Does preoperative neuropathic-like pain and central sensitisation affect the post-operative outcome of knee joint replacement for osteoarthritis? A systematic review and meta analysis
Almost a third of those undergoing knee replacement for osteoarthritis have poor outcomes despite technically successful surgery. Preoperative neuropathic-like pain and/or pain sensitisation may increase the risk of pain following joint replacement. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 10, 2020 Category: Rheumatology Authors: Anita E. Wluka, Mabel K. Yan, Kai Ying Lim, Sultana Monira Hussain, Flavia M. Cicuttini Source Type: research

Age-related changes of micro-morphological subchondral bone properties in the healthy femoral head
Alterations in the subchondral bone (SCB) are likely to play a decisive role in the development of osteoarthritis (OA). Since aging represents a major risk factor for OA, the aim of the current study was to assess the microstructural changes of the subchondral bone in the femoral head during aging. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 10, 2020 Category: Rheumatology Authors: Christian Ries, Christoph Kolja Boese, Julian St ürznickel, Till Koehne, Jan Hubert, Marc-Frederic Pastor, Michael Hahn, Simon Lars Meier, Frank Timo Beil, Klaus Püschel, Michael Amling, Tim Rolvien Source Type: research

Effect of exercise on pain processing and motor output in people with knee osteoarthritis: a systematic review and meta-analysis
Guidelines recommend exercise as a core treatment for knee osteoarthritis. However, it is unclear how exercise affects measures of pain processing and motor function. The aim was to evaluate the effect of exercise on measures of pain processing and motor function in people with knee osteoarthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 8, 2020 Category: Rheumatology Authors: Michelle Hall, Fiona Dobson, Melanie Plinsinga, Catherine Mailloux, Scott Starkey, Esther Smits, Paul Hodges, Bill Vicenzino, Siobhan M. Schabrun, Hugo Masse-Alarie Source Type: research

Hip Symptoms are Associated with Premature Mortality: The Johnston County Osteoarthritis Project
To investigate the impact of hip osteoarthritis (OA) and/or hip symptoms on excess mortality. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 6, 2020 Category: Rheumatology Authors: Rebecca J. Cleveland, Carolina Alvarez, Amanda E. Nelson, Todd A. Schwartz, Jordan B. Renner, Joanne M. Jordan, Leigh F. Callahan Source Type: research

Commentary on: Effect of the dr. Bart application on healthcare use and clinical outcomes in people with osteoarthritis of the knee and/or hip in the Netherlands; a randomized controlled trial
First of all, our sincere compliments to the authors for the clear presentation of their RCT concerning this novel approach in OA self-management. It was truly a pleasure to read and gave an explicit and comprehensible answer to the research question. After discussing the paper, we were left with a few questions regarding the design of the study and the applicability of the results. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 5, 2020 Category: Rheumatology Authors: S.F.J. Chudy, M.M.M. Volwater, Ö.F. Ozbulut, B.W. Koes Tags: Letter to the Editor Source Type: research

Reply to letter to the editor: ‘Effect of the dr. Bart application on healthcare use and clinical outcomes in people with osteoarthritis of the knee and/or hip in the Netherlands; a randomized controlled trial’
This letter is in response to the letter by Chudy et al. regarding our article: ‘Effect of the dr. Bart application on health care use and clinical outcomes in people with osteoarthritis of the knee and/or hip in the Netherlands; a randomized controlled trial’1. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 5, 2020 Category: Rheumatology Authors: Tim Pelle, Karen Bevers, Job van der Palen, Frank H.J. van den Hoogen, Cornelia H.M. van den Ende Tags: Letter to the Editor Source Type: research

The Relation of Oral Bisphosphonates to Bone Marrow Lesion Volume among Women with Osteoarthritis
Bone marrow lesions (BMLs) contribute to pain and progression of knee OA. Bisphosphonates may be a potential disease-modifier through amelioration of BMLs. We sought to determine the effect of oral bisphosphonates on BML volume over 12 months. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 4, 2020 Category: Rheumatology Authors: Priyanka Ballal, Meera Sury, Na Lu, Jeffery Duryea, Yuqing Zhang, Chuck Ratzlaff, Tuhina Neogi Source Type: research

