Dual roles of Misshapen/NIK-related kinase (MINK1) in osteoarthritis subtypes through the activation of TGF β signaling
To identify the role of misshapen/NIK-related kinase (MINK1) in age-related OA and injury-induced OA, and the effects of enhanced TGF β signaling in these progresses. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 21, 2019 Category: Rheumatology Authors: Dongsheng Yu, Jiajie Hu, Zixuan Sheng, Guotong Fu, Yafei Wang, Yishan Chen, Zongyou Pan, Xiaolei Zhang, Yan Wu, Heng Sun, Jun Dai, Linrong Lu, Hongwei Ouyang Source Type: research

Complement component C1q is produced by isolated articular chondrocytes
Inflammation and innate immune responses may contribute to development and progression of Osteoarthritis (OA). Chondrocytes are the sole cell type of the articular cartilage and produce extracellular-matrix molecules. How inflammatory mediators reach chondrocytes is incompletely understood. Previous studies have shown that chondrocytes express mRNA encoding complement proteins such as C1q, suggesting local protein production, which has not been demonstrated conclusively. The aim of this study is to explore C1q production at the protein level by chondrocytes. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 18, 2019 Category: Rheumatology Authors: Rosalie Lubbers, Rosanne A. van Schaarenburg, Joanneke C. Kwekkeboom, Nivine E.W. Levarht, Aleida M. Bakker, Rachid Mahdad, Silvia Monteagudo, Chahrazad Cherifi, Rik J. Lories, Ren é E.M. Toes, Andreea Ioan-Facsinay, Leendert A. Trouw Source Type: research

The Effects of TNF-alpha Inhibition on Cartilage: a Systematic Review of preclinical studies
To report the most up-to-date evidence on the effects of TNF-alpha inhibition on cartilage with a focus on its clinical relevance. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 18, 2019 Category: Rheumatology Authors: Emanuele Chisari, Khaled M. Yaghmour, Wasim S. Khan Tags: Review Source Type: research

Chondrocalcinosis is Associated with Increased Knee Joint Degeneration Over 4 Years: Data from the Osteoarthritis Initiative
To determine if presence of calcium-containing crystals (CaC) is associated with increased knee joint degeneration over four years and assess if total number of CaCs deposited is a useful measure of disease burden. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 17, 2019 Category: Rheumatology Authors: Sarah C. Foreman, Alexandra S. Gersing, Claudio E. von Schacky, Gabby B. Joseph, Jan Neumann, Nancy E. Lane, Charles E. McCulloch, Michael C. Nevitt, Thomas M. Link Source Type: research

Association of Tramadol with Risk of Myocardial Infarction Among Patients with Osteoarthritis
Tramadol has been widely used among patients with osteoarthritis (OA); however, there is paucity of information on its cardiovascular risk. We aimed to examine the association of tramadol with risk of myocardial infarction (MI) among patients with OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 16, 2019 Category: Rheumatology Authors: Jie Wei, Malissa J. Wood, Maureen Dubreuil, Gunnar Tomasson, Marc R. LaRochelle, Chao Zeng, Na Lu, Jianhao Lin, Hyon K. Choi, Guanghua Lei, Yuqing Zhang Source Type: research

Incidence rate and risk factors for radiographic hip osteoarthritis in Japanese men and women: A 10-year follow-up of the ROAD study
To investigate the incidence and progression rate of radiographic hip osteoarthritis (OA) and its risk factors in Japanese men and women using a large-scale population of a nationwide cohort study, Research on Osteoarthritis/osteoporosis Against Disability (ROAD). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 16, 2019 Category: Rheumatology Authors: Toshiko Iidaka, Shigeyuki Muraki, Hiroyuki Oka, Chiaki Horii, Hiroshi Kawaguchi, Kozo Nakamura, Toru Akune, Sakae Tanaka, Noriko Yoshimura Source Type: research

The association of plasma fatty acids with hand and knee osteoarthritis: the NEO study
To investigate the association of postprandial and fasting plasma saturated fatty acid (SFAs), monounsaturated fatty acid (MUFAs) and polyunsaturated fatty acid (PUFAs) concentrations with hand and knee osteoarthritis (OA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 16, 2019 Category: Rheumatology Authors: Marieke Loef, Andreea Ioan-Facsinay, Dennis O. Mook-Kanamori, Ko Willems van Dijk, Ren ée de Mutsert, Margreet Kloppenburg, Frits R. Rosendaal Source Type: research

