Impact of systemic lupus erythematosus on the 5-year survival of critically ill septic patients
Infectious disease is an increasing threat to patients with systemic lupus erythematosus (SLE); however, the long-term outcome in critically ill septic patients with SLE remains unclear, and we aimed to addres... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 21, 2021 Category: Rheumatology Authors: Hsin-Hua Chen, Hsian-Min Chen, Yi-Ming Chen, Yi-Hsing Chen, Ching-Heng Lin and Wen-Cheng Chao Tags: Research article Source Type: research

Correction to: Symptoms in first-degree relatives of patients with rheumatoid arthritis: evaluation of cross-sectional data from the symptoms in persons at risk of rheumatoid arthritis (SPARRA) questionnaire in the Preclinical EValuation of Novel Targets in RA (PREVeNT-RA) Cohort
An amendment to this paper has been published and can be accessed via the original article. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 19, 2021 Category: Rheumatology Authors: R. E. Costello, J. H. Humphreys, J. C. Sergeant, M. Haris, F. Stirling, K. Raza, D. van Schaardenburg and Ian N. Bruce Tags: Correction Source Type: research

A deep learning method for predicting knee osteoarthritis radiographic progression from MRI
The identification of patients with knee osteoarthritis (OA) likely to progress rapidly in terms of structure is critical to facilitate the development of disease-modifying drugs. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 18, 2021 Category: Rheumatology Authors: Jean-Baptiste Schiratti, R émy Dubois, Paul Herent, David Cahané, Jocelyn Dachary, Thomas Clozel, Gilles Wainrib, Florence Keime-Guibert, Agnes Lalande, Maria Pueyo, Romain Guillier, Christine Gabarroca and Philippe Moingeon Tags: Research article Source Type: research

Multiomic study of skin, peripheral blood, and serum: is serum proteome a reflection of disease process at the end-organ level in systemic sclerosis?
Serum proteins can be readily assessed during routine clinical care. However, it is unclear to what extent serum proteins reflect the molecular dysregulations of peripheral blood cells (PBCs) or affected end-o... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 15, 2021 Category: Rheumatology Authors: Victor Farutin, Elma Kurtagic, Jo ël R. Pradines, Ishan Capila, Maureen D. Mayes, Minghua Wu, Anthony M. Manning and Shervin Assassi Tags: Research article Source Type: research

Granulocyte-macrophage colony-stimulating factor and tumor necrosis factor- α in combination is a useful diagnostic biomarker to distinguish familial Mediterranean fever from sepsis
To identify potential biomarkers to distinguish familial Mediterranean fever (FMF) from sepsis. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 15, 2021 Category: Rheumatology Authors: Tomohiro Koga, Kaori Furukawa, Kiyoshi Migita, Shimpei Morimoto, Toshimasa Shimizu, Shoichi Fukui, Masataka Umeda, Yushiro Endo, Remi Sumiyoshi, Shin-ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Tomoki Origuchi, Takahiro Maeda, Akihiro Yach Tags: Research article Source Type: research

bFGF could be a biomarker of malignancy in RS3PE syndrome: an ambispective single-center cohort analysis of 51 patients
Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare inflammatory arthritis, with a higher incidence of malignancy. The aim of this study is to identify biomarkers for predicting mali... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 15, 2021 Category: Rheumatology Authors: Yuzhou Gan, Yi Sun, Jiayang Jin, Yifan Wang, Jiali Chen, Yukchiu Chung, Xue Li and Hua Ye Tags: Research article Source Type: research

Radial BMD and serum CTX-I can predict the progression of carotid plaque in rheumatoid arthritis: a 3-year prospective cohort study
Patients with rheumatoid arthritis (RA) are almost twice as likely to develop cardiovascular disease (CVD) as those without. However, traditional CVD risks have been shown to underperform in RA patients; thus,... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 13, 2021 Category: Rheumatology Authors: Seungwoo Han, Na-Ri Kim, Jong-Wan Kang, Jung-Su Eun and Young-Mo Kang Tags: Research article Source Type: research

