Meta-analysis of pain and function placebo responses in pharmacological osteoarthritis trials
To evaluate contextual effects in the form of placebo responses (PRs) for patient-reported pain and function and objectively measured function in osteoarthritis (OA) clinical trials. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 15, 2019 Category: Rheumatology Authors: ZeYu Huang, Jing Chen, Qin Sheng Hu, Qiang Huang, Jun Ma, Fu Xing Pei, Bin Shen and Virginia Byers Kraus Tags: Review Source Type: research

Distinct biomarkers for different bones in osteoporosis with rheumatoid arthritis
This study aimed to identify biomarkers predictive of bone mineral density (BMD) change at three anatomical sites in ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 15, 2019 Category: Rheumatology Authors: T. Tomizawa, H. Ito, K. Murata, M. Hashimoto, M. Tanaka, K. Murakami, K. Nishitani, M. Azukizawa, A. Okahata, K. Doi, M. Saito, M. Furu, M. Hamaguchi, T. Mimori and S. Matsuda Tags: Research article Source Type: research

Soluble syndecan-3 binds chemokines, reduces leukocyte migration in vitro and ameliorates disease severity in models of rheumatoid arthritis
Syndecans are heparan sulfate proteoglycans that occur in membrane-bound or soluble forms. Syndecan-3, the least well-characterised of the syndecan family, is highly expressed on synovial endothelial cells in ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 12, 2019 Category: Rheumatology Authors: Andrew D. Eustace, Emily F. McNaughton, Sophie King, Oksana Kehoe, Andreas Kungl, Derek Mattey, Angela H. Nobbs, Neil Williams and Jim Middleton Tags: Research article Source Type: research

IL-1 β receptor antagonist (IL-1Ra) combined with autophagy inducer (TAT-Beclin1) is an effective alternative for attenuating extracellular matrix degradation in rat and human osteoarthritis chondrocytes
Autophagy induction is an effective approach for OA therapy. IL-1 β is one of the major inflammatory cytokines linked to OA pathological progression, and its receptor blockade interrupts OA cartilage destructio... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 10, 2019 Category: Rheumatology Authors: Fen Wang, Jijie Liu, Xiaolei Chen, Xinpeng Zheng, Ning Qu, Bing Zhang and Chun Xia Tags: Research article Source Type: research

Chondrogenic induction of human osteoarthritic cartilage-derived mesenchymal stem cells activates mineralization and hypertrophic and osteogenic gene expression through a mechanomiR
While bone marrow-derived mesenchymal stem cells (BMSC) are established sources for stem cell-based cartilage repair therapy, articular cartilage-derived mesenchymal stem cells from osteoarthritis patients (OA... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 8, 2019 Category: Rheumatology Authors: Nan Hu, Yun Gao, Chathuraka T. Jayasuriya, Wenguang Liu, Heng Du, Jing Ding, Meng Feng and Qian Chen Tags: Research article Source Type: research

Disease activity and damage in juvenile idiopathic arthritis: methotrexate era versus biologic era
To compare the long-term disease state, in terms of activity and damage, of children with juvenile idiopathic arthritis (JIA) who had their disease onset in methotrexate (MTX) or biologic eras. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 8, 2019 Category: Rheumatology Authors: Gabriella Giancane, Valentina Muratore, Valentina Marzetti, Neus Quilis, Belen Serrano Benavente, Francesca Bagnasco, Alessandra Alongi, Adele Civino, Lorenzo Quartulli, Alessandro Consolaro and Angelo Ravelli Tags: Research article Source Type: research

Rheumatoid arthritis synovial fibroblasts promote TREM-1 expression in monocytes via COX-2/PGE2 pathway
Triggering receptor expressed on myeloid cells-1 (TREM-1) is inducible on monocyte/macrophages and neutrophils and amplifies the inflammatory response. The aim of this study was to determine whether rheumatoid... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 8, 2019 Category: Rheumatology Authors: Anping Peng, Xinyi Lu, Jun Huang, Min He, Jianhua Xu, Hui Huang and Qubo Chen Tags: Research article Source Type: research