Design-augmented (DA) biologics: BMP chimeras for bone and cartilage regeneration
A recent review by Deng et al1 in this journal provided an excellent overview of bone morphogenetic proteins (BMPs) and their roles in healing bone and cartilage. BMPs have been used clinically in orthopedic procedures but they are typically administered at high, supra-physiological concentrations that have been linked to undesirable local and systemic side effects. BMPs engineered to have enhanced therapeutic potency may circumvent this problem and provide the desired effects of healing bone and cartilage while minimizing the likelihood of adverse events. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 10, 2019 Category: Rheumatology Authors: Peter C. Gray, Senyon Choe Tags: Editorial Source Type: research

An automated workflow based on hip shape improves personalized risk prediction for hip osteoarthritis in the CHECK study
To design an automated workflow for hip radiographs focused on joint shape and tests its prognostic value for future hip osteoarthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 8, 2019 Category: Rheumatology Authors: Willem Paul Gielis, Harrie Weinans, Paco M.J. Welsing, Willem E. van Spil, Rintje Agricola, Timothy F. Cootes, Pim. A. de Jong, Claudia Lindner Source Type: research

Comparison of three sets of clinical classification criteria for knee osteoarthritis: A cross-sectional study of 13,459 patients treated in primary care
To determine and compare the proportion of patients treated in a primary care setting that have knee osteoarthritis (OA) according to the European League Against Rheumatism (EULAR), the American College of Rheumatology (ACR), and the National Institute for Health and Care Excellence (NICE) clinical classification criteria. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 17, 2019 Category: Rheumatology Authors: S øren T. Skou, Bart W. Koes, Dorte T. Grønne, James Young, Ewa M. Roos Tags: Brief Report Source Type: research

Cell-surface markers identify tissue resident multipotential stem/stromal cell subsets in synovial intimal and sub-intimal compartments with distinct chondrogenic properties
Synovium contains multipotent progenitor/stromal cells (MPCs) with potential to participate in cartilage repair. Understanding the identity of these MPCs will allow their therapeutic potential to be fully exploited. Hence this study aimed to identify primary synovial MPCs and characterize them in the context of cartilage regeneration. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 16, 2019 Category: Rheumatology Authors: Kavitha Sivasubramaniyan, Wendy J.L.M. Koevoet, Arnavaz A. Hakimiyan, Maria Sande, Eric Farrell, Martin J. Hoogduijn, Jan A.N. Verhaar, Susan Chubinskaya, Hans-J örg Bühring, Gerjo J.V.M. van Osch Source Type: research

Intra-articular Injection of Magnesium Chloride Attenuates Osteoarthritis Progression in Rats
To explore the effects of Mg2+ on the expression of osteoarthritic markers in human cartilage and synovium tissue explants. To investigate the therapeutic effect of intra-articular injection of Mg2+ in an established rat OA model of anterior cruciate ligament transection with partial medial meniscectomy (ACLT+PMM). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 16, 2019 Category: Rheumatology Authors: Hao Yao, Jian Kun Xu, Nian Ye Zheng, Jia Li Wang, Sze Wing Mok, Yuk Wa Lee, Liu Shi, Jin Yu Wang, Jiang Yue, Shu Hang Yung, Pei Jie Hu, Ye Chun Ruan, Yi Feng Zhang, Ki Wai Ho, Ling Qin Source Type: research

Chondrocyte viability is lost during high-rate impact loading by transfer of amplified strain, but not stress, to pericellular and cellular regions
Deleterious impact loading to cartilage initiates post-traumatic osteoarthritis (OA). While cytokine and enzyme levels regulate disease progression, specific mechanical cues that elucidate cellular OA origins merit further investigation. We defined the dominant pericellular and cellular strain/stress transfer mechanisms following bulk-tissue injury associated with cell death. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 14, 2019 Category: Rheumatology Authors: Pablo F. Argote, Jonathan T. Kaplan, Alan Poon, Xin Xu, Luyao Cai, Nancy C. Emery, David M. Pierce, Corey P. Neu Source Type: research

