Red Blood Cell Exposure Increases Chondrocyte Susceptibility to Oxidative Stress Following Hemarthrosis

The detrimental effects of blood exposure on articular tissues are well characterized, but the individual contributions of specific whole blood components are yet to be fully elucidated. Better understanding of mechanisms that drive cell and tissue damage in hemophilic arthropathy will inform novel therapeutic strategies. The studies here aimed to identify the specific contributions of intact and lysed red blood cells (RBCs) on cartilage and the therapeutic potential of Ferrostatin-1 in the context of lipid changes, oxidative stress, and ferroptosis.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research