Separating friend from foe: Inhibition of TGF- β-induced detrimental SMAD1/5/9 phosphorylation while maintaining protective SMAD2/3 signaling in OA chondrocytes
In this study, we aimed to block TGF-β-induced SMAD1/5/9 signaling in primary huma n OA chondrocytes, while maintaining functional SMAD2/3 signaling. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 29, 2023 Category: Rheumatology Authors: Nathalie G.M. Thielen, Arjan P.M. van Caam, Henk M. v. Beuningen, Elly L. Vitters, Martijn H.J. van den Bosch, Marije I. Koenders, Fons A.J. van de Loo, Esmeralda N. Blaney Davidson, Peter M. van der Kraan Source Type: research
Separating friend from foe; inhibition of TGF- β-induced detrimental SMAD1/5/9 phosphorylation while maintaining protective SMAD2/3 signaling in OA chondrocytes
In this study we aimed to block TGF-β-induced SMAD1/5/9 signaling in primary human OA chondrocytes, while maintaining functional SMAD2/3 signaling. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 29, 2023 Category: Rheumatology Authors: Nathalie G.M. Thielen, Arjan P.M. van Caam, Henk M. v. Beuningen, Elly L. Vitters, Martijn H.J. van den Bosch, Marije I. Koenders, Fons A.J. van de Loo, Esmeralda N. Blaney Davidson, Peter M. van der Kraan Source Type: research
Characterization of adverse joint outcomes in patients with osteoarthritis treated with subcutaneous tanezumab
Due to the risk of rapidly progressive osteoarthritis (RPOA), the phase III studies of subcutaneous (SC) tanezumab in patients with moderate to severe hip or knee osteoarthritis (OA) included comprehensive joint safety surveillance. This pooled analysis summarizes these findings. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 29, 2023 Category: Rheumatology Authors: John A. Carrino, Timothy E McAlindon, Tom J. Schnitzer, Ali Guermazi, Marc C. Hochberg, Philip G. Conaghan, Mark T. Brown, Aimee Burr, Robert J. Fountaine, Glenn C. Pixton, Lars Viktrup, Kenneth M. Verburg, Christine West Source Type: research
Kr üppel-like factor 15 deficiency exacerbates osteoarthritis through reduced expression of peroxisome proliferator-activated receptor gamma signaling in mice
In this study, we investigated the function of KLF15 in the progression of osteoarthritis (OA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 27, 2023 Category: Rheumatology Authors: Kemmei Ikuta, Shinya Hayashi, Kenichi Kikuchi, Masahiro Fujita, Kensuke Anjiki, Yuma Onoi, Shotaro Tachibana, Yoshihito Suda, Kensuke Wada, Yuichi Kuroda, Naoki Nakano, Toshihisa Maeda, Tomoyuki Matsumoto, Tetsuya Hosooka, Wataru Ogawa, Ryosuke Kuroda Source Type: research
Immature bovine cartilage wear is due to fatigue failure from repetitive compressive forces and not reciprocating frictional forces
Wear of articular cartilage is not well understood. We hypothesize that cartilage wears due to fatigue failure in repetitive compression instead of reciprocating friction. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 23, 2023 Category: Rheumatology Authors: C.A. Petersen, C.V. Sise, J.X. Dewing, J. Yun, B.K. Zimmerman, X.E. Guo, C.T. Hung, G.A. Ateshian Source Type: research
Strengthening the case for BMP inhibition as a point of intervention for osteoarthritis
Although numerous osteoarthritis (OA) risk factors have been characterized, and structural changes in joint tissues during OA are well documented, the complex pathological mechanisms regulating the onset and development of OA remain elusive. This conundrum is well exemplified by existing literature on the role of BMP pathways as both drivers of, and protectors against, OA pathology. Results detailed by Jaswal et al. in the current issue of Osteoarthritis and Cartilage add an important new chapter to this dialog. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 23, 2023 Category: Rheumatology Authors: Karen M. Lyons, Vicki Rosen Tags: Editorial Source Type: research
Osteoarthritis year in review 2023: metabolite and protein biomarkers
To highlight the advances over the past year in metabolite/protein biomarkers for osteoarthritis (OA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 21, 2023 Category: Rheumatology Authors: Ming Liu, Nafiza Haque, Jingyi Huang, Guangju Zhai Source Type: research
Factors associated with meniscus volume in knees free of degenerative features
To explore factors that were associated with meniscus volume in knees free of radiographic OA features and symptoms of OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 18, 2023 Category: Rheumatology Authors: Dawei Xu, Dieuwke Schiphof, Jukka Hirvasniemi, Stefan Klein, Edwin H.G. Oei, Sebastia Bierma-Zeinstra, Jos Runhaar Source Type: research
Cam morphology is strongly and consistently associated with development of radiographic hip osteoarthritis throughout 4 follow-up visits within 10 years
To determine the association between cam morphology and the development of radiographic hip osteoarthritis (RHOA) at four time points within 10-year follow-up. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 18, 2023 Category: Rheumatology Authors: Jinchi Tang, Michiel M.A. van Buuren, Noortje S. Riedstra, Fleur Boel, Jos. Runhaar, Sita. Bierma-Zeinstra, Rintje Agricola Source Type: research
Joint-adjacent subcutaneous adipose tissue – An obesity-related imaging biomarker associated with structural osteoarthritis progression?
