Cross-talk of inflammation and chondrocyte intracellular metabolism in osteoarthritis

Osteoarthritis is a disease that impacts millions around the world, leading to significant financial and medical burden for patients and the healthcare system. However, no effective biomarkers or disease modifying therapeutics exist for the early identification and management of the disease. Inflammation drives chondrocytes to express ECM degrading enzymes and interruption of this pathway is a viable target to prevent degradation of cartilage. It has been demonstrated that inflammation can alter the intracellular metabolism of chondrocytes, a process known as metabolic reprogramming.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Tags: Review Source Type: research