Correlation of peripheral CD4+GranzB+CTLs with disease severity in patients with primary Sj ögren’s syndrome
This study was to investigate the correlation of periphe... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 12, 2021 Category: Rheumatology Authors: Qi Wang, Nan Che, Chengyin Lu, Xiaoxuan Sun, Yanyan Wang, Qiang Wang, Wenfeng Tan, Lanlan Zhou, Xiaojun Zhang, Dong Xu, Lei Gu and Miaojia Zhang Tags: Research article Source Type: research

Catastrophic adult-onset Still ’s disease as a distinct life-threatening clinical subset: case–control study with dimension reduction analysis
Adult-onset Still ’s disease (AOSD) is a rare systemic inflammatory disorder. Diagnosing AOSD can be challenging, as disease presentation and clinical course are highly heterogeneous. For unclear reasons, a few... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 11, 2021 Category: Rheumatology Authors: Ana ïs Wahbi, Benoît Tessoulin, Cédric Bretonnière, Julien Boileau, Dorothée Carpentier, Olivier Decaux, Laurence Fardet, Guillaume Geri, Pascal Godmer, Cécile Goujard, Hervé Maisonneuve, Arnaud Mari, Jacques Pouchot, Jean-Marc Ziza, Sophie Georgin Tags: Research article Source Type: research

Machine learning-based prediction model for responses of bDMARDs in patients with rheumatoid arthritis and ankylosing spondylitis
Few studies on rheumatoid arthritis (RA) have generated machine learning models to predict biologic disease-modifying antirheumatic drugs (bDMARDs) responses; however, these studies included insufficient analy... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 9, 2021 Category: Rheumatology Authors: Seulkee Lee, Seonyoung Kang, Yeonghee Eun, Hong-Hee Won, Hyungjin Kim, Jaejoon Lee, Eun-Mi Koh and Hoon-Suk Cha Tags: Research article Source Type: research

Correction to: The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual “window of treatment success” in RA patients
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 9, 2021 Category: Rheumatology Authors: Bianka Marklein, Madeleine Jenning, Zolt án Konthur, Thomas Häupl, Franziska Welzel, Ute Nonhoff, Sylvia Krobitsch, Debbie M. Mulder, Marije I. Koenders, Vijay Joshua, Andrew P. Cope, Mark J. Shlomchik, Hans-Joachim Anders, Gerd R. Burmester, Aase Hensv Tags: Correction Source Type: research

Rapamycin-induced hyperglycemia is associated with exacerbated age-related osteoarthritis
The objective of this study was to determine if mechanistic target of rapamycin (mTOR) inhibition with or without AMP-activated protein kinase (AMPK) activation can protect against primary, age-related OA. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 7, 2021 Category: Rheumatology Authors: Dennis M. Minton, Christian J. Elliehausen, Martin A. Javors, Kelly S. Santangello and Adam R. Konopka Tags: Research article Source Type: research

Longitudinal analysis of the patient pathways to diagnosis of psoriatic arthritis
The occurrence of health events preceding a psoriatic arthritis (PsA) diagnosis may serve as predictors of diagnosis. We sought to assess patients ’ real-world experiences in obtaining a PsA diagnosis. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - October 1, 2021 Category: Rheumatology Authors: Alexis Ogdie, Martin Rozycki, Theresa Arndt, Cheng Shi, Nina Kim and Peter Hur Tags: Research article Source Type: research

Integrative analysis of genome-wide DNA methylation and single-nucleotide polymorphism identified ACSM5 as a suppressor of lumbar ligamentum flavum hypertrophy
Hypertrophy of ligamentum flavum (HLF) is a common lumbar degeneration disease (LDD) with typical symptoms of low back pain and limb numbness owing to an abnormal pressure on spinal nerves. Previous studies re... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 30, 2021 Category: Rheumatology Authors: Yanlin Cao, Yenan Zhan, Sujun Qiu, Zhong Chen, Kaiqin Gong, Songjia Ni and Yang Duan Tags: Research article Source Type: research

Olfactory impairment in patients with primary Sjogren ’s syndrome and its correlation with organ involvement and immunological abnormalities
Patients with autoimmune diseases often present with olfactory impairment. The aim of the study was to assess the olfactory functions of patients with primary Sj ögren’s syndrome and to correlate these findings... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 29, 2021 Category: Rheumatology Authors: Xue Xu, Linyu Geng, Chen Chen, Wentao Kong, Baojie Wen, Wei Kong, Siwen Chen, Huayong Zhang, Jun Liang and Lingyun Sun Tags: Research article Source Type: research

