Magnolin exhibits anti-inflammatory effects on chondrocytes via the NF- κB pathway for attenuating anterior cruciate ligament transection-induced osteoarthritis.
CONCLUSION: MGL demonstrated significant anti-inflammatory bioactivity on chondrocytes by suppressing the activation of NF-κB pathway, which in turn exhibited a significant alleviation of OA. PMID: 32602381 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - July 1, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Therapeutic application of extracellular vesicles for musculoskeletal repair & regeneration.
Therapeutic application of extracellular vesicles for musculoskeletal repair & regeneration. Connect Tissue Res. 2020 Jun 30;:1-16 Authors: Youssef El Baradie KB, Hamrick MW Abstract Traumatic musculoskeletal injuries are common in both the civilian and combat care settings. Significant barriers exist to repairing these injuries including fracture nonunion, muscle fibrosis, re-innervation, and compartment syndrome, as well as infection and inflammation. Recently, extracellular vesicles (EVs), including exosomes and microvesicles, have attracted attention in the field of musculoskeletal regeneration...
Source: Connective Tissue Research - July 1, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Pleiotropin enhances the osteo/dentinogenic differentiation potential of dental pulp stem cells.
CONCLUSION: Our research demonstrated that PTN has a positive role in maintaining DPSCs proliferation and osteo/dentinogenic differentiation potential. PMID: 32580608 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - June 27, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Regenerative rehabilitation of catastrophic extremity injury in military conflicts and a review of recent developmental efforts.
CONCLUSIONS: Both technological improvements and a rapidly advancing understanding of injury pathophysiology will contribute to improved limb-salvage outcomes, and shift the calculus away from early limb amputation. PMID: 32552156 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - June 20, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Maresin-1 suppresses IL-1 β-induced MMP-13 secretion by activating the PI3K/AKT pathway and inhibiting the NF-κB pathway in synovioblasts of an osteoarthritis rat model with treadmill exercise.
CONCLUSIONS: The changes in maresin-1 in IALF, as seen in our single-section treadmill exercise, provides an explanation for the therapeutic effect of appropriate-strength treadmill exercise on osteoarthritis, and our experiments confirmed the therapeutic effect of maresin-1 both in vivo and in vitro. PMID: 32546009 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - June 19, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Naringin inhibits titanium particles-induced up-regulation of TNF- α and IL-6 via the p38 MAPK pathway in fibroblasts from hip periprosthetic membrane.
CONCLUSIONS: These results indicated that naringin could inhibit Ti particle-induced inflammation in fibroblasts by inhibiting p38 MAPK/NF-κB p65 activity and might be a potential drug for the treatment of inflammatory periprosthetic osteolysis after arthroplasty. PMID: 32500755 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - June 7, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Overexpression of laminin α4 facilitates proliferation and migration of fibroblasts in knee arthrofibrosis by targeting canonical Shh/Gli1 signaling.
CONCLUSIONS: LAMA4 positively regulated cellular proliferation and migration in fibroblasts via activating the Shh/Gli1 signaling. LAMA4/Shh/Gli1 signaling axis might be a potential therapeutic target for the prevention of surgery-induced intraarticular fibrosis. PMID: 32449381 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - May 27, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Morphology and Serum and Bone Tissue Calcium and Magnesium Concentrations in the Bones of Male Rats Chronically Treated with Letrozole, a Nonsteroidal Cytochrome P450 Aromatase Inhibitor.
CONCLUSION: Chronic treatment with letrozole affected cortical bone structure and produced histomorphological changes in male rat bone similar to that observed in the aging processes. PMID: 32419518 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - May 20, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Comparison of the efficiency of laminin versus fibronectin as a differential adhesion assay for isolation of human articular cartilage derived chondroprogenitors.
Conclusion: This was the first attempt to successfully isolate human articular cartilage derived chondroprogenitor clones using laminin, which retained stem cell like characteristics. Further evaluation to optimize this method will help enhance chondroprogenitor characteristics, for use in cartilage repair. PMID: 32406271 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - May 15, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Induced neural stem cells-derived spinal cord progenitor cells as stable stage for rapid and efficient generation of human oligodendrocytes and motor neurons.
Conclusion: Our research provides a useful protocol for rapid generation of human oligodendrocytes and motor neurons from human iNSCs and demonstrates a progenitor cell model for exploring the origin of motor neurons and oligodendrocyte in vitro, which will contribute to research on the development of spinal cord and regenerative medicine. PMID: 32380866 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - May 10, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