Lack of Evidence that Beta Blocker Use Reduces Knee Pain, Areas of Joint Pain, or Analgesic Use among Individuals with Symptomatic Knee Osteoarthritis
The objective of this study was to estimate the association between beta blocker use and knee pain, areas of joint pain, and analgesic use among participants with symptomatic knee OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 14, 2019 Category: Rheumatology Authors: Lili Zhou, C. Kent Kwoh, Di Ran, Erin L. Ashbeck, Wei-Hsuan Lo-Ciganic Source Type: research

Infrapatellar fat pad abnormalities are associated with a higher inflammatory synovial fluid cytokine profile in young adults following ACL tear
To evaluate the degree of knee fat pad abnormalities after acute anterior cruciate ligament (ACL) tear via magnetic resonance fat pad scoring and to assess cross-sectionally its association with synovial fluid biomarkers and with early cartilage damage as quantified via T1 ρ and T2 relaxation time measurements. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 14, 2019 Category: Rheumatology Authors: Ursula Heilmeier, Kenji Mamoto, Keiko Amano, Brendan Eck, Matthew Tanaka, Jennifer A. Bullen, Benedikt J. Schwaiger, Janet L. Huebner, Thomas V. Stabler, Virginia B. Kraus, C. Benjamin Ma, Thomas M. Link, Xiaojuan Li Source Type: research

Efficacy and safety of the first-in-class imidazoline-2 receptor ligand CR4056 in pain from knee osteoarthritis and disease phenotypes: a randomized, double-blind, placebo-controlled phase 2 trial
CR4056 is a selective imidazoline-2 (I2) receptor ligand with potent analgesic activity in animal pain models. This proof-of-concept study tested CR4056 efficacy and safety in patients with knee osteoarthritis (OA) and different phenotypes. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 14, 2019 Category: Rheumatology Authors: Lucio C. Rovati, Nadia Brambilla, Tomasz Blicharski, John Connell, Cristina Vitalini, Albino Bonazzi, Giampaolo Giacovelli, Federica Girolami, Massimo D ’Amato Source Type: research

Real-Time Optical Redox Imaging of Cartilage Metabolic Response to Mechanical Loading
This study aimed to assess the effects of a compressive load on cartilage using optical redox imaging. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 9, 2019 Category: Rheumatology Authors: Shannon K. Walsh, Melissa C. Skala, Corinne R. Henak Source Type: research

MRI-based screening for structural definition of eligibility in clinical DMOAD trials: Rapid OsteoArthritis MRI Eligibility Score (ROAMES)
Our aim was to introduce a simplified MRI instrument, Rapid OsteoArthritis MRI Eligibility Score (ROAMES), for defining structural eligibility of patients for inclusion in disease-modifying osteoarthritis drug trials using a tri-compartmental anatomic approach that enables stratification of knees into different structural phenotypes and includes diagnoses of exclusion. We also aimed to define overlap between phenotypes and determine reliability. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 9, 2019 Category: Rheumatology Authors: Frank W. Roemer, Jamie Collins, C. Kent Kwoh, Michael J. Hannon, Tuhina Neogi, David T. Felson, David J. Hunter, John A. Lynch, Ali Guermazi Source Type: research

Differences in the composition of hip and knee synovial fluid in osteoarthritis: a nuclear magnetic resonance (NMR) spectroscopy study of metabolic profiles
The objective was to identify differences in osteoarthritic hip and knee SF metabolites using metabolic profiling with Nuclear Magnetic Resonance (NMR) spectroscopy. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 3, 2019 Category: Rheumatology Authors: P. Akhbari, M.K.J. Jaggard, C.L. Boulange, U. Vaghela, G. Gra ça, R. Bhattacharya, J.C. Lindon, H.R.T. Williams, C.M. Gupte Source Type: research

The role of leptin and adiponectin as mediators in the relationship between adiposity and hand and knee osteoarthritis
To investigate associations of leptin and adiponectin levels with knee and hand osteoarthritis, and explore whether these mediate the association between adiposity and osteoarthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 23, 2019 Category: Rheumatology Authors: F éline P.B. Kroon, Anne I. Veenbrink, Renée de Mutsert, A. Willemien Visser, K. Willems van Dijk, Saskia le Cessie, Frits R. Rosendaal, Margreet Kloppenburg Source Type: research

