Recommendations for the management of hip and knee osteoarthritis: a systematic review of clinical practice guidelines
Guideline adherence for hip and knee osteoarthritis management is often poor, possibly related to the quality and/or inconsistent recommendations. This systematic review of hip and knee osteoarthritis guidelines aimed to appraise the quality and consistency in recommendations across higher-quality guidelines. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 30, 2023 Category: Rheumatology Authors: Alison J Gibbs, Bimbi Gray, Jason A Wallis, Nicholas F Taylor, Joanne L Kemp, David J Hunter, Christian J Barton Tags: Review Source Type: research

Symmetry in Knee Arthrokinematics in Healthy Collegiate Athletes During Fast Running and Drop Jump Revealed through Dynamic Biplane Radiography
Changes in cartilage contact area and/or contact location after knee injury can initiate and exacerbate cartilage degeneration. Typically, the contralateral knee is used as a surrogate for native cartilage contact patterns on the injured knee. However, symmetry in cartilage contact patterns between healthy knees during high-impact activities are unknown. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 30, 2023 Category: Rheumatology Authors: Caiqi Xu, Nicholas Aloi, Tom Gale, Kyohei Nishida, Freddie Fu, William Anderst Source Type: research

BMP signaling: A significant player and therapeutic target for osteoarthritis
To explore the significance of BMP signaling in osteoarthritis (OA) etiology, and thereafter propose a disease-modifying therapy for OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 29, 2023 Category: Rheumatology Authors: Akrit Pran Jaswal, Bhupendra Kumar, Anke J. Roelofs, Sayeda Fauzia Iqbal, Amaresh Kumar Singh, Anna H.K. Riemen, Hui Wang, Sadaf Ashraf, Sanap Vaibhav Nanasaheb, Nitin Agnihotri, Cosimo De Bari, Amitabha Bandyopadhyay Source Type: research

BMP signalling: A significant player and therapeutic target for osteoarthritis
To explore the significance of BMP signaling in osteoarthritis (OA) etiology, and thereafter propose a disease-modifying therapy for OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 29, 2023 Category: Rheumatology Authors: Akrit Pran Jaswal, Bhupendra Kumar, Anke J. Roelofs, Sayeda Fauzia Iqbal, Amaresh Kumar Singh, Anna H.K. Riemen, Hui Wang, Sadaf Ashraf, Sanap Vaibhav Nanasaheb, Nitin Agnihotri, Cosimo De Bari, Amitabha Bandyopadhyay Source Type: research

T1Gd is reduced in bone marrow lesions overlying cartilage in the hip
Bone Marrow Lesions (BMLs) are areas in bone with high fluid signal on MRI associated with painful and progressive OA. While cartilage near BMLs in the knee has been shown to be degenerated, this relationship has not been investigated in the hip. Research question: is T1Gd lower in areas of cartilage overlying BMLs in the hip? (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 27, 2023 Category: Rheumatology Authors: Carly E. Jones, Jolanda Cibere, Hong Qian, Honglin Zhang, Yimeng Guo, David Russell, Bruce B. Forster, Hubert Wong, John M. Esdaile, David R. Wilson, the IMPAKT-HiP study team Tags: Clinical Trial Source Type: research

T1Gd is Reduced in Bone Marrow Lesion Overlying Cartilage in the Hip
Bone Marrow Lesions (BMLs) are areas in bone with high fluid signal on MRI associated with painful and progressive OA. While cartilage near BMLs in the knee has been shown to be degenerated, this relationship has not been investigated in the hip. Research question: is T1Gd lower in areas of cartilage overlying BMLs in the hip? (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 27, 2023 Category: Rheumatology Authors: Carly E. Jones, Jolanda Cibere, Hong Qian, Honglin Zhang, Yimeng Guo, David Russell, Bruce B. Forster, Hubert Wong, John M. Esdaile, David R. Wilson, the IMPAKT-HiP study team Tags: Clinical Trial Source Type: research

Reflections from the OARSI 2022 clinical trials symposium: The pain of OA —Deconstruction of pain and patient-reported outcome measures for the benefit of patients and clinical trial design
Osteoarthritis (OA) drug development is hampered by a number of challenges. One of the main challenges is the apparent discordance between pain and structure, which has had a significant impact on drug development programs and has led to hesitance among stakeholders. Since 2017, the Clinical Trials Symposium (CTS) has been hosted under the Osteoarthritis Research Society International (OARSI) leadership. OARSI and the CTS steering committee yearly invite and encourage discussions on selected special subject matter between regulators, drug developers, clinicians, clinical researchers, biomarker specialists, and basic scient...
Source: Osteoarthritis and Cartilage - June 26, 2023 Category: Rheumatology Authors: MA Karsdal, J Tambiah, D Felson, C Ladel, NP Nikolov, D Hodgins, AR Bihlet, T Neogi, C. Baatenburg de Jong, AC Bay-Jensen, R Baron, A Laslop, A Mobasheri, VB Kraus Tags: Review Source Type: research

