MicroRNA-340-5p inhibits endothelial apoptosis, inflammatory response, and pro-coagulation by targeting KDM4C in anti-neutrophil cytoplasmic antibody (ANCA)-mediated glomerulonephritis through activation of B cells
In conclusion, we found that miR-340-5p inhibited endothelial apoptosis and inflammatory response by targeting KDM4C in ANCA-mediated GN through activation of B cells, implying a potential novel insight for treatment of ANCA-mediated GN.PMID:34121556 | DOI:10.1080/08916934.2021.1937609 (Source: Autoimmunity)
Source: Autoimmunity - June 14, 2021 Category: Allergy & Immunology Authors: Jian Hu Wei Wu Min Yu Zhengkun Xia Chunlin Gao Source Type: research

CircRAB3B suppresses proliferation, motility, cell cycle progression and promotes the apoptosis of IL-22-induced keratinocytes depending on the regulation of miR-1228-3p/PTEN axis in psoriasis
CONCLUSIONS: CircRAB3B suppressed psoriasis progression partly through down-regulating miR-1228-3p and up-regulating PTEN.PMID:34096408 | DOI:10.1080/08916934.2021.1934825 (Source: Autoimmunity)
Source: Autoimmunity - June 7, 2021 Category: Allergy & Immunology Authors: Jiajing Lu Xin Xu Ying Li Ning Yu Yangfeng Ding Yuling Shi Source Type: research

MiR-379-5p aggravates experimental autoimmune uveitis in mice via the regulation of SEMA3A
Autoimmunity. 2021 Jun 1:1-9. doi: 10.1080/08916934.2021.1931841. Online ahead of print.ABSTRACTUveitis is a disease resulting in the inflammation of uveal tracts, but the factors resulting in uveitis is still obscure. Previous studies have shown that miR-379-5p was involved in the pathogenesis of several diseases, however, the role and regulatory mechanism of miR-379-5p in uveitis were unclear. In our study, we established experimental autoimmune uveitis (EAU) mouse models to explore the role of miR-379-5p in uveitis. RT-qPCR identified that miR-379-5p level was increased in serum of EAU mice. In mechanism, SEMA3A 3'UTR w...
Source: Autoimmunity - June 1, 2021 Category: Allergy & Immunology Authors: Mohan Li Xiang Gao Kou Liu Ning Bao Zhengxuan Jiang Source Type: research

Aberrant microRNA expression in B lymphocytes from patients with primary warm autoimmune haemolytic anaemia
CONCLUSION: The expression of miRNAs in B lymphocytes from patients with primary wAIHA was deregulated, and this phenomenon may be involved in the pathogenesis of wAIHA.PMID:34044675 | DOI:10.1080/08916934.2021.1931842 (Source: Autoimmunity)
Source: Autoimmunity - May 28, 2021 Category: Allergy & Immunology Authors: Manjun Zhao Xin He Jin Yang Yingying Feng Huaquan Wang Zonghong Shao Limin Xing Source Type: research

Modulation of miR-382-5p reduces apoptosis of myocardial cells after acute myocardial infarction
CONCLUSION: To summarise, our study showed an increase in miR-382-5p in myocardial tissues in the AMI mouse model. Interference with miR-382-5p reduced apoptosis of myocardial cells after AMI and the effect was achieved by increasing STC1 expression.PMID:34042547 | DOI:10.1080/08916934.2021.1910812 (Source: Autoimmunity)
Source: Autoimmunity - May 27, 2021 Category: Allergy & Immunology Authors: Liqin Zhang Huajie Zhu Xianlin Teng Xiaosheng Sheng Beiwei Yu Source Type: research