Degeneration alters the biomechanical properties and structural composition of lateral human menisci
Because the literature relating to the influence of degeneration on the viscoelasticity and tissue composition of human lateral menisci remains contradictory or completely lacking, the aim of this study was to fill these gaps by comprehensively characterising the biomechanical properties of menisci with regard to the degree of degeneration. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 30, 2020 Category: Rheumatology Authors: Daniela Warnecke, Jonas Balko, Julian Haas, Ralf Bieger, Frank Leucht, Nicolas Wolf, Natalie Schild, Svenja Stein, Andreas Seitz, Anita Ignatius, Heiko Reichel, Boris Mizaikoff, Lutz D ürselen Source Type: research

Multi-vendor multi-site T1 ρ and T2 quantification of knee cartilage
To develop 3D T1 ρ and T2 imaging based on the same sequence structure on MR systems from multiple vendors, and to evaluate intra-site repeatability and inter-site inter-vendor reproducibility of T1ρ and T2 measurements of knee cartilage. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 30, 2020 Category: Rheumatology Authors: Jeehun Kim, Kenji Mamoto, Richard Lartey, Kaipin Xu, Kunio Nakamura, Wanyong Shin, Carl S. Winalski, Nancy Obuchowski, Matthew Tanaka, Emma Bahroos, Thomas M. Link, Peter A. Hardy, Qi Peng, Ravinder Reddy, Angie Botto-van Bemden, Kecheng Liu, Robert D. Pe Source Type: research

Sequencing identifies a distinct signature of circulating microRNAs in early radiographic knee osteoarthritis
MicroRNAs act locally and systemically to impact osteoarthritis pathophysiology, but comprehensive profiling of the circulating miRNome in early versus late stages of osteoarthritis has yet to be conducted. Sequencing has emerged as the preferred method for microRNA profiling since it offers high sensitivity and specificity. Our objective is to sequence the miRNome in plasma from 91 patients with early [Kellgren-Lawrence grade 0 or 1 (n=41)] or late [Kellgren-Lawrence grade 3 or 4 (n=50)] symptomatic radiographic knee osteoarthritis to identify unique microRNA signatures in each disease state. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 29, 2020 Category: Rheumatology Authors: Shabana Amanda Ali, Rajiv Gandhi, Pratibha Potla, Sareh Keshavarzi, Osvaldo Espin-Garcia, Konstantin Shestopaloff, Chiara Pastrello, Dylan Bethune-Waddell, Starlee Lively, Anthony V. Perruccio, Y. Raja Rampersaud, Christian Veillette, Jason S. Rockel, Igo Source Type: research

TAT-Beclin-1 induces severe synovial hyperplasia and does not protect from injury-induced osteoarthritis in mice
Autophagy maintains cartilage homeostasis and is compromised during osteoarthritis (OA), contributing to cartilage degeneration. We sought to determine if D-isomer TAT-Beclin-1, a potent inducer of autophagy, could attenuate post-traumatic OA in mice. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 16, 2020 Category: Rheumatology Authors: Jason S. Rockel, Brian Wu, Sayaka Nakamura, Evgeny Rossomacha, Osvaldo Espin-Garcia, Rajiv Gandhi, Mohit Kapoor Tags: Brief Report Source Type: research

Cartilage calcification is associated with histological degeneration of the knee joint: a highly prevalent, age-independent systemic process
To investigate if cartilage calcification (CC) is a systemic process, the purpose of this study was to determine the prevalence and the amount of meniscal/hyaline CC of the knee joint in the general population by high-resolution imaging (DCR) and to evaluate the association between CC with cartilage degeneration and age. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 16, 2020 Category: Rheumatology Authors: Jan Hubert, Frank Timo Beil, Tim Rolvien, Sebastian Butscheidt, Sandra Hischke, Klaus P üschel, Stephan Frosch, Haider Mussawy, Christian Ries, Thelonius Hawellek Source Type: research

