Identification of salivary volatile organic compounds as potential markers of stomach and colorectal cancer: A pilot study
Publication date: Available online 29 May 2020Source: Journal of Oral BiosciencesAuthor(s): Lyudmila V. Bel’skaya, Elena A. Sarf, Sergey P. Shalygin, Tatyana V. Postnova, Victor K. Kosenok (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 29, 2020 Category: Biomedical Science Source Type: research

Oral lichen planus: a chronic inflammatory model to study the regulation of the Toll-like receptor signaling in oral keratinocytes
Publication date: Available online 26 May 2020Source: Journal of Oral BiosciencesAuthor(s): Yuliana Andrea Osorio-Osorno, Mónica Tatiana Parada-Sanchez, Julian Camilo Arango, David Arboleda Toro (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 27, 2020 Category: Biomedical Science Source Type: research

Bovine lactoferrin enhances osteogenesis through Smad2/3 and p38 MAPK activation
Publication date: Available online 25 May 2020Source: Journal of Oral BiosciencesAuthor(s): Toshihiro Inubushi, Azuma Kosai, Shyunryo Yanagisawa, Chea Chanbora, Mutsumi Miyauchi, Satoshi Yamasaki, Eiji Sugiyama, Atsushi Ishikado, Taketoshi Makino, Takashi Takata (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 26, 2020 Category: Biomedical Science Source Type: research

Inflammatory and fibroblastic effects of azithromycin on cyclosporine-induced gingival overgrowth in renal transplanted patients with and without scaling: A randomized clinical trial
Publication date: Available online 18 May 2020Source: Journal of Oral BiosciencesAuthor(s): Sarah Beihaghi, Mohammad Mohammadi, Mohammad Reza Zarei, Jalal Azmandian, Hamidreza Baghani Aval, Mohammad Sahebkar (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 20, 2020 Category: Biomedical Science Source Type: research

Effect of salivary secretion with mouthguard use on seasonal allergic rhinitis symptom improvement
Publication date: Available online 11 May 2020Source: Journal of Oral BiosciencesAuthor(s): Nobuyuki Tani-Ishii, Koichiro Muromachi, Noriko Mutoh, Jiro Suzuki, Kaori Shimojima, Ryuji Fujimaki, Hajime Kezuka, Taiki Koba, Kyo Ta (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 12, 2020 Category: Biomedical Science Source Type: research

Drinking green tea alleviates alveolar bone resorption in ligature-induced periodontitis in mice
Publication date: Available online 8 May 2020Source: Journal of Oral BiosciencesAuthor(s): Boosana Kaboosaya, Lia Kartika Wulansari, V.N. Trang Nguyen, Shohei Kasugai (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 9, 2020 Category: Biomedical Science Source Type: research

Amixicile depletes the ex vivo periodontal microbiome of anaerobic bacteria
Publication date: Available online 9 April 2020Source: Journal of Oral BiosciencesAuthor(s): Qin Gui, Kane Ramsey, Paul S. Hoffman, Janina P. Lewis (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 14, 2020 Category: Biomedical Science Source Type: research

Effects of N-methyl-D-aspartate receptor antagonist MK-801 (dizocilpine) on bone homeostasis in mice
Publication date: Available online 11 April 2020Source: Journal of Oral BiosciencesAuthor(s): Shuichi Kiyohara, Nobuhiro Sakai, Kazuaki Handa, Tomoyuki Yamakawa, Koji Ishikawa, Masahiro Chatani, Akiko Karakawa, Yuki Azetsu, Motohiro Munakata, Masahiko Ozeki, Takako Negishi-Koga, Masamichi Takami (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 13, 2020 Category: Biomedical Science Source Type: research

Amixicile depletes the ex vivo periodontal microbiome of anaerobic bacteria
Publication date: Available online 9 April 2020Source: Journal of Oral BiosciencesAuthor(s): Qin Gui, Kane Ramsey, Paul S. Hoffman, Janina P. Lewis (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 11, 2020 Category: Biomedical Science Source Type: research

