Identification and characterization of novel human papillomaviruses in oral rinse samples from oral cavity and oropharyngeal cancer patients
ConclusionsOur results demonstrated that there are novel HPVs present in oral rinse samples that may be associated with OCC and OPC. These novel HPVs can be identified and characterized using NGS techniques. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 25, 2019 Category: Biomedical Science Source Type: research

Analysis of oral microbiota in Japanese oral cancer patients using 16S rRNA sequencing
This study aimed to clarify the relationship between oral cancer and oral microbiota in Japanese patients.MethodsDNA was extracted from salivary samples of 60 oral cancer patients and 80 non-cancer individuals as controls. We performed metagenomic analysis using 16S rRNA amplicon sequencing. Statistical analysis in this study was performed using R (version 3.5.0).ResultsOral cancer patients showed higher α-diversity compared to the control group, and the β-diversity between the two groups differed significantly. Further, there was a significant difference in the abundance ratio of bacterial genera between the tw...
Source: Journal of Oral Biosciences - May 16, 2019 Category: Biomedical Science Source Type: research

Phospholipase C-related catalytically inactive protein: A novel signaling molecule for modulating fat metabolism and energy expenditure
ConclusionWe propose PRIP as a new therapeutic target for controlling obesity or developing novel anti-obesity drugs. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 16, 2019 Category: Biomedical Science Source Type: research

Alternating lamellar structure in human cellular cementum and rat compact bone: its structure and formation
ConclusionOur data showed that the alternating lamellar structure was consistent with the twisted plywood model previously proposed for osteonal lamellae. For the formation of this structure, there have been two major hypotheses: a self-assembly hypothesis and a cellular control hypothesis. Our data support the latter; osteoblasts and cementoblasts move their processes synchronously and periodically to control fibril arrangement, thereby forming the alternating lamellar structure. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 16, 2019 Category: Biomedical Science Source Type: research

Degree of orientations of collagen fibers and bone apatite crystals in rat femora by infrared dichroism imaging
ConclusionsPoorly crystalline apatite in the rat femoral cortical bone was aligned along the collagen fibers. The degree of poorly crystalline apatite orientation and collagen fiber orientation in the femoral cortical bone increased until at least 33 weeks; meanwhile, on aging, the stoichiometric hydroxyapatite crystal was not longitudinally aligned. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 16, 2019 Category: Biomedical Science Source Type: research

Medication-related Osteonecrosis of the Jaw: A Literature Review
ConclusionCaution should be taken when dental treatment including implant therapy is performed in patients receiving bisphosphonates, denosumab, and anti-angiogenesis agents. There is limited scientific evidence regarding the relationship between MRONJ and older age. Further ONJ-related research on the aging population is required to manage the treatment of such diseases in older people in the future. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 16, 2019 Category: Biomedical Science Source Type: research

Dental restorative composite materials: A review
ConclusionIt revealed that nanofiller particles enhance the properties of various dental composite materials. The hybrid dental composites also contribute significantly in increasing the mechanical and tribological properties. A silane-treated filler improved the dental composite bonding strength.Graphical abstract (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 16, 2019 Category: Biomedical Science Source Type: research

Periodontal Disease and Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficiency: Is There a Nexus?
ConclusionPeriodontal diseases feature systemic loading of reactive oxygen species, and they may increase the risk of hemolysis in individuals with G6PD deficiency. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 24, 2019 Category: Biomedical Science Source Type: research

Recent Trends of Saliva Omics Biomarkers for the Diagnosis and Treatment of Oral Cancer
ConclusionIn this review, we summarize the potential of omics derived salivary biomarkers as diagnostic and prognostic tools in oral cancer detection and the future clinical benefits associated with these markers.Graphical abstract (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 24, 2019 Category: Biomedical Science Source Type: research

Mechanisms underlying the induction of regulatory T cells by sublingual immunotherapy
ConclusionOral CD103−CD11b+ cDCs are specialized for the induction of Treg cells in mice; thus, targeting their human counterpart may enhance the therapeutic effects of SLIT.Graphical abstract (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 8, 2019 Category: Biomedical Science Source Type: research

Bone metastasis: interaction between cancer cells and bone microenvironment
ConclusionContinued studies are warranted to understand the molecular mechanisms underlying bone metastases and to develop mechanism-based and effective therapeutic interventions. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 6, 2019 Category: Biomedical Science Source Type: research

