Osteoarthritis Year in Review 2023: Epidemiology & therapy
To highlight some important findings from osteoarthritis (OA) epidemiology and therapy research undertaken over the past year. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - November 28, 2023 Category: Rheumatology Authors: Anthony V Perruccio, James J Young, Jessica M Wilfong, J Denise Power, M Canizares, Elizabeth M Badley Source Type: research
Re-imagining rehabilitation after TKA: towards the provision of fit-for-purpose sustainable models of care and a redefinition of scope
Over the past 15 years we have witnessed a seismic shift in the delivery options for physiotherapy-based (predominantly exercise-based) rehabilitation programs after total knee arthroplasty (TKA). Here ‘delivery options’ are tantamount to ‘modes’ of delivery. ‘Mode’, as opposed to ‘type’, is key because it is the mode of delivery and not the type of exercise that carries the greatest resource (and thus sustainability) ramifications. This seismic shift in delivery options is arguabl y overdue. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - November 28, 2023 Category: Rheumatology Authors: JM Naylor, B Brady Tags: Editorial Source Type: research
Fatty acid binding protein 5 inhibition attenuates pronociceptive cytokine/chemokine expression and suppresses osteoarthritis pain: A comparative human and rat study
Osteoarthritis (OA) is often accompanied by debilitating pain that is refractory to available analgesics due in part to the complexity of signaling molecules that drive OA pain and our inability to target these in parallel. Fatty acid binding protein 5 (FABP5) is a lipid chaperone that regulates inflammatory pain; however, its contribution to OA pain has not been characterized. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - November 27, 2023 Category: Rheumatology Authors: Chris Gordon, James Trainor, Rohan J. Shah, Keith Studholme, Alex Gelman, Faniya Doswell, Faisal Sadar, Allessio Giovannetti, Josh Gershenson, Ayesha Khan, James Nicholson, ZeYu Huang, Michael Spurgat, Shao-Jun Tang, Hehe Wang, Iwao Ojima, David Carlson, Source Type: research
How effective are exercises delivered digitally (requiring internet), amongst patients with hip or knee osteoarthritis? A systematic review and meta-analysis
The aim of this systematic review and meta-analysis is to describe the effect of digitally delivered exercise on pain, physical function and quality of life for people with knee or hip osteoarthritis (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - November 27, 2023 Category: Rheumatology Authors: Iryoung Fan, Dhruv Govil, Matthew G King, Mark J Scholes, Adam I Semciw Source Type: research
AI in osteoarthritis: illuminating the meandering path forward
In the recent past, artificial intelligence (AI) techniques have been used extensively to analyze data across domains of language, vision, time-varying signals, and tabular datasets, as well as their multimodal interactions. In the latest issue of Osteoarthritis and Cartilage, Salehi et al. present an exhaustive systematic review and meta-analysis of how AI techniques have been utilized to improve diagnostics of osteoarthritis (OA), which promises to improve our understanding of the pathophysiology and management of OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - November 25, 2023 Category: Rheumatology Authors: Akshay S. Chaudhari Source Type: research
Osteoarthritis pain phenotypes: how best to cut the cake?
Heterogeneity within clinical populations raises challenges and opportunities for improving treatment. Osteoarthritis (OA) treatments often adhere to the ‘one size fits all’ utilitarian approach, suggesting that everyone will gain the greatest benefit from the same treatment. However, OA is a heterogeneous condition, with multiple pathologies driving different outcomes. No single outcome is necessarily equally important for all people. Increasing ly recognized as a disease of the whole joint, OA affects articular cartilage, subchondral bone, and synovium, resulting in a clinical syndrome in which pain is predominant. (...
