What is the rational for mesenchymal stromal cells based therapies in the management of hemophilic arthropathies?
Hemophilia A and B are rare X-linked genetic bleeding disorders due to a complete or partial deficiency in the coagulation factors VIII or IX, respectively. The main treatment for hemophilia is prophylactic and based on coagulation factor replacement therapies. These treatments have significantly reduced bleedings and improved the patients ’ quality of life. Nevertheless, repeated joint bleedings (hemarthroses), even subclinical hemarthroses, can lead to hemophilic arthropathy (HA). This disabling condition is characterized by chronic pain due to synovial inflammation, cartilage and bone destruction requiring ultimately ...
Source: Osteoarthritis and Cartilage - December 29, 2023 Category: Rheumatology Authors: Alexandre Th éron, Marie Maumus, Christine Biron-Andreani, Nicolas Sirvent, Christian Jorgensen, Danièle Noël Tags: Review Source Type: research
Is RANKL a potential molecular target in osteoarthritis?
Osteoarthritis (OA) is a disease of joints, in which the bone under the articular cartilage undergoes increased remodelling activity. The question is whether a better understanding of the causes and mechanisms of bone remodelling can predict disease-modifying treatments. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - December 29, 2023 Category: Rheumatology Authors: Dzenita Muratovic, Gerald J. Atkins, David M Findlay Source Type: research
Inflammation in osteoarthritis: our view on its presence and involvement in disease development over the years
Inflammation, both locally in the joint and systemic, is nowadays considered among the mechanisms involved in osteoarthritis (OA). However, this concept has not always been generally accepted. In fact, for long OA has been described as a relatively simple degeneration of articular cartilage as the result of wear and tear only. In this narrative review, we present what our understanding of OA was at the time of the inaugural release of Osteoarthritis and Cartilage about 30 years ago and discuss a set of pivotal papers that changed our view on the role of inflammation in OA development. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - December 22, 2023 Category: Rheumatology Authors: Martijn H.J. van den Bosch, Arjen B. Blom, Peter M. van der Kraan Source Type: research
Relationships Between Diagnostic Imaging of First Carpometacarpal Osteoarthritis and Pain, Functional Status, and Disease Progression: A Systematic Review
To systematically review the association of pain, function, and progression in first carpometacarpal osteoarthritis with imaging biomarkers and radiography-based staging. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - December 21, 2023 Category: Rheumatology Authors: Dario F. Mazza, Pattira S. Boonsri, Aman Arora, Christopher O. Bayne, Robert M. Szabo, Abhijit J. Chaudhari, Robert D. Boutin Source Type: research
A public health approach to osteoarthritis in the United States
A National Public Health Agenda for Osteoarthritis: 2020 Update (OA Agenda) states, ‘We envision a nation in which adults with osteoarthritis (OA) are able to live full lives with less pain, stiffness, and disability; greater mobility; and preserved function and independence’1. OA affects more than 528 million or 7% of people worldwide, and 32.5 million or 1 in 7 adults in the US1,2. Countries with established market economies, older adult populations, and populations with high rates of obesity may have higher prevalence2. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - December 20, 2023 Category: Rheumatology Authors: Kirsten R. Ambrose, Katie F. Huffman, Erica L. Odom, Anika L. Foster, Nick Turkas, Leigh F. Callahan Source Type: research
Biomarkers have to make sense
In this issue of Osteoarthritis and Cartilage, Kraus and co-workers report that no more than eight serum protein markers are required to separate, on group levels, persons with radiographic knee osteoarthritis (OA) from those free of radiographic OA (non-OA) in hands, hips, knees and spine. Sera from the knee OA cohort Foundation National Institutes of Health (FNIH; n = 596, Kellgren-Lawrence [KL] grade 1-3) were compared with sera from the non-OA multi-joint control cohort Johnston County Osteoarthritis Project (JoCoOA; n = 127, KL = 0). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - December 18, 2023 Category: Rheumatology Authors: Andr é Struglics Source Type: research
Expanding from unilateral to bilateral: a robust deep learning-based approach for predicting radiographic osteoarthritis progression
To develop and validate a deep learning model for predicting osteoarthritis (OA) progression based on bilateral knee joint views. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - December 17, 2023 Category: Rheumatology Authors: Rui Yin, Hao Chen, Tianqi Tao, Kaibin Zhang, Guangxu Yang, Fajian Shi, Yiqiu Jiang, Jianchao Gui Source Type: research
Let ’s DAG it! But wait…which variables should we include in our graphical model?
In Osteoarthritis and Cartilage, Cheema et al. report the process for developing a graphical causal model to guide their statistical analyses when estimating the treatment effects of exercise therapy in trials with long-term follow-up for patients with knee osteoarthritis and symptomatic meniscal tear. They used the 12-year follow-up of the MeTeOR trial1 as a case study. The authors adopted a thorough approach: (1) identified two post-randomization events that can influence clinical outcomes during long-term follow-up, namely, loss to follow-up and total knee replacement (TKR); (2) conducted a review of the literature to i...