Cartilage calcification and osteoarthritis: a pathological association?
Osteoarthritis (OA) remains one of the leading causes of disability worldwide.(1) Despite advances in our understanding of OA pathogenesis, no disease-modifying therapies currently exist. Whilst the association between cartilage calcification (CC) and OA is well recognised, there is ongoing debate as to whether CC plays a pathological role or if it is merely an ‘epiphenomenon’ of the OA disease process. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 15, 2020 Category: Rheumatology Authors: John Stack, Geraldine McCarthy Tags: Editorial Source Type: research

Patients', healthcare providers', and insurance company employees' preferences for knee and hip osteoarthritis care: a discrete choice experiment
To determine patients', healthcare providers', and insurance company employees' preferences for knee and hip osteoarthritis (KHOA) care. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 14, 2020 Category: Rheumatology Authors: I.G. Arslan, S.P.I. Huls, E.W. de Bekker-Grob, R. Rozendaal, M.C.T. Persoons, M.E. Spruijt-van Hell, P.J.E. Bindels, S.M.A. Bierma-Zeinstra, D. Schiphof Tags: Clinical Trial Source Type: research

Patients ’, healthcare providers’, and insurance company employees’ preferences for knee and hip osteoarthritis care: a discrete choice experiment
To determine patients ’, healthcare providers’, and insurance company employees’ preferences for knee and hip osteoarthritis (KHOA) care. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 14, 2020 Category: Rheumatology Authors: Ilgin G. Arslan, Samare P.I. Huls, Esther W. de Bekker-Grob, Rianne Rozendaal, Marco C.T. Persoons, Mari ëlleke E. Spruijt-van Hell, Patrick J.E. Bindels, Sita M.A. Bierma-Zeinstra, Dieuwke Schiphof Source Type: research

Corrigendum to “Anti-inflammatory effects of Lonomia obliqua caterpillar protein rlosac on macrophages and chondrocytesˮ [Osteoarthritis Cartilage 28 (2020) S121–S122]
The authors regret that there was an error in the above article where authors T. Chuba, F.V. Santa-Cec ília and Y. Cury, and the 2nd and 3rd affiliations were missing from the original publication. The authors are correctly listed above. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 13, 2020 Category: Rheumatology Authors: M.P. Alvarez-Flores, R.N. Gomes, G.S. Pazelli, T. Chuba, F.V. Santa-Cec ília, Y. Cury, L. Camargo, J.G. Souza, D.S. Oliveira, C. Deocesano-Pereira, M.B. Goldfeder, A.M. Chudzinski-Tavassi Tags: Corrigendum Source Type: research

Identification of TGF β signatures in six murine models mimicking different osteoarthritis clinical phenotypes
TGF β is a key player in cartilage homeostasis and OA pathology. However, few data are available on the role of TGFβ signalling in the different OA phenotypes. Here, we analysed the TGFβ pathway by transcriptomic analysis in six mouse models of OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 9, 2020 Category: Rheumatology Authors: Marie Maumus, Dani èle Noel, Hang Korng Ea, David Moulin, Maxime Ruiz, Eric Hay, Xavier Houard, Damien Cleret, Martine Cohen-Solal, Claire Jacques, Jean-Yves Jouzeau, Marie-Hélène Lafage-Proust, Pascal Reboul, Jérémie Sellam, Claire Vinatier, Franço Source Type: research

Severity of Intervertebral Disc Herniation Regulates Cytokine and Chemokine Levels In Patients with Chronic Radicular Back Pain
We examined the effects of symptomatic disc herniation (DH) and MRI herniation severity on serum cytokine levels in clinical subjects. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 8, 2020 Category: Rheumatology Authors: Hayley E. Jacobsen, Aysha N. Khan, Mitchell E. Levine, Christopher G. Filippi, Nadeen O. Chahine Source Type: research

