A whole blood-based functional assay to characterize immunoglobulin A effector functions
Autoimmunity. 2024 Dec;57(1):2341629. doi: 10.1080/08916934.2024.2341629. Epub 2024 Apr 14.ABSTRACTMost investigations on the immune cell-activating potency of IgA used purified total IgA and/or specific isolated cell populations. As IgA2 has been reported to be more pro-inflammatory than IgA1, we aimed to employ a fast and convenient whole blood-based assay to individually probe the capacity of the two IgA subclasses to activate immune cells in close physiological conditions. To this end, whole blood from healthy donors (n = 10) was stimulated with immobilized IgA1, IgA2m1 or IgA2m2 (the two main allotypic variants of IgA...
Source: Autoimmunity - April 15, 2024 Category: Allergy & Immunology Authors: Alice Bacon Celia Cartagena Garc ía Karin A van Schie Ren é E M Toes Jean-Marc Busnel Source Type: research
Correction
Autoimmunity. 2024 Dec;57(1):2331362. doi: 10.1080/08916934.2024.2331362. Epub 2024 Apr 1.NO ABSTRACTPMID:38557248 | DOI:10.1080/08916934.2024.2331362 (Source: Autoimmunity)
Source: Autoimmunity - April 1, 2024 Category: Allergy & Immunology Source Type: research
Animal models of neuropsychiatric systemic lupus erythematosus: deciphering the complexity and guiding therapeutic development
Autoimmunity. 2024 Dec;57(1):2330387. doi: 10.1080/08916934.2024.2330387. Epub 2024 Mar 31.ABSTRACTSystemic lupus erythematosus (SLE) poses formidable challenges due to its multifaceted etiology while impacting multiple tissues and organs and displaying diverse clinical manifestations. Genetic and environmental factors contribute to SLE complexity, with relatively limited approved therapeutic options. Murine models offer insights into SLE pathogenesis but do not always replicate the nuances of human disease. This review critically evaluates spontaneous and induced animal models, emphasizing their validity and relevance to ...
Source: Autoimmunity - March 31, 2024 Category: Allergy & Immunology Authors: Baruh Polis Carla M Cuda Chaim Putterman Source Type: research
Novel peripheral blood mononuclear cell mRNA signature for IFN-beta therapy responsiveness prediction in multiple sclerosis
Autoimmunity. 2024 Dec;57(1):2332340. doi: 10.1080/08916934.2024.2332340. Epub 2024 Mar 28.ABSTRACTInterferon-beta (IFN-β) is one of the classical drugs for immunomodulatory therapy in relapsing-remitting multiple sclerosis (RRMS) patients, but the drug responsiveness of different patients varies. Currently, there is no valid model to predict IFN-β responsiveness. This research attempted to develop an IFN-β responsiveness prediction model based on mRNA expression in RRMS patient peripheral blood mononuclear cells. Peripheral blood mononuclear cell mRNA expression datasets including 50 RRMS patients receiving IFN-β trea...
Source: Autoimmunity - March 28, 2024 Category: Allergy & Immunology Authors: Yang Xue Pengqi Yin Hongping Chen Guozhong Li Di Zhong Source Type: research
