Substantial side-to-side differences in knee cartilage contact area exist in healthy knees — should we reconsider comparing to the contralateral side after ligament reconstruction?
Anterior cruciate ligament (ACL) rupture and subsequent surgical reconstruction (ACLR) result in altered knee kinematics, generalized knee loads, and cartilage contact patterns1. These biomechanical alterations can cause aberrant loading to both the reconstructed graft and knee cartilages, which may predispose individuals with ACLR knees to early-onset osteoarthritis2. It has been widely reported that native knee kinematics are not restored by ACLR and meniscal repair3. These studies, and in fact most studies in the ACL literature, use the intact contralateral knee for comparison4. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 16, 2023 Category: Rheumatology Authors: Laura E Diamond, David J Saxby Source Type: research
A new art to treating osteoarthritis pain?
Osteoarthritis (OA) pain involves peripheral and central neural pathways, as well as interactions between multiple cell types and soluble mediators.1 Although therapeutic targeting of peripheral OA pain pathways might prove simpler and be associated with fewer side effects, the complexity of OA pain means that it will likely be the case that what works for one patient will be inefficacious for another. Consequently, it is important to further our understanding of OA pain mechanisms to develop new treatments and thus expand the clinician ’s therapeutic arsenal. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 15, 2023 Category: Rheumatology Authors: Ewan St J Smith Tags: Editorial Source Type: research
Fundamentals of Osteoarthritis. Rehabilitation: exercise, diet, biomechanics, and physical therapist-delivered interventions
Insights related to the pathogenesis of osteoarthritis (OA) have informed rehabilitative treatments that aim to mitigate the influence of several known impairments and risk factors for OA, with the goal to improve pain, function, and quality of life. The purpose of this invited narrative review is to provide fundamental knowledge to non-specialists about exercise and education, diet, biomechanical interventions, and other physical therapist-delivered treatments. In addition to summarizing the rationale for common rehabilitative therapies, we provide a synthesis of current core recommendations. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 7, 2023 Category: Rheumatology Authors: Kendal A. Marriott, Trevor B. Birmingham Tags: Review Source Type: research
‘Just do it’ still applies when it comes to exercise, diet, and education for osteoarthritis
In this issue of Osteoarthritis and Cartilage, Gibbs et al.1 set out to move the needle for clinical care by identifying common themes for treatment recommendations for osteoarthritis (OA). This was previously done almost a decade ago by Nelson et al.2, and the purpose of the current study was to update readers with the latest literature. Added to this installment was a rating of the quality of treatment guidelines, with a focus on those that were of higher quality. Importantly, the authors sought to find consistency among those recommendations that were of higher quality. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 3, 2023 Category: Rheumatology Authors: Daniel K White, Louise M Thoma Source Type: research
Recommendations for the management of hip and knee osteoarthritis: a systematic review of clinical practice guidelines
Guideline adherence for hip and knee osteoarthritis management is often poor, possibly related to the quality and/or inconsistent recommendations. This systematic review of hip and knee osteoarthritis guidelines aimed to appraise the quality and consistency in recommendations across higher-quality guidelines. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 30, 2023 Category: Rheumatology Authors: Alison J Gibbs, Bimbi Gray, Jason A Wallis, Nicholas F Taylor, Joanne L Kemp, David J Hunter, Christian J Barton Tags: Review Source Type: research
Symmetry in Knee Arthrokinematics in Healthy Collegiate Athletes During Fast Running and Drop Jump Revealed through Dynamic Biplane Radiography
Changes in cartilage contact area and/or contact location after knee injury can initiate and exacerbate cartilage degeneration. Typically, the contralateral knee is used as a surrogate for native cartilage contact patterns on the injured knee. However, symmetry in cartilage contact patterns between healthy knees during high-impact activities are unknown. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 30, 2023 Category: Rheumatology Authors: Caiqi Xu, Nicholas Aloi, Tom Gale, Kyohei Nishida, Freddie Fu, William Anderst Source Type: research
BMP signaling: A significant player and therapeutic target for osteoarthritis
To explore the significance of BMP signaling in osteoarthritis (OA) etiology, and thereafter propose a disease-modifying therapy for OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 29, 2023 Category: Rheumatology Authors: Akrit Pran Jaswal, Bhupendra Kumar, Anke J. Roelofs, Sayeda Fauzia Iqbal, Amaresh Kumar Singh, Anna H.K. Riemen, Hui Wang, Sadaf Ashraf, Sanap Vaibhav Nanasaheb, Nitin Agnihotri, Cosimo De Bari, Amitabha Bandyopadhyay Source Type: research
BMP signalling: A significant player and therapeutic target for osteoarthritis