Patient Preferences for Osteoarthritis Pain and Chronic Low Back Pain Treatments in the United States: A Discrete-Choice Experiment
To quantify preferences for attributes of potential analgesic treatments for moderate-to-severe pain associated with osteoarthritis (OA) and/or chronic low back pain (CLBP) as relevant to injectable nerve growth factor (NGF) –inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 8, 2020 Category: Rheumatology Authors: C. Dennis, Marco Boeri, Lucy Abraham, Jo Atkinson, Andrew Bushmakin, Joseph C. Cappelleri, Brett Hauber, Kathleen Klein, Leo Russo, Lars Viktrup, David A. Walsh Source Type: research

Human Articular Cartilage is Orthotropic where Microstructure, Micromechanics, and Chemistry Vary with Depth and Split-line Orientation
Quantitative, micrometer length scale assessment of human articular cartilage is essential to enable progress toward new functional tissue engineering approaches, including utilization of emerging 3D bioprinting technologies, and for improved computational modeling of the osteochondral unit. Thus the objective of this study was to characterize the structural organization, material properties, and chemical composition of human skeletally mature articular cartilage with respect to depth and defined morphological features: normal to the articulating surface, parallel to the split-line, and transverse to the split-line. (Sourc...
Source: Osteoarthritis and Cartilage - July 6, 2020 Category: Rheumatology Authors: Kristine M. Fischenich, Joseph A. Wahlquist, Rachel Wilmoth, Luyao Cai, Corey P. Neu, Virginia L. Ferguson Source Type: research

Leukocyte-dependent effects of platelet-rich plasma on cartilage loss and thermal hyperalgesia in a mouse model of post-traumatic osteoarthritis
Platelet-rich plasma (PRP) is an emerging therapeutic strategy for treatment of osteoarthritis (OA); however, there is a lack of preclinical and clinical evidence for its efficacy and its mechanism of action is unclear. In the current study, we utilized leukocyte poor-PRP (LP-PRP) and leukocyte rich-PRP (LR-PRP) to mimic clinical point of care formulations and assessed their potential to alter disease progression in a mouse model of post-traumatic OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 3, 2020 Category: Rheumatology Authors: P. Jayaram, C. Liu, B. Dawson, S. Ketkar, S.J. Patel, B.H. Lee, M.W. Grol Source Type: research

Leukocyte-Dependent Effects of Platelet Rich Plasma on Cartilage Loss and Thermal Hyperalgesia in a Mouse Model of Post-Traumatic Osteoarthritis
Platelet-rich plasma (PRP) is an emerging therapeutic strategy for treatment of osteoarthritis (OA); however, there is a lack of preclinical and clinical evidence for its efficacy and its mechanism of action is unclear. In the current study, we utilized leukocyte poor-PRP (LP-PRP) and leukocyte rich-PRP (LR-PRP) to mimic clinical point of care formulations and assessed their potential to alter disease progression in a mouse model of post-traumatic OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 3, 2020 Category: Rheumatology Authors: Prathap Jayaram, Christina Liu, Brian Dawson, Shamika Ketkar, Shiv J. Patel, Brendan H. Lee, Matthew W. Grol Source Type: research

Systemic Iron Overload Exacerbates Osteoarthritis in the Strain 13 Guinea Pig
Iron is emerging as a key player in aging-associated diseases due to its propensity for driving free radical formation. Studies examining the role of iron in the pathogenesis of primary osteoarthritis (OA) are limited. Our objective was to establish a direct relationship between excess iron and OA by administering iron dextran to a guinea pig strain with decreased propensity for developing OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 3, 2020 Category: Rheumatology Authors: Lindsey H. Burton, Lauren B. Radakovich, Angela J. Marolf, Kelly S. Santangelo Source Type: research

