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Condition: Osteoarthritis
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Total 352 results found since Jan 2013.
Circular RNA circZNF652 is overexpressed in osteoarthritis and positively regulates LPS-induced apoptosis of chondrocytes by upregulating PTEN
This study was carried to explore the involvement of circZNF652 in OA. RT-qPCR was performed to analyse the expression of circZNF652 and PTEN mRNA in synovial fluid samples from 60 OA patients and 60 healthy controls. Correlations between circZNF652 and PTEN mRNA were analysed by Pearson's correlation coefficient. Overexpression and siRNA silencing of circZNF652 were achieved in chondrocytes, followed by performing RT-qPCR and Western blot to analyse the expression of PTEN. The role of circZNF652 and PTEN in regulating the apoptosis of chondrocytes induced by LPS was analysed by cell apoptosis assay. We found that circZNF6...
Source: Autoimmunity - July 15, 2021 Category: Allergy & Immunology Authors: Xuefeng Yuan Yingchi Zhang Cong Cai Chaoxu Liu Jie Xie Chengla Yi Source Type: research
Total Flavonoids of Rhizoma Drynariae Restore the MMP/TIMP Balance in Models of Osteoarthritis by Inhibiting the Activation of the NF- < em > κB < /em > and PI3K/AKT Pathways
In conclusion, TFRD showed chondroprotective effects by restoring the MMP/TIMP balance in OA models by suppressing the activation of the NF-κB and PI3K/AKT pathways.PMID:33995548 | PMC:PMC8081598 | DOI:10.1155/2021/6634837
Source: Evidence-based Complementary and Alternative Medicine - May 17, 2021 Category: Complementary Medicine Authors: Guang-Yao Chen Jia-Qi Chen Xiao-Yu Liu Yuan Xu Jing Luo Yi-Fei Wang Tong-Liang Zhou Ze-Ran Yan Li Zhou Qing-Wen Tao Source Type: research
Intra ‐articular silencing of periostin via nanoparticle‐based siRNA ameliorates post‐traumatic osteoarthritis in mice
ConclusionIntra-articular delivery of Postn siRNA nanocomplex represents a promising clinical approach to mitigate the severity of joint degeneration and provides an unequivocal scientific rationale for longitudinal studies. Employing a cartilage-specific gene knockout strategy will further illuminate the functional role of Postn in OA.
Source: Arthritis and Rheumatology - May 13, 2021 Category: Rheumatology Authors: Xin Duan,
Lei Cai,
Christine T.N. Pham,
Yousef Abu ‐Amer,
Hua Pan,
Robert H. Brophy,
Samuel A. Wickline,
Muhammad Farooq Rai Tags: FULL LENGTH Source Type: research
Blockade of TRPM7 Alleviates Chondrocyte Apoptosis and Articular Cartilage Damage in the Adjuvant Arthritis Rat Model Through Regulation of the Indian Hedgehog Signaling Pathway
This study focused on the effects of TRPM7 on arthritic chondrocyte injury and its underlying mechanisms of action. Sodium nitroprusside (SNP)-induced rat primary chondrocyte apoptosis and rat adjuvant arthritis (AA) were used as in vitro and in vivo models, respectively. Blockage of TRPM7 with 2-APB or specific siRNA resulted in increased chondrocyte viability and reduced toxicity of SNP. Moreover, treatment with 2-APB enhanced the Bcl-2/Bax ratio and reduced cleaved PARP and IL-6, MMP-13 and ADAMTS-5 expression in SNP-treated chondrocytes. Activation of Indian Hedgehog with purmorphamine reversed the protective effects o...
Source: Frontiers in Pharmacology - April 13, 2021 Category: Drugs & Pharmacology Source Type: research
microRNA-130b downregulation potentiates chondrogenic differentiation of bone marrow mesenchymal stem cells by targeting SOX9
Braz J Med Biol Res. 2021 Feb 12;54(4):e10345. doi: 10.1590/1414-431X202010345. eCollection 2021.ABSTRACTOsteoarthritis (OA) is a chronic health condition. MicroRNAs (miRs) are critical in chondrocyte apoptosis in OA. We aimed to investigate the mechanism of miR-130b in OA progression. Bone marrow mesenchymal stem cells (BMSCs) and chondrocytes were first extracted. Chondrogenic differentiation of BMSCs was carried out and verified. Chondrocytes were stimulated with interleukin (IL)-1β to imitate OA condition in vitro. The effect of miR-130b on the viability, inflammation, apoptosis, and extracellular matrix of OA chondro...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: Penggui Zhang Guangming Gao Ziyu Zhou Xuejun He Source Type: research
