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Condition: Osteoarthritis
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Total 352 results found since Jan 2013.
Mechanism of high expression of high mobility group protein 1 in a rat model of knee osteoarthritis
CONCLUSION: In the pathological process of KOA, NLRPs inflammasome-mediated FLS pyroptosis causes massive release of HMGB1, which is associated with the activation of the downstream molecule caspase-1.PMID:34549703 | DOI:10.12122/j.issn.1673-4254.2021.08.03
Source: Journal of Southern Medical University - September 22, 2021 Category: Universities & Medical Training Authors: W Mei B Hong G Huang Source Type: research
Circ_0128846/miR-140-3p/JAK2 Network in Osteoarthritis Development
This study attempted to confirm the role of a novel circRNA circ_0128846 during osteoarthritis (OA) progression. Tissues and chondrocytes were isolated from OA patients. Overexpression and knockdown of target genes were generated using cell transfection and siRNA interference. Expression levels of genes were measured by qRT-PCR, Western blot, and immunohistochemistry, respectively. The interactions among circ_0128846, miR-140-3p, and JAK2 were verified by bioinformatics prediction, a dual-luciferase reporter assay, and RNA immunoprecipitation assay. The role of circ_0128846 in vivo was confirmed by the construction of expe...
Source: Immunological Investigations - September 21, 2021 Category: Allergy & Immunology Authors: Hongjun Li Zhongyu Liu Xiaoyun Guo Mei Zhang Source Type: research
Platelet-rich plasma attenuates interleukin-1 β-induced apoptosis and inflammation in chondrocytes through targeting hypoxia-inducible factor-2α
Tissue Cell. 2021 Sep 8;73:101646. doi: 10.1016/j.tice.2021.101646. Online ahead of print.ABSTRACTOsteoarthritis (OA) is a prevailing chronic disease in Orthopedics that characterized with severely damaged cartilage and subchondral bone, thus leading to profound disorders of synovial joints. Platelet-rich plasma (PRP) has been applied as a popular non-operative treatment option for promoting musculoskeletal healing. Our previous work demonstrated that PRP protected chondrocytes from interleukin-1β (IL-1β)-induced apoptosis in vitro. However, the underlying mechanism behind the treatment remains unclear. The current study...
Source: Tissue and Cell - September 18, 2021 Category: Cytology Authors: Jinjiang Yang Ai Guo Qiang Li Jie Wu Source Type: research
Zinc finger protein A20 regulates the development and progression of osteoarthritis by affecting the activity of NF- κB p65
CONCLUSION: A20 was reduced in OA cartilage samples, and its overexpression, by suppressing the activity of NF-κB p65, could improve IL-1β-induced chondrocyte degradation and apoptosis in vitro, as well as mitigate the inflammation in OA mice.PMID:34463587 | DOI:10.1080/08923973.2021.1970764
Source: Immunopharmacology and Immunotoxicology - August 31, 2021 Category: Allergy & Immunology Authors: Shu-Bei Cui Tao-Xia Wang Zhen-Wu Liu Ji-Ying Yan Kai Zhang Source Type: research
G protein coupled estrogen receptor attenuates mechanical stress-mediated apoptosis of chondrocyte in osteoarthritis via suppression of Piezo1
CONCLUSION: We propose a novel regulatory mechanism underlying mechanical stress-mediated apoptosis of chondrocyte and elucidate the potential application value of GPER as therapy targets for OA.PMID:34454425 | DOI:10.1186/s10020-021-00360-w
Source: Molecular Medicine - August 29, 2021 Category: Molecular Biology Authors: Yi Sun Ping Leng Pengcheng Guo Huanshen Gao Yikai Liu Chenkai Li Zhenghui Li Haining Zhang Source Type: research
ASAP Top-Down Fabricated microPlates for Prolonged, Intra-articular Matrix Metalloproteinase 13 siRNA Nanocarrier Delivery to Reduce Post-traumatic Osteoarthritis
ACS NanoDOI: 10.1021/acsnano.1c04005
Source: ACS Nano - August 19, 2021 Category: Nanotechnology Authors: Sean K Bedingfield, Juan M. Colazo, Martina Di Francesco, Fang Yu, Danielle D. Liu, Valentina Di Francesco, Lauren E. Himmel, Mukesh K. Gupta, Hongsik Cho, Karen A. Hasty, Paolo Decuzzi, and Craig L. Duvall Source Type: research
4-Aminobutyrate aminotransferase regulates chondrocyte homeostasis and can be targeted using peptide-sirna nanoparticles to attenuate osteoarthritis in a murine injury model
Purpose: Epigenetic changes, including DNA methylation, regulate cellular homeostasis. We previously showed that DNA methyltransferase 3B (DNMT3B) expression is reduced in murine and human osteoarthritic (OA) articular chondrocytes (ACs); and that DNMT3B loss-of-function (LOF) leads to OA in mice. An unbiased screen of genes regulated by DNMT3B showed that 4-aminobutyrate aminotransferase (Abat) is increased with DNMT3B LOF. Moreover, upregulation of Abat expression in articular chondrocytes was observed in human OA and injury induced murine OA cartilage.
Source: Osteoarthritis and Cartilage - August 4, 2021 Category: Rheumatology Authors: A. Kucharski, J. Shen, X. Li, S. Wickline, A. MacAlinden, C. Pham, H. Pan, R. O'Keefe Source Type: research