Evaluating the structural effects of intra-articular sprifermin on cartilage and non-cartilaginous tissue alterations, based on sqMRI assessment over two years
Sprifermin (recombinant human fibroblast growth factor-18), a potential disease-modifying osteoarthritis (OA) drug, demonstrated dose-dependent effects on femorotibial cartilage thickness (by quantitative magnetic resonance imaging [MRI]) in the phase II FORWARD study. This post-hoc analysis evaluated the potential effects of sprifermin on several articular structures in the whole joint over 24 months using semi-quantitative MRI assessment. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 30, 2020 Category: Rheumatology Authors: Frank W. Roemer, Jeffrey Kraines, Aida Aydemir, Stephen Wax, Marc C. Hochberg, Michel D. Crema, Ali Guermazi Tags: Brief Report Source Type: research

The Relation of Peripheral and Central Sensitization to Muscle Co-contraction: The MOST Study
To examine the relation of pain sensitization to altered motor activity in knee OA as assessed by hamstrings muscle co-contraction during maximal effort knee extension. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 22, 2020 Category: Rheumatology Authors: Joshua J. Stefanik, Laura Frey-Law, Neil A. Segal, J. Niu, Cora E. Lewis, Michael C. Nevitt, Tuhina Neogi Source Type: research

Multi-tissue epigenetic analysis of the osteoarthritis susceptibility locus mapping to the plectin gene PLEC
Osteoarthritis (OA) associated single nucleotide polymorphism (SNP) rs11780978 correlates with differential expression of PLEC, and methylation quantitative trait loci (mQTLs) at PLEC CpGs in cartilage. This implies that methylation links chondrocyte genotype and phenotype, thus driving the functional effect. PLEC encodes plectin, a cytoskeletal protein that enables tissues to respond to mechanical forces. We sought to assess whether PLEC functional effects were cartilage specific. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 20, 2020 Category: Rheumatology Authors: A.K. Sorial, I.M.J. Hofer, M. Tselepi, K. Cheung, E. Parker, D.J. Deehan, S.J. Rice, J. Loughlin Source Type: research

Individualized predictions of changes in knee pain, quality of life and walking speed following patient education and exercise therapy in patients with knee osteoarthritis – A prognostic model study
To facilitate shared decision-making for patients with knee osteoarthritis (OA), we aimed at building clinically applicable models to predict the individual change in pain intensity (VAS scale 0 -100), knee-related quality of life (QoL) (KOOS QoL score 0-100) and walking speed (m/sec) immediately following two educational and 12 supervised exercise therapy sessions. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 16, 2020 Category: Rheumatology Authors: Linda Baumbach, Markus List, Dorte Thalund Gr ønne, Søren T. Skou, Ewa M. Roos Source Type: research

Non-ionic CT Contrast Solutions Rapidly Alter Bovine Cartilage and Meniscus Mechanics
To evaluate effects of a common CT contrast agent (iohexol) on the mechanical behaviors of cartilage and meniscus. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 11, 2020 Category: Rheumatology Authors: Eva G. Baylon, Hollis A. Crowder, Garry E. Gold, Marc E. Levenston Source Type: research

Lubricin in experimental and naturally occurring osteoarthritis: a systematic review
Lubricin is increasingly being evaluated as an outcome measure in studies investigating post-traumatic and naturally occurring osteoarthritis. However, there are discrepancies in results, making it unclear as to whether lubricin is increased, decreased or unchanged in osteoarthritis. The purpose of this study was to review all papers that measured lubricin in joint injury or osteoarthritis in order to draw conclusions about lubricin regulation in joint disease. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 3, 2020 Category: Rheumatology Authors: Amanda R. Watkins, Heidi L. Reesink Tags: Review Source Type: research

Depth-dependent Changes in Cartilage T2 under Compressive Strain: A 7T MRI study on Human Knee Cartilage
To assess the potential of using ΔT2 as an indirect index of cartilage strain by quantifying the relationship between local in situ compressive strain and ΔT2 through the full depth of human tibial and femoral articular cartilage. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 28, 2020 Category: Rheumatology Authors: Jane Desrochers, Andrew Yung, David Stockton, David Wilson Source Type: research