RANKL expression of primary osteoblasts is enhanced by an IL-17-mediated JAK2/STAT3 pathway through autophagy suppression.
Conclusion: Overall, our findings demonstrate, for the first time, that IL-17 modulates RANKL expression of osteoblasts through an autophagy-JAK2-STAT3 signaling pathway, thus affecting bone metabolism. PMID: 32370570 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - May 8, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Methods for studying MLO-Y4 osteocytes in collagen-hydroxyapatite scaffolds in the rotary cell culture system.
Authors: Fournier R, Harrison RE Abstract Purpose: The rotary cell culture system (RCCS) is a common clinorotation device for cell culture. It is also used as a low-shear suspension culture bioreactor to form functionalized 3D tissue constructs and to model microgravity. We sought to develop a 3D scaffold composed of type I collagen and hydroxyapatite (collagen-HA) to characterize MLO-Y4 osteocytes following suspension culture or clinorotation.Materials and Methods: MLO-Y4 cells were embedded in collagen-HA. The scaffold was formed into droplets for suspension culture or wall-adhered to the RCCS for clinorotation. ...
Source: Connective Tissue Research - May 8, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Ex vivo models of musculoskeletal tissues.
Authors: Szczesny SE PMID: 32340565 [PubMed - in process] (Source: Connective Tissue Research)
Source: Connective Tissue Research - April 30, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Downregulation of lncRNA XIST promotes proliferation and differentiation, limits apoptosis of osteoblasts through regulating miR-203-3p/ZFPM2 axis.
Conclusion: Downregulation of lncRNA XIST promoted osteoblast proliferation and differentiation, but limited apoptosis by miR-203-3p/ZFPM2 axis. PMID: 32326773 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - April 25, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Proteoglycan-4 and hyaluronan composition in synovial fluid and serum from clinical equine subjects: relationship to cartilage boundary lubrication and viscosity of synovial fluid.
The objectives were to characterize composition (proteoglycan-4, hyaluronan), and function of SF and serum from normal horses compared to clinical groups: osteoarthritis, acute-joint-injury, and osteochondrosis.Materials and Methods: Equine samples of SF (from various joints) and blood were collected at the point-of-care. Proteoglycan-4 concentrations were measured by amplified-luminescence-proximity-assay and enzyme-linked-immunosorbent-assay in SF and serum, respectively. Molecular-weight of hyaluronan was characterized by agarose-gel-electrophoresis, and concentrations were measured by enzyme-linked-immunosorbent-assay ...
Source: Connective Tissue Research - April 21, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Comparison of Dynamic Mechanical Properties of Dentin Between Deciduous and Permanent Teeth.
The objective of the present study was to quantify the differences between deciduous and permanent dentin under cyclic mechanical loading, which is similar to masticatory stress.Materials and Methods: Deciduous and permanent teeth, respectively from children (9~12 years old) and young people (18~25 years old), were wet-sectioned perpendicular to the longitudinal axis and the central specimens of coronal dentin were evaluated by nanoscopic dynamic mechanical analysis (nanoDMA).Results: The average storage, loss, and complex moduli, as well as the hardness of deciduous dentin were significantly (p
Source: Connective Tissue Research - April 21, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

HOXA10 may inhibit the osteogenic differentiation of periodontal ligament stem cells by regulating β-catenin and DKK1.
CONCLUSION: These data demonstrate that HOXA10 inhibits the osteogenic differentiation of periodontal ligament stem cells by regulating β-catenin localization and DKK1. PMID: 32299243 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - April 18, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Compression stress induces nucleus pulposus cell autophagy by inhibition of the PI3K/AKT/mTOR pathway and activation of the JNK pathway.
Conclusions: These results show a new regulatory mechanism involving ROS-mediated autophagy in rat NP cells, which may provide ideas for drug development to improve compression stress-induced IVDD and help avoid eventual surgical treatment of IVD herniation. PMID: 32180463 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - March 19, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