Effects of treadmill running and limb immobilization on knee cartilage degeneration and locomotor joint kinematics in rats following knee meniscal transection
This study examined the effects of reduced and elevated weight bearing on post-traumatic osteoarthritis (PTOA) development, locomotor joint kinematics, and degree of voluntary activity in rats following medial meniscal transection (MMT). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 19, 2019 Category: Rheumatology Authors: Liang-Ching Tsai, Elana S. Cooper, Kevin M. Hetzendorfer, Gordon L. Warren, Young-Hui Chang, Nick J. Willett Source Type: research

Proteomic analysis of synovial fluid identifies periostin as a biomarker for anterior cruciate ligament injury
Emerging evidence suggests that injury to the anterior cruciate ligament (ACL) typically initiates biological changes that contribute to the development of osteoarthritis (OA). The molecular biomarkers or mediators of these biological events remain unknown. The goal of this exploratory study was to identify novel synovial fluid biomarkers associated with early biological changes following ACL injury distinct from findings in end-stage OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 17, 2019 Category: Rheumatology Authors: Robert H. Brophy, Lei Cai, Xin Duan, Qiang Zhang, R. Reid Townsend, Ryan Nunley, Farshid Guilak, Muhammad Farooq Rai Source Type: research

Multiscale and multimodal structure –function analysis of intervertebral disc degeneration in a rabbit model
The objective of this study was to perform a quantitative analysis of the structural and functional alterations in the intervertebral disc during in  vivo degeneration, using emerging tools that enable rigorous assessment from the microscale to the macroscale, as well as to correlate these outcomes with noninvasive, clinically relevant imaging parameters. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 13, 2019 Category: Rheumatology Authors: B.G. Ashinsky, S.E. Gullbrand, E.D. Bonnevie, S.A. Mandalapu, C. Wang, D.M. Elliott, L. Han, R.L. Mauck, H.E. Smith Source Type: research

Multiscale and Multimodal Structure-Function Analysis of Intervertebral Disc Degeneration in a Rabbit Model
The objective of this study was to perform a quantitative analysis of the structural and functional alterations in the intervertebral disc during in vivo degeneration, using emerging tools that enable rigorous assessment from the microscale to the macroscale, as well as to correlate these outcomes with noninvasive, clinically relevant imaging parameters. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 13, 2019 Category: Rheumatology Authors: Beth G. Ashinsky, Sarah E. Gullbrand, Edward D. Bonnevie, Sai A. Mandalapu, Chao Wang, Dawn M. Elliott, Lin Han, Robert L. Mauck, Harvey E. Smith Source Type: research

Metabolic syndrome and osteoarthritis pain: common molecular mechanisms and potential therapeutic implications
There is no clear evidence from epidemiological and animal studies of a direct link between metabolic syndrome (MetS) and cartilage degeneration in osteoarthritis (OA) once body mass index (BMI) has been considered. However, recent epidemiological studies indicate a significant role for MetS in predicting increased knee pain after adjustment for BMI. This implies there are mechanisms that underlie both MetS and OA pain. In addition to the common systemic inflammatory and pro-inflammatory components of the two disorders, there are other molecular mechanisms that may link MetS and OA pain. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 10, 2019 Category: Rheumatology Authors: Ana M. Valdes Tags: Editorial Source Type: research

Racial and Ethnic Disparities in Utilization of Total Knee Arthroplasty among Older Women
To evaluate racial and ethnic disparities in utilization of total knee arthroplasty (TKA) in relation to demographic, health, and socioeconomic status variables. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 9, 2019 Category: Rheumatology Authors: Alyson Cavanaugh, Mitchell J. Rauh, Caroline A. Thompson, John Alcaraz, William M. Mihalko, Chloe E. Bird, Charles B. Eaton, Milagros C. Rosal, Wenjun Li, Aladdin H. Shadyab, Todd Gilmer, Andrea Z. LaCroix Source Type: research

Identifying Key Gait Features Associated with the Radiological Grade of Knee Osteoarthritis
This study assessed key features that can be used as mechanical biomarkers for KOA severity and progression. The identified features were validated statistically and were further examined by developing a classification model based on a machine-learning algorithm. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 7, 2019 Category: Rheumatology Authors: Soon Bin Kwon, Du Hyun Ro, Min Ku Song, Hyuk-soo Han, Myung Chul Lee, Hee Chan Kim Source Type: research