Dysregulation of tumour microenvironment driven by circ-TPGS2/miR-7/TRAF6/NF- κB axis facilitates breast cancer cell motility
Autoimmunity. 2021 May 26:1-10. doi: 10.1080/08916934.2021.1931843. Online ahead of print.ABSTRACTTumour microenvironment (TME) is frequently remodelled and deregulated in cancer development and progression. The underlying mechanisms are complex, multifactorial and largely unknown. Circular RNA (circRNA) is an endogenous RNA with a covalently closed loop that plays critical roles in the pathological and physiological processes of the organism. Here, we identified a TME-associated circRNA, circ-TPGS2, which promoted breast cancer (BC) cell dissemination via altering TME. High circ-TPGS2 was observed in metastatic BC tissues...
Source: Autoimmunity - May 26, 2021 Category: Allergy & Immunology Authors: Shengting Wang Xinghua Feng Yufang Wang Qian Li Xiaoming Li Source Type: research

LncRNA FOXD2-AS1 promotes cell proliferation and invasion of fibroblast-like synoviocytes by regulation of miR-331-3p/PIAS3 pathway in rheumatoid arthritis
Autoimmunity. 2021 May 25:1-10. doi: 10.1080/08916934.2021.1919879. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disorder that leads to systemic inflammation of diarthrodial joint, synovial hyperplasia, cartilage damage, and ultimately joint destruction and deformity. As the dominant non-immune cells in the synovium, fibroblast-like synoviocytes (FLSs) significantly contribute to the deterioration of RA. Our study aimed to explore the regulatory role of long non-coding RNA FOXD2-AS1 in RA progression. Compared to patients with joint trauma, the expression of FOXD2-AS1 was elevated in seru...
Source: Autoimmunity - May 25, 2021 Category: Allergy & Immunology Authors: Qirui Zhao Fengnian Zhao Chang Liu Tongtong Xu Keguan Song Source Type: research

MiR-429 prohibited NF- κB signalling to alleviate contrast-induced acute kidney injury via targeting PDCD4
Autoimmunity. 2021 May 22:1-11. doi: 10.1080/08916934.2021.1919878. Online ahead of print.ABSTRACTMiR-429 was reported to be downregulated in contrast-induced acute kidney injury (CI-AKI). However, whether miR-429 is functionally relevant with CI-AKI needs further investigation. Human renal tubular epithelial cell (HK-2) cells were stimulated with contrast media iodixanol to establish in vitro CI-AKI model. Cell Counting Kit-8 (CCK-8) was applied to access cell viability. Flow cytometry was performed to determine apoptosis. Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to evaluate level of programm...
Source: Autoimmunity - May 24, 2021 Category: Allergy & Immunology Authors: Hui-Min Niu Li-Qin Guo Yan-Hong Qiao Hai-Yan Jiao Source Type: research

Circular RNAs hsa-circ0000175 and hsa-circ0044235 in plasma are novel biomarkers for new-onset rheumatoid arthritis
This study suggests that the combination of plasma hsa-circ0000175 and hsa-circ0044235 improves the diagnostic accuracy for new-onset RA. Moreover, the expression levels of plasma hsa-circ0000175 and hsa-circ0044235 were associated with disease activity and severity of RA.PMID:34008433 | DOI:10.1080/08916934.2021.1922891 (Source: Autoimmunity)
Source: Autoimmunity - May 19, 2021 Category: Allergy & Immunology Authors: Yujie Gao Fangyi Yao Jiayue Rao Lu Zhang Yang Guo Zikun Huang Qingshui Huang Junming Li Qing Luo Source Type: research

LncRNA CRNDE inhibits cardiomyocytes apoptosis by YAP1 in myocardial ischaemia/reperfusion injury
CONCLUSION: Our study suggested that lncRNA CRNDE could regulate YAP1 level by ubiquitination and proteasomal degradation pathway, thus inhibiting cardiomyocytes apoptosis in MI/R injury.PMID:33988471 | DOI:10.1080/08916934.2021.1913580 (Source: Autoimmunity)
Source: Autoimmunity - May 14, 2021 Category: Allergy & Immunology Authors: Xiaohua Zhu Shuiqi Li Chen Huang Gongcheng Huang Jing Xu Source Type: research