Correction to: Association between inflammation and systolic blood pressure in RA compared to patients without RA
Following publication of the original article [1], it has come to our attention that we did not appropriately convert the units for CRP from the National Health and Nutrition Examination Survey (NHANES) from m... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 8, 2019 Category: Rheumatology Authors: Zhi Yu, Seoyoung C. Kim, Kathleen Vanni, Jie Huang, Rishi Desai, Shawn N. Murphy, Daniel H. Solomon and Katherine P. Liao Tags: Correction Source Type: research

The effect of deep or sustained remission on maintenance of remission after dose reduction or withdrawal of etanercept in patients with rheumatoid arthritis
Biologic disease-modifying antirheumatic drugs (bDMARDs) are important options for managing rheumatoid arthritis (RA). Once patients achieve disease control, clinicians may consider dose reduction or withdrawa... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 5, 2019 Category: Rheumatology Authors: Yoshiya Tanaka, Josef S. Smolen, Heather Jones, Annette Szumski, Lisa Marshall and Paul Emery Tags: Research article Source Type: research

High baseline fat mass, but not lean tissue mass, is associated with high intensity low back pain and disability in community-based adults
Low back pain is the largest contributor to disability worldwide. The role of body composition as a risk factor for back pain remains unclear. Our aim was to examine the relationship between fat mass and fat d... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 5, 2019 Category: Rheumatology Authors: Sharmayne R. E. Brady, Donna M. Urquhart, Sultana Monira Hussain, Andrew Teichtahl, Yuanyuan Wang, Anita E. Wluka and Flavia Cicuttini Tags: Research article Source Type: research

Assessing synovitis in the hands in patients with rheumatoid arthritis by ultrasound: an agreement study exploring the most inflammatory active side from two Norwegian trials
To assess if the right hand, the dominant hand, or the hand with more clinically swollen joints (SwJ) is per se the most inflamed and exhibits the greatest change during treatment and hence preferred for unila... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 5, 2019 Category: Rheumatology Authors: Lene Terslev, Robin Christensen, Anna-Birgitte Aga, Joe Sexton, Espen A. Haavardsholm and Hilde B. Hammer Tags: Research article Source Type: research

Effects of tapering tumor necrosis factor inhibitor on the achievement of inactive disease in patients with axial spondyloarthritis: a nationwide cohort study
To investigate the association between the extent of tapering tumor necrosis factor inhibitor (TNFi) and the likelihood of achieving inactive disease in patients with axial spondyloarthritis (axSpA) (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 4, 2019 Category: Rheumatology Authors: Jun Won Park, Hyoun-Ah Kim, Kichul Shin, Yong-Beom Park, Tae-Hwan Kim, Yeong Wook Song and Eun Young Lee Tags: Research article Source Type: research

Effect of disease-modifying anti-rheumatic drugs on bone structure and strength in psoriatic arthritis patients
To address whether the use of methotrexate (MTX) and biological disease-modifying anti-rheumatic drugs (bDMARDs) impacts bone structure and biomechanical properties in patients with psoriatic arthritis (PsA). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 3, 2019 Category: Rheumatology Authors: David Simon, Arnd Kleyer, Sara Bayat, Koray Tascilar, Eleni Kampylafka, Timo Meinderink, Louis Schuster, Ramona Petrov, Anna-Maria Liphardt, Juergen Rech, Georg Schett and Axel J. Hueber Tags: Research article Source Type: research

Anti-D4GDI antibodies activate platelets in vitro: a possible link with thrombocytopenia in primary antiphospholipid syndrome
Thrombocytopenia is a manifestation associated with primary antiphospholipid syndrome (PAPS), and many studies have stressed the leading role played by platelets in the pathogenesis of antiphospholipid syndrom... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - July 1, 2019 Category: Rheumatology Authors: C. Barbati, L. Stefanini, T. Colasanti, E. Cipriano, A. Celia, G. Gabriele, M. Vomero, F. Ceccarelli, F. R. Spinelli, A. Finucci, M. Speziali, G. Orso, D. P. E. Margiotta, F. Conti, F. Violi, A. Afeltra & hellip; Tags: Research article Source Type: research