Source: Osteoarthritis and Cartilage - November 23, 2023 Category: Rheumatology Authors: Stephanie L Smith, David A Walsh Tags: Editorial Source Type: research
Immobilization by 21 days of bed rest results in type II collagen degradation in healthy individuals
To investigate the effects of 21 days of bed rest immobilization (with and without exercise and nutrition interventions) on type II collagen biomarker concentrations in healthy individuals. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - November 18, 2023 Category: Rheumatology Authors: Anna-Maria Liphardt, Elie-Tino Godonou, Maren Dreiner, Annegret M ündermann, Koray Tascilar, Nadja Djalal, Martina Heer, Georg Schett, Frank Zaucke, Anja Niehoff Source Type: research
Immobilization by 21 days of bed rest results in type II collagen degradation in healthy individuals
To investigate the effects of 21 days of bed rest immobilization (with and without exercise and nutrition interventions) on type II collagen biomarker concentrations in healthy individuals. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - November 18, 2023 Category: Rheumatology Authors: Liphardt Anna-Maria, Godonou Elie-Tino, Dreiner Maren, M ündermann Annegret, Tascilar Koray, Djalal Nadja, Heer Martina, Schett Georg, Zaucke Frank, Niehoff Anja Source Type: research
Comparative analysis of late-stage rheumatoid arthritis and osteoarthritis reveals shared histopathological features
Osteoarthritis (OA) is a debilitating and heterogeneous condition, characterized by various levels of articular cartilage degradation, osteophytes formation, and synovial inflammation. Multiple evidences suggest that synovitis may appear early in the disease development and correlates with disease severity and pain, therefore representing a relevant therapeutic target. In a typical synovitis-driven joint disease, namely rheumatoid arthritis (RA), several pathotypes have been described by our group and associated with clinical phenotypes, disease progression, and response to therapy. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - November 18, 2023 Category: Rheumatology Authors: Marie-Astrid Boutet, Alessandra Nerviani, Liliane Fossati-Jimack, Rebecca Hands-Greenwood, Ahmed Manzoor, Felice Rivellese, Costantino Pitzalis Tags: Clinical Trial Source Type: research
Immobilization by 21-days of bed rest results in type II collagen degradation in healthy individuals
To investigate the effects of 21 days of bed rest immobilization (with and without exercise and nutrition interventions) on type II collagen biomarker concentrations in healthy individuals. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - November 18, 2023 Category: Rheumatology Authors: Liphardt Anna-Maria, Godonou Elie-Tino, Dreiner Maren, M ündermann Annegret, Tascilar Koray, Djalal Nadja, Heer Martina, Schett Georg, Zaucke Frank, Niehoff Anja Source Type: research
A comparative analysis of late-stage rheumatoid arthritis and osteoarthritis reveals shared histopathological features
Osteoarthritis (OA) is a debilitating and heterogeneous condition, characterized by various levels of articular cartilage degradation, osteophytes formation and synovial inflammation. Multiple evidence suggest that synovitis may appear early in the disease development and correlates with disease severity and pain, therefore representing a relevant therapeutic target. In a typical synovitis-driven joint disease, namely rheumatoid arthritis (RA), several pathotypes have been described by our group and associated with clinical phenotypes, disease progression and response to therapy. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - November 18, 2023 Category: Rheumatology Authors: Marie-Astrid Boutet, Alessandra Nerviani, Liliane Fossati-Jimack, Rebecca Hands-Greenwood, Ahmed Manzoor, Felice Rivellese, Costantino Pitzalis Tags: Clinical Trial Source Type: research
Multiple Joint Osteoarthritis (MJOA): what ’s in a name?
To summarize the current state of the literature regarding multi-joint osteoarthritis (MJOA) and discuss important future directions. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - November 18, 2023 Category: Rheumatology Authors: Amanda E. Nelson Source Type: research
Osteoarthriris year in review 2023: genetics, genomics, and epigenetics
To elucidate the scientific advances made in the last 12 months within the realm of osteoarthritis genetics, genomics, and epigenetics. This review paper highlights major research publications that enhance our current understanding of the role of genetics, genomics, and epigenetics in osteoarthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - November 16, 2023 Category: Rheumatology Authors: Amina Waheed, Muhammad Farooq Rai Tags: Review Source Type: research
Year in review 2023: genetics, genomics, and epigenetics
To elucidate the scientific advances made in the last 12 months within the realm of osteoarthritis genetics, genomics, and epigenetics. This review paper highlights major research publications that enhance our current understanding of the role of genetics, genomics, and epigenetics in osteoarthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - November 16, 2023 Category: Rheumatology Authors: Amina Waheed, Muhammad Farooq Rai Tags: Review Source Type: research
Three decades of osteoarthritis molecular genetics research: from early discussions to impressive breakthroughs
By the time Osteoarthritis and Cartilage was launched in 1993, geneticists had developed the statistical knowhow and molecular tools to map, clone and characterise genes harbouring DNA mutations that cause Mendelian diseases. This included skeletal diseases, such as chondrodysplasias, that have early-onset osteoarthritis (OA) phenotypes1,2. The focus in the gene mapping community was starting to shift to more common diseases, such as diabetes, that were predicted to arise due to the inheritance of individually low impact and common DNA polymorphisms rather than the large impact and rare mutations responsible for Mendelian ...
Source: Osteoarthritis and Cartilage - November 14, 2023 Category: Rheumatology Authors: J. Loughlin Tags: Commentary Source Type: research