High Microbicidal Effect of Peroxynitric Acid on Biofilm-Infected Dentin in a Root Carious Tooth Model and Verification of Tissue S afety
Publication date: Available online 6 April 2020Source: Journal of Oral BiosciencesAuthor(s): Tatsuya Iwaki, Tomoko Ohshima, Tatsuya Tasaki, Yasuko Momoi, Satoshi Ikawa, Katsuhisa Kitano, Takatsugu Yamamoto (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 6, 2020 Category: Biomedical Science Source Type: research

Intermittent administration of parathyroid hormone improves bone quality and quantity around implants in rat tibiae
Publication date: Available online 6 April 2020Source: Journal of Oral BiosciencesAuthor(s): Yusuke Uchida, Shinichiro Kuroshima, Yusuke Uto, Riho Kanai, Maaya Inoue, Masayoshi Suzue, Takashi Sawase (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 6, 2020 Category: Biomedical Science Source Type: research

In vitro characteristics of human periodontal ligament stem cells incubated with boric acid
Publication date: Available online 17 March 2020Source: Journal of Oral BiosciencesAuthor(s): Thuy Anh Vu Pham (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 21, 2020 Category: Biomedical Science Source Type: research

Editorial Board
Publication date: March 2020Source: Journal of Oral Biosciences, Volume 62, Issue 1Author(s): (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 20, 2020 Category: Biomedical Science Source Type: research

In vitro characteristics of human periodontal ligament stem cells incubated with boric acid
Publication date: Available online 17 March 2020Source: Journal of Oral BiosciencesAuthor(s): Thuy Anh Vu Pham (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 18, 2020 Category: Biomedical Science Source Type: research

Analysis of plaque microbiota and salivary proteins adhering to dental materials
Publication date: Available online 6 March 2020Source: Journal of Oral BiosciencesAuthor(s): Yoko Mukai, Mana Torii, Yu Urushibara, Tomomi Kawai, Yasuharu Takahashi, Maeda Nobuko, Chikahiro Ohkubo, Tomoko Ohshima (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 7, 2020 Category: Biomedical Science Source Type: research

Oral Biosciences: The annual review 2019
Publication date: Available online 25 February 2020Source: Journal of Oral BiosciencesAuthor(s): Hayato Ohshima, Norio Amizuka (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - February 26, 2020 Category: Biomedical Science Source Type: research

Repair processes of flat bones formed via intramembranous versus endochondral ossification
ConclusionOur study findings clarify the differences between parietal bone and scapula repair and suggest that the bone repair process differs among ossification patterns. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - February 19, 2020 Category: Biomedical Science Source Type: research

Osteoclastogenesis in Periodontal Diseases: Possible Mediators and Mechanisms
ConclusionIn this review, we summarize the mechanism of osteoclastogenesis accompanying periodontal diseases at the cellular level. We discuss a) the effects of LPS/TLR signaling and other cytokines on RANKL-dependent and -independent mechanisms involved in osteoclastogenesis; b) the recently identified role of several endogenous factors such as miRNA, IL-22, M1/M2 macrophages, and memory B cells in regulating osteoclastogenesis during periodontal pathogenesis. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - February 18, 2020 Category: Biomedical Science Source Type: research

Investigation of the antimicrobial activity of Bilberry (Vaccinium myrtillus L.) extract against periodontopathic bacteria
ConclusionBilberry contains antibacterial components against periodontopathic bacteria, such as P. gingivalis, F. nucleatum, and P. intermedia. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - February 12, 2020 Category: Biomedical Science Source Type: research

Vitamin C and eggshell membrane facilitate orthodontic tooth movement and induce histological changes in the periodontal tissue
ConclusionsThis study revealed that the combined administration of VC and ESM accelerated tooth movement by protecting the periodontal tissue during orthodontic treatment. The combined clinical application of VC and ESM could potentially shorten orthodontic treatment time. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - February 5, 2020 Category: Biomedical Science Source Type: research

DKK3 expression and function in head and neck squamous cell carcinoma and other cancers
ConclusionOur previously published data, alongside those from other reports, indicate that DKK3 may have an additional oncogenic function other than tumor suppression. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - February 5, 2020 Category: Biomedical Science Source Type: research

Atypical immunohistochemical patterns can complement the histopathological diagnosis of oral premalignant lesions
ConclusionThe proposed atypical IHC patterns might serve as useful markers to supplement the morphological diagnosis of OPLs, and established IHC methods for Ki-67 and TP53 might provide stable results. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - February 2, 2020 Category: Biomedical Science Source Type: research

