Does the money matter? Disparities in total joint replacement outcomes by income
In the current issue of Osteoarthritis and Cartilage, Bonsel et al. used the Dutch arthroplasty register to demonstrate the socioeconomic correlates of outcomes of total joint replacement (TJR).1 They compared TJR outcomes between the lowest quintile and the highest quintile of a socioeconomic indicator based on neighborhood income, unemployment rate, and education level. The most deprived patients in the lowest quintile had a significantly lower preoperative quality of life (QOL) and health utility, which persisted after total knee joint replacement (TKR) or total hip joint replacement (THR). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - November 7, 2023 Category: Rheumatology Authors: Jasvinder A. Singh Source Type: research
Osteoarthritis year in review 2023: Biology
Great progress continues to be made in our understanding of the multiple facets of osteoarthritis (OA) biology. Here, we review the major advances in this field and progress towards therapy development over the past year, highlighting a selection of relevant published literature from a PubMed search covering the year from end of April 2022 to end of April 2023. The selected articles have been arranged in themes. These include 1) molecular regulation of articular cartilage and implications for OA, 2) mechanisms of subchondral bone remodelling, 3) role of synovium and inflammation, 4) role of age-related changes including ca...
Source: Osteoarthritis and Cartilage - November 7, 2023 Category: Rheumatology Authors: Anke J. Roelofs, Cosimo De Bari Source Type: research
Causal relationships between pain, medical treatments, and knee osteoarthritis: a graphical causal model to guide analyses
We describe a process for synthesizing expert knowledge and apply this to long-term follow-up of an RCT of treatments for meniscal tear in patients with knee osteoarthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - November 5, 2023 Category: Rheumatology Authors: Haadiya Cheema, Robert Brophy, Jamie Collins, Charles L. Cox, Ali Guermazi, Mahima Kumara, Bruce A. Levy, Lindsey MacFarlane, Lisa A. Mandl, Robert Marx, Faith Selzer, Kurt Spindler, Jeffrey N. Katz, Eleanor J Murray Source Type: research
Comparison between UK Biobank and Shanghai Changfeng suggests distinct hip morphology may contribute to ethnic differences in the prevalence of hip osteoarthritis
Joint morphology is a risk factor for hip osteoarthritis (HOA) and could explain ethnic differences in HOA prevalence. Therefore, we aimed to compare the prevalence of radiographic HOA (rHOA) and hip morphology between the predominantly White UK Biobank (UKB) and exclusively Chinese Shanghai Changfeng (SC) cohorts. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - November 5, 2023 Category: Rheumatology Authors: Jiayi Zheng, Monika Frysz, Benjamin G. Faber, Huandong Lin, Raja Ebsim, Jieyu Ge, Yanling Yong, Fiona R. Saunders, Jennifer S. Gregory, Richard M. Aspden, Nicholas C. Harvey, Bing-Hua Jiang, Timothy Cootes, Claudia Lindner, Xin Gao, Sijia Wang, Jonathan H Source Type: research
Phenotype and energy metabolism differ between osteoarthritic chondrocytes from male compared to female patients: Implications for sexual dimorphism in osteoarthritis development?
The prevalence and severity of knee osteoarthritis (OA) is greater in females than males. The purpose of this study was to determine whether there is an underlying difference in the biology of OA chondrocytes from males and females. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - November 5, 2023 Category: Rheumatology Authors: Lekha Jain, Caitlin A Jardim, Richard Yulo, Scott M Bolam, A Paul Monk, Jacob T Munro, Rocco Pitto, Jade Tamatea, Nicola Dalbeth, Raewyn C Poulsen Source Type: research
Osteoarthritis year in review 2023: Imaging
This narrative review summarizes the original research in the field of in vivo osteoarthritis (OA) imaging between 1 January 2022 and 1 April 2023. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 23, 2023 Category: Rheumatology Authors: Mohamed Jarraya, Ali Guermazi, Frank W. Roemer Tags: Review Source Type: research
Modulating Mechanobiology as a Therapeutic Target for Synovial Fibrosis to Restore Joint Lubrication
The objective of this study was to probe synovial fibroblast mechanobiology and how essential functions (i.e., lubrica tion) are altered in fibrotic environments. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 20, 2023 Category: Rheumatology Authors: Edward D. Bonnevie, Carla R. Scanzello, Robert L. Mauck Source Type: research
Radiographic Joint Space Width in Individuals with Hand Osteoarthritis: Are their “Healthy” Joints Really Healthy?
