Deletion of the Chondrocyte Glucocorticoid Receptor Attenuates Cartilage Degradation through Suppression of Early Synovial Activation in Murine Posttraumatic Osteoarthritis
Disruption of endogenous glucocorticoid signalling in bone cells attenuates osteoarthritis in aged mice, however, the role of endogenous glucocorticoids in chondrocytes is unknown. Here, we investigated whether deletion of the glucocorticoid receptor, specifically in chondrocytes, also alters osteoarthritis progression. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 24, 2023 Category: Rheumatology Authors: Eugenie Macfarlane, Lauryn Cavanagh, Colette Fong-Yee, Jan Tuckermann, Di Chen, Christopher B. Little, Markus J. Seibel, Hong Zhou Source Type: research
YAP nuclear translocation promotes anabolic activity in human articular chondrocytes
Yes-associated protein (YAP) has been widely studied as a mechanotransducer in many cell types, but its function in cartilage is controversial. The aim of this study was to identify the effect of YAP phosphorylation and nuclear translocation on the chondrocyte response to stimuli relevant to osteoarthritis (OA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 24, 2023 Category: Rheumatology Authors: Yang Cui, Michael Z. Miao, Menglin Wang, Qian Peter Su, Kunyu Qiu, Liubov Arbeeva, Susan Chubinskaya, Brian O. Diekman, Richard F. Loeser Source Type: research
Cross-talk of inflammation and chondrocyte intracellular metabolism in osteoarthritis
Osteoarthritis is a disease that impacts millions around the world, leading to significant financial and medical burden for patients and the healthcare system. However, no effective biomarkers or disease modifying therapeutics exist for the early identification and management of the disease. Inflammation drives chondrocytes to express ECM degrading enzymes and interruption of this pathway is a viable target to prevent degradation of cartilage. It has been demonstrated that inflammation can alter the intracellular metabolism of chondrocytes, a process known as metabolic reprogramming. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 22, 2023 Category: Rheumatology Authors: Manoj Arra, Yousef Abu-Amer Tags: Review Source Type: research
Response to commentary on ‘Instruments to assess appropriateness of hip and knee arthroplasty: a systematic review’
Thank you for the opportunity to respond to the issues raised in the Letter to the Editor from Drs Riddle and Ghomrawi regarding the study by Dr Pacheco-Brousseau et al.1 I would like to thank these colleagues for taking the time to express their concerns. I had the pleasure of providing an editorial to accompany the paper of note, and will respond from my perspective as an academic rheumatologist and arthroplasty health services researcher. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 22, 2023 Category: Rheumatology Authors: Gillian A. Hawker Tags: Letter to the Editor Source Type: research
Prevalence of Intra-articular Mineralization on Knee Computed Tomography: The Multicenter Osteoarthritis Study
The aim of this work was to report the prevalence of computed tomography (CT)-detected intra-articular mineralization. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 21, 2023 Category: Rheumatology Authors: Mohamed Jarraya, Ali Guermazi, Jean W. Liew, Irina Tolstykh, John A. Lynch, Piran Aliabadi, David T. Felson, Margaret Clancy, Michael Nevitt, Cora E. Lewis, James Torner, Tuhina Neogi Source Type: research
The impact of altered neural processing of nociceptive signals on physical function in people with knee OA — we know little and have much to learn
The study of altered neural processing of nociceptive signals in osteoarthritis (OA), particularly of the knee, has taken off over the past two decades, providing valuable insights into our understanding of the complexity of pain mechanisms across the disease course. It is estimated that one in five people with knee OA experiences the effects of this altered neural processing, manifesting in the peripheral and central nervous systems in what is commonly referred to as sensitization1. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 21, 2023 Category: Rheumatology Authors: Lisa C. Carlesso Tags: Editorial Source Type: research
Causal associations between serum amino acid levels and osteoarthritis: A Mendelian randomization study
The association between serum amino acid (AA) levels and osteoarthritis (OA) risk remains unclear. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 21, 2023 Category: Rheumatology Authors: Zhiyong Cui, Hui Feng, Baichuan He, Jinyao He, Hua Tian, Yun Tian Source Type: research
Unravelling the Basic Calcium Phosphate crystal-dependent chondrocyte protein secretome; a role for TGF- β signaling
