Comparative transcriptomic analysis identifies distinct molecular signatures and regulatory networks of chondroclasts and osteoclasts
Chondroclasts and osteoclasts have been previously identified as the cells capable of resorbing mineralized cartilage and bone matrices, respectively. While both cell types appear morphologically similar, cont... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 10, 2020 Category: Rheumatology Authors: Nazir M. Khan, Kari B. Clifton, Joseph Lorenzo, Marc F. Hansen and Hicham Drissi Tags: Research article Source Type: research

Profiling of IgG antibodies targeting unmodified and corresponding citrullinated autoantigens in a multicenter national cohort of early arthritis in Germany
To assess the diagnostic potential of IgG antibodies to citrullinated and corresponding native autoantigens in early arthritis. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 6, 2020 Category: Rheumatology Authors: Stefan Vordenb äumen, Ralph Brinks, Patrick Schriek, Angelika Lueking, Jutta G. Richter, Petra Budde, Peter Schulz-Knappe, Hans-Dieter Zucht, Johanna Callhoff and Matthias Schneider Tags: Research article Source Type: research

High susceptibility to collagen-induced arthritis in mice with progesterone receptors selectively inhibited in osteoprogenitor cells
In this study, we selectively dele... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 2, 2020 Category: Rheumatology Authors: Lixian Liu, Junjing Jia, Min Jiang, Xueping Liu, Chenling Dai, Barton L. Wise, Nancy E. Lane and Wei Yao Tags: Research article Source Type: research

Correction to: Temporary interruption of baricitinib: characterization of interruptions and effect on clinical outcomes in patients with rheumatoid arthritis
An amendment to this paper has been published and can be accessed via the original article. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 2, 2020 Category: Rheumatology Authors: Paul Emery, Yoshiya Tanaka, Tracy Cardillo, Douglas Schlichting, Terence Rooney, Scott Beattie, Cameron Helt and Josef S. Smolen Tags: Correction Source Type: research

Development of a multivariable improvement measure for gout
Gout is a heterogeneous inflammatory disease with numerous clinical manifestations. A composite means to assess the impact of therapy on numerous aspects of gout could be useful. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 29, 2020 Category: Rheumatology Authors: Naomi Schlesinger, N. Lawrence Edwards, Anthony E. Yeo and Peter E. Lipsky Tags: Research article Source Type: research

Serious infections in people with systemic sclerosis: a national US study
To study incidence, time trends, and outcomes of serious infections in systemic sclerosis (SSc). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 29, 2020 Category: Rheumatology Authors: Jasvinder A. Singh and John D. Cleveland Tags: Research article Source Type: research

The relationship between cancer and medication exposure in patients with systemic lupus erythematosus: a nested case-control study
Systemic lupus erythematosus (SLE) is associated with increased risk of cancer and the mechanism remains unclear. Here, we examined the level of auto-antibodies and disease activity index scores in SLE patient... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 26, 2020 Category: Rheumatology Authors: Jinyan Guo, Zhigang Ren, Jianhao Li, Tianfang Li, Shengyun Liu and Zujiang Yu Tags: Research article Source Type: research

Regulation of autoimmune arthritis by the SHP-1 tyrosine phosphatase
The Src homology region 2 domain-containing phosphatase-1 (SHP-1) is known to exert negative regulatory effects on immune cell signaling. Mice with mutations in the Shp1 gene develop inflammatory skin disease and... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 26, 2020 Category: Rheumatology Authors: Adrienn Markovics, Daniel M. Toth, Tibor T. Glant and Katalin Mikecz Tags: Research article Source Type: research

IgG anti-hinge antibodies against IgG4 F(ab ’)2 fragments generated using pepsin are useful diagnostic markers for rheumatoid arthritis: implications of the possible roles of metalloproteinases and IgG subclasses in generating immunogenic hinge epitopes
Pepsin agglutinators, discovered over 50  years ago, have been recently referred to as anti-hinge antibodies (AHAs) because of their reaction with the IgG hinge epitope. AHAs have different reactivity for each ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 26, 2020 Category: Rheumatology Authors: Toshiyuki Ota, Shun-ichiro Ota, Ayumi Uchino and Shuji Nagano Tags: Research article Source Type: research