PBN protects NP cells from AAPH-induced degenerative changes by inhibiting the ERK1/2 pathway.
Conclusions: Our study for the first time identified a novel role and mechanism for PBN in protecting the IVD against oxidative stress, matrix catabolism and apoptosis, which may have implications for its further application in combating IVD degenerative diseases. PMID: 32183547 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - March 19, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Ontogeny informs regeneration: explant models to investigate the role of the extracellular matrix in cartilage tissue assembly and development.
The objective of this review is to highlight methods that investigate cartilage ontogenesis with native and model systems in the context of regenerative medicine. Specific emphasis is placed on the use of cartilage explant cultures that provide a physiologically relevant microenvironment to study tissue assembly and development. Ex vivo cartilage has proven to be a cost-effective and accessible model system that allows researchers to control the culture conditions and stimuli and perform proteomics and imaging studies that are not easily possible using in vivo experiments, while preserving native cell-matrix interactions. ...
Source: Connective Tissue Research - March 19, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

GREM1 inhibits osteogenic differentiation, senescence and BMP transcription of adipose-derived stem cells.
Conclusions: In summary, our findings suggested that GREM1 inhibited ADSCs senescence and osteogenic differentiation and antagonized BMP transcription. PMID: 32151168 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - March 12, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Advances in bioprinting: a toolbox for tissue engineering.
Authors: Gottardi R PMID: 32081098 [PubMed - in process] (Source: Connective Tissue Research)
Source: Connective Tissue Research - February 23, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Evidence that reduction in volume protects in situ articular chondrocytes from mechanical impact.
Authors: Kotelsky A, Carrier JS, Aggouras A, Richards MS, Buckley MR Abstract Chondrocytes, the resident cells in articular cartilage, carry the burden of producing and maintaining the extracellular matrix (ECM). However, as these cells have a low proliferative capacity and are not readily replaced, chondrocyte death due to extreme forces may contribute to the pathogenesis of osteoarthritis (OA) after injury or may inhibit healing after osteochondral transplantation, a restorative procedure for damaged cartilage that requires a series of mechanical impacts to insert the graft. Consequently, there is a need to under...
Source: Connective Tissue Research - January 16, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Tendon explant models for physiologically relevant in vitro study of tissue biology - a perspective.
Authors: Wunderli SL, Blache U, Snedeker JG Abstract Background: Tendon disorders increasingly afflict our aging society but we lack the scientific understanding to clinically address them. Clinically relevant models of tendon disease are urgently needed as established small animal models of tendinopathy fail to capture essential aspects of the disease. Two-dimensional and three-dimensional cell and tissue culture models are similarly limited, lacking many physiological extracellular matrix cues required to maintain tissue homeostasis or guide matrix remodeling. These cues reflect the biochemical and biomechanical ...
Source: Connective Tissue Research - January 15, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Mechanosensitive Ca2+ signaling and coordination is diminished in osteocytes of aged mice during ex vivo tibial loading.
Conclusions: We have demonstrated, for the first time, real-time evidence of the diminished mechanosensing and lack of signaling coordination in aged osteocyte networks in tibial explants, which may contribute to pathology of age-induced bone loss. PMID: 31931640 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - January 15, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Detrimental effects of long sedentary bouts on the biomechanical response of cartilage to sliding.
Conclusions: These results demonstrated that the regularity of ex vivo activity regimens, specifically the duration of sedentary bouts, had a dominant effect on the biomechanical functions of articular cartilage. In more practical terms, the results suggest that brief but regular movement patterns (e.g., every hour) may be biomechanically preferred to long and infrequent movement patterns (e.g., a long walk after a sedentary day) when controlling for daily activity volume (e.g., 30 min). PMID: 31910694 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - January 9, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Authors' answer to a letter to the editor.
Authors: Berteau JP PMID: 31913704 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - January 9, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Letter to the editor.
LETTER TO THE EDITOR. Connect Tissue Res. 2020 Jan 08;:1-2 Authors: Unal M PMID: 31913709 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - January 9, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Editorial Note.
Authors: PMID: 31913717 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - January 9, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Reviewer comments.
REVIEWER COMMENTS. Connect Tissue Res. 2020 Jan 08;:1-2 Authors: PMID: 31913718 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - January 9, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Editorial Commentary: Raman spectroscopic analysis of bone.
Authors: PMID: 31913720 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - January 9, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