Genetic variants in < em > LGALS3 < /em > are related to lower galectin-3 serum levels and clinical outcomes in systemic sclerosis patients: A case-control study
CONCLUSION: The LGALS3 rs4652 A/C was more frequent in SSc patients and related to lower Gal-3 levels. These findings were corroborated through a GLM to estimate Gal-3 values. Also, by model equations, Gal-3 levels may be predicted by HAQ, SHAQ, PAH, myopathy, and LGALS3 rs4652 and rs2075601 factors. In these ways, we suggest that galectins may be promising biomarkers to identify susceptibility to SSc as well as to identify HAQ, SHAQ, PAH, and myopathy outcomes.PMID:33973825 | DOI:10.1080/08916934.2021.1919881 (Source: Autoimmunity)
Source: Autoimmunity - May 11, 2021 Category: Allergy & Immunology Authors: Eudes Gustavo Constantino Cunha Camilla Albertina Dantas de Lima Kamila de Melo Vilar Marcelo Francisco de N óbrega Anderson Rodrigues de Almeida Michelly Cristiny Pereira Andr éa Tavares Dantas Rafaela Silva Guimar ães Gonçalves Moacyr Jesus Barreto Source Type: research

Sema4D correlates with tumour immune infiltration and is a prognostic biomarker in bladder cancer, renal clear cell carcinoma, melanoma and thymoma
Autoimmunity. 2021 May 11:1-9. doi: 10.1080/08916934.2021.1925885. Online ahead of print.ABSTRACTSema4D, a member of the immune semaphorin family, plays crucial roles in the immune regulation, bone resorption and nervous system. It is also involved in angiogenesis and tumour progression. However, systemic studies on the correlation between Sema4D expression and the immune infiltration or clinical outcomes in tumours are still limited. Here, we analysed the landscape of Sema4D expression and its prognostic value in the cancer genome atlas pan-cancer as well as the correlation between Sema4D and immune cell infiltration by T...
Source: Autoimmunity - May 11, 2021 Category: Allergy & Immunology Authors: Qiongyu Lu Ping Cai Yan Yu Ziting Liu Guona Chen Zhao Zeng Source Type: research

Genetic variants in < em > LGALS3 < /em > are related to lower galectin-3 serum levels and clinical outcomes in systemic sclerosis patients: A case-control study
CONCLUSION: The LGALS3 rs4652 A/C was more frequent in SSc patients and related to lower Gal-3 levels. These findings were corroborated through a GLM to estimate Gal-3 values. Also, by model equations, Gal-3 levels may be predicted by HAQ, SHAQ, PAH, myopathy, and LGALS3 rs4652 and rs2075601 factors. In these ways, we suggest that galectins may be promising biomarkers to identify susceptibility to SSc as well as to identify HAQ, SHAQ, PAH, and myopathy outcomes.PMID:33973825 | DOI:10.1080/08916934.2021.1919881 (Source: Autoimmunity)
Source: Autoimmunity - May 11, 2021 Category: Allergy & Immunology Authors: Eudes Gustavo Constantino Cunha Camilla Albertina Dantas de Lima Kamila de Melo Vilar Marcelo Francisco de N óbrega Anderson Rodrigues de Almeida Michelly Cristiny Pereira Andr éa Tavares Dantas Rafaela Silva Guimar ães Gonçalves Moacyr Jesus Barreto Source Type: research

Sema4D correlates with tumour immune infiltration and is a prognostic biomarker in bladder cancer, renal clear cell carcinoma, melanoma and thymoma
Autoimmunity. 2021 May 11:1-9. doi: 10.1080/08916934.2021.1925885. Online ahead of print.ABSTRACTSema4D, a member of the immune semaphorin family, plays crucial roles in the immune regulation, bone resorption and nervous system. It is also involved in angiogenesis and tumour progression. However, systemic studies on the correlation between Sema4D expression and the immune infiltration or clinical outcomes in tumours are still limited. Here, we analysed the landscape of Sema4D expression and its prognostic value in the cancer genome atlas pan-cancer as well as the correlation between Sema4D and immune cell infiltration by T...
Source: Autoimmunity - May 11, 2021 Category: Allergy & Immunology Authors: Qiongyu Lu Ping Cai Yan Yu Ziting Liu Guona Chen Zhao Zeng Source Type: research

