ław Januchowski Source Type: research
The TGFBI gene and protein expression in topotecan resistant ovarian cancer cell lines
CONCLUSION: The expression of TGFBI in ovarian cancer cell lines suggests its role in the development of drug resistance.PMID:37806183 | DOI:10.1016/j.advms.2023.09.013 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - October 8, 2023 Category: Biomedical Science Authors: Karolina Wojtowicz Monika Świerczewska Micha ł Nowicki Rados ław Januchowski Source Type: research
A mouse model of food allergy permitting skin and nasal symptoms
CONCLUSIONS: This method may be useful for evaluating the symptoms of skin and rhinitis that could not be assessed in the conventional food allergy model and could be induced with a low dose of antigen. In particular, the developed method, which measures the number of itching and nasal symptoms, may enable quantitative, objective, and noninvasive evaluation of food allergy severity.PMID:37797366 | DOI:10.1016/j.advms.2023.09.012 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - October 5, 2023 Category: Biomedical Science Authors: Takafumi Morinaga Takuya Yamamoto Yukio Sugimoto Source Type: research
A mouse model of food allergy permitting skin and nasal symptoms
CONCLUSIONS: This method may be useful for evaluating the symptoms of skin and rhinitis that could not be assessed in the conventional food allergy model and could be induced with a low dose of antigen. In particular, the developed method, which measures the number of itching and nasal symptoms, may enable quantitative, objective, and noninvasive evaluation of food allergy severity.PMID:37797366 | DOI:10.1016/j.advms.2023.09.012 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - October 5, 2023 Category: Biomedical Science Authors: Takafumi Morinaga Takuya Yamamoto Yukio Sugimoto Source Type: research
A mouse model of food allergy permitting skin and nasal symptoms
CONCLUSIONS: This method may be useful for evaluating the symptoms of skin and rhinitis that could not be assessed in the conventional food allergy model and could be induced with a low dose of antigen. In particular, the developed method, which measures the number of itching and nasal symptoms, may enable quantitative, objective, and noninvasive evaluation of food allergy severity.PMID:37797366 | DOI:10.1016/j.advms.2023.09.012 (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - October 5, 2023 Category: Biomedical Science Authors: Takafumi Morinaga Takuya Yamamoto Yukio Sugimoto Source Type: research
