Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms.

CONCLUSIONS: These results support the potential of HT as a chondroprotective nutraceutical compound against OA, not merely for its antioxidant ability, but as an autophagy and SIRT-1 inducer as well.
GENERAL SIGNIFICANCE: HT may exert a cytoprotective action by promoting autophagy in cell types that may be damaged in degenerative diseases by oxidative and other stress stimuli.
PMID: 26947008 [PubMed - as supplied by publisher]

Source: Biochimica et Biophysica Acta - March 3, 2016 Category: Biochemistry Authors: Cetrullo S, D'Adamo S, Guidotti S, Borzì RM, Flamigni F Tags: Biochim Biophys Acta Source Type: research