Comparison of an interactive voice response system and smartphone application in the identification of gout flares
To examine the feasibility, preference, and satisfaction of an interactive voice response (IVR) system versus a customized smartphone application (StudyBuddy) to capture gout flares (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 29, 2019 Category: Rheumatology Authors: Nada Elmagboul, Brian W. Coburn, Jeffrey Foster, Amy Mudano, Joshua Melnick, Debra Bergman, Shuo Yang, David Redden, Lang Chen, Cooper Filby, Jeffrey R. Curtis, Ted R. Mikuls and Kenneth G. Saag Tags: Research article Source Type: research

Prostaglandin receptor EP4 expression by Th17 cells is associated with high disease activity in ankylosing spondylitis
Th17 cells are involved in the pathogenesis of ankylosing spondylitis (AS). However, the mechanism underlying enhanced Th17 cell accumulation in AS remains unknown. The prostaglandin E2 receptor EP2/EP4 signaling... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 28, 2019 Category: Rheumatology Authors: Charlotte Klasen, Anja Meyer, Paula S. Wittekind, Iris Waqu é, Schafiq Nabhani and David M. Kofler Tags: Research article Source Type: research

Higher baseline global leukocyte DNA methylation is associated with MTX non-response in early RA patients
Low-dose methotrexate (MTX) is the first-line therapy in early rheumatoid arthritis (eRA). Up to 40% of eRA patients do not benefit from MTX therapy. MTX has been shown to inhibit one-carbon metabolism, which ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 26, 2019 Category: Rheumatology Authors: Helen R. Gosselt, Bertrand D. van Zelst, Maurits C. F. J. de Rotte, Johanna M. W. Hazes, Robert de Jonge and Sandra G. Heil Tags: Research article Source Type: research

Hand exercise for women with rheumatoid arthritis and decreased hand function: an exploratory randomized controlled trial
People with hand-related rheumatoid arthritis (RA) experience problems performing activities of daily living (ADL). Compensatory strategies to improve ADL ability have shown effective. Similarly, hand exercise... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 26, 2019 Category: Rheumatology Authors: Karen Ellegaard, Cecilie von B ülow, Alice Røpke, Cecilie Bartholdy, Inge Skovby Hansen, Signe Rifbjerg-Madsen, Marius Henriksen and Eva Ejlersen Wæhrens Tags: Research article Source Type: research

Survival and death causes of patients with giant cell arteritis in Western Norway 1972 –2012: a retrospective cohort study
Our objective was to determine the survival and causes of death in a large and well-characterized cohort of patients with giant cell arteritis (GCA). (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 25, 2019 Category: Rheumatology Authors: L. K. Brekke, B.-T. S. Fevang, A. P. Diamantopoulos, J. Assmus, E. Esper ø and C. G. Gjesdal Tags: Research article Source Type: research

Health service utilization among African American women living with systemic lupus erythematosus: perceived impacts of a self-management intervention
Healthcare access, utilization, and quality play critical roles in shaping mortality and morbidity among patients diagnosed with systemic lupus erythematosus (SLE), and yet healthcare access, utilization, and ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 25, 2019 Category: Rheumatology Authors: Abena A. Twumasi, Anna Shao, Charmayne Dunlop-Thomas, Cristina Drenkard and Hannah L. F. Cooper Tags: Research article Source Type: research

Juvenile idiopathic arthritis associated with a mutation in GATA3
GATA3 is a transcription factor that is important during development and plays a role in differentiation and activity of immune cells, particularly T cells. Abnormal T cell function is found in autoimmune arth... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 25, 2019 Category: Rheumatology Authors: Anna E. Patrick, Wei Wang, Elly Brokamp, Thomas Brent Graham, Thomas M. Aune and Jessica B. Duis Tags: Research article Source Type: research

Antibodies against specific extractable nuclear antigens (ENAs) as diagnostic and prognostic tools and inducers of a profibrotic phenotype in cultured human skin fibroblasts: are they functional?
The importance of systemic sclerosis (SSc) autoantibodies for diagnosis has become recognized by their incorporation into the 2013 ACR/EULAR classification criteria. Clear prognostic and phenotypic association... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 24, 2019 Category: Rheumatology Authors: Claudio Corallo, Sara Cheleschi, Maurizio Cutolo, Stefano Soldano, Antonella Fioravanti, Nila Volpi, Daniela Franci, Ranuccio Nuti and Nicola Giordano Tags: Research article Source Type: research

