Associations of inflammatory and metabolic biomarkers with incident erosive hand osteoarthritis in the osteoarthritis initiative cohort
Erosive hand osteoarthritis (eHOA) is a subtype of hand OA that develops in finger joints with pre-existing osteoarthritis and is differentiated by clinical characteristics (hand pain/disability, inflammation, and erosions) that suggest inflammatory or metabolic processes. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - February 2, 2024 Category: Rheumatology Authors: Timothy E. McAlindon, Jennifer L. Hunnicutt, Mary B. Roberts, Ida K. Haugen, Lena F. Schaefer, Jeffrey B. Driban, Bing Lu, Jeffrey Duryea, Stacy E. Smith, Sarah L. Booth, Gayle A. Petty, Alexander Mathiessen, Li Zeng, Charles Eaton Source Type: research
Molecular pathogenesis of OA pain: past, present, and future
To provide a historical perspective and narrative review on research into the molecular pathogenesis of osteoarthritis pain. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - January 18, 2024 Category: Rheumatology Authors: Tonia L Vincent, Rachel E Miller Source Type: research
Anaphylatoxins and their corresponding receptors as potential drivers in cartilage calcification during osteoarthritis progression
This study aims on elucidating whether complement activation products contribute to cartilage calcification of OA cartilage. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - January 17, 2024 Category: Rheumatology Authors: Leonie Ruths, Markus Huber-Lang, Gundula Schulze-Tanzil, Jana Riegger Tags: Clinical Trial Source Type: research
Assessing the association of epigenetic age acceleration with osteoarthritis in the Multicenter Osteoarthritis Study (MOST)
Advancing age is one of the strongest risk factors for osteoarthritis (OA). DNA methylation-based measures of epigenetic age acceleration may provide insights into mechanisms underlying OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - January 17, 2024 Category: Rheumatology Authors: Michelle S. Yau, Paul C. Okoro, Ida K. Haugen, John A. Lynch, Michael C. Nevitt, Cora E. Lewis, James C. Torner, David T. Felson Tags: Clinical Trial Source Type: research
Looking Back on 30+ years of The Johnston County Osteoarthritis Project while Looking Forward with The Johnston County Health Study: a Narrative Review
Over the last 30 years, knowledge of the epidemiology of osteoarthritis (OA) has dramatically advanced, and Osteoarthritis and Cartilage has been on the forefront of disseminating research findings from large OA cohort studies, including the Johnston County OA Project (JoCoOA). The JoCoOA is a population-based, prospective longitudinal cohort that began roughly 30 years ago with a key focus on understanding prevalence, incidence, and progression of OA, as well as its risk factors, in a predominantly rural population of Black and White adults 45+ years old in a county in the southeastern United States. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - January 15, 2024 Category: Rheumatology Authors: Yvonne M. Golightly, Jordan B. Renner, Charles G. Helmick, Joanne M. Jordan, Amanda E. Nelson Source Type: research
Optimising the implementation of evidence-based osteoarthritis guidelines in primary care: Development of a knowledge mobilisation toolkit
Implementing clinical guidelines for osteoarthritis in primary care is complex. Whilst international guidelines detail what best practice for osteoarthritis looks like, little is known about how this is best implemented. Limited resources are available to guideline developers, practitioners, researchers, or the public to facilitate implementation. Set in the context of a larger research project which sought to understand the factors that influence knowledge mobilisation (KM) in implementation for osteoarthritis guidelines, this study reports the development of a toolkit to optimise KM for the implementation of evidence-bas...