Oral biosciences: The annual review 2018
ConclusionThese reviews published in the Journal of Oral Biosciences have inspired the readers of the Journal to broaden their knowledge of various aspects in the oral biosciences. This editorial review summarizes these exciting articles. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - February 2, 2019 Category: Biomedical Science Source Type: research

Pain mechanism of oral ulcerative mucositis and the therapeutic traditional herbal medicine hangeshashinto
ConclusionElucidation of the pain mechanism of oral ulcerative mucositis and analgesic mechanism of hangeshashinto will allow identification of novel therapeutic approaches against oral ulcerative mucositis-induced pain in patients. The traditional Japanese herbal medicine hangeshashinto is a reliable drug with supporting scientific evidence. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 30, 2019 Category: Biomedical Science Source Type: research

Oral Biosciences: The annual review, 2018
ConclusionThese reviews published in the Journal of Oral Biosciences have inspired the readers of the Journal to broaden their knowledge of various aspects in the oral biosciences. This editorial review summarizes these exciting articles. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 29, 2019 Category: Biomedical Science Source Type: research

Three-dimensional configuration of apical epithelial compartments including stem cell niches in guinea pig cheek teeth
ConclusionsOur findings suggest that guinea pig cheek teeth have three ABs, and the complex configuration of these types of teeth may be attributed to the prompt formation of crown-analogue dentin followed by the long-term formation of root-analogue dentin.Graphical abstract (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 22, 2019 Category: Biomedical Science Source Type: research

RANKL-independent modulation of osteoclastogenesis
Publication date: Available online 11 January 2019Source: Journal of Oral BiosciencesAuthor(s): Wei Feng, Jie Guo, Minqi LiAbstractOsteoclasts are functional cells required for bone resorption. They are derived from hematopoietic precursors and undergo a series of differentiation and fusion steps in response to various humoral factors. Depending on the importance in osteoclastogenesis, the pathways for the differentiation of hematopoietic precursors to mature osteoclasts can be divided into two categories: canonical and the non-canonical. Receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast forma...
Source: Journal of Oral Biosciences - January 12, 2019 Category: Biomedical Science Source Type: research

Honey in oral health and care: a mini review
ConclusionFor the first time this review addresses the usefulness of honey against Streptococcus mutans infections, dental plaque and caries, gingivitis and halitosis. Honey was also useful in preventing side effects associated with treatment of cancers of the head and neck, namely, radiation induced mucositis, xerostomia and poor wound healing. This is well supported by evidence in literature and was examined in this review.Graphical abstract (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 4, 2019 Category: Biomedical Science Source Type: research

Potential function of TGF-β isoforms in maturation-stage ameloblasts
ConclusionsWe propose that TGF-β is regulated in an isoform-specific manner to perform multiple biological functions such as gene expression related to the structure of basal lamina/ameloblasts, mineral ion transport, apoptosis, and endocytosis in maturation-stage ameloblasts.Graphical abstract (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 4, 2019 Category: Biomedical Science Source Type: research

Role of nicotinic acetylcholine receptors for modulation of microcircuits in the agranular insular cortex
ConclusionThe activation of nAChRs layer specifically modulates synaptic transmission and plasticity in the mouse agranular insular cortex. These synaptic mechanisms are critical to understand the modulating effects of ACh or nicotine on physiological and pathophysiological functions associated with the insular cortex. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - December 21, 2018 Category: Biomedical Science Source Type: research

Genomic and phenotypic diversity of Streptococcus mutans
ConclusionWe review the current literature on the main processes that generate S. mutans genomic diversity, as well as the phenotypic variability of its main virulence factors. S. mutans achieves its pathogenesis by sensing the intra- and extracellular environments and regulating gene transcription according to perceived environmental modifications. Consequently, this regulation gives rise to differential synthesis of proteins, allowing this species to potentially express virulence factors. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - November 16, 2018 Category: Biomedical Science Source Type: research

Analysis of the Mechanism in Salivary Gland Development using Gene Database
ConclusionsA thorough understanding of the mechanisms involved in salivary gland is necessary in order to design effective therapies for regeneration of damaged salivary glands. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - October 14, 2018 Category: Biomedical Science Source Type: research

Nanocrystalline cellulose as a reinforcing agent for electrospun polyacrylonitrile (PAN) nanofibers
ConclusionsRegardless of concentration, the addition of NCC resulted in increased UTS, E, and YS of the nanofibers. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - October 14, 2018 Category: Biomedical Science Source Type: research