We aimed to investigate the systemic nature of hand osteoarthritis (OA). We hypothesized that people who suffer from hand OA will display narrower radiographic joint space width (JSW) - not only in joints with apparent radiographic OA but also in their unaffected “healthy” joints. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 19, 2023 Category: Rheumatology Authors: Alexander Mathiessen, Immanuel Onuoha, Rebecca Luh, Jeffrey B Driban, Mary B Roberts, Charles B Eaton, Timothy E. McAlindon, Jeffrey Duryea Source Type: research
Artificial intelligence in osteoarthritis detection: a systematic review and meta-analysis
As an increasing number of studies apply artificial intelligence (AI) algorithms in osteoarthritis (OA) detection, we performed a systematic review and meta-analysis to pool the data on diagnostic performance metrics of AI, and to compare them with clinicians ’ performance. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 18, 2023 Category: Rheumatology Authors: Soheil Mohammadi, Mohammad Amin Salehi, Ali Jahanshahi, Mohammad Shahrabi Farahani, Seyed Sina Zakavi, Sadra Behrouzieh, Mahdi Gouravani, Ali Guermazi Tags: Review Source Type: research
Longer-term quality of care, effectiveness, and cost-effectiveness of implementing a model of care for osteoarthritis: a cluster-randomized controlled trial
To assess the quality of care, effectiveness, and cost-effectiveness over 12 months after implementing a structured model of care for hip and knee osteoarthritis in primary healthcare as compared to usual care. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 13, 2023 Category: Rheumatology Authors: Nina Østerås, Eline Aas, Tuva Moseng, Leti van Bodegom-Vos, Krysia Dziedzic, Bård Natvig, Jan Harald Røtterud, Thea Vliet Vlieland, Ove Furnes, Anne Marie Fenstad, Kåre Birger Hagen Tags: Clinical Trial Source Type: research
30 years with the Knee injury and Osteoarthritis Outcome Score (KOOS)
This narrative review describes the development and use of patient-reported outcomes over 30 years, focusing on the Knee Injury and Osteoarthritis Outcome Score (KOOS). KOOS is a five-subscale patient-reported instrument intended for use from the time of knee injury to the development of OA. Numerous studies have confirmed that the psychometric properties of the KOOS and its short-form KOOS-12 are acceptable. More recent research has focused on the use and interpretation of KOOS scores in clinical trials using thresholds, such as minimal important difference, patient-acceptable symptom state, and treatment failure. (Source...
Source: Osteoarthritis and Cartilage - October 12, 2023 Category: Rheumatology Authors: Ewa M Roos Source Type: research
Association of Synovial Fluid and Urinary C2C-HUSA levels with Surgical Outcomes Post-Total Knee Arthroplasty
This study determines whether C2C levels in urine, synovial fluid, or their ratio, are associated with post-surgical outcomes. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 5, 2023 Category: Rheumatology Authors: Amit Sandhu, Osvaldo Espin-Garcia, Jason S. Rockel, Starlee Lively, Kimberly Perry, Nizar N. Mohamed, Y. Raja Rampersaud, Anthony V. Perruccio, A. Robin Poole, Rajiv Gandhi, Mohit Kapoor Source Type: research
Counsel and weight loss in knee/hip osteoarthritis
International guidelines seem to agree on very few recommendations for the treatment of knee OA, which are mostly non-pharmaceutical. Among these is that weight loss for individuals with a combination of OA in weight-bearing joints and obesity/overweight should be part of the essential advice from health professionals, aiming at a 10% weight loss1. This is an obvious suggestion, because the combination is worsened by the lack of exercise, further increasing the risk of metabolic syndrome. In summary, it is quite dangerous for these patients, who face all sorts of life-threatening comorbidities2. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 5, 2023 Category: Rheumatology Authors: Henning Bliddal Source Type: research
CCR2 monocytes as therapeutic targets for acute disc herniation and radiculopathy in mouse models
Back pain and radiculopathy caused by disc herniation are major health issues worldwide. While macrophages are key players in disc herniation induced inflammation, their roles and origin in disease progression remain unclear. We aim to study the roles of monocytes and derivatives in a mouse model of disc herniation. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 4, 2023 Category: Rheumatology Authors: Li Jin, Li Xiao, Brock J Manley, Eunha G Oh, Wendy Huang, Yi Zhang, Jialun Chi, Weibin Shi, Jason R Kerrigan, Sun-Sang J Sung, Chia-Yi Kuan, Xudong Li Source Type: research
CD206+ M2-like macrophages protect against intervertebral disc degeneration partially by targeting R-spondin-2
This study aimed to explore the specific function of M2 macrophages in intervertebral disc degeneration (IDD). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 4, 2023 Category: Rheumatology Authors: Xiao-Chuan Li, Wei Wang, Cheng Jiang, Yong-Long Chen, Jiong-Hui Chen, Zhen-Wu Zhang, Shao-Jian Luo, Rong-Chun Chen, Ping-Fan Mo, Ming-Liang Zhong, Jiang-You Shi, Chun-Ming Huang, Qin Chen, Yao-Hong Wu Source Type: research