Weight loss interventions, such as the combination of diet and exercise, have been shown to have beneficial effects on pain and function in osteoarthritis (OA) patients,1 with most guidelines for the non-pharmacological treatment of OA, therefore, recommending weight loss for overweight or obese patients with knee OA.2 Numerous studies have also investigated the impact of a change in body weight on structural outcome measures, with a recent systematic review reporting weight gain to be associated not only with clinical outcomes, such as pain and susceptibility to total knee replacement but also with structural outcomes, su...
Source: Osteoarthritis and Cartilage - August 17, 2023 Category: Rheumatology Authors: Wolfgang Wirth Tags: Editorial Source Type: research
Joint-adjacent subcutaneous adipose tissue — an obesity-related imaging biomarker associated with structural osteoarthritis progression?
Weight loss interventions, such as the combination of diet and exercise, have been shown to have beneficial effects on pain and function in OA patients,1 with most guidelines for the non-pharmacological treatment of osteoarthritis therefore recommending weight loss for overweight or obese patients with knee OA.2 Numerous studies have also investigated the impact of a change in body weight on structural outcome measures, with a recent systematic review reporting weight gain to be associated not only with clinical outcomes, such as pain and susceptibility to total knee replacement, but also with structural outcomes, such as ...
Source: Osteoarthritis and Cartilage - August 17, 2023 Category: Rheumatology Authors: Wolfgang Wirth Tags: Editorial Source Type: research
Is synovitis inevitable after ACL injury?
Synovitis is now well recognized as being a part of the pathophysiology of posttraumatic osteoarthritis (PTOA). Chronic synovial inflammation that does not resolve is not only well-documented in clinical imaging and histopathological studies of OA and PTOA, but is now also associated with driving joint pain and the multifaceted disease processes in the joint. In the setting of anterior cruciate ligament (ACL) rupture, a major risk factor for PTOA development, surgical reconstruction of the ACL results in long-term restoration of joint stability with overwhelmingly positive patient-reported outcomes and a high degree of pat...
Source: Osteoarthritis and Cartilage - August 16, 2023 Category: Rheumatology Authors: Tristan Maerz Tags: Editorial Source Type: research
Microstructural analysis on the innervation of the anterior, medial, and lateral human hip capsule: Preliminary evidence on its neuromechanical contribution
Capsular repair aims to minimize damage to the hip joint capsular complex (HJCC) and subsequent dislocation risk following total hip arthroplasty (THA). Numerous explanations for its success have been advocated, including neuromuscular feedback loops originating from within the intact HJCC. This research investigates the hypothesis that the HJCC contributes to hip joint stability by analyzing HJCC innervation. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 11, 2023 Category: Rheumatology Authors: Joanna C.L. Tomlinsona, Johann Zwirner, Dorothy E. Oorschot, Markus Morawski, Benjamin Ondruschka, Ming Zhang, Niels Hammer Source Type: research
Associations between Weight Change, Knee Subcutaneous Fat and Cartilage Thickness in Overweight and Obese Individuals: 4-Year Data from the Osteoarthritis Initiative
To assess (i) the impact of changes in body weight on changes in joint-adjacent subcutaneous fat (SCF) and cartilage thickness over 4-years and (ii) the relation between changes in joint-adjacent SCF and knee cartilage thickness. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 11, 2023 Category: Rheumatology Authors: Gabby B. Joseph, Melia Takakusagi, Gino Arcilla, John A. Lynch, Valentina Pedoia, Sharmila Majumdar, Nancy E. Lane, Michael C. Nevitt, Charles E. McCulloch, Thomas M. Link Source Type: research
Basic fibroblast growth factor promotes meniscus regeneration through the cultivation of synovial mesenchymal stem cells via the CXCL6 –CXCR2 pathway
To investigate the efficacy of basic fibroblast growth factor (bFGF) in promoting meniscus regeneration by cultivating synovial mesenchymal stem cells (SMSCs) and to validate the underlying mechanisms. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - August 8, 2023 Category: Rheumatology Authors: Atsushi Goshima, Yuki Etani, Makoto Hirao, Satoshi Yamakawa, Gensuke Okamura, Akira Miyama, Kenji Takami, Taihei Miura, Yuji Fukuda, Takuya Kurihara, Nagahiro Ochiai, Shohei Oyama, Shunya Otani, Masashi Tamaki, Teruya Ishibashi, Tetsuya Tomita, Takashi Ka Source Type: research