Genetic variants in < em > LGALS3 < /em > are related to lower galectin-3 serum levels and clinical outcomes in systemic sclerosis patients: A case-control study
CONCLUSION: The LGALS3 rs4652 A/C was more frequent in SSc patients and related to lower Gal-3 levels. These findings were corroborated through a GLM to estimate Gal-3 values. Also, by model equations, Gal-3 levels may be predicted by HAQ, SHAQ, PAH, myopathy, and LGALS3 rs4652 and rs2075601 factors. In these ways, we suggest that galectins may be promising biomarkers to identify susceptibility to SSc as well as to identify HAQ, SHAQ, PAH, and myopathy outcomes.PMID:33973825 | DOI:10.1080/08916934.2021.1919881 (Source: Autoimmunity)
Source: Autoimmunity - May 11, 2021 Category: Allergy & Immunology Authors: Eudes Gustavo Constantino Cunha Camilla Albertina Dantas de Lima Kamila de Melo Vilar Marcelo Francisco de N óbrega Anderson Rodrigues de Almeida Michelly Cristiny Pereira Andr éa Tavares Dantas Rafaela Silva Guimar ães Gonçalves Moacyr Jesus Barreto Source Type: research

Sema4D correlates with tumour immune infiltration and is a prognostic biomarker in bladder cancer, renal clear cell carcinoma, melanoma and thymoma
Autoimmunity. 2021 May 11:1-9. doi: 10.1080/08916934.2021.1925885. Online ahead of print.ABSTRACTSema4D, a member of the immune semaphorin family, plays crucial roles in the immune regulation, bone resorption and nervous system. It is also involved in angiogenesis and tumour progression. However, systemic studies on the correlation between Sema4D expression and the immune infiltration or clinical outcomes in tumours are still limited. Here, we analysed the landscape of Sema4D expression and its prognostic value in the cancer genome atlas pan-cancer as well as the correlation between Sema4D and immune cell infiltration by T...
Source: Autoimmunity - May 11, 2021 Category: Allergy & Immunology Authors: Qiongyu Lu Ping Cai Yan Yu Ziting Liu Guona Chen Zhao Zeng Source Type: research

The prevalence and role of functional autoantibodies to angiotensin-converting-enzyme-2 in patients with systemic sclerosis
CONCLUSIONS: Anti-ACE2 antibodies appear to be other functional autoantibodies with the potential to dysregulate the balance between Ang II and Ang-(1-7). They are non-specific for SSc and probably result from polyautoimmunity which affect some of SSc patients. Their occurrence in SSc settings may be associated with a severe depletion of plasma Ang-(1-7).PMID:33910447 | DOI:10.1080/08916934.2021.1916915 (Source: Autoimmunity)
Source: Autoimmunity - April 29, 2021 Category: Allergy & Immunology Authors: Bartosz Mizio łek Marcin Sie ńczyk Renata Grzywa Agnieszka Łupicka-Słowik Eugeniusz Kucharz Przemys ław Kotyla Beata Bergler-Czop Source Type: research

SChLAP1 contributes to non-small cell lung cancer cell progression and immune evasion through regulating the AUF1/PD-L1 axis
In conclusion, our data for the first time uncover that SChLAP1 functions an oncogene in NSCLC by promoting cancer cell immune evasion via regulating the AUF1/PDL1 axis, targeting of SChLAP1 may be a potential approach to improve the efficacy of immunotherapy in NSCLC patients.PMID:33904361 | DOI:10.1080/08916934.2021.1913582 (Source: Autoimmunity)
Source: Autoimmunity - April 27, 2021 Category: Allergy & Immunology Authors: Zhonghai Du Shuxian Niu Juan Wang Jun Wu Sheng Li Xiuxiu Yi Source Type: research