Source: Osteoarthritis and Cartilage - December 17, 2023 Category: Rheumatology Authors: Daniel Cury Ribeiro Tags: Editorial Source Type: research
Mechanical Loading of Joint Modulates T Cells in Lymph Nodes to Regulate Osteoarthritis
The crosstalk of joint pathology with local lymph nodes in osteoarthritis (OA) is poorly understood. We characterized the change in T cells in lymph nodes following load-induced OA and established the association of the presence and migration of T cells to the onset and progression of OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - December 8, 2023 Category: Rheumatology Authors: Tibra A. Wheeler, Adrien Y. Antoinette, Eshant Bhatia, Matthew J. Kim, Chiemezue N. Ijomanta, Ann Zhao, Marjolein C.H. van der Meulen, Ankur Singh Source Type: research
Cationic tantalum oxide nanoparticle contrast agent for micro computed tomography reveals articular cartilage proteoglycan distribution and collagen architecture alterations
In this study, we aim to establish the depth-dependent relationship between Ta2O5-cNP diffusion and cartilage constituents (proteoglycan content, collagen content and network architecture). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - December 5, 2023 Category: Rheumatology Authors: Jiri J äntti, Anisha Joenathan, Maria Fugazzola, Juuso Tuppurainen, Juuso T.J. Honkanen, Juha Töyräs, René van Weeren, Brian D. Snyder, Mark W. Grinstaff, Hanna Matikka, Janne T.A. Mäkelä Source Type: research
Three Decades of Advancements in Osteoarthritis Research: Insights from Transcriptomic, Proteomic, and Metabolomic Studies
The objective of this review is to highlight the advancements achieved by omic studies in enhancing our understanding of OA pathogenesis over the last three decades. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - December 2, 2023 Category: Rheumatology Authors: Muhammad Farooq Rai, Kelsey H. Collins, Annemarie Lang, Tristan Maerz, Jeroen Geurts, Cristina Ruiz-Romero, Ronald K. June, Yolande Ramos, Sarah J. Rice, Shabana Amanda Ali, Chiara Pastrello, Igor Jurisica, C. Thomas Appleton, Jason S. Rockel, Mohit Kapoo Source Type: research
Aging and the Emerging Role of Cellular Senescence in Osteoarthritis
The correlation between age and incidence of osteoarthritis (OA) is well known but the causal mechanisms involved are not completely understood. This narrative review summarizes selected key findings from the past 30 years that have elucidated key aspects of the relationship between aging and OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - December 2, 2023 Category: Rheumatology Authors: Brian O. Diekman, Richard F. Loeser Source Type: research
Cost and outcomes of Hospital-based Usual cAre versus Tele-monitor self-directed Rehabilitation (HUATR) in patients with total knee arthroplasty: A randomized, controlled, non-inferiority trial
To evaluate the clinical efficacy and cost-effectiveness of telemonitored self-directed rehabilitation (TR) compared with hospital-based rehabilitation (HBR) for patients with total knee arthroplasty (TKA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - December 1, 2023 Category: Rheumatology Authors: Yong-Hao Pua, Seng-Jin Yeo, Ross Allan Clark, Bryan Yijia Tan, Terry Haines, Janet Prvu Bettger, Ee-Lin Woon, Hong Han Tan, John Wei-Ming Tan, Juanita Low, Eleanor Chew, Julian Thumboo Tags: Clinical Trial Source Type: research
Constructing a Clinical Radiographic Knee Osteoarthritis Database Using Artificial Intelligence Tools with Limited Human Labor: A Proof of Principle
To create a scalable and feasible retrospective consecutive knee osteoarthritis (OA) radiographic database with limited human labor using commercial and custom-built artificial intelligence (AI) tools. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - December 1, 2023 Category: Rheumatology Authors: Anders Lenskjold, Mathias W Brejneb øl, Janus U Nybing, Martin H Rose, Henrik Gudbergsen, Anders Troelsen, Anne Moller, Henriette Raaschou, Mikael Boesen Source Type: research
Osteoarthritis year in review 2023: biomechanics
Biomechanics plays a significant yet complex role in osteoarthritis (OA) onset and progression. Identifying alterations in biomechanical factors and their complex interactions is critical for gaining new insights into OA pathophysiology and identification of clearly defined and modifiable mechanical treatment targets. This review synthesized biomechanics studies from March 2022 to April 2023, from which three themes relating to human gait emerged: (1) new insights into the pathogenesis of OA using computational modelling and machine learning, (2) technology-enhanced biomechanical interventions for OA, and (3) out-of-lab bi...
Source: Osteoarthritis and Cartilage - December 1, 2023 Category: Rheumatology Authors: Laura E Diamond, Tamara Grant, Scott D Uhlrich Tags: Review Source Type: research