Bioprinting on sheet-based scaffolds applied to the creation of implantable tissue-engineered constructs with potentially diverse clinical applications: Tissue-Engineered Muscle Repair (TEMR) as a representative testbed.
Conclusions: Bioprinting can enable automated fabrication of TEMR constructs with high fidelity and scalability, while reducing biomanufacturing costs and timelines. Such bioprinting applications are underappreciated, yet critical, to expand the overall biomanufacturing paradigm for tissue engineered medical products. In addition, biofabrication of sheet-like implantable constructs, with cells deposited on both sides, is a process that is both scaffold and cell-type agnostic, and furthermore, is amenable to many geometries, and thus, additional tissue engineering applications beyond skeletal muscle. PMID: 31899969 [Pub...
Source: Connective Tissue Research - January 5, 2020 Category: Research Tags: Connect Tissue Res Source Type: research

The age-dependent effect of high-dose X-ray radiation on NF κB signaling, structure, and mechanical behavior of the intervertebral disc.
Conclusions: These results suggest that high-dose radiation affects the IVDs' NFκB-dependent inflammatory processes that subsequently lead to functional deterioration. Blocking the transactivation potential of NFκB via MyD88 ablation preserved the structure and mechanical function of the FSUs. The long-term effects of radiation on IVD homeostasis should be considered in individuals susceptible to occupational and medical exposure. PMID: 31875721 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - December 27, 2019 Category: Research Tags: Connect Tissue Res Source Type: research

Tissue interactions are indispensable for the cavity formation and disc separation in temporomandibular joint.
Conclusion: Joint capsule formation was essential for cavity formation and disc separation during TMJ development. PMID: 31875727 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - December 27, 2019 Category: Research Tags: Connect Tissue Res Source Type: research

Marrow aspiration in aged mice: intramedullary osteogenesis, reduced mechano-adaptation, increased marrow fat.
Conclusion: These data demonstrate that, in old mice, bone forms in the medullary canal following aspiration. Adiposity is increased following marrow aspiration, and periosteal mechano-adaptation is reduced. PMID: 31868022 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - December 25, 2019 Category: Research Tags: Connect Tissue Res Source Type: research

Explant models for meniscus metabolism, injury, repair, and healing.
Conclusion: Despite few outstanding challenges, meniscus explant models have potential to serve as an effective tool for investigations of meniscus metabolism, injury, repair and healing. PMID: 31842590 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - December 19, 2019 Category: Research Tags: Connect Tissue Res Source Type: research

Changes in cartilage and subchondral bone in a growing rabbit experimental model of developmental trochlear dysplasia of the knee.
Conclusions: This study proved that trochlear dysplasia can be caused by patellar dislocation in growing rabbits, accompanied by significant subchondral bone loss. What is more, this study also shows that degenerative cartilage changes occur in the patellar dislocation model and become aggravated with time, accompanied by decreased TRPV4 and collagen II, but increased MMP-13. PMID: 31829044 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - December 13, 2019 Category: Research Tags: Connect Tissue Res Source Type: research

MiR-21-5p inhibits the progression of human chondrosarcoma by regulating CCR7/STAT3/NF- κB pathway.
Conclusion: miR-21-5p targeted CCR7 expression to inhibit the STAT3 and NF-κB signaling, thereby suppressing cell proliferation, migration, invasion and EMT in CS cells, which might be a novel mechanistic study for CS therapy. PMID: 31813289 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - December 10, 2019 Category: Research Tags: Connect Tissue Res Source Type: research

Contribution of extracellular matrix components to the stiffness of skeletal muscle contractures in patients with cerebral palsy.
Conclusions: These data demonstrate a novel adaptation of muscle extracellular matrix in children with cerebral palsy that includes alterations in extracellular matrix protein composition and structure related to mechanical function. PMID: 31779492 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - November 30, 2019 Category: Research Tags: Connect Tissue Res Source Type: research

Dynamic interplay between connective tissues and the surrounding environment during aging.
Authors: Diekman BO PMID: 31782325 [PubMed - in process] (Source: Connective Tissue Research)
Source: Connective Tissue Research - November 30, 2019 Category: Research Tags: Connect Tissue Res Source Type: research

A rat model of arthrofibrosis developed after anterior cruciate ligament reconstruction without rigid joint immobilization.
Discussions: We developed a rat model of ACLR-induced joint contracture due to arthrofibrosis without rigid immobilization. Joint contracture was also observed in the ACLT group, but to a considerably milder degree than in the ACLR group. Thus, signs of inflammation as a result of reconstruction surgery, rather than ACL transection, play an important role in the formation of joint contracture after ACLR. Our animal model is suited to examine the mechanisms and efficacy of therapeutic strategies for arthrofibrosis following ACLR treated without rigid joint immobilization. PMID: 31771380 [PubMed - as supplied by publishe...
Source: Connective Tissue Research - November 29, 2019 Category: Research Tags: Connect Tissue Res Source Type: research

