Effects of strength focussed, multidisciplinary online prehabilitation on pain and function in long waiter ( & gt52 weeks) knee arthroplasty patients; the joint approach programme.
Purpose: The COVID-19 pandemic has significantly impacted the length of wait for joint replacement surgery in the UK. Consequent deterioration in patients' health and quality of life pre-operatively leads to longer lengths of stay post-operatively and inferior outcomes.The purpose of this pilot service evaluation, delivered within a UK NHS setting (Betsi Cadwaladr University Health Board (BCUHB)) was to evaluate the effectiveness of a multidisciplinary, online prehabilitation and education programme (Joint Approach) on the pain, function and quality of life of patients who had been waiting for knee replacement surgery for>...
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: C. Minshull, S. Simmons, Y. Rimmer, I. Malek, M. Brownlow Source Type: research
Evaluation of a knowledge mobilisation meeting between people with osteoarthritisandresearchers in the field of osteoarthritis.
Purpose: In 2020 we developed the online platform ‘Healthy with osteoarthritis’ for people with osteoarthritis (OA) with the purpose to exchange knowledge and experiences between people with OA and researchers in the field of OA, at first only in the region of Rijnmond, the Netherlands. Knowledge and experiences of people with OA give researche rs information about the gaps in knowledge and struggles in care of people with OA. The knowledge of researchers and health care professionals provides information for people with OA about the state of the art of OA-research and what they can expect from health care professional...
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: M. Chamoro, U. Sharma, E. Molen dijk, S.M. Bierma-Zeinstra, R. Rozendaal, M. van Middelkoop, D. Schiphof Source Type: research
A feasibility study of combined treatment using aerobic exercise and duloxetine in adults with symptomatic knee osteoarthritis and comorbid depression
Purpose: Depression is common in patients with knee OA, and clinical guidelines do not advise treating both conditions simultaneously. However, recent research recommends combining interventions that address symptoms of both conditions to maximize efficacy. Exercise improves pain, disability, and mood, but chronic pain and depression are barriers to physical activity in this population. Duloxetine is indicated to treat neuropathic pain and depression among knee OA patients and could serve as a therapeutic complement to exercise. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: A.M. Rathbun, R. Mehta, A.S. Ryan, Y. Dong, B.A. Beamer, J. Golden, J.J. Gallo, M.R. Luborsky, M.D. Shardell, J.E. Peer, M.C. Hochberg Source Type: research
Supported motivational interviewing (sumit) to improve physical activity for people with knee osteoarthritis. a pilot, feasibility randomised controlled trial.
Purpose: Our primary objective was to determine the feasibility of conducting a fully powered trial to evaluate the clinical effectiveness of using SUpported Motivational InTerviewing (SUMIT) to increase physical activity following completion of an education and exercise-therapy program (GLA:D ®) in people with knee osteoarthritis. Our secondary objective was to determine if a worthwhile treatment effect following SUMIT could be observed for device measured physical activity (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: E.C. Bell, P. O'Halloran, J.A. Wallis, K.M. Crossley, A. Gibbs, L. Annemarie, S. Jennings, C.J. Barton Source Type: research
A 12-week user trial of the intelligent knee osteoarthritis lifestyle app
Purpose: The intelligent knee osteoarthritis app (iKOALA) has been developed to extend the support for PA and musculoskeletal health, beyond short-term structured rehabilitation, using personalised PA guidance, education, and social support. The purpose of this study was to assess the impact of iKOALA on indices of musculoskeletal (MSK) health, symptoms, and phys ical activity levels in a broad range of individuals with knee osteoarthritis (KOA) over 12 weeks. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: R.D. Stevenson Source Type: research
The description of knee brace interventions for knee osteoarthritis: a review of published randomised controlled trials
Purpose: Many systematic reviews have summarised evidence from randomised controlled trials (RCTs) on the clinical effectiveness of knee bracing for knee osteoarthritis (OA). However, a detailed synthesis of the descriptions of the actual bracing interventions tested is lacking. The absence of full descriptions of these complex interventions could limit efforts to replicate and extend research findings as well as hamper reliable implementation in clinical practice. We therefore aimed to synthesise and critically evaluate the content and quality of intervention descriptions in published RCTs of bracing for knee OA according...
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: M. Holden, M. Murphy, J. Simkins, M. Thomas, J. Quicke, L. Huckfield, G. Peat, the PROP OA Trial Team Source Type: research
The impact of covid-19 lockdown on older adults with persistent joint pain: objective and self-reported measures of physical activity, walking and sedentary behaviour
Purpose: In the United Kingdom (UK) rates of physical inactivity are particularly marked in older people aged 65 years and over. Persistent joint pain is one of the most common symptoms in older adults with up to 90% of all persistent pain related to the musculoskeletal system. Given levels of physical activity in older people and people with joint pain were already lower than the general population before the COVID-19 pandemic, there is a need to investigate the impact of ‘lockdowns’ on physical activity, walking and sedentary behaviour, in order to make recommendations about how to maintain or increase physical activ...