Evaluation of Aberrant Metabolism Related Proteins in Oral Submucous Fibrosis: A Pilot Study
This study aims to examine the altered metabolism-related proteins using immunohistochemistry (IHC).MethodsThe expression levels of glucose transporter 1 (GLUT1), hexokinase 2 (HK2), and fatty acid synthase (FASN) were analyzed in normal oral mucosa (NOM) (n = 30) and oral sub mucous fibrosis (OSF) (n = 30) using IHC. The degree of intensity and distribution of immunostaining was semi-quantitatively assessed.ResultsThe expression levels of GLUT-1, HK 2, and FASN were higher in the OSF group (p
Source: Journal of Oral Biosciences - September 9, 2018 Category: Biomedical Science Source Type: research

Differential distribution of microtubules in immature osteocytes in vivo
ConclusionThese results suggest that the early arrangement of microtubules may be correlated with the initial development of osteocyte processes. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 14, 2018 Category: Biomedical Science Source Type: research

Involvement of orexin in lipid accumulation in the liver
ConclusionsOrexin likely contributes to the regulation of lipid metabolism in the liver. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 28, 2018 Category: Biomedical Science Source Type: research

Effects of salt taste disorder on behavior and lifespan in Drosophila melanogaster
ConclusionsThe results of this study suggest that although NaCl taste disorder results in reduced feeding and breeding behaviors in Drosophila, it does not impact lifespan. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research

The temporospatial pattern of energy metabolism coordinates the interactions between the bones and other organ systems
ConclusionStudies on the connections between bones and other organ systems indicate the possible existence of a temporospatial pattern of energy metabolism through the cellular biorhythm and migration. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research

Comparative gene expression profiles of dental follicle at different stages of periodontal development: Combined use of laser capture microdissection and microarray
ConclusionsThe delineation of the differential gene expressions between pre- and post-natal developmental stages of DF in vivo will increase the understanding of periodontal tissue development. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research

Donor–host tissue interaction in allogenic transplanted tooth germ with special reference to periodontal tissue
ConclusionsThe current tooth germ transplantation suggests that the PDL contains putative stem cells, which never proliferate during E15–17, and is composed of resident dental follicle-derived cells and other cell population. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research

Oral biosciences: The annual review 2017
ConclusionThese reviews in the Journal of Oral Biosciences have inspired its readers to broaden their knowledge regarding the various aspects of oral biosciences. The current editorial review introduces these exciting review articles. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research

Free fatty acids may be involved in the pathogenesis of oral-related and cardiovascular diseases
ConclusionIn this review, we summarize a potential link between FFAs and the pathogenesis of craniofacial and cardiovascular diseases. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research

Mechanisms of orofacial sensory processing in the rat insular cortex
ConclusionThe insular cortex processes multiple types of sensations from orofacial regions and likely plays a critical role in integrating these sensations with limbic information. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research

Orthodontic tooth movement and HMGB1
ConclusionOrthodontic force modulates HMGB1 expression in PDL fibroblasts, and HMGB1 is an accessory regulator of bone resorption and bone formation during OTM. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research

Roles of non-canonical Wnt signaling pathways in bone resorption
ConclusionWnt5a and Wnt16 tightly regulate osteoclast differentiation and function in order to maintain bone mass under physiological conditions. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research

Synergistic findings from microbiological and evolutional analyses of virulence factors among pathogenic streptococcal species
ConclusionBacterial pathogens rapidly adapt to clinical intervention, such as antimicrobial agents and vaccination, via horizontal gene transfer, recombination, and/or natural point mutation. It is vital to continue development of innovative analysis methods to counter the mounting threats from evolving bacteria. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research

Epigenetics and its implications for oral health
ConclusionEpigenetic mechanisms are highly sensitive and reversible, thereby offers significant potential for their use to develop novel diagnostic tools, pharmacotherapies and personalized based treatment care. However, there is lack of integrated approaches combining epigenomics with proteomics and genomics comparing the usefulness of epigenetic biomarkers in oral health research. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research

Elevated concentrations of specific periodontopathic pathogens associated with severe periodontitis in Japanese patients with cardiovascular disease and concomitant obesity
ConclusionsPatients with CVD and concomitant obesity showed more severe periodontitis with increased concentrations of major periodontopathic bacteria than patients without obesity. These bacteria may cause deterioration of CVD and metabolic disorder. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research