Comparison of CD34 Expression in Fibrous Reactive Hyperplasia and Healthy Oral Mucosa
ConclusionsThese findings suggest that the increase in collagen synthesis in CD34-positive fibroblasts in the submucosa leads to the development of FRH. To our knowledge, this is the first report confirming the mRNA expression patterns of CD34 in FRH. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 31, 2020 Category: Biomedical Science Source Type: research

PLAG1 enhances the stemness profiles of acinar cells in normal human salivary glands in a cell type-specific manner
ConclusionPLAG1 enhanced the stemness profiles in the acinar cells of normal human salivary glands in a cell type-specific manner. Thus, it may be involved in salivary gland tumorigenesis by increasing the stemness character of the normal salivary gland cells. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 31, 2020 Category: Biomedical Science Source Type: research

Lipopolysaccharide (LPS) inhibits ectopic bone formation induced by bone morphogenetic protein-2 and TGF-β1 through IL-1β production
ConclusionsLPS suppresses the ectopic bone formation induced by BMP-2 and TGF-β1 through IL-1β production. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 26, 2020 Category: Biomedical Science Source Type: research

Quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone: An all-rounder in mammalian cell modification
ConclusionThe purpose of this review is to identify a valid target for quenching OdDHL, which could potentially eliminate the pathogenic effect of P. aeruginosa. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 24, 2020 Category: Biomedical Science Source Type: research

Degree of conversion and microhardness of bulk-fill dental composites polymerized by LED and QTH light curing units
ConclusionsThe polymerization efficacies of the two bulk-fill composites were different in terms of the depth of cure and type of light source. The DC and microhardness of the X-tra fill bulk-fill composite polymerized by either QTH or LED did not decrease up to a thickness of 4 mm. Thus, new generations of LED light sources are better options for polymerizing the bulk-fill resin composites than QTH. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - December 20, 2019 Category: Biomedical Science Source Type: research

High-fat diet increases labial groove formation in maxillary incisors and is related to aging in C57BL/6 mice
ConclusionsThe study findings indicate that, in C57BL/6 mice, consumption of a high-fat diet increases labial groove formation in maxillary incisors, which is related to aging of the tissue stem cells in the apical root end of the teeth. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - December 18, 2019 Category: Biomedical Science Source Type: research

Molecular mechanisms in palatal rugae development
ConclusionThis review highlights the current understanding of the molecular mechanisms of palatal rugae development. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - December 18, 2019 Category: Biomedical Science Source Type: research

Oral stem cells in intraoral bone formation
ConclusionOral stem cells have excellent potential for bone formation and can be successfully used to replace traditionally used bone marrow stem cells. Some sources like stem cells from human exfoliated deciduous teeth (SHED), dental follicle stem cells (DFSC), Stem Cells from Apical Papilla (SCAP), and others need assessment beyond animal models and require human studies for clinical use. More clinical trials of randomized nature are suggested to standardize the clinical procedure and strengthen the claim of oral stem cells as potential replacement of bone marrow counterparts. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - December 18, 2019 Category: Biomedical Science Source Type: research

Noggin inhibition of mouse dentinogenesis
ConclusionsThe phenotypes we observed in Noggin-overexpressing and Smad4-conditional knockout teeth resemble the phenotype of Dentinogenesis Imperfecta (DGI) type III. Our results show that BMPs regulate post-natal dentinogenesis and that BMP-inhibitory proteins like Noggin play a role in that regulation. The increased severity of the Smad4 phenotype indicates that Tgfß ligands, in addition to BMPs, play a crucial role in post-developmental dentinogenesis. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - December 18, 2019 Category: Biomedical Science Source Type: research

Fabrication of Calcium Phosphate Composite Polymer/SLS-stabilized Emulsion-based Bioactive Gels and Their Application for Dentine Tubule Occlusion
ConclusionsThe bioactive gels were effectively used as bioactive fillers to occlude exposed human dentine tubules.Graphical abstract (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - December 17, 2019 Category: Biomedical Science Source Type: research

Editorial Board
Publication date: December 2019Source: Journal of Oral Biosciences, Volume 61, Issue 4Author(s): (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - December 10, 2019 Category: Biomedical Science Source Type: research