Correction to: Prime-boost vaccination strategy enhances immunogenicity compared to single pneumococcal conjugate vaccination in patients receiving conventional DMARDs, to some extent in abatacept but not in rituximab-treated patients
An amendment to this paper has been published and can be accessed via the original article. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 26, 2020 Category: Rheumatology Authors: Per Nived, G öran Jönsson, Bo Settergren, Jon Einarsson, Tor Olofsson, Charlotte Sværke Jørgensen, Lillemor Skattum and Meliha C. Kapetanovic Tags: Correction Source Type: research

A multi-biomarker disease activity score can predict sustained remission in rheumatoid arthritis
In this study, we used the multi-biomarker disease activity (MBDA) test to explore the role of bi... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 24, 2020 Category: Rheumatology Authors: M. H. Y. Ma, N. Defranoux, W. Li, E. H. Sasso, F. Ibrahim, D. L. Scott and A. P. Cope Tags: Research article Source Type: research

Correction to: Safety and effectiveness of peficitinib (ASP015K) in patients with rheumatoid arthritis: interim data (22.7 months mean peficitinib treatment) from a long-term, open-label extension study in Japan, Korea, and Taiwan
An amendment to this paper has been published and can be accessed via the original article. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 23, 2020 Category: Rheumatology Authors: Tsutomu Takeuchi, Yoshiya Tanaka, Sakae Tanaka, Atsushi Kawakami, Yeong-Wook Song, Yi-Hsing Chen, Mitsuhiro Rokuda, Hiroyuki Izutsu, Satoshi Ushijima, Yuichiro Kaneko, Yoshihiro Nakashima, Teruaki Shiomi and Emi Yamada Tags: Correction Source Type: research

An integrative Bayesian network approach to highlight key drivers in systemic lupus erythematosus
A comprehensive intuition of the systemic lupus erythematosus (SLE), as a complex and multifactorial disease, is a biological challenge. Dealing with this challenge needs employing sophisticated bioinformatics... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 23, 2020 Category: Rheumatology Authors: Samaneh Maleknia, Zahra Salehi, Vahid Rezaei Tabar, Ali Sharifi-Zarchi and Kaveh Kavousi Tags: Research article Source Type: research

Elevated expression of BAFF receptor, BR3, on monocytes correlates with B cell activation and clinical features of patients with primary Sj ögren’s syndrome
We reported that the production of BAFF (B cell-activating factor) and IL-6, both of which are involved in survival and differentiation of B cells, is dysregulated in monocytes of patients with primary Sj ögren... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 23, 2020 Category: Rheumatology Authors: Keiko Yoshimoto, Katsuya Suzuki, Eriko Takei, Yumi Ikeda and Tsutomu Takeuchi Tags: Research article Source Type: research

Predictors of cartilage degeneration in patients with subchondral insufficiency fracture of the femoral head: a retrospective study
There is evidence that the cause of primary osteoarthritis (OA) is related to the changes in subchondral bone; however, the influence of subchondral insufficiency fracture (SIF) of the femoral head on the dege... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 22, 2020 Category: Rheumatology Authors: Tomohiro Shimizu, Shunichi Yokota, Yosuke Kimura, Tsuyoshi Asano, Hirokazu Shimizu, Hotaka Ishizu, Norimasa Iwasaki and Daisuke Takahashi Tags: Research article Source Type: research