TGF-β autocrine signaling at secretory-stage enamel
ConclusionLatent TGF-β1 produced and secreted from secretory-stage ameloblasts is activated by MMP20, and the activated TGF-β1 maintains its activity by combining with amelogenin cleavage products processed by the same protease. TGF-β1 moves through the aqueous phase with the water-soluble 13 kDa amelogenin and binds to its receptor on the ameloblast surface, thereby inducing autocrine signaling. Once the ameloblasts differentiate and enter the maturation stage, TGF-β1 is degraded by KLK4, which is produced and secreted by maturation-stage ameloblasts, and loses its activity. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 11, 2018 Category: Biomedical Science Source Type: research

Effects of salt taste disorder on behavior and lifespan in Drosophila melanogaster
ConclusionsThe results of this study suggest that although NaCl taste disorder results in reduced feeding and breeding behaviors in Drosophila, it does not impact lifespan. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 6, 2018 Category: Biomedical Science Source Type: research

The temporospatial pattern of energy metabolism coordinates the interactions between the bones and other organ systems
ConclusionStudies on the connections between bones and other organ systems indicate the possible existence of a temporospatial pattern of energy metabolism through the cellular biorhythm and migration. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 6, 2018 Category: Biomedical Science Source Type: research

Comparative gene expression profiles of dental follicle at different stages of periodontal development: Combined use of laser capture microdissection and microarray
ConclusionsThe delineation of the differential gene expressions between pre- and post-natal developmental stages of DF in vivo will increase the understanding of periodontal tissue development. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 6, 2018 Category: Biomedical Science Source Type: research

Donor–host tissue interaction in allogenic transplanted tooth germ with special reference to periodontal tissue
ConclusionsThe current tooth germ transplantation suggests that the PDL contains putative stem cells, which never proliferate during E15–17, and is composed of resident dental follicle-derived cells and other cell population. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 6, 2018 Category: Biomedical Science Source Type: research

Oral biosciences: The annual review 2017
ConclusionThese reviews in the Journal of Oral Biosciences have inspired its readers to broaden their knowledge regarding the various aspects of oral biosciences. The current editorial review introduces these exciting review articles. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 6, 2018 Category: Biomedical Science Source Type: research

Free fatty acids may be involved in the pathogenesis of oral-related and cardiovascular diseases
ConclusionIn this review, we summarize a potential link between FFAs and the pathogenesis of craniofacial and cardiovascular diseases. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 6, 2018 Category: Biomedical Science Source Type: research

Mechanisms of orofacial sensory processing in the rat insular cortex
ConclusionThe insular cortex processes multiple types of sensations from orofacial regions and likely plays a critical role in integrating these sensations with limbic information. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 6, 2018 Category: Biomedical Science Source Type: research

Orthodontic tooth movement and HMGB1
ConclusionOrthodontic force modulates HMGB1 expression in PDL fibroblasts, and HMGB1 is an accessory regulator of bone resorption and bone formation during OTM. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 6, 2018 Category: Biomedical Science Source Type: research

Roles of non-canonical Wnt signaling pathways in bone resorption
ConclusionWnt5a and Wnt16 tightly regulate osteoclast differentiation and function in order to maintain bone mass under physiological conditions. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 6, 2018 Category: Biomedical Science Source Type: research

Synergistic findings from microbiological and evolutional analyses of virulence factors among pathogenic streptococcal species
ConclusionBacterial pathogens rapidly adapt to clinical intervention, such as antimicrobial agents and vaccination, via horizontal gene transfer, recombination, and/or natural point mutation. It is vital to continue development of innovative analysis methods to counter the mounting threats from evolving bacteria. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 6, 2018 Category: Biomedical Science Source Type: research

Epigenetics and its implications for oral health
ConclusionEpigenetic mechanisms are highly sensitive and reversible, thereby offers significant potential for their use to develop novel diagnostic tools, pharmacotherapies and personalized based treatment care. However, there is lack of integrated approaches combining epigenomics with proteomics and genomics comparing the usefulness of epigenetic biomarkers in oral health research. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 6, 2018 Category: Biomedical Science Source Type: research

Elevated concentrations of specific periodontopathic pathogens associated with severe periodontitis in Japanese patients with cardiovascular disease and concomitant obesity
ConclusionsPatients with CVD and concomitant obesity showed more severe periodontitis with increased concentrations of major periodontopathic bacteria than patients without obesity. These bacteria may cause deterioration of CVD and metabolic disorder. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 6, 2018 Category: Biomedical Science Source Type: research