Presence of early radiographic features of osteoarthritis differs between subgroups 5 years after anterior cruciate ligament injury
Purpose: Outcomes after anterior cruciate ligament (ACL) rupture vary highly across individuals. Data suggests up to 35% of patients do not return to pre-injury sport, anywhere from 12-27% of patients sustain a second injury, and over 50% develop posttraumatic osteoarthritis (OA). These data suggest there may be subgroups that exist among those who have ruptured their ACL. Posttraumatic osteoarthritis (PTOA) in the knee joint is one of many concerning long-term outcomes facing individuals who have torn their ACL. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: E.K. Arhos, R.T. Pohlig, S. Di Stasi, M. Risberg, L. Snyder-Mackler, K.G. Silbernagel Source Type: research
Ultrasound measurement of decreased vastus medialis quality as a marker for increased structural abnormalities in early knee osteoarthritis: a case-control study
Purpose: The proper management for KOA prior to the occurrence of major structural damage may allow restoration of joint homeostasis. Identification of sensitive markers of the earlier stage would expand opportunities for effective disease managements. As muscle quality is associated with muscle strength, fatty infiltration (i.e., poor quality) in quadriceps lead to initiation of KOA via loss of shock absorption and loading distribution. While fatty infiltration of the quadriceps muscles is seen in patients with KOA, it is unclear if the degree of infiltration is associated with a decline in structural integrity of the kne...
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: A. Hoki, E. D'Amico, F. Ambrosio, T. Iwasaki, Y. Matsuda, H. Iijima Source Type: research
Knee arthroscopic surgery in middle-aged patients with meniscal symptoms. a 10-year follow-up of a prospective, randomized study
Purpose: To evaluate the long-term results of knee arthroscopy combined with an exercise program compared to an exercise program alone, in middle-aged patients with meniscal symptoms. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: J. Kvist, S. Sonesson, H. Gauffin Source Type: research
Surgeries within two years after acute anterior cruciate ligament injury. results from the nacox-study
Purpose: To describe the number of knee surgeries within two years after an anterior cruciate ligament (ACL) injury in patients treated with or without ACL-reconstruction (ACLR). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: J. Kvist, A. Samuelsson Selin, A. F ältström, H. Gauffin Source Type: research
Automated quantitative methods facilitating clinical manufacturing of engineered osteochondral tissues in compliance with current good manufacturing practice
Purpose: We have developed a mesenchymal stem cell (MSC)-based tissue engineered osteochondral tissue (eOCT), which is being translated from bench to bedside with the aim to benefit patients directly. Before conducting the first-in-human clinical trial on the safety profile of eOCT, cGMP manufacturing, which emphasizes on consistency and reproductivity, is mandatory. Consistent manufacture of reproducible products is a critical component of cGMP compliance. To achieve this, every step in the manufacture process must be well controlled so that the final product can meet its quality standards. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: H. CHENG, B. CHAN Source Type: research
Inhibition of a signaling modality within gp130 receptor enhances tissue regeneration and mitigates osteoarthritis
Purpose: Adult mammals are incapable of multi-tissue regeneration and augmentation of this potential may drastically shift current therapeutic paradigms. The loss of regenerative capacity in the adult may be due to the inability to activate a pro-regenerative process, which may be in turn suppressed by the dysregulated levels of inflammatory response. IL-6 family of cytokines, which signal through glycoprotein 130 (gp130) receptor, are pleiotropic key players in inflammatory responses following injury that can promote both, regeneration and pathogenesis, depending on the perseverance of inflammatory signal. (Source: Osteoa...
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: R. Shkhyan, C. Flynn, A. Sarkar, B. Van Handel, J. Tassey, H. Harn, C.-M. Chuong, N. Liu, M. Hurtig, D. Evseenko Source Type: research
Genicular artery embolization versus sham embolization for symptomatic osteoarthritis of the knee.
