FBN2 pathogenic variants in congenital contractural arachnodactyly with severe cardiovascular manifestations
CONCLUSIONS: This study enriched the pathogenic spectrum of CCA and identified a hotspot region in FBN2 gene associated with severe cardiovascular manifestations. We recommend that patients carrying pathogenic variants in exons 31 to 35 of FBN2 pay more attention to cardiac evaluation.PMID:38602424 | DOI:10.1080/03008207.2024.2340004 (Source: Connective Tissue Research)
Source: Connective Tissue Research - April 11, 2024 Category: Research Authors: Shulin Yang Zongzhe Li Source Type: research
Effects of the ferroptosis inducer erastin on osteogenic differentiation and biological pathways of primary osteoblasts
CONCLUSION: The ferroptosis inducer erastin inhibited osteoblast proliferation and differentiation. Our study provides novel insights into the effect of ferroptosis on osteogenesis, suggesting that targeting ferroptosis may present a promising approach in the treatment of periodontitis.PMID:38578221 | DOI:10.1080/03008207.2024.2338348 (Source: Connective Tissue Research)
Source: Connective Tissue Research - April 5, 2024 Category: Research Authors: Jiaqi Bao Xufei Yu Yuting Yang Weilian Sun Zhongxiu Wang Lili Chen Source Type: research
Independent and combined effects of obesity and traumatic joint injury to the structure and composition of rat knee cartilage
Connect Tissue Res. 2024 Mar;65(2):117-132. doi: 10.1080/03008207.2024.2310838. Epub 2024 Mar 26.ABSTRACTOsteoarthritis (OA) is a multifactorial joint disease characterized by articular cartilage degradation. Risk factors for OA include joint trauma, obesity, and inflammation, each of which can affect joint health independently, but their interaction and the associated consequences of such interaction were largely unexplored. Here, we studied compositional and structural alterations in knee joint cartilages of Sprague-Dawley rats exposed to two OA risk factors: joint injury and diet-induced obesity. Joint injury was impose...
Source: Connective Tissue Research - March 26, 2024 Category: Research Authors: Kalle Karjalainen Petri Tanska Kelsey H Collins Walter Herzog Rami K Korhonen Eng Kuan Moo Source Type: research
Independent and combined effects of obesity and traumatic joint injury to the structure and composition of rat knee cartilage
Connect Tissue Res. 2024 Mar 26:1-16. doi: 10.1080/03008207.2024.2310838. Online ahead of print.ABSTRACTOsteoarthritis (OA) is a multifactorial joint disease characterized by articular cartilage degradation. Risk factors for OA include joint trauma, obesity, and inflammation, each of which can affect joint health independently, but their interaction and the associated consequences of such interaction were largely unexplored. Here, we studied compositional and structural alterations in knee joint cartilages of Sprague-Dawley rats exposed to two OA risk factors: joint injury and diet-induced obesity. Joint injury was imposed...
Source: Connective Tissue Research - March 26, 2024 Category: Research Authors: Kalle Karjalainen Petri Tanska Kelsey H Collins Walter Herzog Rami K Korhonen Eng Kuan Moo Source Type: research
