Recent Progress in the Application of Tau Protein Biosensors for Diagnosis of Neurodegenerative Diseases
Appl Biochem Biotechnol. 2024 May 2. doi: 10.1007/s12010-024-04960-0. Online ahead of print.ABSTRACTThe microtubule-associated Tau protein is found in the central nervous system (CNS) in six major isoforms. Neurodegenerative diseases have been linked to post-translational changes of Tau, most notably phosphorylation. Tau protein's molecular diversity is highly helpful in the identification of neurodegenerative illnesses. Nonetheless, one major obstacle to the early detection of brain illness is the nanoscale identification of tau proteins. The standard methods for identifying tau protein include western blotting, polymeras...
Source: Applied Biochemistry and Biotechnology - May 2, 2024 Category: Biochemistry Authors: Sophia Nazir Rabail Azhar Iqbal Source Type: research
The possible causal relationship between COVID-19 and imaging markers of cerebral small vessel disease: a Mendelian randomization study
This study aims to explore the causal correlation between COVID-19 and the imaging markers of CSVD using Mendelian randomization (MR) methods.METHODS: Summary-level genome-wide association study (GWAS) statistics for COVID-19 susceptibility, hospitalization, and severity were utilized as proxies for exposure. Large-scale meta-analysis GWAS data on three neuroimaging markers of white matter hyperintensity, lacunar stroke, and brain microbleeds, were employed as outcomes. Our primary MR analysis employed the inverse variance weighted (IVW) approach, supplemented by MR-Egger, weighted median, and MR-PRESSO methods. We also co...
Source: Neurological Research - May 2, 2024 Category: Neurology Authors: Jiahao Song Da Zhou Lina Jia Mengqi Wang Duo Lan Jingrun Li Fatime Zara Hassan Hamit Yuchuan Ding Xunming Ji Ran Meng Source Type: research
Predictions and errors are distinctly represented across V1 layers
Curr Biol. 2024 Apr 25:S0960-9822(24)00476-7. doi: 10.1016/j.cub.2024.04.036. Online ahead of print.ABSTRACTPopular accounts of mind and brain propose that the brain continuously forms predictions about future sensory inputs and combines predictions with inputs to determine what we perceive.1,2,3,4,5,6 Under "predictive processing" schemes, such integration is supported by the hierarchical organization of the cortex, whereby feedback connections communicate predictions from higher-level deep layers to agranular (superficial and deep) lower-level layers.7,8,9,10 Predictions are compared with input to compute the "prediction...
Source: Current Biology - May 2, 2024 Category: Biology Authors: Emily R Thomas Joost Haarsma Jessica Nicholson Daniel Yon Peter Kok Clare Press Source Type: research
Translation feedback control in the brain
Nat Rev Mol Cell Biol. 2024 May 2. doi: 10.1038/s41580-024-00741-z. Online ahead of print.NO ABSTRACTPMID:38698077 | DOI:10.1038/s41580-024-00741-z (Source: Mol Biol Cell)
Source: Mol Biol Cell - May 2, 2024 Category: Molecular Biology Authors: Stephanie L Moon Source Type: research
Active Donor Management Goals in Serial Donors After Brain Death
CONCLUSIONS: Our data strongly suggested that a strict hemodynamic monitoring schedule allows the achievement of donor goals both in older and in younger brain death donors. We confirmed our previous findings that hemodynamic management in brain death donors is influenced by age. A strict hemodynamic monitoring schedule of brain death donors is useful to consistently achieve donor goals.PMID:38695586 | DOI:10.6002/ect.2024.0030 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - May 2, 2024 Category: Transplant Surgery Authors: Manuela Bonizzoli Chiara Lazzeri Simona Di Valvasone Stefano Batacchi Cristiana Guetti Alessandra Ottaviano Adriano Peris Source Type: research
Optimization of Epigenetic Modifier Drug Combination for Synergistic Effect against Glioblastoma Multiform Cancer Cell Lines
Cancer Invest. 2024 May 2:1-14. doi: 10.1080/07357907.2024.2345183. Online ahead of print.ABSTRACTGlioblastoma multiforme (GBM), is a frequent class of malignant brain tumors. Epigenetic therapy, especially with synergistic combinations is highly paid attention for aggressive solid tumors like GBM. Here, RSM optimization has been used to increase the efficient arrest of U87 and U251 cell lines due to synergistic effects. Cell lines were treated with SAHA, 5-Azacytidine, GSK-126, and PTC-209 individually and then RSM was used to find most effective combinations. Results showed that optimized combinations significantly reduc...
