Commentary on: ‘Do we understand sex-related differences governing dimorphic disease mechanisms in preclinical animal models of osteoarthritis?’ by Dvir-Ginzberg et al.
The commentary by Dvir-Ginzberg et al. challenges the field to improve rigor by evaluating OA mechanisms and therapeutic interventions in both male and female mice. The authors use the lens of senescence to evaluate how the preferential use of male mice has possibly skewed the current understanding of OA. Much like sex, age is a biological variable with a striking mismatch between clinical reality and preclinical models. There is a sharp increase in OA incidence after the age of 501, and yet most studies use joint injury in young mice to initiate consistent OA, with a defined window for intervention. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - March 27, 2024 Category: Rheumatology Authors: Dr. Brian Diekman Source Type: research
One leg testing in hip and knee osteoarthritis: A comparison with a two-leg oriented functional outcome measure and self-reported functional measures
To compare the responsiveness of two unilateral lower-limb performance-based tests, the one-leg rise test and the maximal step-up test, with the bilateral 30-second chair-stand test and the self-reported measure of physical function (HOOS/KOOS). Specific aims were to evaluate responsiveness, floor/ceiling effect and association between the instruments. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - March 26, 2024 Category: Rheumatology Authors: R. Bendrik, B. Sundstr öm, K. Bröms, M. Emtner, LV Kallings, M. Peterson Source Type: research
One leg testing in hip and knee osteoarthritis - a comparison with a two-leg oriented functional outcome measure and self-reported functional measures
To compare the responsiveness of two unilateral lower-limb performance-based tests, the one-leg rise test and the maximal step-up test, with the bilateral 30-second chair-stand test and the self-reported measure of physical function (HOOS/KOOS). Specific aims were to evaluate responsiveness, floor/ceiling effect and association between the instruments. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - March 26, 2024 Category: Rheumatology Authors: R Bendrik, B Sundstr öm, K Bröms, M Emtner, LV Kallings, M Peterson Source Type: research
Do we understand sex-related differences governing dimorphic disease mechanisms in preclinical animal models of osteoarthritis?
Research conducted using murine preclinical models of osteoarthritis (OA) over the last three decades has brought forth many exciting developments showcasing mechanisms and pathways that drive disease pathogenesis. These models have identified therapeutic targets that can be modulated via innovative biologicals and pharmaceuticals. However, many of these approaches have failed to translate to humans and reach the clinic. This commentary aims to highlight some of the key hur dles in the translation of novel findings using preclinical OA models. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - March 24, 2024 Category: Rheumatology Authors: Mona Dvir-Ginzberg, Yonathan H. Maatuf, Ali Mobasheri Source Type: research
In response to comment from E. V. Tchetina and E. A. Taskina re. ‘Association of synovial fluid and urinary C2C-HUSA levels with surgical outcomes post-total knee arthroplasty’
Dear Editor, (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - March 23, 2024 Category: Rheumatology Authors: Jason S. Rockel, Amit Sandhu, Osvaldo Espin-Garcia, A. Robin Poole, Mohit Kapoor Tags: Response to letter to the Editor Source Type: research
Response to Commentary by Dvir-Ginzberg et al.
Dvir-Ginzberg et al. highlight important limitations of the bench-to-bedside translational targeting approaches to treat OA. The lack of success in OA treatments discussed by the authors —with a focus on chondrosenescence— should be a wake-up call for improving preclinical models in OA. Nevertheless, the biology of sex differences has multiple levels of complexity including genetic contribution, epigenetic modifications, abundance of transcription factors, influence of sex hormo nes, gender, as well as environmental, cultural and behavioral cues. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - March 23, 2024 Category: Rheumatology Authors: Paula A. Hernandez Source Type: research
Sex-specific effects of injury and beta-adrenergic activation on metabolic and inflammatory mediators in a murine model of post-traumatic osteoarthritis
Metabolic processes are intricately linked to the resolution of innate inflammation and tissue repair, two critical steps for treating post-traumatic osteoarthritis (PTOA). Based on lipolytic and immunoregulatory actions of norepinephrine, we hypothesized that intra-articular β-adrenergic receptor (βAR) stimulation would suppress PTOA-associated inflammation in the infrapatellar fat pad (IFP) and synovium. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - March 23, 2024 Category: Rheumatology Authors: Ravi K. Komaravolu, Padmaja Mehta-D ’souza, Taylor Conner, Madeline Allen, Jessica Lumry, Albert Batushansky, Nathan P. Pezant, Courtney G. Montgomery, Timothy M. Griffin Source Type: research
Mechanical loading rescues mechanoresponsiveness in a human osteoarthritis explant model despite Wnt activation
This study aims to elucidate the role of Wnt signaling in the mechanoresponsiveness of healthy and osteoar thritic human cartilage. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - March 15, 2024 Category: Rheumatology Authors: R Castro-Vi ñuelas, N Viudes-Sarrión, AV Rojo-García, S Monteagudo, RJ Lories, I Jonkers Source Type: research
Exercise for knee osteoarthritis pain: association or causation?
