I κB kinase ε contributes to the pathogenesis of osteoarthritis by promoting cartilage degradation

ConclusionThese results suggest that IKK ε regulates cartilage degradation through a catabolic response mediated by NF-κB signaling, and is a potential target for OA treatment. Furthermore, BAY-985 may serve a major compound in drugs developed for OA.This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatology - December 19, 2022 Category: Rheumatology Authors: Taisuke Uchida, Yukio Akasaki, Takuya Sueishi, Ichiro Kurakazu, Masakazu Toya, Masanari Kuwahara, Ryota Hirose, Yuki Hyodo, Hidetoshi Tsushima, Martin K. Lotz, Yasuharu Nakashima Tags: Full Length Source Type: research