Source: Cancer Investigation - May 2, 2024 Category: Cancer & Oncology Authors: Morvarid Soleiman Mehrnoosh Fathi-Roudsari Khosro Khajeh Amir Maghsoudi Source Type: research
Decompressive craniectomy surgery in a dog with intracranial extradural hematoma following blunt force trauma
This report describes the diagnosis and surgical management of an intracranial extradural hematoma in a dog with increased intracranial pressure refractory to medical management. Furthermore, this report describes the diagnostic imaging findings used to diagnose this particular form of primary brain injury.PMID:38694740 | PMC:PMC11017925 (Source: The Canadian Veterinary Journal)
Source: The Canadian Veterinary Journal - May 2, 2024 Category: Veterinary Research Authors: Ciaran C O'Carroll Bryan T Welch Meagan A Walker Adam T Ogilvie Lorrie Gaschen Katie L Hoddinott Source Type: research
Emotion regulation across psychiatric disorders
CNS Spectr. 2024 May 2:1-15. doi: 10.1017/S1092852924000270. Online ahead of print.NO ABSTRACTPMID:38695189 | DOI:10.1017/S1092852924000270 (Source: CNS Spectrums)
Source: CNS Spectrums - May 2, 2024 Category: Neurology Authors: Ibrahim H Aslan Lucy Dorey Jon E Grant Samuel R Chamberlain Source Type: research
Virtual dynamic interaction games reveal impaired multisensory integration in women with migraine
CONCLUSION: The virtual dynamic game approach showed for the first time that the gaming performance of patients with migraine without aura was negatively affected by the addition of auditory, verbal, and haptic stimuli onto visual stimuli. Multisensory integration of sensory modalities including haptic stimuli is disturbed even in the interictal period in women with migraine. Virtual games can be employed to assess the impact of sensory problems in the course of the disease. Also, sensory training could be a potential therapy target to improve multisensory processing in migraine.PMID:38693749 | DOI:10.1111/head.14720 (Source: Headache)
Source: Headache - May 2, 2024 Category: Neurology Authors: Merve S Ince Ilkem Guzel Merve C Akgor Meltem Bahcelioglu Kutluk B Arikan Amr Okasha Sabahat Sengezer Hayrunnisa Bolay Source Type: research
Neuroticism and relationship quality: A meta-analytic review
J Pers Soc Psychol. 2024 May 2. doi: 10.1037/pspi0000463. Online ahead of print.ABSTRACTRegardless of participant age, length of relationship, country of origin, and numerous other factors, prior research has established a robust negative association between neuroticism and relationship quality. As so much has already been studied on the topic of neuroticism and relationship quality, this study explored the association between neuroticism and relationship quality using meta-analytic methodology, examined moderators, and outlined future studies for the field. After searching through databases and the references of included ...
Source: Journal of Personality and Social Psychology - May 2, 2024 Category: Psychiatry & Psychology Authors: Charlotte R Esplin Benjamin D Rasmussen Stephen G Hatch Alan J Hawkins Scott R Braithwaite Source Type: research
From islet transplantation to beta-cell regeneration: an update on beta-cell-based therapeutic approaches in type 1 diabetes
Expert Rev Endocrinol Metab. 2024 May 1:1-11. doi: 10.1080/17446651.2024.2347263. Online ahead of print.ABSTRACTINTRODUCTION: Type 1 diabetes (T1D) mellitus is an autoimmune disease in which immune cells, predominantly effector T cells, destroy insulin-secreting beta-cells. Beta-cell destruction led to various consequences ranging from retinopathy and nephropathy to neuropathy. Different strategies have been developed to achieve normoglycemia, including exogenous glucose compensation, whole pancreas transplantation, islet transplantation, and beta-cell replacement.AREAS COVERED: The last two decades of experience have show...
Source: Expert Review of Endocrinology and Metabolism - May 2, 2024 Category: Endocrinology Authors: Asef Azad Hasan Ali Altunbas Ayse Esra Manguoglu Source Type: research
Comparing Neuromuscular Blockade Measurement Between Upper Arm (TOF Cuff ®) and Eyelid (TOF Scan®) Using Mivacurium during General Anesthesia
CONCLUSIONS When measurement on the limb is not possible, TOF-Scan on the eyelid can be an alternative for TOF-Cuff on the upper arm, if the time to relaxation is multiplied by at least 8, which is enough for 90% of patients.PMID:38693676 | DOI:10.12659/MSM.943630 (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 2, 2024 Category: Research Authors: Pawe ł Radkowski Jakub Ru ść Mariusz K ęska Klaudia Sztaba Source Type: research
Fibrocartilaginous embolism: a rare cause of cervical spine infarction
CONCLUSION: When a practitioner suspects that a patient may have fibrocartilaginous embolism (FCE), they should take the patient's history and do a neurological examination. An MRI is required since it is thought to be the most accurate method of diagnosing FCE.PMID:38694385 | PMC:PMC11060198 | DOI:10.1097/MS9.0000000000002005 (Source: Hand Surgery)
Source: Hand Surgery - May 2, 2024 Category: Surgery Authors: Widad Abu Mayyala Nawras Abu Aqeel Afnan W M Jobran Farah Shaheen Mohammed Abdulrazzak Yousef Alhroub Source Type: research
Management of Seizures and Epilepsy in patients with Autoimmune Encephalitis
Can J Neurol Sci. 2024 May 2:1-2. doi: 10.1017/cjn.2024.63. Online ahead of print.NO ABSTRACTPMID:38695146 | DOI:10.1017/cjn.2024.63 (Source: The Canadian Journal of Neurological Sciences)
Source: The Canadian Journal of Neurological Sciences - May 2, 2024 Category: Neurology Authors: Jorge G Burneo Source Type: research
Fear, defense, and emotion: A neuroethological understanding of the negative valence research domain criteria
We describe the close correspondence between predatory imminence continuum theory (PICT) and the National Institute of Mental Health's Research Domain Criteria (RDoC) for negative valence. RDoC's negative valence constructs relate aversively motivated behavioral reactions to various levels of threat. PICT divides defensive responses into distinct modes that vary along a continuum of the psychological closeness of predatory threat. While there is a close correspondence between PICT modes and negative valence threat constructs, based on PICT, we describe some potential elaborations of RDoC constructs. Both have consonant vie...
Source: The American Psychologist - May 2, 2024 Category: Psychiatry & Psychology Authors: Michael S Fanselow Ann N Hoffman Source Type: research