Parenchymal lung disease in adult onset Still ’s disease: an emergent marker of disease severity—characterisation and predictive factors from Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort of patients
Adult-onset Still ’s disease (AOSD) is a systemic inflammatory disorder of unknown aetiology usually affecting young adults. Interestingly, recent evidence from the juvenile counterpart of AOSD suggested the em... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 22, 2020 Category: Rheumatology Authors: Piero Ruscitti, Onorina Berardicurti, Daniela Iacono, Ilenia Pantano, Vasiliki Liakouli, Francesco Caso, Giacomo Emmi, Rosa Daniela Grembiale, Francesco Paolo Cantatore, Fabiola Atzeni, Federico Perosa, Raffaele Scarpa, Giuliana Guggino, Francesco Ciccia, Tags: Research article Source Type: research

DNA vaccine encoding heat shock protein 90 protects from murine lupus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies to multiple self-antigens, including heat shock proteins (HSP). Because of the increased expre... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 22, 2020 Category: Rheumatology Authors: Aijing Liu, Fu-Dong Shi, Irun R. Cohen, Giuseppe Castaldo, Giuseppe Matarese, Francisco J. Quintana and Antonio La Cava Tags: Research article Source Type: research

Identification of novel genes associated with dysregulation of B cells in patients with primary Sj ögren’s syndrome
The aim of this study was to identify the molecular mechanism of dysregulation of B cell subpopulations of primary Sj ögren’s syndrome (pSS) at the transcriptome level. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 22, 2020 Category: Rheumatology Authors: Jun Inamo, Katsuya Suzuki, Masaru Takeshita, Yoshiaki Kassai, Maiko Takiguchi, Rina Kurisu, Yuumi Okuzono, Shinya Tasaki, Akihiko Yoshimura and Tsutomu Takeuchi Tags: Research article Source Type: research

Modifiable environmental exposure and risk of rheumatoid arthritis —current evidence from genetic studies
Rheumatoid arthritis (RA) is a multifactorial chronic autoimmune disease, which involves a complex interplay of environmental triggers and genetic components in its etiology. It has been shown that genetics on... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 22, 2020 Category: Rheumatology Authors: Xia Jiang and Lars Alfredsson Tags: Review Source Type: research

TNF- α inhibitor therapy can improve the immune imbalance of CD4+ T cells and negative regulatory cells but not CD8+ T cells in ankylosing spondylitis
Studies into ankylosing spondylitis (AS) and its relationship with immune imbalance are controversial, and the correlation between the efficacy of TNF- α inhibitor and changes in immune imbalance is unclear. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 19, 2020 Category: Rheumatology Authors: Mingcan Yang, Qing Lv, Qiujing Wei, Yutong Jiang, Jun Qi, Min Xiao, Linkai Fang, Ya Xie, Shuangyan Cao, Zhiming Lin, Yanli Zhang, Liudan Tu, Minjing Zhao, Yunfeng Pan, Ou Jin and Jieruo Gu Tags: Research article Source Type: research

Proteomic analysis in lupus mice identifies Coronin-1A as a potential biomarker for lupus nephritis
Approximately 50% of systemic lupus erythematosus (SLE) patients develop nephritis, which is among the most severe and frequent complications of the disease and a leading cause of morbidity and mortality. Desp... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 18, 2020 Category: Rheumatology Authors: Orthodoxia Nicolaou, Kleitos Sokratous, Zuzanna Makowska, Mar ía Morell, Aurélie De Groof, Pauline Montigny, Andreas Hadjisavvas, Kyriaki Michailidou, Anastasis Oulas, George M. Spyrou, Christiana Demetriou, Marta E. Alarcón-Riquelme, Savvas Psarellis, Tags: Research article Source Type: research

Neutrophil activation identifies patients with active polyarticular gout
Gout is the most prevalent inflammatory arthritis in developed countries. A gout flare is mediated by phagocytosis of monosodium urate crystals by macrophages and neutrophils leading to subsequent activation o... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 18, 2020 Category: Rheumatology Authors: D. Vedder, M. Gerritsen, B. Duvvuri, R. F. van Vollenhoven, M. T. Nurmohamed and C. Lood Tags: Research article Source Type: research

