Deletion of the Chondrocyte Glucocorticoid Receptor Attenuates Cartilage Degradation through Suppression of Early Synovial Activation in Murine Posttraumatic Osteoarthritis

Disruption of endogenous glucocorticoid signalling in bone cells attenuates osteoarthritis in aged mice, however, the role of endogenous glucocorticoids in chondrocytes is unknown. Here, we investigated whether deletion of the glucocorticoid receptor, specifically in chondrocytes, also alters osteoarthritis progression.

Source: Osteoarthritis and Cartilage - April 24, 2023 Category: Rheumatology Authors: Eugenie Macfarlane, Lauryn Cavanagh, Colette Fong-Yee, Jan Tuckermann, Di Chen, Christopher B. Little, Markus J. Seibel, Hong Zhou Source Type: research