Basic Calcium Phosphate crystals play an active role in the progression of osteoarthritis. However, the cellular consequences remain largely unknown. Therefore, we characterized for the first time the changes in the protein secretome of human OA articular chondrocytes as a result of BCP stimulation using two unbiased proteomic analysis methods. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 17, 2023 Category: Rheumatology Authors: Roderick H.M.J. Stassen, Guus G.H. van den Akker, Don A.M. Surtel, Bas A.C. Housmans, Andy Cremers, Marjolein M.J. Caron, Aibek Smagul, Mandy J. Peffers, Lodewijk W.van Rhijn, Tim J.M. Welting Source Type: research
Comments on ‘Instruments to assess appropriateness of hip and knee arthroplasty: a systematic review’
The paper by Pacheco-Brousseau et al. describes a systematic review of psychometric properties of appropriateness criteria for knee and hip arthroplasty — a topic of interest to us1–3. Appropriateness criteria continue to be highly relevant, especially given the substantial variation in arthroplasty utilization worldwide — a likely indicator of both over- and underuse5,6. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 16, 2023 Category: Rheumatology Authors: Daniel L. Riddle, Hassan M.K. Ghomrawi Tags: Letter to the Editor Source Type: research
Evaluation of S201086/GLPG1972, an ADAMTS-5 inhibitor, for the treatment of knee osteoarthritis in ROCCELLA: a phase 2 randomized clinical trial
To evaluate the efficacy and safety of the anti-catabolic ADAMTS-5 inhibitor S201086/GLPG1972 for the treatment of symptomatic knee osteoarthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 12, 2023 Category: Rheumatology Authors: T. Schnitzer, M. Pueyo, H. Deckx, E. van der Aar, K. Bernard, S. Hatch, M. van der Stoep, S. Grankov, D. Phung, O. Imbert, D. Chimits, K. Muller, M.C. Hochberg, H. Bliddal, W. Wirth, F. Eckstein, P.G. Conaghan Source Type: research
Synovial Fluid Mitochondrial DNA Concentration Reflects the Degree of Cartilage Damage After Naturally Occurring Articular Injury
To evaluate mitochondrial DNA (mtDNA) release from injured chondrocytes and investigate the utility of synoadvial fluid mtDNA concentration in early detection of posttraumatic osteoarthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 5, 2023 Category: Rheumatology Authors: Lindsay A. Seewald, Isabella G. Sabino, Kaylee L. Montney, Michelle L. Delco Source Type: research
Quantifying Sustained Pain Worsening in Knee Osteoarthritis
Recent work suggests that many persons with knee osteoarthritis (OA) experience stable symptoms over time. Whether patients experience periods of symptom exacerbation or flare which interrupt this stable course, and how long such periods last, has received little study. Our objective is to describe the frequency and duration of episodes of pain worsening in persons with knee OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 4, 2023 Category: Rheumatology Authors: Jamie E. Collins, Y. Heidi Yang, Maame B. Opare-Addo, Elena Losina Source Type: research
Expanding and explaining symptoms in knee osteoarthritis trajectories: fluctuations, flares, and future directions
Over the past decade, our understanding of knee osteoarthritis (OA) as a chronic long-term condition has evolved. Once primarily viewed as a chronic disease process of steady, inevitable decline, variations in the symptomatic course have now been demonstrated and replicated1. Group-based trajectory modeling, such as latent class growth models and growth mixture models, are data-driven processes designed to identify subgroups of people within longitudinal cohort datasets2. The application of these approaches to knee OA pain has identified distinct subgroups demonstrating stable pain trajectories, ranging from mild to severe...
Source: Osteoarthritis and Cartilage - April 4, 2023 Category: Rheumatology Authors: Martin J. Thomas Tags: Editorial Source Type: research
OAC 30th anniversary special issue- call for articles
2023 marks the 30th anniversary of Osteoarthritis and Cartilage, the main journal of the Osteoarthritis Research Society International (OARSI). OAC was established in 1993 by its founding Editor-in-Chief, the late Roy Altman. Through the many contributions from our community, the journal has grown into the premier journal for the dissemination of osteoarthritis content to both the research and clinical community. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 1, 2023 Category: Rheumatology Source Type: research
Relation of pain sensitization to self-reported and performance-based measures of physical functioning: the Multicenter Osteoarthritis (MOST) Study
It is unclear if alterations in nociceptive signaling contribute to poor physical functioning in persons with knee osteoarthritis (OA). We aimed to characterize the relation of pain sensitization to physical functioning in persons with or at risk for knee OA, and determine if knee pain severity mediates these relationships. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - March 30, 2023 Category: Rheumatology Authors: Patrick Corrigan, Tuhina Neogi, Laura Frey-Law, S. Reza Jafarzadeh, Neil Segal, Michael C. Nevitt, Cora E. Lewis, Joshua J. Stefanik Source Type: research