Methotrexate-loaded multifunctional nanoparticles with near-infrared irradiation for the treatment of rheumatoid arthritis
Despite the advances of rheumatoid arthritis (RA) therapeutics, several patients do not receive adequate treatment due to the toxicity and/or insufficient response of drugs. The aim of this study is to design ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 18, 2020 Category: Rheumatology Authors: You-Jung Ha, Sun-Mi Lee, Chin Hee Mun, Hyung Joon Kim, Yonghee Bae, Ji-Hee Lim, Kyu-Hyung Park, Soo-Kon Lee, Kyung-Hwa Yoo and Yong-Beom Park Tags: Research article Source Type: research

Longitudinal immune cell monitoring identified CD14++ CD16+ intermediate monocyte as a marker of relapse in patients with ANCA-associated vasculitis
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune disease that affects small- to medium-sized blood vessels. Despite treatments having been improved, patients often exper... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 16, 2020 Category: Rheumatology Authors: Kotaro Matsumoto, Katsuya Suzuki, Keiko Yoshimoto, Noriyasu Seki, Hideto Tsujimoto, Kenji Chiba and Tsutomu Takeuchi Tags: Research article Source Type: research

Favorable efficacy of rituximab in ANCA-associated vasculitis patients with excessive B cell differentiation
B cell depletion by rituximab (RTX) is an effective treatment for anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV). However, peripheral B cell phenotypes and the selection criteria f... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 15, 2020 Category: Rheumatology Authors: Yusuke Miyazaki, Shingo Nakayamada, Satoshi Kubo, Yuichi Ishikawa, Maiko Yoshikawa, Kei Sakata, Shigeru Iwata, Ippei Miyagawa, Kazuhisa Nakano and Yoshiya Tanaka Tags: Research article Source Type: research

Drug retention of 7 biologics and tofacitinib in biologics-na ïve and biologics-switched patients with rheumatoid arthritis: the ANSWER cohort study
This multi-center, retrospective study aimed to clarify retention rates and reasons for discontinuation of 7 biological disease-modifying antirheumatic drugs (bDMARDs) and tofacitinib (TOF), one of the janus k... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 15, 2020 Category: Rheumatology Authors: Kosuke Ebina, Toru Hirano, Yuichi Maeda, Wataru Yamamoto, Motomu Hashimoto, Koichi Murata, Tohru Takeuchi, Hideyuki Shiba, Yonsu Son, Hideki Amuro, Akira Onishi, Kengo Akashi, Ryota Hara, Masaki Katayama, Keiichi Yamamoto, Atsushi Kumanogoh & hellip; Tags: Research article Source Type: research

Influence of age on the occurrence of adverse events in rheumatic patients at the onset of biological treatment: data from the BIOBADASER III register
To assess whether age, at the beginning of biologic treatment, is associated with the time a first adverse event (AE) appears in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), or psoriat... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 15, 2020 Category: Rheumatology Authors: Paloma Vela, Carlos Sanchez-Piedra, Carolina Perez-Garcia, Mar ía C. Castro-Villegas, Mercedes Freire, Lourdes Mateo, Cesar Díaz-Torné, Cristina Bohorquez, Juan M. Blanco-Madrigal, Inmaculada Ros-Vilamajo, Silvia Gómez, Rocio Caño, Fernando Sánchez- Tags: Research article Source Type: research

The first composite score predicting Digital Ulcers in systemic sclerosis patients using Clinical data, Imaging and Patient history —CIP-DUS
Digital ulcers (DU) present a challenging complication in systemic sclerosis (SSc). The aim of this study was to combine clinical characteristics and imaging methods to a composite score for the prediction of ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 15, 2020 Category: Rheumatology Authors: S. Friedrich, S. L üders, J. Klotsche, G. R. Burmester, G. Riemekasten and S. Ohrndorf Tags: Research article Source Type: research

