Dynamic knee joint stiffness during running is associated with cartilage t1rho relaxation times 12- months post anterior cruciate ligament reconstruction
Purpose: Abnormal knee joint mechanics are believed to play a key role in the development and progression of post traumatic osteoarthritis (PTOA) after an anterior cruciate ligament (ACL) tear. One of the emerging hallmark imaging features of PTOA is a longer T1rho relaxation time indicative of a deterioration in cartilage quality. The load experienced by the knee during gait is largely determined by the joint angle excursion and the magnitude of the moment generated over that excursion. Potentially, dynamic knee joint stiffness (KJS) which is a measure of the change in knee moment in relation to the change in knee flexion...
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: M.K. Owen, M. Jacobs, N. Heebner, C. Latterman, A. Stone, C. Conley, C. Jacobs, M. Samaan, B. Noehren Source Type: research
Osteoarthritis young onset and stickler syndrome: a complex disease, between genetic and clinical manifestations
Purpose: The aim of this study is to describe the clinical manifestations and radiologic characteristics of a family with type I Stickler Syndrome, a disease with young onset osteoarthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: K.A. IBARRA STONE, V.G. PACHECO PILCO, I.D. GUTIERREZ FARFAN, R.A. LOPEZ GAMBOA, M.C. FUENTES CATA ÑO, A. HIDALGO BRAVO, L.J. JARA QUEZADA, R. ESPINOSA MORALES Source Type: research
3 Year results from a prospective study of polyacrylamide hydrogel for knee osteoarthritis
Purpose: In previous clinical studies intra-articular injection of polyacrylamide hydrogel has been investigated using 2 injections of 3 ml separated by a month. The primary objective of this study was to evaluate the efficacy and safety of a single injection of 6 ml intra-articular Arthrosamid ® on knee symptoms in participants with moderate to severe knee OA. The study has been extended to evaluate the long-term efficacy and safety of Arthrosamid® for up to 5 years after treatment. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: M. Henriksen, J. Beier, A. Hartkopp, P.G. Conaghan, H. Bliddal Source Type: research
Physical function status in hip and knee osteoarthritis: pain, psychological features and functional capacity play a major role
Purpose: Osteoarthritis (OA) is the most common cause of articular disease and a leading cause of chronic pain and functional impairment around the world. Knee and hip osteoarthritis (KOA and HOA, respectively) have been known to impair multiple facets of functional ability, including the potential to perform activities of daily living and the capacity to maintain healthy levels of physical activity and exercise. Predisposing and intervening factors for disability in OA have been infrequently investigated in the past. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: S. Espinosa-Salas, L. Bagherzadeh, T.J. Schnitzer, J. Barroso Source Type: research
GLA:D ® to be walking better: change in self-reported difficulty walking after exercise therapy and education in persons with knee osteoarthritis
Purpose: Difficulty walking is a primary reason that individuals with knee osteoarthritis (OA) seek care, including joint replacement; it is also a precursor to disability and is associated with increased risk of all-cause death. Therefore, addressing difficulty walking is a therapeutic priority. International guidelines strongly recommend exercise and education as first-line treatments for knee OA. Good Life with osteoArthritis in Denmark (GLA:D ®) is a structured group-based hip and knee OA treatment program that includes 2-3 patient education sessions and 12 supervised exercise sessions delivered over 8 weeks by certif...
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: L.K. King, J. Young, D.T. Gr ønne, A. Bricca, E.M. Roos, S.T. Skou, G.A. Hawker Source Type: research
A qualitative study exploring patient perceptions of personalized prediction and monitoring in rehabilitation after total knee arthroplasty
Purpose: Rehabilitation following total knee arthroplasty (TKA) is typically conducted using a one-size-fits-all protocol, however, rehabilitation should be individualized as patients have unique goals and healthcare needs after surgery. We have developed and externally validated a novel clinical decision support tool that can accurately predict patient recovery after TKA using historical recovery data of similar patients. The tool provides information on how the patient is recovering relative to “people-like-me”, as opposed to the entire heterogenous TKA population; and allows rehabilitation clinicians to monitor pati...
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: L. Churchill, J. Graber, M. Mealer, M.J. Bade, J.E. Stevens-Lapsley Source Type: research
Prediction of post-surgical disability in knee osteoarthritis patients
Purpose: As a highly prevalent disease, knee osteoarthritis (OA) causes both structural and functional impairments leading to limitation in activities of daily living (ADL) and disability. For people with advanced knee OA, total knee arthroplasty (TKA) is often a preferred approach to management. As outcomes of TKA are variable, being able to identify pre-surgical factors that are related to less favorable outcomes, particularly regarding function and activities of daily living disability, would be important to allow for possible pre-surgical care interventions and tailored post-surgical rehabilitation care. (Source: Osteo...
