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Condition: Osteoarthritis
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Total 352 results found since Jan 2013.
Regulatory effect of zinc finger protein A20 on rheumatoid arthritis through NLRP3/Caspase-1 signaling axis mediating pyroptosis of HFLS- RA cells
In conclusion, this study is of great significance for understanding the role of the NLRP3-caspase-1-IL-1β/ pyroptosis signaling pathway in the occurrence and development of RA. It is expected that the results will provide a theoretical basis for the immune regulation of innate immunity in the occurrence and development of RA, while providing a new therapeutic target for the clinical treatment of RA.PMID:37715399 | DOI:10.14715/cmb/2023.69.8.27
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Ziqin Zhao Xinlong Ma Shuhui Dong Haibo Yin Yong Yang Guangyi Xiong Source Type: research
ASIC1a-CMPK2-mediated M1 macrophage polarization exacerbates chondrocyte senescence in osteoarthritis through IL-18
CONCLUSION: These results demonstrate a novel pathogenic process that results in OA cartilage damage, in which M1 macrophage derived IL-18 induces articular chondrocytes senescence. Further, the ASIC1a-CMPK2 axis was shown to positively regulate M1 macrophage polarization. Hence, ASIC1a is a promising treatment target for M1 macrophage-mediated diseases, such as OA.PMID:37660594 | DOI:10.1016/j.intimp.2023.110878
Source: International Immunopharmacology - September 3, 2023 Category: Allergy & Immunology Authors: Lei Dong Yingjie Zhao Cheng Sun Ziwei Ou Yang Fan Chen Weirong Hu Hailin Zhang Yan Wang Rendi Zhu Yuanzhi Cheng Yong Chen Shufang Li Ke Wang Changhai Ding Renpeng Zhou Wei Hu Source Type: research
Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF ‑κB and MAPK signalling transduction through integrin αVβ3
Int J Mol Med. 2023 Oct;52(4):97. doi: 10.3892/ijmm.2023.5300. Epub 2023 Sep 1.ABSTRACTOsteoarthritis (OA) is a chronic progressive articular illness which commonly affects older‑aged adults, presenting with cartilage inflammation and degradation. Rutaecarpine (RUT) has been shown to exert promising anti‑inflammatory effects; however, the efficacy of RUT in the treatment of OA is debatable. The present study investigated the potential of RUT in alleviating OA in a mouse model. Treatment with RUT inhibited the inflammatory response and extracellular matrix degradation by suppressing process regulators in interleukin (...
Source: Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Junlai Wan Mengwei Li Xi Yuan Xiaojun Yu Anmin Chen Ming Shao Hao Kang Peng Cheng Source Type: research
Down-regulation of Jun induces senescence through destabilizing chromatin in osteoarthritis chondrocytes
CONCLUSION: Jun plays a crucial role in OA development and causes senescence by destabilizing chromatin in chondrocytes. These findings provide new insights into OA progression and suggest promising therapeutic targets.PMID:37560235 | PMC:PMC10408544
Source: American Journal of Translational Research - August 10, 2023 Category: Research Authors: Ting Xie Xunshan Ren Huangming Zhuang Fuze Jiang Yuelong Zhang Panghu Zhou Source Type: research
