B-cell capacity for expansion and differentiation into plasma cells are altered in osteoarthritis
Autoantibody (autoAbs) production in osteoarthritis (OA), coupled with evidence of disturbed B-cell homeostasis, suggest a potential role for B-cells in OA. B-cells can differentiate with T-cell help (T-dep) or using alternative TLR co-stimulation (TLR-dep). We analysed the capacity for differentiation of B-cells in OA versus age-matched heathy controls and compared the capacity of OA synovitis-derived stromal cells to provide support for plasma cell maturation. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 6, 2023 Category: Rheumatology Authors: Xuanxiao Xie, Gina M. Doody, Farag Shuweihdi, Philip G. Conaghan, Frederique Ponchel Source Type: research
Within-person change in patient-reported outcomes and their association with the wish to undergo joint surgery during a digital first-line intervention for osteoarthritis
To study the association between within-person changes in patient-reported outcomes (PROMs) and wish for joint surgery during participation in a digital first-line intervention comprising exercise and education for knee/hip osteoarthritis (OA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 31, 2023 Category: Rheumatology Authors: Andrea Dell ’Isola, Håkan Nero, Leif E Dahlberg, Majda Misini Ignjatovic, L Stefan Lohmander, Anna Cronström, Ali Kiadaliri Source Type: research
The recombinant Link module of human TSG-6 suppresses cartilage damage in models of osteoarthritis: a potential disease-modifying OA drug
To investigate the role of endogenous TSG-6 in human osteoarthritis (OA) and assess the disease-modifying potential of a TSG-6-based biological treatment in cell, explant and animal models of OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 29, 2023 Category: Rheumatology Authors: Sheona P Drummond, Eckart Bartnik, Nikolaos Kouvatsos, Jenny Scott, Douglas P Dyer, Jennifer M Thomson, Andrew J Price, Sanjay Anand, Leela C Biant, Thomas Leeuw, Matthias Herrmann, Caroline M Milner, Anthony J Day Source Type: research
Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank
Acute knee injury is associated with post-traumatic OA (PTOA). Very little is known about the genome-wide associations of PTOA when compared with idiopathic OA (iOA). Our objective was to describe the development of knee OA after knee injury and its genetic associations in UK Biobank (UKB). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 27, 2023 Category: Rheumatology Authors: B Hollis, C Chatzigeorgiou, L Southam, K Hatzikotoulas, S Kluzek, A Williams, E Zeggini, L Jostins-Dean, FE Watt, the Genetics of Osteoarthritis Consortium Source Type: research
Postvaccination immune responses and risk of primary total hip arthroplasty —A population-based cohort study
To investigate the relationship between individual postvaccination immune responses and subsequent risk of total hip arthroplasty (THA) due to idiopathic osteoarthritis (OA) or rheumatoid arthritis (RA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 23, 2023 Category: Rheumatology Authors: Sonia Rojewski, Marianne Westberg, Lars Nordsletten, Haakon E. Meyer, Kristin Holvik, Ove Furnes, Anne Marie Fenstad, Jesper Dahl Source Type: research
Post-vaccination immune responses and risk of primary total hip arthroplasty - a population-based cohort study
To investigate the relationship between individual post-vaccination immune responses and subsequent risk of total hip arthroplasty (THA) due to idiopathic osteoarthritis (OA) or rheumatoid arthritis (RA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 23, 2023 Category: Rheumatology Authors: Sonia Rojewski, Marianne Westberg, Lars Nordsletten, Haakon E. Meyer, Kristin Holvik, Ove Furnes, Anne Marie Fenstad, Jesper Dahl Source Type: research
Are basic calcium phosphate crystals the driver of inflammation in osteoarthritis?
