DDIT3 aggravates TMJOA cartilage degradation via Nrf2/HO-1/NLRP3-mediated autophagy
DNA damage-inducible transcript 3 (DDIT3), as a downstream transcription factor of endoplasmic reticulum (ER) stress, is reported to regulate chondrogenic differentiation under physiological and pathological state. However, the specific involvement of DDIT3 in the degradation of condylar cartilage of TMJOA is unclarified. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 5, 2024 Category: Rheumatology Authors: Chang Yang, Wei Dong, Yan Wang, Xiaofei Dong, Xiaoxiao Xu, Xijie Yu, Jiawei Wang Source Type: research
Collaborative Model of Care between Orthopaedics and Allied Healthcare Professionals (CONNACT) in knee osteoarthritis: Effectiveness-implementation hybrid randomized controlled trial of a community-based, multidisciplinary, stratified intervention
To compare the clinical and cost effectiveness of the Collaborative Model of Care between Orthopaedics and Allied Healthcare Professionals (CONNACT), a community-based, stratified, multidisciplinary intervention consisting of exercise, education, psychological and nutrition delivered through a chronic care model to usual hospital care in adults with knee osteoarthritis (OA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 4, 2024 Category: Rheumatology Authors: Bryan Yijia TAN, YANG Su-Yin, Michelle Jessica Pereira, TAN Chun Yue, LIM Chien Joo, NG Julia Poh-Hwee, LEE Keng Thiam, PUA Yong Hao, Andrew M. Briggs, David J. Hunter, Soren T. Skou, Julian Thumboo, Josip Car Tags: Clinical Trial Source Type: research
Impact of Depressive Symptoms on Direct Medical Cost among Medicare Recipients with Knee Osteoarthritis
Depressive symptoms are prevalent among knee osteoarthritis (KOA) patients and may lead to additional medical costs. We compared medical costs in Medicare Current Beneficiary Survey (MCBS) respondents with KOA with and without self-reported depressive symptoms. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 3, 2024 Category: Rheumatology Authors: Heidi Y. Yang, Zoey S. Song, Jamie E. Collins, Elena Losina Source Type: research
Unraveling sex-specific risks of knee osteoarthritis before menopause: Do sex differences start early in life?
Sufficient evidence within the past two decades have shown that osteoarthritis (OA) has a sex-specific component. However, efforts to reveal the biological causes of this disparity have emerged more gradually. In this narrative review, we discuss anatomical differences within the knee, incidence of injuries in youth sports, and metabolic factors that present early in life (childhood and early adulthood) that can contribute to a higher risk of OA in females. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 1, 2024 Category: Rheumatology Authors: Paula A. Hernandez, John Churchill Bradford, Priyanka Brahmachary, Sophia Ulman, Jennifer L. Robinson, Ronald K. June, Magali Cucchiarini Tags: Review Source Type: research
The efficacy and safety of a fixed-dose combination of apocynin and paeonol, APPA, in symptomatic knee OA: A double-blind, randomized, placebo-controlled, clinical trial
This study assessed of a fixed-dose combination of APPA in people with symptomatic knee osteoarthritis (OA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 30, 2024 Category: Rheumatology Authors: Asger Reinstrup Bihlet, Inger Byrjalsen, Jeppe Ragnar Andersen, Alan Reynolds, Nicholas Larkins, Peter Alexandersen, Helene Rovsing, Robert Moots, Philip G. Conaghan Source Type: research
Hand osteoarthritis phenotypes based on a biopsychosocial approach, and their associations with cross-sectional and longitudinal pain
Hand osteoarthritis (OA) pain is characterized as heterogeneous and multifactorial. Differences in pain may be explained by underlying phenotypes, which have not been previously explored. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 30, 2024 Category: Rheumatology Authors: Elisabeth Mulrooney, Tuhina Neogi, Hanne Dagfinrud, Hilde Berner Hammer, Pernille Steen Pettersen, Tore K Kvien, Karin Magnusson, Ida K Haugen Source Type: research
Surgical restabilization reduces the progression of post-traumatic osteoarthritis initiated by ACL rupture in mice
People who sustain joint injuries such as anterior cruciate ligament (ACL) rupture often develop post-traumatic osteoarthritis (PTOA). In human patients, ACL injuries are often treated with ACL reconstruction. However, it is still unclear how effective joint restabilization is for reducing the progression of PTOA. The goal of this study was to determine how surgical restabilization of a mouse knee joint following non-invasive ACL injury affects PTOA progression. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 30, 2024 Category: Rheumatology Authors: Yu-Yang , Elias H. , Priscilla M. , Michael C. , Michael , Seif B. , Connor M. , Kristin K. , Heejung , Jill L. , Cassandra A. , Blaine A. Source Type: research
Gender differences in patterns of cartilage loss: Data from the Osteoarthritis Initiative
