CCR2 monocytes as therapeutic targets for acute disc herniation and radiculopathy in mouse models
Back pain and radiculopathy caused by disc herniation are major health issues worldwide. While macrophages are key players in disc herniation induced inflammation, their roles and origin in disease progression remain unclear. We aim to study the roles of monocytes and derivatives in a mouse model of disc herniation. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 4, 2023 Category: Rheumatology Authors: Li Jin, Li Xiao, Brock J Manley, Eunha G Oh, Wendy Huang, Yi Zhang, Jialun Chi, Weibin Shi, Jason R Kerrigan, Sun-Sang J Sung, Chia-Yi Kuan, Xudong Li Source Type: research
CD206+ M2-like macrophages protect against intervertebral disc degeneration partially by targeting R-spondin-2
This study aimed to explore the specific function of M2 macrophages in intervertebral disc degeneration (IDD). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - October 4, 2023 Category: Rheumatology Authors: Xiao-Chuan Li, Wei Wang, Cheng Jiang, Yong-Long Chen, Jiong-Hui Chen, Zhen-Wu Zhang, Shao-Jian Luo, Rong-Chun Chen, Ping-Fan Mo, Ming-Liang Zhong, Jiang-You Shi, Chun-Ming Huang, Qin Chen, Yao-Hong Wu Source Type: research
Associations between Anterior Knee Pain and 2-year Patellofemoral Cartilage Worsening: The MOST Study
Anterior knee pain (AKP) is associated with patellofemoral osteoarthritis (PFOA), but longitudinal studies are lacking. If AKP precedes PFOA, it may create an opportunity to identify and intervene earlier in the disease process. The purpose of this study was to examine the longitudinal relation of AKP to worsening PF cartilage over two years. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 29, 2023 Category: Rheumatology Authors: CJ Lanois, N Collins, T Neogi, A Guermazi, FW Roemer, M LaValley, M Nevitt, J Torner, CE Lewis, JJ Stefanik Tags: Brief Report Source Type: research
Evaluation of Weight Loss Counsel for Osteoarthritis Patients: A Cross-Sectional Analysis of NHANES 2011-2018
Though health care providers (HCPs) know the importance of weight loss counsel for Osteoarthritis (OA), little is known about how frequently it is practiced and even less of its effectiveness. Thus, we analyzed the prevalence and effectiveness of weight counsel receipt in overweight/obese OA patients. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 27, 2023 Category: Rheumatology Authors: Steven R. Carlson, Nareena Imam, Ari Seidenstein, Gregg Klein Source Type: research
Microscopic and transcriptomic changes in porcine synovium one year following disruption of the anterior cruciate ligament
There is no disease-modifying treatment for posttraumatic osteoarthritis (PTOA). This may be partly due to an incomplete understanding of synovitis, which has been causally linked to PTOA progression. The microscopic and transcriptomic changes in synovium seen in early- to mid-stage PTOA were evaluated to better characterize this knowledge gap. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 22, 2023 Category: Rheumatology Authors: Jonah I. Donnenfield, Braden C. Fleming, Benedikt L. Proffen, Archana Podury, Martha M. Murray Source Type: research
Serum Proteomic Biomarkers Diagnostic of Knee Osteoarthritis
To better understand the pathogenesis of knee osteoarthritis (OA) through identification of serum diagnostics. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 19, 2023 Category: Rheumatology Authors: Virginia Byers Kraus, Alexander Reed, Erik J Soderblom, Yvonne M. Golightly, Amanda E. Nelson, Yi-Ju Li Source Type: research
Advanced glycation end products promote intervertebral disc degeneration by transactivation of matrix metallopeptidase genes
Examine the mechanism by which advanced glycation end products (AGEs) induce intervertebral disc (IVD) degeneration (IDD) in C57BL/6J mice. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 16, 2023 Category: Rheumatology Authors: Changchun Tseng, Bin Chen, Yingchao Han, Kun Wang, Qingxin Song, Hongxing Shen, Zhi Chen Source Type: research
Metabolic Phenotypes Reflect Patient Sex and Injury Status: A Cross-Sectional Analysis of Human Synovial Fluid
The objective was to compare differences in underlying cellular mechanisms and endogenous repair pathways between synovial fluid from male and female participants with different injuries to improve current understanding of the pathophysiology of downstream post-traumatic osteoarthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 15, 2023 Category: Rheumatology Authors: Hope D. Welhaven, Avery H. Welfley, Prayag Pershad, James Satalich, Robert O'Connell, Brian Bothner, Alexander R. Vap, Ronald K. June Source Type: research