How the diversity of the faces arises
ConclusionWe have gained much knowledge with respect to cis-regulatory elements, gene expression, cellular behavior, and the physical forces in facial development in the past two decades. Significant interdisciplinary work is needed to integrate these varied pieces of information into a complete picture of how the diversity of faces arises. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - November 18, 2019 Category: Biomedical Science Source Type: research

Amixicile targets anaerobic bacteria within the oral microbiome
ConclusionsCollectively, our data expand on the so far reported inhibitory spectrum of amixicile and demonstrates that it inhibits anaerobic bacteria, including both clinical isolates and laboratory strains.Graphical abstract (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - November 7, 2019 Category: Biomedical Science Source Type: research

Histopathological analysis of the differential diagnosis of peripheral odontogenic fibroma from fibrous epulis
Publication date: Available online 25 October 2019Source: Journal of Oral BiosciencesAuthor(s): Kei Manabe, Mayumi Yakeishi, Wakako Sakaguchi, Juri Saruta, Keiichi TsukinokiAbstractObjectivesPeripheral odontogenic fibroma (POF) is a relatively rare odontogenic tumor of the gingiva. Although its histological differential diagnosis from fibrous epulis (FE) is important, no study has reported the differences in their expression of immunohistochemical markers. Here, we compared the expression of tumor markers that are frequently used for the differential diagnosis of fibroproliferative lesions between POF and FE.MethodsForty c...
Source: Journal of Oral Biosciences - October 26, 2019 Category: Biomedical Science Source Type: research

Dietary constituent genistein inhibits the hyperexcitability of trigeminal nociceptive neurons associated with mechanical hyperalgesia following orofacial inflammation
ConclusionHerein, we present the first evidence that genistein attenuates hyperexcitability of SpVc neurons associated with inflammatory mechanical hyperalgesia. These findings suggest that genistein could be a potential therapeutic agent in complementary alternative medicine for the prevention of trigeminal inflammatory hyperalgesia. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - October 26, 2019 Category: Biomedical Science Source Type: research

Spectroscopic analyses reveal radiotherapy-induced variations in elemental composition and crystallite properties of human permanent teeth envamel
Publication date: Available online 25 October 2019Source: Journal of Oral BiosciencesAuthor(s): Jagadish Kudkuli, Riaz Abdulla, P.D. Rekha, S.D. Sharma, Omprakash GurjarAbstractObjectiveTo study the effect of radiation therapy on the structural and elemental composition of permanent teeth enamel in vitro.MethodsSections from 21 noncarious healthy human teeth were exposed to a cumulative radiation dose of 20 - 80 Gy. The sections were subjected to electron dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis to study the elemental composition, the ratio of inorga...
Source: Journal of Oral Biosciences - October 26, 2019 Category: Biomedical Science Source Type: research

The rise in glucose concentration in saliva samples mixed with test foods monitored using a glucometer: An observational pilot study
ConclusionsThis pilot study presents glucose release rate characteristics from specific food particles mixed with saliva in vitro suggesting that the same process takes place in the oral cavity. However, the characteristics of this process when occurring in the mouth would expectedly be modified by different factors such as rinsing effect of salivary flow, oral temperature, etc. Prolonged release of low molecular carbohydrates such as maltose and glucose from food particles can be considered cariogenic and therefore unfavorable for individuals with other risk factors contributing to the development of dental caries. (Sourc...
Source: Journal of Oral Biosciences - October 25, 2019 Category: Biomedical Science Source Type: research

Editorial Board
Publication date: September 2019Source: Journal of Oral Biosciences, Volume 61, Issue 3Author(s): (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - September 12, 2019 Category: Biomedical Science Source Type: research

Dynamic Photoacoustic Imaging Of Neurovascular Coupling In Salivary Glands
Publication date: Available online 3 September 2019Source: Journal of Oral BiosciencesAuthor(s): Laurie J. Rich, Eftekhar Rajab Bolookat, Mukund SeshadriAbstractThe purpose of this study was to apply photoacoustic imaging (PAI), a relatively new imaging method, to non-invasively map neurovascular dynamics in salivary glands. Dynamic PAI with co-registered ultrasound (US) was performed in mice to monitor salivary gland hemodynamics in response to exogenous muscarinic receptor stimulation (pilocarpine) and blockade (atropine). Pilocarpine increased salivary gland oxygen saturation (%sO2) within minutes after administration, ...
Source: Journal of Oral Biosciences - September 4, 2019 Category: Biomedical Science Source Type: research