Understanding gender-specific differences in patterns of cartilage loss can improve our knowledge of the pathogenesis of knee osteoarthritis (KOA) development and progression and may inform clinical trials of treatments for KOA. The goal of our observational study was to examine gender differences in patterns of cartilage loss in the central weight-bearing regions of the femur. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 28, 2024 Category: Rheumatology Authors: Rebecca Amesbury, Hedieh Ragati-Haghi, Alexander Mathiessen, Todd Laffaye, Rebekkah I. Stein, Jamie E. Collins, C. Kent Kwoh, Jeffrey Duryea Source Type: research
HSP70 —A key regulator in chondrocyte homeostasis under naturally coupled hydrostatic pressure-thermal stimuli
During physical activities, chondrocytes experience coupled stimulation of hydrostatic pressure (HP) and a transient increase in temperature (T), with the latter varying within a physiological range from 32.5 °C to 38.7 °C. Previous short-term in vitro studies have demonstrated that the combined HP-T stimuli more significantly enhance chondroinduction and chondroprotection of chondrocytes than isolated applications. Interestingly, this combined benefit is associated with a corresponding increase i n HSP70 levels when HP and T are combined. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 26, 2024 Category: Rheumatology Authors: Yanheng Guo, Theofanis Stampoultzis, Peyman Karami, Naser Nasrollahzadeh, Vijay K. Rana, Dominique P. Pioletti Source Type: research
Comparative effectiveness of different placebos and comparator groups for hand osteoarthritis exploring the impact of contextual factors: A systematic review and meta-analysis of randomised trials
To examine the pain relief effects of comparators (placebos and untreated control groups) in hand osteoarthritis trials and the impact of contextual factors. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 26, 2024 Category: Rheumatology Authors: Ida Maria Balsby, Sabrina M. Nielsen, Robin Christensen, Marius Henriksen, Louise Ulff-M øller Dahl, Johannes Iuel Berg, Simon Tarp, Féline Kroon, Margreet Kloppenburg, Weiya Zhang, David J. Hunter, Henning Bliddal, Anna Døssing Source Type: research
Non-invasive electroarthrography measures cartilage in live horses and correlates to direct measurements of cartilage streaming potentials in weight bearing regions of equine metacarpophalangeal joints
To perform non-invasive Electroarthrography (EAG) on live horses and establish relationships between EAG and direct measurements of cartilage streaming potentials in weight bearing areas of the equine metacarpophalangeal joint. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 26, 2024 Category: Rheumatology Authors: Adele Changoor, Martin Garon, Eric Quenneville, Pierre Savard, Michael D. Buschmann, Mark B. Hurtig Source Type: research
HSP70 — A Key Regulator in Chondrocyte Homeostasis Under Naturally Coupled Hydrostatic Pressure-Thermal Stimuli
During physical activities, chondrocytes experience coupled stimulation of hydrostatic pressure (HP) and a transient increase in temperature (T), with the latter varying within a physiological range from 32.5 °C to 38.7 °C. Previous short-term in vitro studies have demonstrated that the combined HP-T stimuli more significantly enhance chondroinduction and chondroprotection of chondrocytes than isolated applications. Interestingly, this combined benefit is associated with a corresponding increase in HSP 70 levels when HP and T are combined. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 26, 2024 Category: Rheumatology Authors: Yanheng Guo, Theofanis Stampoultzis, Peyman Karami, Naser Nasrollahzadeh, Vijay Kumar Rana, Dominique P. Pioletti Source Type: research
Comment on: How effective are exercises delivered digitally (requiring internet), amongst patients with hip or knee osteoarthritis? A systematic review and meta-analysis
Dear Editor, (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 24, 2024 Category: Rheumatology Authors: Yingang You, Qiufang Wei, Yuepeng Teng, Miaomiao Miao Source Type: research
Corrigendum to ‘Advances in organ-on-a-chip systems for modelling joint tissue and osteoarthritic diseases’ Osteoarthritis Cartilage 30 (2022) 1050-1061
The authors have notified us that there were minor errors in Table I of the above published article which are as follows: (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 21, 2024 Category: Rheumatology Authors: L. Banh, K.K. Cheung, M.W.Y. Chan, E.W.K. Young, S. Viswanathan Tags: Corrigendum Source Type: research
Serum levels of hydroxylated metabolites of arachidonic acid cross-sectionally and longitudinally predict knee pain progression: an observational cohort study.
To examine associations between serum oxylipins, which regulate tissue repair and pain signalling, and knee pain/radiographic osteoarthritis (OA) at baseline and knee pain at 3 year follow-up. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 20, 2024 Category: Rheumatology Authors: James Turnbull, Rakesh R. Jha, Peter R.W. Gowler, Rose Ferrands-Bentley, Dong-Hyun Kim, David A. Barrett, Aliya Sarmanova, Gwen S. Fernandes, Michael Doherty, Weiya Zhang, David A. Walsh, Ana M. Valdes, Victoria Chapman Source Type: research
