Are we underestimating cardiovascular disease onset risk for males and females with osteoarthritis?
Purpose: Osteoarthritis (OA) and cardiovascular disease (CVD) are highly prevalent in the population. There is evidence OA increases the risk for CVD, and emerging evidence of greater risk in subgroups defined by sex. Prior cross-sectional work from our group found that the profile of CVD risk factors differed for females and males with OA, reflecting a more inflammatory profile for females and more metabolic profile for males. In this longitudinal population-based study, we investigated CVD onset over a six-year period for those with and without OA, overall and by sex. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: A. Perruccio, C. Kral, J. Wilfong, L. Eder, J. Power, M. Canizares, G. Heckman, E.M. Badley Source Type: research
Diagnostic accuracy of ultrasound for identification of radiographic knee oa: the johnston county osteoarthritis project
Purpose: Ultrasound (US) is a non-invasive and efficient imaging technique that allows for visualization of many features relevant to knee osteoarthritis (KOA) including osteophytes, meniscal extrusion, synovitis, and articular cartilage damage. The current analysis aimed to determine the diagnostic accuracy of index US definitions for radiographic KOA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: K.A. Yates, C. Alvarez, T.A. Schwartz, S. Savage-Guin, J.B. Renner, C.J. Bakewell, M.J. Kohler, J. Lin, J. Samuels, A.E. Nelson Source Type: research
Development of cartilage damage on knee mri after anterior cruciate ligament tear: early anterior cruciate ligament reconstruction versus rehabilitation with optional delayed anterior cruciate ligament reconstruction - a secondary analysis of a randomized controlled trial
Purpose: There is limited evidence to support claims of superiority of early ACL reconstruction versus optional delayed ACL reconstruction in the prevention of cartilage damage. Analysis of semi-quantitative cartilage scores from knee MRI is often done by dichotomizing data into presence or absence on a compartmental basis, which may result in loss of information regarding ordinal grades and subregional assessment, resulting in reduced sensitivity to detect change. Our aim was to explore whether there is any difference in development of cartilage damage on knee MRI after 5 years in ACL-injured knees between patients random...
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: B. Snoeker, F. Roemer, A. Turkiewicz, S. Lohmander, R. Frobell, M. Englund Source Type: research
Hip geometric parameters are associated with radiographic and clinical hip osteoarthritis: findings from a cross-sectional study in uk biobank
Purpose: Abnormalities in hip shape have been shown to increase risk of hip osteoarthritis (HOA). These can be quantified using geometric parameters (GPs), although the independent effects of these measures are unclear. The aim of this study was to examine the cross-sectional relationships between three GPs and radiographic HOA (rHOA) and hospital diagnosed OA (HESOA), as well as the longitudinal relationships between GPs and total hip replacement (THR) to establish which of these are independent as assessed in mutually adjusted models in a large sample of dual-energy x-ray absorptiometry (DXA) scans in UK Biobank (UKB). (...
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: S.V. Heppenstall, R. Ebsim, F.R. Saunders, C. Lindner, J.S. Gregory, N.C. Harvey, T. Cootes, J.H. Tobias, M. Frysz, B.G. Faber Source Type: research
Identification of phenotype differences in articular cartilage and meniscus at knee joint in collagen xxii null mouse
Purpose: Collagen XXII, encoded by the Col22a1 gene, is a newly identified extracellular matrix (ECM) protein localized at the articular cartilage-synovial fluid junction and expressed by the superficial zone (SZ) chondrocytes at the lining of articular cartilage (AC) and Meniscus (MC) whereas, originally identified at the myotendinous junction of heart and skeletal muscle. With the knowledge of COL22A1 expression pattern from prenatal to postnatal development marking the Joint progenitor cells (JPCs), the work aims to explore whether COL22A1 is crucial to SZ outer lining of AC and MC in maintaining the progenitor potentia...
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: A. Rubab Source Type: research
Impaired synovial macrophage-mediated efferocytosis in a rat model of post-traumatic knee osteoarthritis
Purpose: The synovial lining is critical for maintaining joint health. Synovial macrophages that inhabit the synovium have a large role in maintaining tissue homeostasis through the clearance of metabolic products, cell debris and recycling components of the synovial fluid. A large part of maintaining homeostasis is the efficient clearance of apoptotic cells which is accomplished by macrophages, termed efferocytosis. However, our lab has previously found that the apoptotic cell burden in the synovium was significantly higher and that synovial-derived macrophage-mediated efferocytosis was impaired in patients with end-stage...