Association of retroperitoneal fibrosis with malignancy and its outcomes
Retroperitoneal fibrosis (RPF) is characterized by a highly fibrotic retroperitoneal mass and encompasses the idiopathic form and secondary to malignancies. Because we have limited knowledge whether RPF is ass... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 26, 2021 Category: Rheumatology Authors: Sang Jin Lee, Jung Su Eun, Min Jung Kim, Yeong Wook Song and Young Mo Kang Tags: Research article Source Type: research

Long-term efficacy, safety, and immunogenicity of the adalimumab biosimilar, PF-06410293, in patients with rheumatoid arthritis after switching from reference adalimumab (Humira ®) or continuing biosimilar therapy: week 52–92 data from a randomized, double-blind, phase 3 trial
REFLECTIONS B538 –02 is a randomized, double-blind comparative study of the adalimumab (ADL) biosimilar PF-06410293, (ADL-PF), and reference ADL sourced from the European Union (ADL-EU) in patients with active ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 25, 2021 Category: Rheumatology Authors: Roy M. Fleischmann, Daniel F. Alvarez, Amy E. Bock, Carol Cronenberger, Ivana Vranic, Wuyan Zhang and Rieke Alten Tags: Research article Source Type: research

Monocyte transcriptomes from patients with axial spondyloarthritis reveal dysregulated monocytopoiesis and a distinct inflammatory imprint
In patients with axial spondyloarthritis (axSpA), monocytes show a pre-activated phenotype. Gut inflammation is a trigger of monocyte activation and may also affect their development in the bone marrow (BM). A... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 24, 2021 Category: Rheumatology Authors: Fabian Karow, Biljana Smiljanovic, Joachim R. Gr ün, Denis Poddubnyy, Fabian Proft, Alice Talpin, Christophe Hue, Anne Boland, Jean-François Deleuze, Henri-Jean Garchon, Ilkay Ergenç, Ann-Sophie De Craemer, Ulrike Erben, Thomas Häupl, Dirk Elewaut, Ma Tags: Research article Source Type: research

Accelerated diastolic dysfunction in premenopausal women with rheumatoid arthritis
Disturbances of diastolic function precede systolic heart failure and, although clinically silent, represent the earliest sign of cardiac involvement. Diastolic dysfunction (DD) is associated with age, gender ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 24, 2021 Category: Rheumatology Authors: Gee Hee Kim and Yune-Jung Park Tags: Research article Source Type: research

Risk of rheumatoid arthritis diagnosis in statin users in a large nationwide US study
To evaluate the association between statin use and the risk of developing rheumatoid arthritis (RA) in a large, US case-control study. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 18, 2021 Category: Rheumatology Authors: Madeline N. Peterson, Hayley J. Dykhoff, Cynthia S. Crowson, John M. Davis III, Lindsey R. Sangaralingham and Elena Myasoedova Tags: Research article Source Type: research

HLA-DRB1 risk alleles for RA are associated with differential clinical responsiveness to abatacept and adalimumab: data from a head-to-head, randomized, single-blind study in autoantibody-positive early RA
Certain risk alleles associated with autoantibody-positive rheumatoid arthritis (RA) have been linked to poorer prognoses. In patients with autoantibody-positive RA, abatacept shows differential efficacy to tu... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 18, 2021 Category: Rheumatology Authors: William Rigby, Jane H. Buckner, S. Louis Bridges Jr, Marleen Nys, Sheng Gao, Martin Polinsky, Neelanjana Ray and Vivian Bykerk Tags: Research article Source Type: research

Study TPX-100-5: intra-articular TPX-100 significantly delays pathological bone shape change and stabilizes cartilage in moderate to severe bilateral knee OA
TPX-100, a promotor of osteoblast and chondroblast differentiation, is a potential osteoarthritis (OA) therapy. This retrospective study compared MRI 3D femoral bone shape changes (B-scores) after intra-articular... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 17, 2021 Category: Rheumatology Authors: Dawn McGuire, Michael Bowes, Alan Brett, Neil A. Segal, Meghan Miller, David Rosen and Yoshinari Kumagai Tags: Research article Source Type: research