Correction to: Influence of HLA-B27 on the Ankylosing Spondylitis phenotype: results from the REGISPONSER database
An amendment to this paper has been published and can be accessed via the original article. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 11, 2020 Category: Rheumatology Authors: Marta Ar évalo, Jordi Gratacós Masmitjà, Mireia Moreno, Joan Calvet, Cristobal Orellana, Desirée Ruiz, Carmen Castro, Pilar Carreto, Marta Larrosa, Eduardo Collantes and Pilar Font Tags: Correction Source Type: research

Efficacy and safety of sarilumab in combination with csDMARDs or as monotherapy in subpopulations of patients with moderately to severely active rheumatoid arthritis in three phase III randomized, controlled studies
The interleukin-6 receptor inhibitor sarilumab demonstrated efficacy in combination with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) or as monotherapy in patients with moderately to... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 10, 2020 Category: Rheumatology Authors: Mark C. Genovese, Roy Fleischmann, Alan Kivitz, Eun-Bong Lee, Hubert van Hoogstraten, Toshio Kimura, Gregory St John, Erin K. Mangan and Gerd R. Burmester Tags: Research article Source Type: research

Correction to: Upadacitinib improves patient-reported outcomes in patients with rheumatoid arthritis and inadequate response to conventional synthetic disease-modifying antirheumatic drugs: results from SELECT-NEXT
An amendment to this paper has been published and can be accessed via the original article. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 9, 2020 Category: Rheumatology Authors: Vibeke Strand, Janet Pope, Namita Tundia, Alan Friedman, Heidi S. Camp, Aileen Pangan, Arijit Ganguli, Mahesh Fuldeore, Debbie Goldschmidt and Michael Schiff Tags: Correction Source Type: research

Non-histologic factors discriminating proliferative lupus nephritis from membranous lupus nephritis
To investigate non-histologic factors that can discriminate proliferative lupus nephritis (LN) from membranous LN in patients with systemic lupus erythematosus with renal manifestations. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 9, 2020 Category: Rheumatology Authors: Oh Chan Kwon, Jung Hwan Park, Hyeong-Cheon Park, Seung Min Jung, Sang-Won Lee, Jason Jungsik Song, Yong-Beom Park and Min-Chan Park Tags: Research article Source Type: research

Differential long-term retention of biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis by age group from the FIRST registry
The effectiveness and safety of biological disease-modifying antirheumatic drugs (bDMARDs) by age group ( (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 8, 2020 Category: Rheumatology Authors: Akio Kawabe, Kazuhisa Nakano, Satoshi Kubo, Takeshi Asakawa and Yoshiya Tanaka Tags: Research article Source Type: research

The effect of transtheoretical model-lead intervention for knee osteoarthritis in older adults: a cluster randomized trial
Knee osteoarthritis (KOA) is a common joint disease in people over 60  years old. Exercise therapy is one of the most effective non-pharmacological treatments for KOA, but low exercise adherence needs to be imp... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 8, 2020 Category: Rheumatology Authors: Limin Wang, Hongbo Chen, Han Lu, Yunlin Wang, Congying Liu, Xu Dong, Jieru Chen, Nan Liu, Fang Yu, Qiaoqin Wan and Shaomei Shang Tags: Research article Source Type: research

Cerebral microvascular and microstructural integrity is regionally altered in patients with systemic lupus erythematosus
To measure regional brain microvascular and microstructural changes in childhood-onset SLE (cSLE) using diffusion-weighted imaging (DWI) at multiple b values and investigate relationships of those measures with n... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 8, 2020 Category: Rheumatology Authors: Mark W. DiFrancesco, Gregory Lee, Mekibib Altaye, Dean W. Beebe, Jamie Meyers-Eaton and Hermine I. Brunner Tags: Research article Source Type: research

Involvement of the pulmonary arteries in patients with Takayasu arteritis: a prospective study from a single centre in China
Takayasu arteritis (TA) is a large vessel vasculitis that can involve pulmonary arteries (PAs). We studied multiple clinical characteristics related to pulmonary artery involvement (PAI) in TA patients. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 5, 2020 Category: Rheumatology Authors: Xiufang Kong, Lili Ma, Peng Lv, Xiaomeng Cui, Rongyi Chen, Zongfei Ji, Huiyong Chen, Jiang Lin and Lindi Jiang Tags: Research article Source Type: research