A novel function of artesunate on inhibiting migration and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients
Anti-malarial drug artesunate can suppress inflammation and prevent cartilage and bone destruction in collagen-induced arthritis model in rats —suggesting it may be a potent drug for rheumatoid arthritis (RA) t... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 24, 2019 Category: Rheumatology Authors: Jian-Da Ma, Jun Jing, Jun-Wei Wang, Tao Yan, Qian-Hua Li, Ying-Qian Mo, Dong-Hui Zheng, Jin-Long Gao, Ky-Anh Nguyen and Lie Dai Tags: Research article Source Type: research

Comparative study of corticosteroid monotherapy, and TNF inhibitors with or without corticosteroid in patients with refractory entero-Behcet ’s disease
Tumor necrosis factor (TNF) inhibitors (TNF-i) are effective in the treatment of entero-Behcet ’s disease (BD). However, there is no objective tool for assessment of disease activity in entero-BD; therefore, it... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 22, 2019 Category: Rheumatology Authors: Ippei Miyagawa, Kazuhisa Nakano, Shigeru Iwata, Shingo Nakayamada, Kazuyoshi Saito, Kentaro Hanami, Shunsuke Fukuyo, Satoshi Kubo, Akio Kawabe, Yusuke Miyazaki and Yoshiya Tanaka Tags: Research article Source Type: research

Concurrent validity of provisional remission criteria for gout: a dual-energy CT study
Provisional gout remission criteria including five domains (serum urate, tophus, flares, pain due to gout, and patient global assessment) have been proposed. The aim of this study was to test the concurrent va... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 21, 2019 Category: Rheumatology Authors: Nicola Dalbeth, Christopher Frampton, Maple Fung, Scott Baumgartner, Savvas Nicolaou and Hyon K. Choi Tags: Research article Source Type: research

Expression analysis of the osteoarthritis genetic susceptibility mapping to the matrix Gla protein gene MGP
Osteoarthritis (OA) is a common disease of older individuals that impacts detrimentally on the quality and the length of life. It is characterised by the painful loss of articular cartilage and is polygenic an... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 18, 2019 Category: Rheumatology Authors: Colin Shepherd, Abigail E. Reese, Louise N. Reynard and John Loughlin Tags: Research article Source Type: research

Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles
To investigate the relationships between interferon alpha (IFN α) and the clinical and serological phenotype of patients with systemic autoimmune rheumatic disease (SARDs) in order to determine whether a distin... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 14, 2019 Category: Rheumatology Authors: John A. Reynolds, Tracy A. Briggs, Gillian I. Rice, Sathya Darmalinggam, Vincent Bondet, Ellen Bruce, Mumtaz Khan, Sahena Haque, Hector Chinoy, Ariane L. Herrick, Eoghan M. McCarthy, Leo Zeef, Andrew Hayes, Darragh Duffy, Ben Parker and Ian N. Bruce Tags: Research article Source Type: research

Testing the effects of gentle vibrotactile stimulation on symptom relief in fibromyalgia
Sensory disturbances in fibromyalgia extend beyond nociception. It has been proposed that imbalance in the mutual competition between painful input and non-painful sensory activity may, to a significant extent... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 14, 2019 Category: Rheumatology Authors: Jesus Pujol, Daniel Ramos-L ópez, Laura Blanco-Hinojo, Guillem Pujol, Héctor Ortiz, Gerard Martínez-Vilavella, Josep Blanch, Jordi Monfort and Joan Deus Tags: Research article Source Type: research

Calorie restriction with regular chow, but not a high-fat diet, delays onset of spontaneous osteoarthritis in the Hartley guinea pig model
Obesity is a leading risk factor for osteoarthritis (OA). In contrast, calorie restriction (CR) may lessen OA due to improved systemic inflammatory status and reduced weight-bearing. The aim of this study was ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 13, 2019 Category: Rheumatology Authors: Lauren B. Radakovich, Angela J. Marolf, Lauren A. Culver and Kelly S. Santangelo Tags: Research article Source Type: research

Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation
To identify a synovial fluid (SF) biomarker profile characteristic of individuals with an inflammatory osteoarthritis (OA) endotype. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 13, 2019 Category: Rheumatology Authors: Collin A. Haraden, Janet L. Huebner, Ming-Feng Hsueh, Yi-Ju Li and Virginia Byers Kraus Tags: Research article Source Type: research

The activin-follistatin anti-inflammatory cycle is deregulated in synovial fibroblasts
Activin A and follistatin exhibit immunomodulatory functions, thus affecting autoinflammatory processes as found in rheumatoid arthritis (RA). The impact of both proteins on the behavior of synovial fibroblast... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 10, 2019 Category: Rheumatology Authors: Magnus Diller, Klaus Frommer, Berno Dankbar, Ingo Tarner, Marie-Lisa H ülser, Lali Tsiklauri, Rebecca Hasseli, Michael Sauerbier, Thomas Pap, Stefan Rehart, Ulf Müller-Ladner and Elena Neumann Tags: Research article Source Type: research

Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis
Most therapies for autoimmune and inflammatory diseases either neutralize or suppress production of inflammatory cytokines produced by activated macrophages (e.g., TNF α, IL-1, IL-6, IL-17, GM-CSF). However, no... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 7, 2019 Category: Rheumatology Authors: Yingwen Hu, Bingbing Wang, Jiayin Shen, Stewart A. Low, Karson S. Putt, Hans W. M. Niessen, Eric L. Matteson, Linda Murphy, Clemens Ruppert, Gerrit Jansen, Stephen J. Oliver, Yang Feng, Dimiter S. Dimitrov, Cheryl Nickerson-Nutter and Philip S. Low Tags: Research article Source Type: research

Safety of abatacept compared with other biologic and conventional synthetic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: data from an observational study
To assess the risks of malignancies, infections and autoimmune diseases in patients with rheumatoid arthritis (RA) treated with abatacept compared with other biologic (b) disease-modifying antirheumatic drugs ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 7, 2019 Category: Rheumatology Authors: Gulsen Ozen, Sofia Pedro, Rebecca Schumacher, Teresa A. Simon and Kaleb Michaud Tags: Research article Source Type: research

Spinal radiographic progression over 2 years in ankylosing spondylitis patients treated with secukinumab: a historical cohort comparison
The aim of this study was to compare radiographic progression in patients with ankylosing spondylitis (AS) treated for up to 2  years with secukinumab (MEASURE 1) with a historical cohort of biologic-naïve pati... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 7, 2019 Category: Rheumatology Authors: J. Braun, H. Haibel, M. de Hooge, R. Landew é, M. Rudwaleit, T. Fox, A. Readie, H. B. Richards, B. Porter, R. Martin, D. Poddubnyy, J. Sieper and D. van der Heijde Tags: Research article Source Type: research

Outcome of patients with early arthritis without rheumatoid factor and ACPA and predictors of rheumatoid arthritis in the ESPOIR cohort
To describe the disease course of patients with early arthritis without rheumatoid factor (RF) and anti-citrullinated protein auto-antibodies (ACPA) in an inception cohort. To determine baseline predictors of ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 6, 2019 Category: Rheumatology Authors: Ga ël Mouterde, Nathalie Rincheval, Cédric Lukas, Claire Daien, Alain Saraux, Philippe Dieudé, Jacques Morel and Bernard Combe Tags: Research article Source Type: research

Persistence rates of abatacept and TNF inhibitors used as first or second biologic DMARDs in the treatment of rheumatoid arthritis: 9 years of experience from the Rhumadata ® clinical database and registry
Treatment persistence is an important consideration when selecting a therapy for chronic conditions such as rheumatoid arthritis (RA). We assessed the long-term persistence of abatacept or a tumor necrosis fac... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 6, 2019 Category: Rheumatology Authors: Denis Choquette, Louis Bessette, Evo Alemao, Boulos Haraoui, Roelien Postema, Jean-Pierre Raynauld and Louis Coupal Tags: Research article Source Type: research