Isopsoralen ameliorates rheumatoid arthritis by targeting MIF
Isopsoralen (IPRN), one of the active ingredients of Psoralea corylifolia Linn, has anti-inflammatory properties. We attempted to investigate the inhibitory effects of IPRN on rheumatoid arthritis (RA) and charac... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 17, 2021 Category: Rheumatology Authors: Yi Han, Jinguang Wang, Shufeng Li, Yi Li, Yongli Zhang, Ruojia Zhang, Yuang Zhang, Huancai Fan, Haojun Shi, Jihong Pan, Guanhua Song, Luna Ge and Lin Wang Tags: Research article Source Type: research

The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual “window of treatment success” in RA patients
There is a need for biomarker to identify patients “at risk” for rheumatoid arthritis (risk-RA) and to better predict the therapeutic response and in this study we tested the hypothesis that novel native and c... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 14, 2021 Category: Rheumatology Authors: Bianka Marklein, Madeleine Jenning, Zolt án Konthur, Thomas Häupl, Franziska Welzel, Ute Nonhoff, Sylvia Krobitsch, Debbie M. Mulder, Marije I. Koenders, Vijay Joshua, Andrew P. Cope, Mark J. Shlomchik, Hans-Joachim Anders, Gerd R. Burmester, Aase Hensv Tags: Research article Source Type: research

Gut microbiota mediated the therapeutic efficacies and the side effects of prednisone in the treatment of MRL/lpr mice
Growing evidences indicate that the alterations in gut microbiota are associated with the efficacy of glucocorticoids (GCs) in the treatment of systemic lupus erythematosus (SLE). However, there is no evidence... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 14, 2021 Category: Rheumatology Authors: Mingzhu Wang, Zhengyang Zhu, Xiaoying Lin, Haichang Li, Chengping Wen, Jie Bao and Zhixing He Tags: Research article Source Type: research

Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration
Synovial macrophages perform a multitude of functions that include clearance of cell debris and foreign bodies, tissue immune surveillance, and resolution of inflammation. The functional diversity of macrophag... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 14, 2021 Category: Rheumatology Authors: Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Tannin A. Schmidt, Jennifer Totonchy and Khaled A. Elsaid Tags: Research article Source Type: research

HLA-B52 allele in giant cell arteritis may indicate diffuse large-vessel vasculitis formation: a retrospective study
This study aimed to identify new characteristics of elderly onset large-vessel vasculitis (EOLVV) by focusing on human leucocyte antigen (HLA) genotype, polymyalgia rheumatica (PMR), and affected vascular lesi... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 13, 2021 Category: Rheumatology Authors: Kazuo Kushimoto, Masahiro Ayano, Keisuke Nishimura, Miki Nakano, Yasutaka Kimoto, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi and Hiroaki Niiro Tags: Research article Source Type: research

Correction to: Denosumab alleviates intervertebral disc degeneration adjacent to lumbar fusion by inhibiting endplate osteochondral remodeling and vertebral osteoporosis in ovariectomized rats
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 9, 2021 Category: Rheumatology Authors: Qi Sun, Fa-Ming Tian, Fang Liu, Jia-Kang Fang, Yun-Peng Hu, Qiang-Qiang Lian, Zhuang Zhou and Liu Zhang Tags: Correction Source Type: research

Treatment patterns in rheumatoid arthritis patients newly initiated on biologic and conventional synthetic disease-modifying antirheumatic drug therapy and enrolled in a North American clinical registry
Understanding the evolving treatment patterns in patients with rheumatoid arthritis (RA) is important for rheumatologists to make the best practice decisions and optimize treatment. Here, we describe treatment... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 8, 2021 Category: Rheumatology Authors: Philip J. Mease, Scott Stryker, Mei Liu, Bob Salim, Sabrina Rebello, Mahdi Gharaibeh and David H. Collier Tags: Research article Source Type: research

Prognostic factors of total hip replacement during a 2-year period in participants enrolled in supervised education and exercise therapy: a prognostic study of 3657 participants with hip osteoarthritis
Evidence on prognostic factors associated with progression to total hip replacement (THR) in hip osteoarthritis (OA) is for the most patient- and disease-specific characteristics either conflicting or inconclu... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 7, 2021 Category: Rheumatology Authors: Stine Clausen, Jan Hartvigsen, Eleanor Boyle, Ewa M. Roos, Dorte Thalund Gr ønne, Martin Thomsen Ernst, Bodil Arnbak and Søren T. Skou Tags: Research article Source Type: research