Immunosuppressive treatment in diffuse cutaneous systemic sclerosis is associated with an improved composite response index (CRISS)
Outcomes of therapeutic studies in diffuse cutaneous systemic sclerosis (dcSSc) have mainly been measured for specific organs, particularly the skin and lungs. A new composite response index in dcSSc (CRISS) h... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 5, 2020 Category: Rheumatology Authors: Boyang Zheng, Marie Hudson, Mianbo Wang and Murray Baron Tags: Research article Source Type: research

Ezh2-mediated epigenetic modification is required for allogeneic T cell-induced lupus disease
The mechanisms involved in the pathogenesis of autoimmune disorders, including systemic lupus erythematosus (SLE), have not been fully elucidated. Some of these mechanisms involve epigenetic regulation of gene... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 5, 2020 Category: Rheumatology Authors: Yuxuan Zhen, Roger D. Smith, Fred D. Finkelman and Wen-Hai Shao Tags: Research article Source Type: research

The regulation and pharmacological modulation of immune complex induced type III IFN production by plasmacytoid dendritic cells
Patients with systemic lupus erythematosus (SLE) have an ongoing interferon (IFN) production due to an activation of plasmacytoid dendritic cells (pDCs), which can be triggered to type I IFN synthesis by RNA c... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 5, 2020 Category: Rheumatology Authors: Karin Hjorton, Niklas Hagberg, Pascal Pucholt, Maija-Leena Eloranta and Lars R önnblom Tags: Research article Source Type: research

Validation of the suction device Nimble for the assessment of skin fibrosis in systemic sclerosis
Skin fibrosis is a main hallmark of systemic sclerosis (SSc). Clinical assessment is done semi-quantitatively using the modified Rodnan skin score (mRSS). Objective measurements for quantifying skin fibrosis c... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 3, 2020 Category: Rheumatology Authors: Bettina M üller, Lisa Ruby, Suzana Jordan, Marga B. Rominger, Edoardo Mazza and Oliver Distler Tags: Research article Source Type: research

Nocturnal blood pressure dipping as a marker of endothelial function and subclinical atherosclerosis in pediatric-onset systemic lupus erythematosus
Loss of the normal nocturnal decline in blood pressure (BP), known as non-dipping, is a potential measure of cardiovascular risk identified by ambulatory blood pressure monitoring (ABPM). We sought to determin... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 3, 2020 Category: Rheumatology Authors: Joyce C. Chang, Rui Xiao, Kevin E. Meyers, Laura Mercer-Rosa, Shobha S. Natarajan, Pamela F. Weiss and Andrea M. Knight Tags: Research article Source Type: research

Interleukin-32 in systemic sclerosis, a potential new biomarker for pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a severe complication of systemic sclerosis (SSc), associated with a progressive elevation in pulmonary vascular resistance and subsequent right heart failure and death... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 1, 2020 Category: Rheumatology Authors: Paola Di Benedetto, Giuliana Guggino, Giovanna Manzi, Piero Ruscitti, Onorina Berardicurti, Noemi Panzera, Nicol ò Grazia, Roberto Badagliacca, Valeria Riccieri, Carmine Dario Vizza, Ganna Radchenko, Vasiliki Liakouli, Francesco Ciccia, Paola Cipriani an Tags: Research article Source Type: research

Measurement of hydroxychloroquine in blood from SLE patients using LC-HRMS —evaluation of whole blood, plasma, and serum as sample matrices
Hydroxychloroquine (HCQ) is the standard of care in the treatment of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and other inflammatory rheumatic diseases and potentially for the treatment i... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 1, 2020 Category: Rheumatology Authors: Henrik Carlsson, Karin Hjorton, Sandy Abujrais, Lars R önnblom, Torbjörn Åkerfeldt and Kim Kultima Tags: Research article Source Type: research