Exosomes derived from lipopolysaccharide-preconditioned human dental pulp stem cells regulate Schwann cell migration and differentiation.
Conclusions: Exosomes from hDPSCs, especially from LPS- preconditioned hDPSCs, can promote the proliferation, migration and odontogenic differentiation of SCs. LPS might change the hDPSCs' intercellular signals, which might mediate the odontogenic differentiation of SCs, transmitting in the manner of "exosomes". PMID: 31769319 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - November 28, 2019 Category: Research Tags: Connect Tissue Res Source Type: research

ERK5 negatively regulates Kruppel-like factor 4 and promotes osteogenic lineage cell proliferation in response to MEK5 overexpression or fluid shear stress.
Conclusions: KLF4 negatively regulates osteogenic lineage cell proliferation, and ERK5 negatively regulates KLF4 expression and promotes osteogenic lineage cell proliferation. PMID: 31749391 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - November 23, 2019 Category: Research Tags: Connect Tissue Res Source Type: research

SDF-1 preconditioned HPC scaffolds mobilize cartilage-derived progenitors and stimulate meniscal fibrocartilage repair in human explant tissue culture.
Conclusion: C-PCs migrate in response to SDF-1. Exposure to SDF-1 does not significantly alter the unique mRNA profile of C-PCs that make them desirable for cartilaginous tissue repair applications. SDF-1 pretreated mesenchymal progenitors successfully disperse into injured tissues to help facilitate tissue reintegration. PMID: 31744353 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - November 22, 2019 Category: Research Tags: Connect Tissue Res Source Type: research

Wnt signaling and the transcription factor Foxn1 contribute to cutaneous wound repair in mice.
Conclusions. Wnt ligands contribute to cutaneous wound repair, predominantly by engagement in ECM maturation. The data indicates a possible relationship between Foxn1 and Wnts in post-traumatic skin tissue. PMID: 31690137 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - November 8, 2019 Category: Research Tags: Connect Tissue Res Source Type: research

Evaluation of culture conditions for in vitro meniscus repair model systems using bone marrow-derived mesenchymal stem cells.
Conclusions: The meniscal tissue defect model established in this paper can be used to perform in vitro screening to identify and optimize biological treatments to enhance meniscus tissue repair prior to conducting preclinical animal studies. PMID: 31661326 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - October 30, 2019 Category: Research Tags: Connect Tissue Res Source Type: research

Transcriptional profiling of the murine intervertebral disc and age-associated changes in the nucleus pulposus.
Conclusions: This study provided insight into the phenotypes of NP and AF cells, and identified candidate pathways that may regulate degeneration. PMID: 31597481 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - October 12, 2019 Category: Research Tags: Connect Tissue Res Source Type: research

Evidence of biglycan structure-function in bone homeostasis and aging.
Conclusions: Biglycan is a key player in skeletal bone homeostasis, and overall, there is more evidence on the role of biglycan in development and less in the adult physiological or diseased young and aged systems. Further understanding of its conformation, degradation peptides and post-translational modifications will be required to understand the role of biglycan in bone maintenance and to support the development of treatments for age-related bone dysfunctions. PMID: 31597498 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - October 12, 2019 Category: Research Tags: Connect Tissue Res Source Type: research

Ehlers-Danlos syndrome-related genes and serum strontium, zinc, and lithium levels in generalized joint hypermobility: A case-control study.
Conclusion: Our findings provide valuable basal levels for conducting gene function analysis of joint hypermobility-related connective tissue disorders. PMID: 31594391 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - October 10, 2019 Category: Research Tags: Connect Tissue Res Source Type: research

Effects of combination TGF-B1 transfection and Platelet Rich Plasma (PRP) on Three-Dimension Chondrogenic Differentiation of Rabbit Dental Pulp-derived Mesenchymal Stem Cells.
Conclusion: The combination in culture medium of TGF-B1 gene transfection and 10% PRP are accelerate in chondrogenic differentiation of DPSCs. PMID: 31581853 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)
Source: Connective Tissue Research - October 6, 2019 Category: Research Tags: Connect Tissue Res Source Type: research