Unraveling sex-specific risks of knee osteoarthritis before menopause: Do sex differences start early in life?

Sufficient evidence within the past two decades have shown that osteoarthritis (OA) has a sex-specific component. However, efforts to reveal the biological causes of this disparity have emerged more gradually. In this narrative review, we discuss anatomical differences within the knee, incidence of injuries in youth sports, and metabolic factors that present early in life (childhood and early adulthood) that can contribute to a higher risk of OA in females.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Tags: Review Source Type: research