Intracluster correlation coefficients in osteoarthritis cluster randomized trials: a systematic review
The design, analysis and interpretation of cluster randomized clinical trials (RCTs) requires accounting for potential correlation of observations on individuals within the same cluster. Reporting of observed intracluster correlation coefficients (ICCs) in cluster RCTs, as recommended by CONSORT, facilitates sample size calculation of future cluster RCTs and understanding of the trial statistical power. Our objective was to summarize observed ICCs in osteoarthritis (OA) cluster RCTs. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 15, 2023 Category: Rheumatology Authors: Lauren K. King, Nicolas S. Bodmer, Pakeezah Saadat, Pavlos Bobos, Gillian A. Hawker, Bruno R. da Costa Tags: Brief Report Source Type: research
Streamlining quantitative joint-wide medial femoro-tibial histopathological scoring of mouse post-traumatic knee osteoarthritis models
Histological scoring remains the gold-standard for quantifying post-traumatic osteoarthritis (ptOA) in animal models, allowing concurrent evaluation of numerous joint tissues. Available systems require scoring multiple sections/joint making analysis laborious and expensive. We investigated if a single section allowed equivalent quantitation of pathology in different joint tissues and disease stages, in three ptOA models. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 14, 2023 Category: Rheumatology Authors: Patrick Haubruck, Raban Heller, Carina L. Blaker, Elizabeth C. Clarke, Susan M. Smith, Daniel Burkhardt, Yolanda Liu, Shihani Stoner, Sanaa Zaki, Cindy C. Shu, Christopher B. Little Source Type: research
Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury
Osteoarthritis is a disease with sex-dependent prevalence and severity in both humans and animal models. We sought to elucidate sex differences in synovitis, mechanical sensitization, structural damage, bone remodeling, and the synovial transcriptome in the anterior cruciate ligament rupture (ACLR) mouse model of post-traumatic osteoarthritis (PTOA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 13, 2023 Category: Rheumatology Authors: Rachel F. Bergman, Lindsey Lammlin, Lucas Junginger, Easton Farrell, Sam Goldman, Rose Darcy, Cody Rasner, Alia M. Obeidat, Anne-Marie Malfait, Rachel E. Miller, Tristan Maerz Source Type: research
Minimal important change and difference in health outcome: an overview of approaches, concepts and methods
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 12, 2023 Category: Rheumatology Authors: Joost Dekker, Michiel de Boer, Raymond Ostelo Tags: Review Source Type: research
Minimal important change and difference in health outcome: an overview of approaches, concepts, and methods
To provide an overview of approaches, concepts and methods used to define and assess minimal important change and difference in health outcome. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 12, 2023 Category: Rheumatology Authors: Joost Dekker, Michiel de Boer, Raymond Ostelo Source Type: research
Exploring Different Models of Pain Phenotypes and Their Association with Pain Worsening in People with Early Knee Osteoarthritis: The MOST Cohort Study
To determine i) pain phenotypes (PP) in people with early-stage knee osteoarthritis (EKOA); ii) the longitudinal association between the phenotypes and pain worsening at two years. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 12, 2023 Category: Rheumatology Authors: Y V Raghava Neelapala, Tuhina Neogi, Deepak Kumar, Mohamed Jarraya, Luciana Macedo, Dylan Kobsar, Steven Hanna, Laura A Frey-Law, Cora E Lewis, Michael Nevitt, Tom Appleton, Trevor Birmingham, Lisa Carlesso Source Type: research
Hip geometric parameters are associated with radiographic and clinical hip osteoarthritis: findings from a cross-sectional study in UK Biobank
To examine the extent to which geometric parameters derived from dual-energy x-ray absorptiometry (DXA) scans in the UK Biobank study are related to hip osteoarthritis (HOA) independently of sex, age and body size. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - September 11, 2023 Category: Rheumatology Authors: SV Heppenstall, R Ebsim, FR Saunders, C Lindner, JS Gregory, RM Aspden, NC Harvey, T Cootes, JH Tobias, M Frysz, BG Faber Source Type: research