Metabolic syndrome and trajectory of knee pain in older adults
To examine the association of metabolic syndrome (MetS) and its components with knee pain severity trajectories. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 5, 2019 Category: Rheumatology Authors: Feng Pan, Jing Tian, Flavia Cicuttini, Graeme Jones Source Type: research

Tropomyosin-related Kinase A (TrkA) Inhibition for the Treatment of Painful Knee Osteoarthritis: Results From a Randomized Controlled Phase 2a Trial
To investigate the TrkA inhibitor, ASP7962, for treatment of painful knee osteoarthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 26, 2019 Category: Rheumatology Authors: Fiona Watt, Mary Beth Blauwet, Allam Fakhoury, H élène Jacobs, Ronald Smulders, Nancy E. Lane Source Type: research

A Tale of Two TrkA Inhibitor Trials: Same Target, Divergent Results
Nerve growth factor (NGF), a neurotrophin involved in the development of the nervous system, plays a key role in pain by sensitizing peripheral nociceptors following tissue injury or inflammation. This peripheral sensitization by NGF is mediated through binding to the high-affinity receptor tropomyosin-related kinase (Trk)A localized to peptidergic sensory nerves.1 The NGF-TrkA complex is internalized and transported to the dorsal root ganglion, where it increases TRPV1 phosphorylation and the expression and release of neuropeptides including substance P and calcitonin gene-related peptide. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 26, 2019 Category: Rheumatology Authors: D.A. Walsh, T. Neogi Tags: Editorial Source Type: research

The Nociceptive Innervation Of The Normal And Osteoarthritic Mouse Knee
To document the nociceptive innervation of the normal and osteoarthritic murine knee. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 25, 2019 Category: Rheumatology Authors: Alia M. Obeidat, Rachel E. Miller, Richard J. Miller, Anne-Marie Malfait Source Type: research

Efficacy and safety of intra-articular injection of tropomyosin receptor kinase A inhibitor in painful knee osteoarthritis: a randomized, double-blind and placebo-controlled study
This trial evaluated the efficacy and safety of GZ389988A, a tropomyosin receptor kinase A (TrkA) inhibitor, in subjects with painful knee osteoarthritis (OA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 25, 2019 Category: Rheumatology Authors: Emmanuel Krupka, Guang-Liang Jiang, Christelle Jan Source Type: research

The importance of Getting it right the first time
Both authors wrote the first draft, and edited and approved the final submitted manuscript. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 23, 2019 Category: Rheumatology Authors: LStefan Lohmander, Teppo LN. J ärvinen Tags: Editorial Source Type: research

Exostosin-1 enhances canonical Wnt signaling activity during chondrogenic differentiation
Exostosin-1 (Ext1) encodes a glycosyltransferase required for heparan sulfate (HS) chain elongation in HS-proteoglycan biosynthesis. HS chains serve as binding partners for signaling proteins, affecting their distribution and activity. The Wnt/ β-catenin pathway emerged as critical regulator of chondrogenesis. Yet, how EXT1 and HS affect Wnt/β-catenin signaling during chondrogenesis remains unexplored. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 19, 2019 Category: Rheumatology Authors: X. Wang, F.M.F. Cornelis, R.J. Lories, S. Monteagudo Source Type: research

The different influence of high levels of physical activity on the incidence of knee OA in overweight and obese men and women-a gender specific analysis
To investigate the influence of physical activity on incidence of knee osteoarthritis (OA) in overweight and obese men and women. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 18, 2019 Category: Rheumatology Authors: Hessam Soutakbar, Sarah E Lamb, Alan J Silman Source Type: research

Raloxifene Retards Cartilage Degradation and Improves Subchondral Bone Micro-architecture in Ovariectomized Rats with Patella Baja-Induced- Patellofemoral Joint Osteoarthritis
This study was performed to evaluate the efficacy of RAL on patella baja-induced patellofemoral joint OA (PFJOA) in an ovariectomized rat model. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 18, 2019 Category: Rheumatology Authors: M.-J. Bei, F.-M. Tian, Y.-P. Xiao, X.-H. Cao, N. Liu, Z.-Y. Zheng, M.-W. Dai, W.-Y. Wang, H.-P. Song, L. Zhang Source Type: research