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: L. Del Sordo, E. Sodhi, G. Blackler, M. Grol, B. Heit, C.T. Appleton Source Type: research
Matrix stiffness aggravates osteoarthritis progression through h3k27me3 demethylation induced by mitochondrial damage
Purpose: Chondrocytes can sense changes in matrix stiffness and affect energy metabolism through mitochondria. Mechanically associated changes in mitochondria are closely involved in osteoarthritis (OA) progression. In addition to their well-known roles in energy metabolism, mitochondria communicate with the nucleus, reprogramming transcriptional profiles to adapt to mechanical stimulation, which is essential for organismal health. Emerging studies have documented that mitochondrial-to nuclear communication via metabolites causes various epigenetic changes, affecting disease development and progression. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: T. Kan, H. Li, L. Hou, J. Cui, Y. Wang, L. Sun, L. Wang, M. Yan, Z. Yu Source Type: research
Structural analysis on postnatal cartilage development of the patellar femoral joint in mice
Purpose: Knee Osteoarthritis (OA) is an irreversible orthopaedic disease that causes many limitations in our daily activities. Knee OA developed in the femorotibial joint and the patellofemoral (PF) joint. Many researchers have been focusing on the degeneration mechanism of femorotibial joint cartilage. However, the PF joint is an essential source of symptoms in knee OA. In the knee OA cohorts, the prevalence of radiographic PF joint OA is 57% (Hart H+, Br J Spot Med. 2017). Patellar dislocation is one of the factors leading to OA in PF joints (Liebensteiner M+, J Orthop Surg Res. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: S. Hirata, K. Takahata, M. Yoneno, Y. Usami, T. Kokubun Source Type: research
Synovial invasion in the acl-t model might cause unexpected cartilage degeneration in the early stage
Purpose: Knee osteoarthritis (OA) is recognized as irreversible disease and one of the factors leading knee OA is mechanical stress. There are several kinds of mechanical stress such as compression stress and shear stress. To reveal the mechanism of developing the knee OA by mechanical stress, Anterior Cruciate Ligament transection (ACL-T) model was established; however, unexpected inflammation occurs when making this model. Recently, we succeeded to establish a novel ACL-Rupture model (Takahata et al, OAC. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: K. Takahata, K. Arakawa, H. Takahashi, M. Yoneno, T. Kokubun Source Type: research
The varied genetic impact of medium-term anterior cruciate ligament injury on articular cartilage and synovium
Purpose: Alterations in gene expression of articular cartilage and synovium are one of the first detectable markers of post-traumatic osteoarthritis (PTOA) following injury. However, little is known about the gene expression relationship between these two tissues several months into disease progression. The purpose of this study was to gauge the extent to whic h anterior cruciate ligament (ACL) transection induces different transcriptomic changes in synovium compared to articular cartilage 52 weeks following injury. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: J.I. Donnenfield, B.C. Fleming, M.M. Murray Source Type: research
The impact of pain on funcional activities in individuals with hip osteoarthritis
This study aimed to assess the impact of OAH on functional activities and the quality of life of individuals with OAH. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: C.d. Melo, P.R. Mendes da Silva Serr ão, L.A. Selistre Source Type: research
Feasibility of a pain informed movement program for people with symptomatic knee osteoarthritis
Purpose: Disability in knee osteoarthritis (KOA) is known to be largely due to pain, the mechanism of which is complex and multidimensional with alterations in nociceptive processing in the peripheral and central nervous system (CNS) leading to persistent pain. Current clinical practice guidelines for KOA provide strong recommendations for education and exercise including land-based or mind-body approaches. However, individually these strategies are only moderately effective. One potential reason for this is a lack of understanding of their underlying mechanisms and how their combination might impact nervous system modulat...
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: S. Modarresi, N. Pearson, K. Madden, M. Fahnestock, D. Bowdish, L.C. Carlesso Source Type: research
Structural damage and effects on knee pain during different activities as assessed by the western ontario and mcmaster universities osteoarthritis index (womac)
Purpose: Due to its major public health impact, knee osteoarthritis (KOA) has been designated as a serious disease by the US Food and Drug Administration (FDA). Approval of a disease modifying osteoarthritis drug (DMOAD) to slow or prevent disease progression hinges on demonstrating both symptomatic (i.e., how a patient feels or functions) and structural improvement. The WOMAC, commonly used to assess symptomatic improvement, may not adequately reflect pain reporting in KOA due to the complex relationship of structural damage and pain experience in KOA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: C. Kwoh, F. Roemer, A. Guermazi, E.L. Ashbeck Source Type: research
Exploring pain phenotypes in people with early knee osteoarthritis:the multicenter osteoarthritis study (most)
Purpose: Pain phenotyping in the early stages of knee osteoarthritis (KOA) has been proposed to represent the multifactorial nature of pain. Identification of early KOA pain phenotypes can help with prognosis and the limitation of pain progression through the development of targeted treatment interventions. A mechanism informed approach to KOA pain is recommended to understand contributions arising from alterations in the peripheral or central nervous system. However, the ideal components to assess phenotypes are not known. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: Y. Neelapala, T. Neogi, D. Kumar, M. Jarraya, L. Frey-Law, C. Lewis, M. Nevitt, D. Kobsar, L. Macedo, S. Hanna, T. Appleton, T. Birmingham, L.C. Carlesso Source Type: research
Tissuegene-c induces long-term analgesic effects through modulation of pain mediators and neuronal sensitization in a monoiodoacetate-induced osteoarthritis pain rat model.
Purpose: TissueGene-C (TG-C), comprising human allogeneic chondrocytes and irradiated GP2-293 cells manipulated to overexpress transforming growth factor- β1 (TGF-β1), has been developed as a novel cell-based gene therapy for osteoarthritis (OA) drug. We aim to determine analgesic mechanism of TG-C in a pre-clinical animal model with MIA-induced pain. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: E. Park, J. Seo, Y. Lee, K. Park, K-r. Kim, H. Lee, S. Lee, S. Kim, A. Mobasheri, H. Choi Source Type: research