The calcification of cartilage matrix is a naturally occurring process in endochondral bone formation1. The articular cartilage of mature and healthy individuals remains non-calcified. However, a thin layer of calcified cartilage connecting the deep zone of articular cartilage with the subchondral bone is present in healthy joints. This dense mineralized layer is formed during puberty when vascular invasion and bone growth stops2, 3. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 23, 2023 Category: Rheumatology Authors: Andrea Schwab, Jessica Bertrand Tags: Editorial Source Type: research
Tick Tock, the Cartilage Clock
Osteoarthritis (OA) is the most common age-related joint disease, affecting articular cartilage and other joint structures, causing severe pain and disability. Due to limited understanding of the underlying disease pathogenesis, there are currently no disease modifying drugs for OA. Circadian rhythms are generated by cell-intrinsic timekeeping mechanisms which are known to dampen during ageing, increasing disease risks. In this review, we focus on one emerging area of chondrocyte biology, the circadian clocks. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 23, 2023 Category: Rheumatology Authors: Natalie Rogers, Qing-Jun Meng Tags: Review Source Type: research
A scoping review of how early-stage knee osteoarthritis has been defined
Early-stage knee osteoarthritis (KOA) classification criteria will enable consistent identification and trial recruitment of individuals with knee OA at an earlier stage of disease, when interventions may be more effective. Towards this goal, we identified how early-stage KOA has been defined in the literature. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 22, 2023 Category: Rheumatology Authors: Jean W. Liew, Lauren K. King, Armaghan Mahmoudian, Qiuke Wang, Hayden F. Atkinson, David B. Flynn, C. Thomas Appleton, Martin Englund, Ida K. Haugen, L. Stefan Lohmander, Jos Runhaar, Tuhina Neogi, Gillian Hawker, on behalf of the OARSI Early Osteoarthrit Source Type: research
The GM-CSF/CCL17 pathway in obesity-associated osteoarthritic pain and disease in mice
We have previously identified a granulocyte macrophage-colony stimulating factor (GM-CSF)/C-C motif ligand 17 (CCL17) pathway in monocytes/macrophages, in which GM-CSF regulates the formation of CCL17 and it is important for an experimental osteoarthritis (OA) model. We explore here in additional OA models, including in the presence of obesity, such a requirement for this pathway. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 22, 2023 Category: Rheumatology Authors: Heonsu Shin, Varun Prasad, Tanya Lupancu, Shveta Malik, Adrian Achuthan, Mark Biondo, Bronwyn A. Kingwell, Manja Thiem, Marlene Gottschalk, Heike Weighardt, Irmgard F örster, Richard de Steiger, John A. Hamilton, Kevin M.-C. Lee Source Type: research
Comparison of Evaluation Metrics of Deep Learning for Imbalanced Imaging Data in Osteoarthritis Studies
To compare the evaluation metrics for deep learning methods that were developed using imbalanced imaging data in osteoarthritis (OA) studies. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 18, 2023 Category: Rheumatology Authors: Shen Liu, Frank Roemer, Yong Ge, Edward J. Bedrick, Zong-Ming Li, Ali Guermazi, Leena Sharma, Charles Eaton, Marc C. Hochberg, David J. Hunter, Michael C. Nevitt, Wolfgang Wirth, C. Kent Kwoh, Xiaoxiao Sun Source Type: research
Are pro-regenerative therapies the future of osteoarthritis disease modification?
Osteoarthritis (OA) has historically been regarded as a disease of imbalance between synthetic, anabolic responses in the joint tissues and catabolic, degradative ones. Since adult articular cartilage has always been thought to have poor reparative capability, most research over the past two decades has focused on targeting inflammatory and degradative pathways in OA to halt progression. Despite gaining important mechanistic insights from human and preclinical molecular analyses, none of the randomized controlled trials targeting inflammatory cytokines or disease-relevant proteases has met its primary endpoints,1 leaving m...
Source: Osteoarthritis and Cartilage - May 15, 2023 Category: Rheumatology Authors: Tonia L Vincent, Philip G Conaghan Tags: Commentary Source Type: research
Towards disease modification in osteoarthritis
We share the enthusiasm of Vincent and Conaghan, and very much welcome this study, which has the potential to result, in due course, in a disease-modifying osteoarthritis drug (DMOAD).1 (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 15, 2023 Category: Rheumatology Authors: Francesco Dell ’Accio, Cosimo De Bari Tags: Commentary Source Type: research
Microstructural and cellular characterisation of the subchondral trabecular bone in human knee and hip osteoarthritis using synchrotron tomography
It is unclear if different factors influence osteoarthritis (OA) progression and degenerative changes characterising OA disease in hip and knee. We investigated the difference between hip OA and knee OA at the subchondral bone tissue and cellular level, relative to the degree of cartilage degeneration. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 11, 2023 Category: Rheumatology Authors: Dzenita Muratovic, David M. Findlay, Micaela J. Quinn, Ryan D. Quarrington, Lucian B. Solomon, Gerald J. Atkins Source Type: research
The proof of the pudding is in the eating
In their commentary, Tonia Vincent and Philip Conaghan ask ‘Are pro-regenerative therapies the future of OA disease modification?’ They provide some interesting examples of study results in support of their guardedly positive response to their own question. To the examples of novel findings mentioned by the authors that may prove to be important in the present context, we might add yet more targets and an emerging understanding of the diversity of cell populations in synovium and cartilage.1–4 (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 8, 2023 Category: Rheumatology Authors: L Stefan Lohmander Tags: Commentary Source Type: research