Evaluation of concomitant peripheral arthritis in patients with recent onset axial spondyloarthritis: 5-year results from the DESIR cohort
(a) To describe the prevalence and incidence of peripheral arthritis during 5  years of follow-up in recent axial spondyloarthritis (axSpA), (b) to evaluate factors associated with their appearance and (c) to a... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 6, 2019 Category: Rheumatology Authors: Clementina L ópez-Medina, Maxime Dougados, Adeline Ruyssen-Witrand and Anna Moltó Tags: Research article Source Type: research

Targeting inflammatory pathways in axial spondyloarthritis
The triggers and pathogenesis of axial spondyloarthritis (axSpA) are not yet completely understood. However, therapeutic agents targeting tumor necrosis factor- α and interleukin-17 inflammatory pathways have p... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 4, 2019 Category: Rheumatology Authors: Daniel E. Furst and James S. Louie Tags: Review Source Type: research

Metformin improves salivary gland inflammation and hypofunction in murine Sj ögren’s syndrome
Activated T and B cells participate in the development and progression of Sj ögren’s syndrome (SS). Metformin, a first-line anti-diabetic drug, exerts anti-inflammatory and immunomodulatory effects by activatin... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 4, 2019 Category: Rheumatology Authors: Ji-Won Kim, Sung-Min Kim, Jin-Sil Park, Sun-Hee Hwang, JeongWon Choi, Kyung-Ah Jung, Jun-Geol Ryu, Seon-Yeong Lee, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park Tags: Research article Source Type: research

Haploinsufficiency of A20 caused by a novel nonsense variant or entire deletion of TNFAIP3 is clinically distinct from Beh çet’s disease
Haploinsufficiency of A20 (HA20) is caused by loss-of-function TNFAIP3 variants. Phenotypic and genetic features of HA20 remain uncertain; therefore, the clinical distinction between HA20 and Beh çet’s disease (BD... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 4, 2019 Category: Rheumatology Authors: Naomi Tsuchida, Yohei Kirino, Yutaro Soejima, Masafumi Onodera, Katsuhiro Arai, Eiichiro Tamura, Takashi Ishikawa, Toshinao Kawai, Toru Uchiyama, Shigeru Nomura, Daisuke Kobayashi, Masataka Taguri, Satomi Mitsuhashi, Takeshi Mizuguchi, Atsushi Takata, Nor Tags: Research article Source Type: research

Best practices in DNA methylation: lessons from inflammatory bowel disease, psoriasis and ankylosing spondylitis
Advances in genomic technology have enabled a greater understanding of the genetics of common immune-mediated diseases such as ankylosing spondylitis (AS), inflammatory bowel disease (IBD) and psoriasis. The s... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 3, 2019 Category: Rheumatology Authors: Jessica M. Whyte, Jonathan J. Ellis, Matthew A. Brown and Tony J. Kenna Tags: Review Source Type: research

miR-449a inhibits cell proliferation, migration, and inflammation by regulating high-mobility group box protein 1 and forms a mutual inhibition loop with Yin Yang 1 in rheumatoid arthritis fibroblast-like synoviocytes
We previously found that high-mobility group box protein 1 (HMGB1) promoted cell proliferation, migration, invasion, and autophagy in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS), but little is k... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - June 3, 2019 Category: Rheumatology Authors: Yongsong Cai, Congshan Jiang, Jialin Zhu, Ke Xu, Xiaoyu Ren, Lin Xu, Peijing Hu, Bo Wang, Qiling Yuan, Yuanxu Guo, Jian Sun, Peng Xu and Yusheng Qiu Tags: Research article Source Type: research

Gout, flares, and allopurinol use: a population-based study
There is a paucity of community-based data regarding the prevalence and impact of gout flares as these may often be self-managed. The aim of this study was to determine the prevalence of self-reported gout and... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 31, 2019 Category: Rheumatology Authors: Charlotte Proudman, Susan E. Lester, David A. Gonzalez-Chica, Tiffany K. Gill, Nicola Dalbeth and Catherine L. Hill Tags: Research article Source Type: research

The RIG-I pathway is involved in peripheral T cell lymphopenia in patients with dermatomyositis
Peripheral T cell lymphopenia is a clinical phenomenon in some patients with dermatomyositis (DM). Patients with T cell lymphopenia are more susceptible to life-threatening infections. However, the pathogenesi... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 29, 2019 Category: Rheumatology Authors: Lu Zhang, Qisheng Xia, Wenli Li, Qinglin Peng, Hanbo Yang, Xin Lu and Guochun Wang Tags: Research Source Type: research