Retraction notice to “Synthetic triterpenoids, CDDO-Imidazolide and CDDO-Ethyl amide, induce chondrogenesis” [Osteoarthr Cartil 20 (2012) 446–450]
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 27, 2020 Category: Rheumatology Authors: N. Suh, S. Paul, H.J. Lee, T. Yoon, N. Shah, A.I. Son, A.H. Reddi, D. Medici, M.B. Sporn Source Type: research

Melatonin activates autophagy via the NF- κB signaling pathway to prevent extracellular matrix degeneration in intervertebral disc
This study investigated whether melatonin alleviates intervertebral disc degeneration (IVDD) by promoting autophagy through inhibiting the NF- κB signaling pathway. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 26, 2020 Category: Rheumatology Authors: Fan Chen, Hui Liu, Xiaolin Wang, Zemin Li, Jian Zhang, Yuxin Pei, Zhaomin Zheng, Jianru Wang Source Type: research

Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats
Subchondral bone may contribute to knee osteoarthritis (OA) pain. Nerve growth factor (NGF) can stimulate nerve growth through TrkA. We aimed to identify how sensory nerve growth at the osteochondral junction in human and rat knees associates with OA pain. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 25, 2020 Category: Rheumatology Authors: Koji Aso, Seyed Mohsen Shahtaheri, Roger Hill, Deborah Wilson, Daniel F. McWilliams, Lilian N. Nwosu, Victoria Chapman, David A. Walsh Source Type: research

Efficacy and safety of duloxetine in osteoarthritis or chronic low back pain? The tip of an iceberg!
Weng and colleagues must be commended for their attempts to clarify the benefit/harm ratio of duloxetine in osteoarthritis and chronic low back pain1. Indeed, the high number of therapeutic options available shows the state of affairs is a lottery while these frequent conditions “associated with substantial work disability, morbidity, costs, and increased mortality rates” deserve robust evidence2. However, their conclusion “Duloxetine had modest to moderate effects… with mild adverse events” claiming “future randomized controlled trials should focus on comparing duloxetine…&rdquo...
Source: Osteoarthritis and Cartilage - May 20, 2020 Category: Rheumatology Authors: A. Braillon Tags: Letter to the Editor Source Type: research

The effect of hydrostatic pressure on proteoglycan production in articular cartilage in vitro: a meta-analysis
In previous research the use of hydrostatic pressure (HP) has been applied to enhance the formation of engineered cartilage, through the up-regulation of proteoglycan synthesis by mechanotransduction. However, the HP stimulation approach has been shown to vary between studies with a wide disparity in results, including anabolic, catabolic and non-responsive outcomes. To this end, a meta-analysis of HP publications using 3D cultured chondrocytes was performed to elucidate the key experiment factors involved in achieving a mechanotransducive response. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 20, 2020 Category: Rheumatology Authors: Ella Hodder, Fergus Guppy, Derek Covill, Peter Bush Tags: Review Source Type: research

Association of knee OA structural phenotypes to risk for progression: a secondary analysis from the Foundation for National Institutes of Health Osteoarthritis Biomarkers study (FNIH)
Aim was to stratify the knee MRIs of the Foundation for National Institutes of Health Osteoarthritis Biomarkers Consortium (FNIH) cohort into distinct structural phenotypes based on semiquantitative assessment and to determine risk for pain and structural progression over 48 months. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 17, 2020 Category: Rheumatology Authors: Frank W. Roemer, Jamie E. Collins, Tuhina Neogi, Michel D. Crema, Ali Guermazi Tags: Brief Report Source Type: research

Mitochondrial biogenesis: a potential therapeutic target for osteoarthritis
Mitochondrial dysfunction of human articular chondrocytes is considered a hallmark of cartilage degradation and OA pathogenesis. Due to the huge number of cellular processes in which mitochondria is implicated, even in the closed context of cellular respiration, the term mitochondrial function can refer to a variety of features which include fusion and fission, turnover (biogenesis and mitophagy), and plasticity. Mitochondrial biogenesis and mainly mitochondrial fusion and reduced mitophagy, contribute to the metabolic disorder and inflammation that occurs during OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 14, 2020 Category: Rheumatology Authors: F.J. Blanco, M. Fern ández-Moreno Tags: Editorial Source Type: research