Accuracy and usability of a diagnostic decision support system in the diagnosis of three representative rheumatic diseases: a randomized controlled trial among medical students
An increasing number of diagnostic decision support systems (DDSS) exist to support patients and physicians in establishing the correct diagnosis as early as possible. However, little evidence exists that supp... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 6, 2021 Category: Rheumatology Authors: Johannes Knitza, Koray Tascilar, Eva Gruber, Hannah Kaletta, Melanie Hagen, Anna-Maria Liphardt, Hannah Schenker, Martin Krusche, Jochen Wacker, Arnd Kleyer, David Simon, Nicolas Vuillerme, Georg Schett and Axel J. Hueber Tags: Research article Source Type: research

The pan-PPAR agonist lanifibranor reduces development of lung fibrosis and attenuates cardiorespiratory manifestations in a transgenic mouse model of systemic sclerosis
The T βRII∆k-fib transgenic (TG) mouse model of scleroderma replicates key fibrotic and vasculopathic complications of systemic sclerosis through fibroblast-directed upregulation of TGFβ signalling. We have exa... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 6, 2021 Category: Rheumatology Authors: Emma Derrett-Smith, Kristina E. N. Clark, Xu Shiwen, David J. Abraham, Rachel K. Hoyles, Olivier Lacombe, Pierre Broqua, Jean Louis Junien, Irena Konstantinova, Voon H. Ong and Christopher P. Denton Tags: Research article Source Type: research

Secukinumab in non-radiographic axial spondyloarthritis: subgroup analysis based on key baseline characteristics from a randomized phase III study, PREVENT
To investigate the efficacy of secukinumab in patients with active non-radiographic axial spondyloarthritis (nr-axSpA) grouped by disease activity as assessed by C-reactive protein (CRP) levels and/or magnetic... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 4, 2021 Category: Rheumatology Authors: J ürgen Braun, Ricardo Blanco, Helena Marzo-Ortega, Lianne S. Gensler, Filip van den Bosch, Stephen Hall, Hideto Kameda, Denis Poddubnyy, Marleen van de Sande, Anna S. Wiksten, Brian O. Porter, Abhijit Shete, Hanno B. Richards, Sibylle Haemmerle and Atul Tags: Research article Source Type: research

High incidence and mortality of Pneumocystis jirovecii infection in anti-MDA5-antibody-positive dermatomyositis: experience from a single center
Idiopathic inflammatory myopathies (IIM) are associated with a significantly higher risk of opportunistic infections including Pneumocystis jirovecii pneumonia (PJP), a potentially fatal opportunistic infection. ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 4, 2021 Category: Rheumatology Authors: Linlin Huang, Qiong Fu, Yan Ye, Yanwei Lin, Qingran Yan and Sheng Chen Tags: Research article Source Type: research

The prevalence of oral mucosal lesions and related factors in systemic lupus erythematosus patients
Systemic lupus erythematosus (SLE) is a chronic inflammatory multi systematic disease of unknown aetiology. SLE has a wide range of symptoms. The most common symptoms are joint pain, skin rash and fever. Oral ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 3, 2021 Category: Rheumatology Authors: Mayssoun Kudsi, Louei Darjazini Nahas, Rama Alsawah, Ahmad Hamsho and Abdullah Omar Tags: Research article Source Type: research

Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load
Anti-modified protein antibodies (AMPA) targeting citrullinated, acetylated and/or carbamylated self-antigens are hallmarks of rheumatoid arthritis (RA). Although AMPA-IgG cross-reactivity to multiple post-tra... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 3, 2021 Category: Rheumatology Authors: Sanne Reijm, Theresa Kissel, Gerrie Stoeken-Rijsbergen, Linda M. Slot, Corrie M. Wortel, Hugo J. van Dooren, Nivine E. W. Levarht, Arieke S. B. Kampstra, Veerle F. A. M. Derksen, Pleuni Ooijevaar-de Heer, Holger Bang, Jan W. Drijfhout, Leendert A. Trouw, Tags: Research article Source Type: research