Disc degeneration induces a mechano-sensitization of disc afferent nerve fibers that associates with low back pain
We aimed to investigate mechano-sensitivity at the afferent nerve fibers projecting to degenerated intervertebral disc (IVD) and nociceptive behaviour in a rat model of low back pain (LBP). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 18, 2019 Category: Rheumatology Authors: Eui Ho Park, Sun Wook Moon, Hye Rim Suh, Shawn Hochman, Min-Goo Lee, Yang In Kim, Il Tae Jang, Hee Chul Han Source Type: research

Type II Collagen peptide Coll2-1 is an actor of synovitis
We evaluated the ability of Coll2-1, a type II collagen peptide, to activate pro-inflammatory pathways in synovial cells and to induce arthritis in Lewis rats. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 17, 2019 Category: Rheumatology Authors: C écile Lambert, Didier Borderie, Jean-Emile Dubuc, François Rannou, Yves Henrotin Source Type: research

Protective effects of extracorporeal shockwave on rat chondrocytes and temporomandibular joint osteoarthritis; preclinical evaluation with in vivo 99mTc-HDP SPECT and ex vivo micro-CT
Extracorporeal shockwave therapy (ESWT) has been shown to have chondroprotective effects on arthritic diseases. We investigated the effects of ESWT on temporomandibular joint osteoarthritis (TMJOA) using rat chondrocytes and TMJOA rat models. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 16, 2019 Category: Rheumatology Authors: Young-Hwa Kim, Ji-In Bang, Hye-Jin Son, Yemi Kim, JiHoi Kim, Hasuk Bae, Soo Jeong Han, Hai-Jeon Yoon, Bom Sahn Kim Source Type: research

Human Articular Cartilage Mechanosensitivity is Related to Histological Degeneration – A Functional MRI Study
To investigate changes in response to sequential pressure-controlled loading and unloading in human articular cartilage of variable histological degeneration using serial T1 ρ mapping. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 15, 2019 Category: Rheumatology Authors: Sven Nebelung, Manuel Post, Matthias Knobe, Dhaval Shah, Christoph Schleich, Lea Hitpass, Christiane Kuhl, Johannes Th üring, Daniel Truhn Source Type: research

Bone Marrow Lesions in Knee Osteoarthritis: Regional Differences in Tibial Subchondral Bone Microstructure and their Association with Cartilage Degeneration
The aim of this study was to investigate how bone microstructure within bone marrow lesions (BMLs) relates to the bone and cartilage across the whole human tibial plateau. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 12, 2019 Category: Rheumatology Authors: Dzenita Muratovic, David M. Findlay, Flavia M. Cicuttini, Anita E. Wluka, Yea Rin Lee, Suzanne Edwards, Julia S. Kuliwaba Source Type: research

Physical inactivity and knee osteoarthritis in guinea pigs
To investigate whether and how a sedentary lifestyle contributes to knee osteoarthritis (OA) incidence and severity. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 11, 2019 Category: Rheumatology Authors: I.J. Wallace, A.M. Bendele, G. Riew, E.H. Frank, H.-H. Hung, N.B. Holowka, A.S. Bolze, E.M. Venable, A. Yegian, H.L. Dingwall, R.N. Carmody, A.J. Grodzinsky, D.E. Lieberman Source Type: research

Three-Dimensional Microstructure Of Human Meniscus Posterior Horn In Health And Osteoarthritis
To develop and perform ex vivo 3D imaging of meniscus posterior horn microstructure using micro-computed tomography ( μCT), and to compare specimens from healthy references against end-stage osteoarthritis (OA) using conventional section-based histology and qualitative μCT. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 10, 2019 Category: Rheumatology Authors: Iida Kestil ä, Elin Folkesson, Mikko A. Finnilä, Aleksandra Turkiewicz, Patrik Önnerfjord, Velocity Hughes, Jon Tjörnstrand, Martin Englund, Simo Saarakkala Source Type: research

Radiographically normal knees with contralateral joint space narrowing display greater change in cartilage transverse relaxtion time than those with normal contralateral knees: a model of early oa? – Data From The Osteoarthritis Initiative
To develop a model of early osteoarthritis, by examining whether radiographically normal knees with contralateral joint space narrowing (JSN), but without contralateral trauma history, display greater longitudinal cartilage composition change (transverse relaxation time; T2) than subjects with bilaterally normal knees. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 10, 2019 Category: Rheumatology Authors: W. Wirth, S. Maschek, F.W. Roemer, L. Sharma, G.N. Duda, F. Eckstein Tags: Brief Report Source Type: research