Purpose: Genicular artery embolization is a novel minimally invasive procedure used to alleviate pain in patients with symptomatic knee osteoarthritis. The target of this treatment is peri-genicular angiogenesis, which has been stated to be a contributor to KOA pain. The aim of GAE is to reduce blood flow to the hyperaemic synovium through embolization and subsequently reduce synovitis and the pain it produces. Multiple cohort studies have shown promising results, however, data from a randomized controlled trial is lacking. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: T.A. van Zadelhoff, E.H. Oei, A. Moelker, R.A. van der Heijden, P.K. Bos, S.M. Bierma-Zeinstra Source Type: research
Suppression of tumorigenic signaling in chondrosarcoma by mesenchymal stem cell derived conditioned medium
In this study, we evaluated the role of conditioned medium (CM) derived from MSCs in chondrosarcoma metabolism and tumorigenic signaling. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: S. Ahandoust, X. Xiong, K. Li, H. Yokota, S. Na Source Type: research
Nanoparticle based dnmt3b gene therapy attenuates arthritis progression in a murine injury model
Purpose: Previous work has demonstrated the importance of DNA methylation in maintaining joint homeostasis. Specifically, Dnmt3b has been implicated to be a key regulator of articular chondrocyte (AC) homeostasis and metabolism. Furthermore, while targeted deletion of Dnmt3b in ACs accelerates joint degeneration, Dnmt3b overexpression attenuates osteoarthritis (OA) progression. Thus, we sought to use an established, self-assembled peptide-based polyplex to deliver Dnmt3b mRNA to ACs in vitro and in vivo (via intra-articular injection). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: A. Kucharski, A. Hollenberg, H. Pan, S. Wickline, C.T. Pham, A. McAlinden, J. Shen, R. O'Keefe Source Type: research
Novel small molecule modulator of the gp130 receptor shows dose-dependent therapeutic efficacy in a canine model of osteoarthritis
Purpose: The pathogenesis of OA often begins from an injury to articular cartilage, which establishes chronic, low-grade inflammation principally mediated by IL-6 family cytokines that signal through the obligate receptor gp130; this promotes matrix degradation leading to the destruction of cartilage. Currently, there are no agents that efficiently slow or inhibit this process. Here, we unveil an advanced late pre-clinical candidate CX-011 that has significant, dose-dependent effects on joint structure, function and pain via modulation of gp130. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: B. Van Handel, C. Flynn, N. Liu, J. Lu, N. Lane, M. Hurtig, D. Evseenko Source Type: research
Gingival fibroblast treatment of secondary osteoarthritis in dogs: early and one-year follow-up
Purpose: Treatments for osteoarthritis (OA) have no positive impact on cartilage regeneration and only target symptoms (to reduce pain mostly caused by joint inflammation). Recently, research on alternative treatments has led to the development of cell-based therapies, mainly in light of their possible regenerative potential. Current allogeneic cell therapy is limited by its half-life post-administration to subjects. After an injury, the gum regenerates ad integrum thanks to the gingival fibroblasts (GF) suggesting a perfect healing process. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: F. Rannou Source Type: research
Suppression of the epigenetic modulator usp16 reverses aging and degenerative features in in vitro and in vivo models of osteoarthritis
Purpose: Osteoarthritis (OA) is a highly prevalent disorder affecting more that 300 million people globally and no treatment is currently available to prevent, stop or even restrain joint degeneration. Many targets potentially involved in its pathology have been identified so far but unfortunately the clinical translation have shown only limited success. The purpose of this study was to test a novel approach where we genetically target a key epigenetic modulator of stem cells and tissue aging, USP16, to develop a novel disease-modifying treatment for osteoarthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: M. Adorno, E. Besnard, A. Joshi, S. Brown, H. Akbal, B. Nicolis Di Robilant, L. Rovati Source Type: research
The combination of depression and obesity associated with increased incidence of subsequent total knee arthroplasty
Purpose: Symptomatic knee osteoarthritis (OA) is the most common joint disorder in the United States and is projected to affect more than 67 million Americans by 2030. Approximately one third of patients with knee OA experience significant progression of cartilage degradation, knee pain, and disability, leading to greater healthcare utilization and subsequent total knee arthroplasty (TKA). Depression and obesity are each individually associated with worse OA pain and pain progression but are also risk factors for poor outcomes and complication following TKA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: C.E. Conley, D. Landy, C. Lattermann, J. Borg-Stein, J. Collins, A.-M. Vranceanu, C. Jacobs Source Type: research
Are we underestimating cardiovascular disease onset risk for males and females with osteoarthritis?
Purpose: Osteoarthritis (OA) and cardiovascular disease (CVD) are highly prevalent in the population. There is evidence OA increases the risk for CVD, and emerging evidence of greater risk in subgroups defined by sex. Prior cross-sectional work from our group found that the profile of CVD risk factors differed for females and males with OA, reflecting a more inflammatory profile for females and more metabolic profile for males. In this longitudinal population-based study, we investigated CVD onset over a six-year period for those with and without OA, overall and by sex. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: A. Perruccio, C. Kral, J. Wilfong, L. Eder, J. Power, M. Canizares, G. Heckman, E.M. Badley Source Type: research
Diagnostic accuracy of ultrasound for identification of radiographic knee oa: the johnston county osteoarthritis project
Purpose: Ultrasound (US) is a non-invasive and efficient imaging technique that allows for visualization of many features relevant to knee osteoarthritis (KOA) including osteophytes, meniscal extrusion, synovitis, and articular cartilage damage. The current analysis aimed to determine the diagnostic accuracy of index US definitions for radiographic KOA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: K.A. Yates, C. Alvarez, T.A. Schwartz, S. Savage-Guin, J.B. Renner, C.J. Bakewell, M.J. Kohler, J. Lin, J. Samuels, A.E. Nelson Source Type: research