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: L. Bagherzadeh, S. Espinosa-Salas, T.J. Schnitzer, J. De Brito Barroso Monteiro Source Type: research
Randomized control trials on platelet-rich plasma intervention for knee osteoarthritis poorly adhere to the minimum information for studies evaluating biologics (mibo) guidelines: a systematic review
Purpose: Platelet-rich plasma (PRP) treatment of knee osteoarthritis grew exponentially over the past decade; however, scientific evaluation was highly variable. The American Academy of Orthopaedic Surgeons addressed the need for standardization of orthobiologics studies by publishing the Minimum Information for Studies Evaluating Biologics in Orthopaedic (MIBO) guidelines in May 2017. The purpose of this systematic review was to analyze how well randomized controlled trials (RCTs) on PRP intervention for knee osteoarthritis adhered to the MIBO guidelines. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: A.V. Stone, V. Abed, M. Owens, N. Brunty, M. Skinner, C. Jacobs Source Type: research
Assessment of hip joint structural and clinical outcomes in people with marfan syndrome
Purpose: Marfan Syndrome (MFS) is a genetic condition caused by a mutation in FBN1. MFS is associated with a higher risk of developing hip osteoarthritis (OA) compared to the general population, yet early-stage hip joint structural and clinical outcomes in the MFS population are not well understood. Therefore, the objective of this study was to assess the effects of MFS on hip joint cartilage, hip-related patient reported outcomes (PRO), and OARSI-based tasks including the 30-second chair rise test, 40-meter walk test and timed stair climb test. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: L. Steele, A. Fain, S. Duncan, M. Sheppard, M.A. Samaan Source Type: research
Intra-articular mm-ii, a novel suspension of large empty multilamellar liposomes, in painful knee osteoarthritis: a 26 week phase 2b placebo-controlled double blind randomized trial
Purpose: Additional safe and effective therapies are needed for osteoarthritis (OA) pain. MM-II, a novel suspension of empty large multilamellar liposomes composed of dimyristoylphosphatidylcholine (DMPC) and dipalmitoylphosphatidylcholine (DPPC), has been shown to have beneficial effects in OA animal models. In a previously reported first-in-man study, a single intra-articular injection of MM-II demonstrated lower pain in knee OA patients for up to 3 months. The aim of the current phase 2b study was to determine an effective dose of MM-II, durability of response through 26 wks, and safety of MM-II in patients with symptom...
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: T.J. Schnitzer, H. Rovsing, E. Lau, S.L. Boll, B. Brahmachari, R.C. Chou, T. Joshi, R. Wechsler, S.L. Yao, S. Weiner, A.R. Bihlet, P.C. Conaghan Source Type: research
Place not race: community-level social determinants of health may be more important than patient race in total hip arthroplasty outcomes
Purpose: With total hip arthroplasty (THA) utilization rising rapidly, it is important to understand social determinants of health (SDOH) that contribute to disparities in THA outcomes.We sought to explore the relationship of multiple community-level SDOH with 90-day readmission, 90-day mortality, 1-year revision post-THA, and length of stay (LOS) using prediction modelling. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: B. Mehta, Y. Wu, D. Pearce-Fisher, K. Ho, S.M. Goodman, M. Parks, F. Wang, M. Fontana, S. Ibrahim, P. Cram, R. Caruana Source Type: research
Presence of early radiographic features of osteoarthritis differs between subgroups 5 years after anterior cruciate ligament injury
Purpose: Outcomes after anterior cruciate ligament (ACL) rupture vary highly across individuals. Data suggests up to 35% of patients do not return to pre-injury sport, anywhere from 12-27% of patients sustain a second injury, and over 50% develop posttraumatic osteoarthritis (OA). These data suggest there may be subgroups that exist among those who have ruptured their ACL. Posttraumatic osteoarthritis (PTOA) in the knee joint is one of many concerning long-term outcomes facing individuals who have torn their ACL. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: E.K. Arhos, R.T. Pohlig, S. Di Stasi, M. Risberg, L. Snyder-Mackler, K.G. Silbernagel Source Type: research
Ultrasound measurement of decreased vastus medialis quality as a marker for increased structural abnormalities in early knee osteoarthritis: a case-control study
Purpose: The proper management for KOA prior to the occurrence of major structural damage may allow restoration of joint homeostasis. Identification of sensitive markers of the earlier stage would expand opportunities for effective disease managements. As muscle quality is associated with muscle strength, fatty infiltration (i.e., poor quality) in quadriceps lead to initiation of KOA via loss of shock absorption and loading distribution. While fatty infiltration of the quadriceps muscles is seen in patients with KOA, it is unclear if the degree of infiltration is associated with a decline in structural integrity of the kne...
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: A. Hoki, E. D'Amico, F. Ambrosio, T. Iwasaki, Y. Matsuda, H. Iijima Source Type: research
Knee arthroscopic surgery in middle-aged patients with meniscal symptoms. a 10-year follow-up of a prospective, randomized study
Purpose: To evaluate the long-term results of knee arthroscopy combined with an exercise program compared to an exercise program alone, in middle-aged patients with meniscal symptoms. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: J. Kvist, S. Sonesson, H. Gauffin Source Type: research
Surgeries within two years after acute anterior cruciate ligament injury. results from the nacox-study
Purpose: To describe the number of knee surgeries within two years after an anterior cruciate ligament (ACL) injury in patients treated with or without ACL-reconstruction (ACLR). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: J. Kvist, A. Samuelsson Selin, A. F ältström, H. Gauffin Source Type: research