To explore the significance of BMP signaling in osteoarthritis (OA) etiology, and thereafter propose a disease-modifying therapy for OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 29, 2023 Category: Rheumatology Authors: Akrit Pran Jaswal, Bhupendra Kumar, Anke J. Roelofs, Sayeda Fauzia Iqbal, Amaresh Kumar Singh, Anna H.K. Riemen, Hui Wang, Sadaf Ashraf, Sanap Vaibhav Nanasaheb, Nitin Agnihotri, Cosimo De Bari, Amitabha Bandyopadhyay Source Type: research
T1Gd is reduced in bone marrow lesions overlying cartilage in the hip
Bone Marrow Lesions (BMLs) are areas in bone with high fluid signal on MRI associated with painful and progressive OA. While cartilage near BMLs in the knee has been shown to be degenerated, this relationship has not been investigated in the hip. Research question: is T1Gd lower in areas of cartilage overlying BMLs in the hip? (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 27, 2023 Category: Rheumatology Authors: Carly E. Jones, Jolanda Cibere, Hong Qian, Honglin Zhang, Yimeng Guo, David Russell, Bruce B. Forster, Hubert Wong, John M. Esdaile, David R. Wilson, the IMPAKT-HiP study team Tags: Clinical Trial Source Type: research
T1Gd is Reduced in Bone Marrow Lesion Overlying Cartilage in the Hip
Bone Marrow Lesions (BMLs) are areas in bone with high fluid signal on MRI associated with painful and progressive OA. While cartilage near BMLs in the knee has been shown to be degenerated, this relationship has not been investigated in the hip. Research question: is T1Gd lower in areas of cartilage overlying BMLs in the hip? (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 27, 2023 Category: Rheumatology Authors: Carly E. Jones, Jolanda Cibere, Hong Qian, Honglin Zhang, Yimeng Guo, David Russell, Bruce B. Forster, Hubert Wong, John M. Esdaile, David R. Wilson, the IMPAKT-HiP study team Tags: Clinical Trial Source Type: research
Reflections from the OARSI 2022 clinical trials symposium: The pain of OA —Deconstruction of pain and patient-reported outcome measures for the benefit of patients and clinical trial design
Osteoarthritis (OA) drug development is hampered by a number of challenges. One of the main challenges is the apparent discordance between pain and structure, which has had a significant impact on drug development programs and has led to hesitance among stakeholders. Since 2017, the Clinical Trials Symposium (CTS) has been hosted under the Osteoarthritis Research Society International (OARSI) leadership. OARSI and the CTS steering committee yearly invite and encourage discussions on selected special subject matter between regulators, drug developers, clinicians, clinical researchers, biomarker specialists, and basic scient...
Source: Osteoarthritis and Cartilage - June 26, 2023 Category: Rheumatology Authors: MA Karsdal, J Tambiah, D Felson, C Ladel, NP Nikolov, D Hodgins, AR Bihlet, T Neogi, C. Baatenburg de Jong, AC Bay-Jensen, R Baron, A Laslop, A Mobasheri, VB Kraus Tags: Review Source Type: research
Red Blood Cell Exposure Increases Chondrocyte Susceptibility to Oxidative Stress Following Hemarthrosis
The detrimental effects of blood exposure on articular tissues are well characterized, but the individual contributions of specific whole blood components are yet to be fully elucidated. Better understanding of mechanisms that drive cell and tissue damage in hemophilic arthropathy will inform novel therapeutic strategies. The studies here aimed to identify the specific contributions of intact and lysed red blood cells (RBCs) on cartilage and the therapeutic potential of Ferrostatin-1 in the context of lipid changes, oxidative stress, and ferroptosis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 24, 2023 Category: Rheumatology Authors: Andy J. Lee, Lianna R. Gangi, Fereshteh Zandkarimi, Brent R. Stockwell, Clark T. Hung Source Type: research
Artemin sensitizes nociceptors that innervate the osteoarthritic joint to produce pain
There have been significant developments in understanding artemin/GFR α3 signaling in recent years, and there is now accumulating evidence that artemin has important roles to play in pain signaling, including that derived from joint and bone, and that associated with OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 21, 2023 Category: Rheumatology Authors: Michael Morgan, Vida Nazemian, Li Sha Ooi, Sarah Burger, Jenny Thai, Jason Ivanusic Source Type: research
Fundamentals of Osteoarthritis: Inflammatory mediators in Osteoarthritis
As more has become known of the pathophysiology of osteoarthritis (OA), evidence that inflammation plays a critical role in its development and progression has accumulated. Here, we aim to review current knowledge of the complex inflammatory network in the OA joint. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 21, 2023 Category: Rheumatology Authors: Astrid De Roover, Ana Escribano-N úñez, Silvia Monteagudo, Rik Lories Source Type: research
Metabolic syndrome and osteoarthritis: implications for the management of an increasingly common phenotype
Metabolic syndrome is an accumulation of three or more seemingly benign and relatively common conditions (central obesity, hypertension, raised triglycerides, low HDL-cholesterol, glucose intolerance) that, together, increase the risk of developing serious chronic disease.1 It is estimated that one-quarter of adults worldwide have metabolic syndrome2 — a concerning statistic considering that this population is five times more likely to develop diabetes, and two-to-three times more likely to develop heart disease, stroke, and certain cancers. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 20, 2023 Category: Rheumatology Authors: Casey L Peiris, Adam G Culvenor Tags: Editorial Source Type: research