Biological treatment of ankylosing spondylitis: a nationwide study of treatment trajectories on a patient level in clinical practice
There is substantial evidence that patients with ankylosing spondylitis (AS) have high response rates to tumour necrosis factor inhibitors (TNFi), a low likelihood of successful treatment termination, but yet ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 28, 2019 Category: Rheumatology Authors: Ulf Lindstr öm, Tor Olofsson, Sara Wedrén, Ilia Qirjazo and Johan Askling Tags: Research article Source Type: research

Skin thickness score as a surrogate marker of organ involvements in systemic sclerosis: a retrospective observational study
Previous studies have shown the relationship between higher skin thickness score and the existence of organ involvements in systemic sclerosis (SSc). Here, we firstly investigated the correlation between skin ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 28, 2019 Category: Rheumatology Authors: Kazuki M. Matsuda, Ayumi Yoshizaki, Ai Kuzumi, Takemichi Fukasawa, Satoshi Ebata, Shunsuke Miura, Tetsuo Toyama, Asako Yoshizaki, Hayakazu Sumida, Yoshihide Asano, Koji Oba and Shinichi Sato Tags: Research article Source Type: research

Switch from reference etanercept to SDZ ETN, an etanercept biosimilar, does not impact efficacy, safety, and immunogenicity of etanercept in patients with moderate-to-severe rheumatoid arthritis: 48-week results from the phase III, randomized, double-blind EQUIRA study
Sandoz etanercept (SDZ ETN; GP2015) is an etanercept biosimilar with equivalent efficacy and comparable safety and immunogenicity to reference etanercept (ETN) in patients with moderate-to-severe chronic plaqu... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 28, 2019 Category: Rheumatology Authors: Janusz Jaworski, Marco Matucci-Cerinic, Hendrik Schulze-Koops, Maya H. Buch, Eugeniusz J. Kucharz, Yannick Allanore, Arthur Kavanaugh, Philip Young and Goran Babic Tags: Research article Source Type: research

Incorporation of the anteroposterior lumbar radiographs in the modified Stoke Ankylosing Spondylitis Spine Score improves detection of radiographic spinal progression in axial spondyloarthritis
To evaluate the performance of the extended modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) incorporating information from anteroposterior (AP) lumbar radiographs as compared to the conventional mSA... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 24, 2019 Category: Rheumatology Authors: Maria Llop, Valeria Rios Rodriguez, Imke Redeker, Joachim Sieper, Hildrun Haibel, Martin Rudwaleit and Denis Poddubnyy Tags: Research article Source Type: research

Association between metformin use and disease progression in obese people with knee osteoarthritis: data from the Osteoarthritis Initiative —a prospective cohort study
To examine whether metformin use was associated with knee cartilage volume loss over 4  years and risk of total knee replacement over 6 years in obese individuals with knee osteoarthritis. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 24, 2019 Category: Rheumatology Authors: Yuanyuan Wang, Sultana Monira Hussain, Anita E. Wluka, Yuan Z. Lim, Fran çois Abram, Jean-Pierre Pelletier, Johanne Martel-Pelletier and Flavia M. Cicuttini Tags: Research article Source Type: research

Etanercept treatment for extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis, or psoriatic arthritis: 6-year efficacy and safety data from an open-label trial
To describe the 6-year safety and efficacy of etanercept (ETN) in children with extended oligoarticular juvenile idiopathic arthritis (eoJIA), enthesitis-related arthritis (ERA), and psoriatic arthritis (PsA) (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 23, 2019 Category: Rheumatology Authors: Ivan Foeldvari, Tam às Constantin, Jelena Vojinović, Gerd Horneff, Vyacheslav Chasnyk, Joke Dehoorne, Violeta Panaviene, Gordana Sušić, Valda Stanevicha, Katarzyna Kobusinska, Zbigniew Zuber, Bogna Dobrzyniecka, Irina Nikishina, Brigitte Bader-Meunier Tags: Research article Source Type: research