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Condition: Osteoarthritis

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Total 352 results found since Jan 2013.

Altered expression of the core circadian clock component PERIOD2 contributes to osteoarthritis-like changes in chondrocyte activity.
Abstract In osteoarthritis, chondrocytes undergo a phenotype shift characterised by reduced expression of SOX9 (sry-box 9) and increased production of cartilage-degrading enzymes, e.g. MMP13 (matrix metalloproteinase 13) and ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5). The chondrocyte clock is also altered. Specifically, the peak level of PER2 is elevated, but peak level of BMAL1 reduced in osteoarthritic chondrocytes. The purpose of this study was to determine whether increased PER2 expression causes disease-associated changes in chondrocyte activity and to identify whether known ri...
Source: Chronobiology International - November 7, 2018 Category: Biology Authors: Rong J, Zhu M, Munro J, Cornish J, McCarthy GM, Dalbeth N, Poulsen RC Tags: Chronobiol Int Source Type: research

Single vs. repeated matrix metalloproteinase-13 knockdown with intra-articular short interfering RNA administration in a murine osteoarthritis model.
CONCLUSIONS: Our results suggested that the duration of siRNA effect in the knee joint lasts for at least 1 week, and that no further benefit is achieved by multiple injections. PMID: 30345823 [PubMed - as supplied by publisher]
Source: Connective Tissue Research - October 23, 2018 Category: Research Tags: Connect Tissue Res Source Type: research

Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis.
This study was designed to explore whether exosomal lncRNA-KLF3-AS1 derived from human mesenchymal stem cells (hMSCs) can serve as a positive treatment for osteoarthritis (OA). hMSCs and MSC-derived exosomes (MSC-exo) were prepared for morphological observation and identification by transmission electron microscopy (TEM) and flow cytometry. IL-1β-induced OA chondrocytes and collagenase-induced rat model of OA were established for the further experiments. Lentivirus mediated siRNA targeting KLF3-AS1 was transfected into MSCs for silencing KLF3-AS1. The real-time quantitative PCR (qRT-PCR) and western blotting analysis were...
Source: The Biochemical Journal - October 19, 2018 Category: Biochemistry Authors: Liu Y, Zou R, Wang Z, Wen C, Zhang F, Lin F Tags: Biochem J Source Type: research

GACAT3 promoted proliferation of osteoarthritis synoviocytes by IL-6/STAT3 signaling pathway.
CONCLUSIONS: In this study, we found that lncRNA GACAT3 was closely related to the osteoarthritis. GACAT3 may be involved in the development and progression of osteoarthritis and become a potential target for treating. PMID: 30178830 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - September 5, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Inhibition of C5a prevents IL-1β-induced alternations in rat synoviocytes in vitro
Publication date: Available online 6 August 2018Source: Molecular and Cellular ProbesAuthor(s): Wei Lu, Lin Wang, Jing Yao, Wen Wang, Yu ChenAbstractC5a is an important pro-inflammatory peptide involved in complement activation, membrane attack complex formation, immune cell chemotaxis, and allergic responses. Osteoarthritis is a disease characterized by degenerative changes in articular cartilage. It has recently been found that inflammatory responses play an important role in the pathogenesis of osteoarthritis and also in rheumatoid arthritis, where dysfunctional synoviocytes are involved. We performed a series of studie...
Source: Molecular and Cellular Probes - August 6, 2018 Category: Molecular Biology Source Type: research

Up-regulation of TRAF2 inhibits chondrocytes apoptosis in lumbar facet joint osteoarthritis.
In conclusion, our results show that the up-regulation of TRAF2 may play an important role in the inhibition of chondrocyte apoptosis of FJOA. PMID: 30054040 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - July 24, 2018 Category: Biochemistry Authors: Jiang J, Zhang J, Wu C, Guo X, Chen C, Bao G, Sun Y, Chen J, Xue P, Xu G, Cui Z Tags: Biochem Biophys Res Commun Source Type: research

LncRNA FAS-AS1 promotes the degradation of extracellular matrix of cartilage in osteoarthritis.
CONCLUSIONS: The expression of FAS-AS1 was increased in osteoarthritis, and FAS-AS1 could be involved in the development of the disease by regulating the proliferation, apoptosis of chondrocytes and promoting the degradation of extracellular matrix. PMID: 29863238 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 8, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Sirtuin-1 (SIRT1) stimulates growth-plate chondrogenesis by attenuating the PERK-eIF-2{alpha}-CHOP pathway in the unfolded protein response Signal Transduction
The NAD+-dependent deacetylase sirtuin-1 (SIRT1) has emerged as an important regulator of chondrogenesis and cartilage homeostasis, processes that are important for physiological skeletal growth and that are dysregulated in osteoarthritis. However, the functional role and underlying mechanism by which SIRT1 regulates chondrogenesis remain unclear. Using cultured rat metatarsal bones and chondrocytes isolated from rat metatarsal rudiments, here we studied the effects of the SIRT1 inhibitor EX527 or of SIRT1 siRNA on chondrocyte proliferation, hypertrophy, and apoptosis. We show that EX527 or SIRT1 siRNA inhibits chondrocyte...
Source: Journal of Biological Chemistry - June 1, 2018 Category: Chemistry Authors: Xiaomin Kang, Wei Yang, Ruiqi Wang, Tianping Xie, Huixia Li, Dongxu Feng, Xinxin Jin, Hongzhi Sun, Shufang Wu Tags: Cell Biology Source Type: research