Defective WNT Signaling May Protect From Articular Cartilage Deterioration – A Quantitative Mri Study On Subjects With A Heterozygous WNT1 Mutation
WNT signaling is of key importance in chondrogenesis and defective WNT signaling may contribute to the pathogenesis of osteoarthritis and other cartilage diseases. Biochemical composition of articular cartilage in patients with aberrant WNT signaling has not been studied. Our objective was to assess the knee articular cartilage in WNT1 mutation-positive individuals using a 3.0T MRI unit to measure cartilage thickness, relaxation times, and texture features. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 9, 2019 Category: Rheumatology Authors: Sami Lehtovirta, Riikka E. M äkitie, Victor Casula, Marianne Haapea, Jaakko Niinimäki, Tuukka Niinimäki, Arttu Peuna, Eveliina Lammentausta, Outi Mäkitie, Miika T. Nieminen Source Type: research

Clinical, humanistic, and economic burden of osteoarthritis among noninstitutionalized adults in the United States
To estimate the burden of osteoarthritis (OA) among noninstitutionalized adults ( ≥18 years of age) in the US. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 9, 2019 Category: Rheumatology Authors: Xiaohui Zhao, Drishti Shah, Kavita Gandhi, Wenhui Wei, Nilanjana Dwibedi, Lynn Webster, Usha Sambamoorthi Source Type: research

Accelerated post traumatic osteoarthritis in a dual injury murine model
Joint injury involving destabilisation of the joint and damage to the articular cartilage (e.g. sports-related injury) can result in accelerated post-traumatic osteoarthritis (PTOA). Destabilised medial meniscotibial ligament (DMM) surgery is one of the most commonly used murine models and whilst it recapitulates OA pathology, it does not necessarily result in multi-tissue injury, as occurs in PTOA. We hypothesised that simultaneous cartilage damage and joint destabilisation would accelerate the onset of OA pathology. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 5, 2019 Category: Rheumatology Authors: Kendal McCulloch, Carmen Huesa, Lynette Dunning, Gary J. Litherland, Rob J. Van ‘T Hof, John C. Lockhart, Carl S. Goodyear Source Type: research

Antimicrobial peptides derived from the cartilage.-specific C-type Lectin Domain Family 3 Member A (CLEC3A) – potential in the prevention and treatment of septic arthritis
To investigate the antimicrobial activity of peptides derived from C-type Lectin Domain Family 3 Member A (CLEC3A), shed light on the mechanism of antimicrobial activity and assess their potential application in prevention and treatment of septic arthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 4, 2019 Category: Rheumatology Authors: D. Elezagic, M. M örgelin, G. Hermes, A. Hamprecht, G. Sengle, D. Lau, S. Höllriegl, R. Wagener, M. Paulsson, T. Streichert, A.R. Klatt Source Type: research

Osteoarthritis development related to cartilage quality-the prognostic value of dGEMRIC after anterior cruciate ligament injury
Rupture of the anterior cruciate ligament (ACL) increases the risk of developing osteoarthritis (OA). Delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) investigates cartilage integrity through T1-analysis after intravenous contrast injection. A high Delayed Gadolinium enhanced MRI of cartilage (dGEMRIC) index represents good cartilage quality. The main purpose of this prospective cohort study was to investigate the prognostic value of the dGEMRIC index regarding future knee OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 4, 2019 Category: Rheumatology Authors: J. Tj örnstrand, P. Neuman, J. Svensson, B. Lundin, L.E. Dahlberg, C.J. Tiderius Source Type: research

Antimicrobial Peptides Derived from the Cartilage-specific C-type Lectin Domain Family 3 Member A (CLEC3A) – Potential in the Prevention and Treatment of Septic Arthritis
To investigate the antimicrobial activity of peptides derived from C-type Lectin Domain Family 3 Member A (CLEC3A), shed light on the mechanism of antimicrobial activity and assess their potential application in prevention and treatment of septic arthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 4, 2019 Category: Rheumatology Authors: Dzemal Elezagic, Matthias M örgelin, Gabriele Hermes, Axel Hamprecht, Gerhard Sengle, Daniela Lau, Stefan Höllriegl, Raimund Wagener, Mats Paulsson, Thomas Streichert, Andreas R. Klatt Source Type: research