Red Blood Cell Exposure Increases Chondrocyte Susceptibility to Oxidative Stress Following Hemarthrosis
The detrimental effects of blood exposure on articular tissues are well characterized, but the individual contributions of specific whole blood components are yet to be fully elucidated. Better understanding of mechanisms that drive cell and tissue damage in hemophilic arthropathy will inform novel therapeutic strategies. The studies here aimed to identify the specific contributions of intact and lysed red blood cells (RBCs) on cartilage and the therapeutic potential of Ferrostatin-1 in the context of lipid changes, oxidative stress, and ferroptosis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 24, 2023 Category: Rheumatology Authors: Andy J. Lee, Lianna R. Gangi, Fereshteh Zandkarimi, Brent R. Stockwell, Clark T. Hung Source Type: research

Artemin sensitizes nociceptors that innervate the osteoarthritic joint to produce pain
There have been significant developments in understanding artemin/GFR α3 signaling in recent years, and there is now accumulating evidence that artemin has important roles to play in pain signaling, including that derived from joint and bone, and that associated with OA. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 21, 2023 Category: Rheumatology Authors: Michael Morgan, Vida Nazemian, Li Sha Ooi, Sarah Burger, Jenny Thai, Jason Ivanusic Source Type: research

Fundamentals of Osteoarthritis: Inflammatory mediators in Osteoarthritis
As more has become known of the pathophysiology of osteoarthritis (OA), evidence that inflammation plays a critical role in its development and progression has accumulated. Here, we aim to review current knowledge of the complex inflammatory network in the OA joint. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 21, 2023 Category: Rheumatology Authors: Astrid De Roover, Ana Escribano-N úñez, Silvia Monteagudo, Rik Lories Source Type: research

Metabolic syndrome and osteoarthritis: implications for the management of an increasingly common phenotype
Metabolic syndrome is an accumulation of three or more seemingly benign and relatively common conditions (central obesity, hypertension, raised triglycerides, low HDL-cholesterol, glucose intolerance) that, together, increase the risk of developing serious chronic disease.1 It is estimated that one-quarter of adults worldwide have metabolic syndrome2 — a concerning statistic considering that this population is five times more likely to develop diabetes, and two-to-three times more likely to develop heart disease, stroke, and certain cancers. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 20, 2023 Category: Rheumatology Authors: Casey L Peiris, Adam G Culvenor Tags: Editorial Source Type: research

B cells in osteoarthritis: simply a sign or a target for therapy?
Osteoarthritis (OA) has been historically categorized as a noninflammatory arthritis, driven by mechanical wear and tear and characterized by progressive deterioration of joint structure (e.g. cartilage degeneration, subchondral bone sclerosis, osteophytosis). However, inflammation is being increasingly recognized as a contributor to joint structural damage and symptoms in OA. Specifically, synovial inflammation is associated with radiographic OA incidence, progression, and pain severity.1 –3 (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 14, 2023 Category: Rheumatology Authors: Kevin G. Burt, Carla R. Scanzello Source Type: research

The importance of context and intent when defining early-stage knee osteoarthritis
Historically, the medical and research community has focused on improving symptoms and structural progression among people with established osteoarthritis — defined by the presence of illness (patient-reported symptoms) and disease (structural changes).1 There is a compelling argument that focusing on later-stage disease has been a barrier to developing ever-elusive disease-modifying osteoarthritis interventions. These factors have predicated recent endeavors to better understand and identify the earlier stages of osteoarthritis, to test secondary prevention strategies, or to halt or slow the long-term burden of symptoma...
Source: Osteoarthritis and Cartilage - June 14, 2023 Category: Rheumatology Authors: Jeffrey B. Driban, Matthew S. Harkey, Timothy E. McAlindon, Grace H. Lo Tags: Editorial Source Type: research

A multidisciplinary lifestyle program for metabolic syndrome-associated osteoarthritis: the "Plants for Joints" randomized controlled trial
To determine the effectiveness of the “Plants for Joints” multidisciplinary lifestyle program in patients with metabolic syndrome-associated osteoarthritis (MSOA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 14, 2023 Category: Rheumatology Authors: Wendy Walrabenstein, Carlijn A. Wagenaar, Marieke van de Put, Marike van der Leeden, Martijn Gerritsen, Jos W.R. Twisk, Martin van der Esch, Henri ët van Middendorp, Peter J.M. Weijs, Leo D. Roorda, Dirkjan van Schaardenburg Source Type: research

B-cell capacity for expansion and differentiation into plasma cells are altered in osteoarthritis
Autoantibody (autoAbs) production in osteoarthritis (OA), coupled with evidence of disturbed B-cell homeostasis, suggest a potential role for B-cells in OA. B-cells can differentiate with T-cell help (T-dep) or using alternative TLR co-stimulation (TLR-dep). We analysed the capacity for differentiation of B-cells in OA versus age-matched heathy controls and compared the capacity of OA synovitis-derived stromal cells to provide support for plasma cell maturation. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - June 6, 2023 Category: Rheumatology Authors: Xuanxiao Xie, Gina M. Doody, Farag Shuweihdi, Philip G. Conaghan, Frederique Ponchel Source Type: research