A matrix metalloproteinase-generated neoepitope of CRP can identify knee and multi-joint inflammation in osteoarthritis
To compare C-reactive protein (CRP) and matrix metalloproteinase-generated neoepitope of CRP (CRPM) as biomarkers of inflammation and radiographic severity in patients with knee osteoarthritis. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 31, 2021 Category: Rheumatology Authors: Louie C. Alexander Jr, Grant McHorse, Janet L. Huebner, Anne-Christine Bay-Jensen, Morten A. Karsdal and Virginia B. Kraus Tags: Research article Source Type: research

Comparison of properties determined using electromechanical assessment (Arthro-BST ™) with macroscopic and histological properties in symptomatic human articular cartilage of the hip
Cartilage degeneration is assessed using various methods. Although macroscopic evaluation can directly measure cartilage degeneration, it cannot accurately assess cartilage properties. Histological examination... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 31, 2021 Category: Rheumatology Authors: Taku Ukai, Masato Sato, Shiho Wasai, Takumi Takahashi, Haruka Omura and Masahiko Watanabe Tags: Research article Source Type: research

Impact of the HLA-DRB1 shared epitope on responses to treatment with tofacitinib or abatacept in patients with rheumatoid arthritis
The aim of this study was to compare the clinical effectiveness of tofacitinib and abatacept and clarify the impact of the HLA-DRB1 shared epitope (SE) on responses to these treatments in patients with rheumat... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 31, 2021 Category: Rheumatology Authors: Wataru Hirose, Masayoshi Harigai, Koichi Amano, Toshihiko Hidaka, Kenji Itoh, Kazutoshi Aoki, Masahiro Nakashima, Hayato Nagasawa, Yukiko Komano and Toshihiro Nanki Tags: Research article Source Type: research

Epidemiology and treatment of Beh çet’s disease in the USA: insights from the Rheumatology Informatics System for Effectiveness (RISE) Registry with a comparison with other published cohorts from endemic regions
Beh çet’s disease (BD), a chronic systemic vasculitis, has distinct geographical and ethnic variation. Data regarding the epidemiology of patients with BD in the U.S. are limited; therefore, we sought to descri... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 30, 2021 Category: Rheumatology Authors: Nevin Hammam, Jing Li, Michael Evans, Julia L. Kay, Zara Izadi, Christine Anastasiou, Milena A. Gianfrancesco, Jinoos Yazdany and Gabriela Schmajuk Tags: Research article Source Type: research

Accelerated osteoarthritis in women with polycystic ovary syndrome: a prospective nationwide registry-based cohort study
Osteoarthritis (OA) is the most common form of arthritis with multiple risk factors implicated including female sex and obesity. Metabolic dysregulation associated with obesity leading to metabolic syndrome is... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 30, 2021 Category: Rheumatology Authors: Stefan Kluzek, Katrine Hass Rubin, Maria Sanchez-Santos, Mary S. O ’Hanlon, Marianne Andersen, Dorte Glintborg and Bo Abrahamsen Tags: Research article Source Type: research

Microarray-based analysis of renal complement components reveals a therapeutic target for lupus nephritis
Screening abnormal pathways and complement components in the kidneys of patients with lupus nephritis (LN) and NZB/W mice may help to identify complement-related therapeutic targets for LN. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 25, 2021 Category: Rheumatology Authors: Tao Liu, Mingyue Yang, Ying Xia, Chuan Jiang, Chenxu Li, Zhenyu Jiang and Xiaosong Wang Tags: Research article Source Type: research

Differences and similarities in clinical and functional responses among patients receiving tofacitinib monotherapy, tofacitinib plus methotrexate, and adalimumab plus methotrexate: a post hoc analysis of data from ORAL Strategy
This post hoc analysis assessed clinical and functional responses to tofacitinib monotherapy, tofacitinib  + methotrexate (MTX), and adalimumab + MTX, in patients with rheumatoid arthritis enrolled in the ORAL ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 24, 2021 Category: Rheumatology Authors: Tsutomu Takeuchi, Roy Fleischmann, Noriko Iikuni, Harry Shi, Koshika Soma, Jerome Paulissen, Tomohiro Hirose and Josef S. Smolen Tags: Research article Source Type: research