Individuals with High Bone Mass have increased progression of radiographic and clinical features of knee osteoarthritis
High bone mass (HBM) is associated with an increased prevalence of radiographic knee OA (kOA), characterized by osteophytosis. We aimed to determine if progression of radiographic kOA, and its sub-phenotypes, is increased in HBM and whether observed changes are clinically relevant. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 14, 2020 Category: Rheumatology Authors: April Hartley, Sarah A. Hardcastle, Lavinia Paternoster, Eugene McCloskey, Kenneth ES. Poole, Muhammad K. Javaid, Mo Aye, Katie Moss, Raquel Granell, Jenny Gregory, Martin Williams, Jon H. Tobias, Celia L. Gregson Source Type: research

High Bone Density and Radiographic Osteoarthritis: Questions Answered and Unanswered
Osteoarthritis (OA) has long been known to be associated with high bone mineral density (BMD). Epidemiological studies are consistent in finding that older women and men who have higher systemic BMD (i.e. BMD measured at appendicular and axial sites distal from joints) have an increased risk for the subsequent onset, or incidence, of knee radiographic OA (ROA) [1, 2] and hip ROA [2]. A Mendelian randomization study also showed a strong association, consistent with a causal relationship between high femoral neck bone density and knee and hip OA [3]. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 14, 2020 Category: Rheumatology Authors: Michael C. Nevitt, David T. Felson Tags: Editorial Source Type: research

Comment on the TARGET trial by Bennell et  al.: was the interpretation of similar improvement based on equivalence analysis?
I read with considerable pleasure the interesting study comparing efficacy of two exercise programs (home-based non-weight bearing {NWB} quadriceps strengthening exercise and weight bearing {WB} functional exercise) in patients with medial knee osteoarthritis and co-morbid obesity1. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 13, 2020 Category: Rheumatology Authors: S. Karde ş Tags: Letter to the Editor Source Type: research

Comment on the TARGET trial by Bennell et al: Was the interpretation of similar improvement based on equivalence analysis?
I read with considerable pleasure the interesting study comparing efficacy of two exercise programs (home-based non-weight bearing {NWB} quadriceps strengthening exercise and weight bearing {WB} functional exercise) in patients with medial knee osteoarthritis and co-morbid obesity [1]. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 13, 2020 Category: Rheumatology Authors: Sinan Karde ş Tags: Letter to the Editor Source Type: research

Estimating Contextual Effect in Nonpharmacological Therapies for Pain in Knee Osteoarthritis: A Systematic Analytic Review
Conduct a systematic review and use meta-analytic techniques to estimate the proportion of total treatment effect that can be attributable to contextual effects (PCE) in adults receiving nonpharmacological, nonsurgical (NPNS) treatments for knee osteoarthritis (OA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 13, 2020 Category: Rheumatology Authors: Angela T. Chen, Swastina Shrestha, Jamie E. Collins, James K. Sullivan, Elena Losina, Jeffrey N. Katz Tags: Review Source Type: research

MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis
This study was performed to ascertain whether MFN2 was involved in the aging of chondrocytes and OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 13, 2020 Category: Rheumatology Authors: Langhai Xu, Zhipeng Wu, Yuzhe He, Zhonggai Chen, Kai Xu, Wei Yu, Weijing Fang, Chiyuan Ma, Safwat Adel Abdo Moqbel, Jisheng Ran, Yan Xiong, Lidong Wu Source Type: research

Risk Scoring for Time to End-Stage Knee Osteoarthritis: Data from the Osteoarthritis Initiative
This study constructs a risk score for patients ’ progression to end-stage knee osteoarthritis (OA) within four years. 
 (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 13, 2020 Category: Rheumatology Authors: Robin Dunn, Joel Greenhouse, David James, David Ohlssen, Peter Mesenbrink Source Type: research