Source: Osteoarthritis and Cartilage - April 29, 2023 Category: Rheumatology Authors: E.L. Healey, E. Nicholls, C. Woodcock, C.A. Chew-Graham, S.A. Lawton, C. Jinks, the iPOPP study team Source Type: research
Persistent Underloading of Patellofemoral Joint following Hamstring Autograft ACL Reconstruction is Associated with Cartilage Health
To determine the longitudinal changes of patellofemoral joint (PFJ) contact pressure following anterior cruciate ligament reconstruction (ACLR). To identify the associations between PFJ contact pressure and cartilage health. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 25, 2023 Category: Rheumatology Authors: Tzu-Chieh Liao, Alyssa Bird, Michael A. Samaan, Valentina Pedoia, Sharmila Majumdar, Richard B. Souza Source Type: research
A functional genomics approach reveals suggestive quantitative trait loci associated with combined TLR4 and BCP crystal-induced inflammation and osteoarthritis
Basic calcium phosphate (BCP) crystals can activate the NLRP3 inflammasome and are potentially involved in the pathogenesis of osteoarthritis (OA). In order to elucidate relevant inflammatory mechanisms in OA, we used a functional genomics approach to assess genetic variation influencing BCP crystal-induced cytokine production. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 25, 2023 Category: Rheumatology Authors: Viola Kl ück, Collins K. Boahen, Brenda Kischkel, Jéssica C. Dos Santos, Vasiliki Matzaraki, Cindy G. Boer, Joyce B.J. van Meurs, Genetics of Osteoarthritis (GO) consortium, Kiki Schraa, Heidi Lemmers, Helga Dijkstra, Megan P. Leask, Tony R. Merriman, T Source Type: research
Yes-associated protein nuclear translocation promotes anabolic activity in human articular chondrocytes
Yes-associated protein (YAP) has been widely studied as a mechanotransducer in many cell types, but its function in cartilage is controversial. The aim of this study was to identify the effect of YAP phosphorylation and nuclear translocation on the chondrocyte response to stimuli relevant to osteoarthritis (OA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 24, 2023 Category: Rheumatology Authors: Y. Cui, M.Z. Miao, M. Wang, Q.P. Su, K. Qiu, L. Arbeeva, S. Chubinskaya, B.O. Diekman, R.F. Loeser Source Type: research
Serum Tryptophan Metabolites are Associated with Erosive Hand Osteoarthritis and Pain: Results from the DIGICOD Cohort
To investigate host and gut-microbiota related Tryptophan metabolism in hand osteoarthritis (HOA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 24, 2023 Category: Rheumatology Authors: Marie Binvignat, Patrick Emond, Francois Mifsud, Brenda Miao, Alice Courties, Antoine Lef èvre, Emmanuel Maheu, Michel D. Crema, David Klatzmann, Margreet Kloppenburg, Pascal Richette, Atul J. Butte, Encarnita Mariotti-Ferrandiz, Francis Berenbaum, Harry Source Type: research
Deletion of the Chondrocyte Glucocorticoid Receptor Attenuates Cartilage Degradation through Suppression of Early Synovial Activation in Murine Posttraumatic Osteoarthritis
Disruption of endogenous glucocorticoid signalling in bone cells attenuates osteoarthritis in aged mice, however, the role of endogenous glucocorticoids in chondrocytes is unknown. Here, we investigated whether deletion of the glucocorticoid receptor, specifically in chondrocytes, also alters osteoarthritis progression. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 24, 2023 Category: Rheumatology Authors: Eugenie Macfarlane, Lauryn Cavanagh, Colette Fong-Yee, Jan Tuckermann, Di Chen, Christopher B. Little, Markus J. Seibel, Hong Zhou Source Type: research
YAP nuclear translocation promotes anabolic activity in human articular chondrocytes
Yes-associated protein (YAP) has been widely studied as a mechanotransducer in many cell types, but its function in cartilage is controversial. The aim of this study was to identify the effect of YAP phosphorylation and nuclear translocation on the chondrocyte response to stimuli relevant to osteoarthritis (OA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 24, 2023 Category: Rheumatology Authors: Yang Cui, Michael Z. Miao, Menglin Wang, Qian Peter Su, Kunyu Qiu, Liubov Arbeeva, Susan Chubinskaya, Brian O. Diekman, Richard F. Loeser Source Type: research
Cross-talk of inflammation and chondrocyte intracellular metabolism in osteoarthritis
Osteoarthritis is a disease that impacts millions around the world, leading to significant financial and medical burden for patients and the healthcare system. However, no effective biomarkers or disease modifying therapeutics exist for the early identification and management of the disease. Inflammation drives chondrocytes to express ECM degrading enzymes and interruption of this pathway is a viable target to prevent degradation of cartilage. It has been demonstrated that inflammation can alter the intracellular metabolism of chondrocytes, a process known as metabolic reprogramming. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 22, 2023 Category: Rheumatology Authors: Manoj Arra, Yousef Abu-Amer Tags: Review Source Type: research
Response to commentary on ‘Instruments to assess appropriateness of hip and knee arthroplasty: a systematic review’
Thank you for the opportunity to respond to the issues raised in the Letter to the Editor from Drs Riddle and Ghomrawi regarding the study by Dr Pacheco-Brousseau et al.1 I would like to thank these colleagues for taking the time to express their concerns. I had the pleasure of providing an editorial to accompany the paper of note, and will respond from my perspective as an academic rheumatologist and arthroplasty health services researcher. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 22, 2023 Category: Rheumatology Authors: Gillian A. Hawker Tags: Letter to the Editor Source Type: research