Patient- and physician-reported outcomes from two phase 3 randomized studies (RAJ3 and RAJ4) of peficitinib (ASP015K) in Asian patients with rheumatoid arthritis
This study evaluated the effect of peficitinib on p... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 24, 2021 Category: Rheumatology Authors: Yoshiya Tanaka, Tsutomu Takeuchi, Hiroyuki Izutsu, Yuichiro Kaneko, Daisuke Kato, Musashi Fukuda, Mitsuhiro Rokuda and Neil M. Schultz Tags: Research article Source Type: research

Incidence and severity of G6PI-induced arthritis are not increased in genetically distinct mouse strains upon aging
In this study, we analyzed the association of the incidence and severity of glucose-6-phosphate isomerase (G6PI)-induced arthritis with age in two ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 24, 2021 Category: Rheumatology Authors: Nico Andreas, Sylvia M üller, Nicole Templin, Paul M. Jordan, Harald Schuhwerk, Michael Müller, Jana Gerstmeier, Laura Miek, Saskia Andreas, Oliver Werz and Thomas Kamradt Tags: Research article Source Type: research

Hyaluronic acid synthesis, degradation, and crosslinking in equine osteoarthritis: TNF- α-TSG-6-mediated HC-HA formation
TNF- α-stimulated gene 6 (TSG-6) protein, a TNF-α-responsive hyaladherin, possesses enzymatic activity that can catalyze covalent crosslinks of the polysaccharide hyaluronic acid (HA) to another protein to form... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 20, 2021 Category: Rheumatology Authors: Diana C. Fasanello, Jin Su, Siyu Deng, Rose Yin, Marshall J. Colville, Joshua M. Berenson, Carolyn M. Kelly, Heather Freer, Alicia Rollins, Bettina Wagner, Felipe Rivas, Adam R. Hall, Elaheh Rahbar, Paul L. DeAngelis, Matthew J. Paszek and Heidi L. Reesin Tags: Research article Source Type: research

Mediterranean diet in axial spondyloarthritis: an observational study in an Italian monocentric cohort
This study evaluated the impact of a 6-month nutritional advice based on the Mediterranean diet on ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 20, 2021 Category: Rheumatology Authors: Francesca Ometto, Augusta Ortolan, Davide Farber, Mariagrazia Lorenzin, Giulia Dellamaria, Giacomo Cozzi, Marta Favero, Romina Valentini, Andrea Doria and Roberta Ramonda Tags: Research article Source Type: research

S100A8/A9 is not essential for the development of inflammation and joint pathology in interleukin-1 receptor antagonist knockout mice
Excessive osteoclast activity, which is strongly stimulated by pro-inflammatory mediators, results in bone and cartilage degeneration as central features of many arthritides. Levels of the alarmin S100A8/A9 an... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 19, 2021 Category: Rheumatology Authors: Irene Di Ceglie, Peter L. E. M. van Lent, Edwin J. W. Geven, Marije I. Koenders, Arjen B. Blom, Thomas Vogl, Johannes Roth and Martijn H. J. van den Bosch Tags: Research article Source Type: research

Diagnosis of early stage knee osteoarthritis based on early clinical course: data from the CHECK cohort
Early diagnosis of knee osteoarthritis (OA) is important in managing this disease, but such an early diagnostic tool is still lacking in clinical practice. The purpose of this study was to develop diagnostic m... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 19, 2021 Category: Rheumatology Authors: Qiuke Wang, Jos Runhaar, Margreet Kloppenburg, Maarten Boers, Johannes W. J. Bijlsma and Sita M. A. Bierma-Zeinstra Tags: Research article Source Type: research

Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants
Failing of intrinsic chondrocyte repair after mechanical stress is known as one of the most important initiators of osteoarthritis. Nonetheless, insight into these early mechano-pathophysiological processes in... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - August 16, 2021 Category: Rheumatology Authors: Evelyn Houtman, Margo Tuerlings, Janne Riechelman, Eka H. E. D. Suchiman, Robert J. P. van der Wal, Rob G. H. H. Nelissen, Hailiang Mei, Yolande F. M. Ramos, Rodrigo Coutinho de Almeida and Ingrid Meulenbelt Tags: Research article Source Type: research