Regulation of IGF-I by IGFBP3 and IGFBP5 during odontoblast differentiation in mice
ConclusionThe present study demonstrated the expression patterns of IGF-I, IGF-IR, IGFBP3, and IGFBP5 during odontoblast differentiation in mouse incisors. These results suggested that IGFBP3 regulates the transition from the proliferative to differentiation stage by inhibiting the action of IGF-I on the proliferation of dental papilla cells, and that IGFBP5 plays an important role in the maintenance of the differentiated odontoblasts during tooth development. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 17, 2019 Category: Biomedical Science Source Type: research

Novel effects of rooibos extract on tear and saliva secretion mediated by the muscarinic acetylcholine receptor 3 in mice
ConclusionThese results suggest that RE administration is an effective treatment for symptoms of dryness and may be used in clinical settings against sicca syndrome. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 9, 2019 Category: Biomedical Science Source Type: research

Degradation of extracellular matrices propagates calcification during development and healing in bones and teeth
ConclusionThe ECM proteins may inhibit mineral deposition and calcification, similar to the role of amelogenin during enamel development. The candidates for the amelogenin equivalents in bone and dentin have not been identified. Further studies are required to elucidate the regulatory mechanisms of bone and dentin calcification in light of specific ECM proteins that prevent calcification and enzymes that degrade these ECM proteins. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 9, 2019 Category: Biomedical Science Source Type: research

Regulation of IGF-1 by IGFBP3 and IGFBP5 during odontoblast differentiation in mice
ConclusionThe present study demonstrated the expression patterns of IGF-1, IGF-1R, IGFBP3, and IGFBP5 during odontoblast differentiation in mouse incisors. These results suggested that IGFBP3 regulates the transition from the proliferative to differentiation stage by inhibiting the action of IGF-1 on the proliferation of dental papilla cells, and that IGFBP5 plays an important role in the maintenance of the differentiated odontoblasts during tooth development. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 9, 2019 Category: Biomedical Science Source Type: research

Correlation of plasma osteopontin and osteocalcin with lower renal function in dental patients with carotid artery calcification and tooth loss
Publication date: Available online 7 August 2019Source: Journal of Oral BiosciencesAuthor(s): Supanee Thanakun, Chantida Pawaputanon Na Mahasarakham, Suchaya Pornprasertsuk-Damrongsri, Yuichi IzumiAbstractObjectivesTo investigate plasma osteopontin (OPN) and osteocalcin (OCN) levels in dental patients with carotid artery calcification (CAC) and determine the correlations between these proteins and renal function and tooth loss.MethodsThe health parameters and number of teeth of 99 participants were recorded. Panoramic radiographs were taken for CAC evaluation, and OPN and OCN levels were measured.ResultsNone of the partici...
Source: Journal of Oral Biosciences - August 9, 2019 Category: Biomedical Science Source Type: research

Regulation of osteoclast function via Rho-Pkn3-c-Src pathways
ConclusionWnt5a-Ror2 signaling promotes the bone-resorbing activity of osteoclasts by activating the Daam2-Rho-Pkn3-c-Src pathways. Pkn3 inhibitors, therefore, have potential as therapeutic agents for osteoporosis and bone destruction in inflammatory diseases. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 9, 2019 Category: Biomedical Science Source Type: research

Molecular and cellular basis of hypophosphatasia
ConclusionMolecular characterization of TNSALP mutants helps establish the etiology and onset of HPP. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 9, 2019 Category: Biomedical Science Source Type: research

Comparative assessment of the crystalline structures of powder and bulk human dental enamel by X-ray diffraction analysis
ConclusionsThe results of this study revealed that the sample preparation method for human tooth enamel can affect the crystalline data obtained from XRD analysis. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 12, 2019 Category: Biomedical Science Source Type: research

Porcine keratin 75 in developing enamel
ConclusionWe propose that K75 is present in the developing enamel and undergoes different processing/degradation compared to other enamel proteins. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 27, 2019 Category: Biomedical Science Source Type: research