Exercise is universally recommended as a primary strategy for the management of knee osteoarthritis (OA) pain. The recommendations are based on results from more than 100 randomized controlled trials (RCTs) that compare exercise to no-attention control groups. However, due to the inherent difficulties with adequate placebo control, participant blinding and the use of patient reported outcomes, the existing RCT evidence is imperfect. To better understand the evidence used to support a causal relationship between exercise and knee OA pain relief, we examined the existing evidence through the Bradford Hill considerations for ...
Source: Osteoarthritis and Cartilage - March 12, 2024 Category: Rheumatology Authors: Marius Henriksen, Jos Runhaar, Aleksandra Turkiewicz, Martin Englund Tags: Review Source Type: research
Appraisal of quality and analysis of the similarities and differences between osteoarthritis Clinical Practice Guideline recommendations: A systematic review
Clinical Practice Guidelines (CPGs) aim to support management of hip and knee osteoarthritis (OA), but recommendations are often conflicting and implementation is poor, contributing to evidence-to-practice gaps. This systematic review investigated the contextual and methodological factors contributing to conflicting recommendations for hip and knee OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - March 5, 2024 Category: Rheumatology Authors: Bimbi Gray, Alison Gibbs, Jocelyn L Bowden, Jillian P Eyles, Sandra Grace, Kim Bennell, Rinie Geenen, Sharon Kolasinski, Christian Barton, Philip G Conaghan, Timothy McAlindon, Olivier Bruyere, Quentin G éczy, David J Hunter Tags: Review Source Type: research
Exploratory Neutron Tomography of Articular Cartilage
To investigate the feasibility of using neutron tomography to gain new knowledge of human articular cartilage degeneration in osteoarthritis (OA). Different sample preparation techniques were evaluated to identify maximum intra-tissue contrast. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - March 4, 2024 Category: Rheumatology Authors: Edvin Tobias Bokvist Wrammerfors, Elin T örnquist, Maria Pierantoni, Amanda Sjögren, Alessandro Tengattini, Anders Kaestner, René in ’t Zandt, Martin Englund, Hanna Isaksson Tags: Clinical Trial Source Type: research
Modulation of early osteoarthritis by tibiofemoral re-alignment in sheep
To investigate whether tibiofemoral alignment influences early knee osteoarthritis (OA). We hypothesized that varus overload exacerbates early degenerative osteochondral changes, and that valgus underload diminishes early OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - March 2, 2024 Category: Rheumatology Authors: Jan Reinhard, Tam ás Oláh, Matthias W. Laschke, Lars K.H. Goebel, Gertrud Schmitt, Susanne Speicher-Mentges, Michael D. Menger, Magali Cucchiarini, Dietrich Pape, Henning Madry Source Type: research
Hip contact forces can be predicted with a neural network using only synthesised key points and electromyography in people with hip osteoarthritis.
To develop and validate a neural network to estimate hip contact forces (HCF), and lower body kinematics and kinetics during walking in individuals with hip osteoarthritis (OA) using synthesised anatomical key points and electromyography. To assess the capability of the neural network to detect directional changes in HCF resulting from prescribed gait modifications. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - March 2, 2024 Category: Rheumatology Authors: Bradley M. Cornish, Claudio Pizzolato, David J. Saxby, Zhengliang Xia, Daniel Devaprakash, Laura E. Diamond Source Type: research
Timing is everything: towards classification criteria for early-stage symptomatic knee osteoarthritis
More than three decades ago, the American College of Rheumatology introduced the first widely accepted classification criteria for knee osteoarthritis (OA). These criteria provided a standardized framework for identifying OA in research settings1. Since then, OA clinical trials have recruited participants based on these criteria, but have failed to identify disease-modifying interventions, raising the possibility that the ACR criteria do not capture patients early enough for interventions to restore joint homeostasis and slow or arrest the OA disease process2,3. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - March 2, 2024 Category: Rheumatology Authors: Armaghan Mahmoudian, Lauren K King, Jean W Liew, Qiuke Wang, C Thomas Appleton, Martin Englund, Ida K Haugen, L Stefan Lohmander, Jos Runhaar, Aleksandra Turkiewicz, Tuhina Neogi, Gillian A Hawker, on behalf of the OARSI Early-stage Symptomatic Knee Osteo Tags: Commentary Source Type: research
Inhibition of Phlpp1 preserves the mechanical integrity of articular cartilage in a murine model of post-traumatic osteoarthritis
Phlpp1 inhibition is a potential therapeutic strategy for cartilage regeneration and prevention of post-traumatic osteoarthritis (PTOA). To understand how Phlpp1 loss affects cartilage structure, cartilage elastic modulus was measured with atomic force microscopy (AFM) in male and female mice after injury. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - March 1, 2024 Category: Rheumatology Authors: Katherine M. Arnold, Samantha R. Weaver, Elizabeth L. Zars, Daniel J. Tschumperlin, Jennifer J. Westendorf Source Type: research