Commentary on the article Risk scoring for time to end-stage knee osteoarthritis: data from the Osteoarthritis Initiative
Estimates are that 45% of adult Americans are at risk of developing knee osteoarthritis (KOA) during their lifetime1,2. A chronic disease with no cure, KOA progresses often slowly over the course of many years. Non-surgical treatment options mainly address symptoms, and slow disease progression. End-stage KOA is associated with significant functional limitations and pain, and the course of the disease varies widely across patients3 –6. Defining measurable endpoints along the course of KOA, and being able to predict its progression, are essential to advancing our understanding of KOA and therefore improving medical ca...
Source: Osteoarthritis and Cartilage - May 13, 2020 Category: Rheumatology Authors: H. Ghomrawi, J. Lee Tags: Editorial Source Type: research

Response to Letter to the Editor: “Osteoarthritis progression after exercise therapy or meniscectomy in patients with degenerative meniscal tears”
We thank Yu et al. for their interest in our recent publication entitled “Development of osteoarthritis in patients with degenerative meniscal tears treated with exercise therapy or surgery: a randomized controlled trial”1. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 13, 2020 Category: Rheumatology Authors: Bj ørnar Berg, Ewa M. Roos, Nina Jullum Kise, Lars Engebretsen, May Arna Risberg Tags: Letter to the Editor Source Type: research

Response to Letter to Editor: “Comment on the TARGET trial by Bennell et al: Was the interpretation of similar improvement based on equivalence analysis?”
We thank Dr Kardes for their comment on our randomized controlled trial comparing efficacy of non-weight bearing quadriceps exercise and weight bearing functional exercise in people with medial knee osteoarthritis and co-morbid obesity [1]. Dr Kardes highlights that we performed a superiority trial and not an equivalence trial. They correctly point out that the language we used in the conclusion of ‘similar improvement between groups’ is not aligned with our superiority trial design. Instead more appropriate wording would have been ‘although improvements were observed with both exercise programs, there wa...
Source: Osteoarthritis and Cartilage - May 12, 2020 Category: Rheumatology Authors: Kim L. Bennell, Rachel K. Nelligan, Alexander J. Kimp, Sarah Schwartz, Jessica Kasza, Tim V. Wrigley, Ben Metcalf, Paul W. Hodges, Rana S. Hinman Tags: Letter to the Editor Source Type: research

Osteoarthritis progression after exercise therapy or meniscectomy in patients with degenerative meniscal tears
We read with deep interest a recent article published in this journal by Berg et al1, who found no statistically significant differences in osteoarthritis progression after surgical and non-surgical treatment for degenerative meniscal tear. We really appreciate the work which was done by the authors. However, some worthwhile issues need to be explored. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 12, 2020 Category: Rheumatology Authors: Yang Yu, Shitao Lu, Jinpeng Sun, Jianzhong Xu Tags: Letter to the Editor Source Type: research

Neurophysiological Assessment of Joint Nociceptors in the Rat Medial Meniscus Transection Model of Post-Traumatic Osteoarthritis
Meniscal injury is a common prelude to post-traumatic osteoarthritis (PTOA). Joint nerves can become damaged in arthritic joints leading to the manifestation of neuropathic pain. Both PTOA and neuropathic pain are more common in females; however, it is unknown whether the neural processing of joint pain is sex-specific. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 12, 2020 Category: Rheumatology Authors: Melissa S. O ’Brien, Jason J. McDougall Source Type: research

Comparison of radiographic and MRI osteoarthritis definitions and their combination for prediction of tibial cartilage loss, knee symptoms and total knee replacement: a longitudinal study
To describe the value of radiographic- and MRI-defined tibiofemoral osteoarthritis (ROA and MRI-OA, respectively) and in combination for predicting tibial cartilage loss, knee pain and disability and total knee replacement (TKR) in a population-based cohort. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 12, 2020 Category: Rheumatology Authors: Guoqi Cai, Flavia Cicuttini, Dawn Aitken, Laura L. Laslett, Zhaohua Zhu, Tania Winzenberg, Graeme Jones Source Type: research