Source: Osteoarthritis and Cartilage - January 15, 2024 Category: Rheumatology Authors: Laura Swaithes, Zoe Paskins, Andrew Finney, Nicola Walsh, Magdalena Skrybant, Christian Mallen, Krysia Dziedzic Source Type: research
Efficacy and safety of collagen derivatives for osteoarthritis: a trial sequential meta-analysis
To investigate the efficacy and safety of collagen derivatives for osteoarthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - January 10, 2024 Category: Rheumatology Authors: Chun-Wei Liang, Hsiao-Yi Cheng, Yu-Hao Lee, Chun-De Liao, Shih-Wei Huang Source Type: research
A perspective on the evolution of semi-quantitative MRI assessment of osteoarthritis: Past, present and future
This perspective describes the evolution of semi-quantitative (SQ) MRI in characterizing structural tissue pathologies in osteoarthritis (OA) imaging research over the last 30 years. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - January 9, 2024 Category: Rheumatology Authors: Frank W. Roemer, Mohamed Jarraya, Daichi Hayashi, Michel D. Crema, Ida K. Haugen, David J. Hunter, Ali Guermazi Source Type: research
The Evolving Landscape of Gene Therapy Strategies for The Treatment of Osteoarthritis
Significant advances have been made in our understanding of osteoarthritis (OA) pathogenesis; however, no disease-modifying therapies have been identified. This review will summarize the gene therapy landscape, its initial successes for OA, and possible challenges using recent studies and examples of gene therapies in clinical trials. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - January 8, 2024 Category: Rheumatology Authors: Matthew W. Grol Source Type: research
Mitonuclear epistasis involving TP63 and haplogroup Uk: risk of rapid progression of knee OA in patients from the OAI
To investigate genetic interactions between mtDNA haplogroups and nuclear single nucleotide polymorphisms (nSNPs) to analyze their impact on the development of the rapid progression of knee osteoarthritis (OA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - January 6, 2024 Category: Rheumatology Authors: Alejandro Dur án-Sotuela, Natividad Oreiro, Mercedes Fernández-Moreno, Jorge Vázquez-García, Sara Relaño-Fernández, Vanesa Balboa-Barreiro, Francisco J. Blanco, Ignacio Rego-Pérez Source Type: research
Causal relationships between anthropometric traits, bone mineral density, osteoarthritis and spinal stenosis: a Mendelian randomization investigation
This study aims to explore causal relationships between anthropometric risk factors, osteoarthritis, and spinal stenosis using Mendelian randomization (MR) techniques. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - December 29, 2023 Category: Rheumatology Authors: Maria K Sobczyk, Benjamin G Faber, Lorraine Southam, Monika Frysz, April Hartley, Eleftheria Zeggini, The Genetics of Osteoarthritis Consortium, Haotian Tang, Tom R Gaunt Source Type: research
Priming Chondrocytes During Expansion Alters Cell Behavior and Improves Matrix Production in 3D Culture
Cartilage tissue engineering strategies that use autologous chondrocytes require in vitro expansion of cells to obtain enough cells to produce functional engineered tissue. However, chondrocytes dedifferentiate during expansion culture, limiting their ability to produce chondrogenic tissue and their utility for cell-based cartilage repair strategies. The current study identified conditions that favor cartilage production and the mechanobiological mechanisms responsible for these benefits. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - December 29, 2023 Category: Rheumatology Authors: Emily D. Lindberg, Tiffany Wu, Kristen L. Cotner, Amanda Glazer, Amir A. Jamali, Lydia L. Sohn, Tamara Alliston, Grace D. O ’Connell Source Type: research
What is the rational for mesenchymal stromal cells based therapies in the management of hemophilic arthropathies?
Hemophilia A and B are rare X-linked genetic bleeding disorders due to a complete or partial deficiency in the coagulation factors VIII or IX, respectively. The main treatment for hemophilia is prophylactic and based on coagulation factor replacement therapies. These treatments have significantly reduced bleedings and improved the patients ’ quality of life. Nevertheless, repeated joint bleedings (hemarthroses), even subclinical hemarthroses, can lead to hemophilic arthropathy (HA). This disabling condition is characterized by chronic pain due to synovial inflammation, cartilage and bone destruction requiring ultimately ...
Source: Osteoarthritis and Cartilage - December 29, 2023 Category: Rheumatology Authors: Alexandre Th éron, Marie Maumus, Christine Biron-Andreani, Nicolas Sirvent, Christian Jorgensen, Danièle Noël Tags: Review Source Type: research
Is RANKL a potential molecular target in osteoarthritis?
Osteoarthritis (OA) is a disease of joints, in which the bone under the articular cartilage undergoes increased remodelling activity. The question is whether a better understanding of the causes and mechanisms of bone remodelling can predict disease-modifying treatments. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - December 29, 2023 Category: Rheumatology Authors: Dzenita Muratovic, Gerald J. Atkins, David M Findlay Source Type: research
Inflammation in osteoarthritis: our view on its presence and involvement in disease development over the years
Inflammation, both locally in the joint and systemic, is nowadays considered among the mechanisms involved in osteoarthritis (OA). However, this concept has not always been generally accepted. In fact, for long OA has been described as a relatively simple degeneration of articular cartilage as the result of wear and tear only. In this narrative review, we present what our understanding of OA was at the time of the inaugural release of Osteoarthritis and Cartilage about 30 years ago and discuss a set of pivotal papers that changed our view on the role of inflammation in OA development. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - December 22, 2023 Category: Rheumatology Authors: Martijn H.J. van den Bosch, Arjen B. Blom, Peter M. van der Kraan Source Type: research