IL-23 in arthritic and inflammatory pain development in mice
The cytokine, interleukin-23 (IL-23), can be critical for the progression of inflammatory diseases, including arthritis, and is often associated with T lymphocyte biology. We previously showed that certain lym... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 29, 2020 Category: Rheumatology Authors: Kevin M.-C. Lee, Zihao Zhang, Adrian Achuthan, Andrew J. Fleetwood, Julia E. Smith, John A. Hamilton and Andrew D. Cook Tags: Research article Source Type: research

Proteoglycan loss in the articular cartilage is associated with severity of joint inflammation in psoriatic arthritis —a compositional magnetic resonance imaging study
Even though cartilage loss is a known feature of psoriatic arthritis (PsA), little is known about its role in the pathogenesis of PsA. Using delayed gadolinium-enhanced magnetic resonance imaging of cartilage ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 29, 2020 Category: Rheumatology Authors: Daniel B. Abrar, Christoph Schleich, Sven Nebelung, Miriam Frenken, Tim Ullrich, Karl Ludger Radke, Gerald Antoch, Stefan Vordenb äumen, Ralph Brinks, Matthias Schneider, Benedikt Ostendorf and Philipp Sewerin Tags: Research article Source Type: research

Neutrophil Fc γRIIA availability is associated with disease activity in systemic lupus erythematosus
Immune complexes (ICs) are detectable in a variety of inflammatory diseases, including systemic lupus erythematosus (SLE), reflecting autoantibody binding to antigens. Though ICs are the main contributors to d... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 29, 2020 Category: Rheumatology Authors: Anders A. Bengtsson, Helena Tyden and Christian Lood Tags: Research article Source Type: research

Urinary activated leukocyte cell adhesion molecule as a novel biomarker of lupus nephritis histology
Lupus nephritis (LN) is one of the most severe complications of SLE patients. We aim to validate urinary ALCAM as a biomarker in predicting renal disease histpathology in a Chinese lupus cohort. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 27, 2020 Category: Rheumatology Authors: Huihua Ding, Cheng Lin, Jingyi Cai, Qiang Guo, Min Dai, Chandra Mohan and Nan Shen Tags: Research article Source Type: research

Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis
Antibodies binding to cartilage proteins are present in the blood and synovial fluid of early rheumatoid arthritis patients. In order to develop animal models mimicking the human disease, we have characterized... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 24, 2020 Category: Rheumatology Authors: Yanpeng Li, Dongmei Tong, Peibin Liang, Erik L önnblom, Johan Viljanen, Bingze Xu, Kutty Selva Nandakumar and Rikard Holmdahl Tags: Research article Source Type: research

Effects of dihydrotestosterone on osteoblast activity in curdlan-administered SKG mice and osteoprogenitor cells in patients with ankylosing spondylitis
Ankylosing spondylitis (AS) is characteristically male-predominant, and progressive spinal ankylosis affects male patients more severely; however, the hormonal effects in males with AS are poorly understood. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 24, 2020 Category: Rheumatology Authors: Sungsin Jo, Eun-Ju Lee, Bora Nam, Juyeon Kang, Seunghun Lee, Jeehee Youn, Ye-Soo Park, Yong-Gil Kim and Tae-Hwan Kim Tags: Research article Source Type: research

Overexpression of MIG-6 in the cartilage induces an osteoarthritis-like phenotype in mice
Osteoarthritis (OA) is the most common form of arthritis and characterized by degeneration of the articular cartilage. Mitogen-inducible gene 6 (Mig-6) has been identified as a negative regulator of the epider... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 19, 2020 Category: Rheumatology Authors: Melina Bellini, Michael A. Pest, Manuela Miranda-Rodrigues, Ling Qin, Jae-Wook Jeong and Frank Beier Tags: Research article Source Type: research