CXCR3 mediates chondrocyte injury through regulating nitric oxide.
CONCLUSIONS: Endoplasmic reticulum (ER) stress signaling pathway CHOP and GRP78 are involved in CXCR3 receptor attenuating chondrocyte apoptosis induced by SNP. PMID: 29762848 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - May 17, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

E74-Like Factor (ELF3) and Leptin, a Novel Loop Between Obesity and Inflammation Perpetuating a Pro-Catabolic State in Cartilage
Conclusion: Here we show, for the first time, the regulation of ELF3 expression by leptin, suggesting that this transcription factor likely mediates the inflammatory responses triggered by leptin in articular chondrocytes.Cell Physiol Biochem 2018;45:2401 –2410
Source: Cellular Physiology and Biochemistry - March 16, 2018 Category: Cytology Source Type: research

Downregulation of microRNA-448 inhibits IL-1 β-induced cartilage degradation in human chondrocytes via upregulation of matrilin-3.
Conclusion: The findings showed that miR-448 contributed to the progression of osteoarthritis by directly targeting matrilin-3. This indicates that it has potential as a therapeutic target for the treatment of osteoarthritis. PMID: 29483929 [PubMed - in process]
Source: Cellular and Molecular Biology Letters - February 28, 2018 Category: Biochemistry Authors: Yang H, Wu D, Li H, Chen N, Shang Y Tags: Cell Mol Biol Lett Source Type: research

Functional characterisation of ADP ribosylation factor-like protein 15 in rheumatoid arthritis synovial fibroblasts.
CONCLUSIONS: This first report on ARL15 expression in RASF and its likely role in inflammation and metabolic syndromes through a TNF independent pathway, encourages hypothesis-free studies to identify additional pathways underlying RA disease biology. PMID: 29465355 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Roles of microRNA-539 and osteopontin in rheumatoid arthritis.
Authors: Liu Y, Qian K, Li C, Ma Y, Chen X Abstract The present study aimed to investigate the role and mechanism of microRNA-539 (miR-539) in rheumatoid arthritis (RA). A total of 68 RA patients and 46 osteoarthritis patients were enrolled into the current study. Peripheral blood and joint fluid were collected prior to treatment. Reverse transcription-quantitative polymerase chain reaction was performed to detect osteopontin (OPN) mRNA and miR-539 expression levels, while ELISA and western blot analysis were applied to detect OPN protein expression. In addition, bioinformatics analysis predicted that miR-539 direc...
Source: Experimental and Therapeutic Medicine - February 24, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Role of IFT88 in icariin ‑regulated maintenance of the chondrocyte phenotype.
Role of IFT88 in icariin‑regulated maintenance of the chondrocyte phenotype. Mol Med Rep. 2018 Jan 25;: Authors: Xiang W, Zhang J, Wang R, Wang L, Wang S, Wu Y, Dong Y, Guo F, Xu T Abstract Maintenance of the chondrocyte phenotype is crucial for cartilage repair during tissue engineering. Intraflagellar transport protein 88 (IFT88) is an essential component of primary cilia, shuttling signals along the axoneme. The hypothesis of the present study was that IFT88 could exert an important role in icariin‑regulated maintenance of the chondrocyte phenotype. To this end, the effects of icariin on prolife...
Source: Molecular Medicine Reports - February 4, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Antagonism of cysteinyl leukotriene receptor 1 (cysLTR1) by montelukast suppresses cell senescence of chondrocytes.
Abstract Aging is closely associated with osteoarthritis (OA). Although its underlying mechanisms remain unknown, cellular senescence in chondrocytes has become an important therapeutic target for the treatment of OA. Cysteinyl leukotriene receptors (cysLTRs) mediate the pathobiological function of cysteinyl leukotrienes (cysLTs). However, the roles of cysLTRs in the pathogenesis of OA have not been reported before. In the current study, we found that cysLTR1 but not cysLTR2 is expressed in human primary chondrocytes. In addition, stimulation with tumor necrosis factor α (TNF-α) resulted in a significant increas...
Source: Cytokine - January 10, 2018 Category: Molecular Biology Authors: Song W, Zhang Y, Wang J, Ma T, Hao L, Wang K Tags: Cytokine Source Type: research