Intra ‐articular silencing of periostin via nanoparticle‐based siRNA ameliorates post‐traumatic osteoarthritis in mice

ConclusionIntra-articular delivery of Postn siRNA nanocomplex represents a promising clinical approach to mitigate the severity of joint degeneration and provides an unequivocal scientific rationale for longitudinal studies. Employing a cartilage-specific gene knockout strategy will further illuminate the functional role of Postn in OA.

Source: Arthritis and Rheumatology - May 13, 2021 Category: Rheumatology Authors: Xin Duan, Lei Cai, Christine T.N. Pham, Yousef Abu ‐Amer, Hua Pan, Robert H. Brophy, Samuel A. Wickline, Muhammad Farooq Rai Tags: FULL LENGTH Source Type: research